JCI - Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. Kylie M. Quinn,1 Daniel E. Zak ... Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates. J ... Vaccines that induce robust and durable CD8 T cells will be critical for preventative and therapeutic vaccines against a range ... A novel chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines. Vaccine. 2009;27(9):1293-1300.. View ...https://www.jci.org/articles/view/78280
Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing
... ... and replace the use of animals for human and veterinary vaccine post-licensing potency and safety testing. The workshop was ... and replace the use of animals for vaccine potency and safety testing. However, these tests still account for the largest ... and replace the use of animals in vaccine potency and safety testing, and discuss ways to promote their implementation ...https://ntp.niehs.nih.gov/pubhealth/evalatm/3rs-meetings/past-meetings/vaccine-wksp-2010/index.html
Sleep Affects Potency of Vaccines | UC San Francisco
Society Scholar at UCSF and UC Berkeley shows that poor sleep can reduce the effectiveness of vaccines. ... Sleep Affects Potency of Vaccines. Study Raises Awareness of Connection Between Sleep and Health ... The study is the first performed outside a sleep laboratory to show that sleep duration is directly tied to vaccine immune ... Antibody levels were measured prior to the second and third vaccine injection and six months after the final vaccination to ...https://www.ucsf.edu/news/2012/08/12458/sleep-affects-potency-vaccines?topic=616
Sweet Remedy: Scientists Say Delay Breastfeeding to 'Improve' Vaccine Potency
Labels: Bill and Melinda Gates Foundation, breast milk, efficacy of vaccines, eugenics, UN, vaccine potency ... The authors state that the immune-boosting effects of breast milk could negatively affect the vaccine potency. Of course the ... In fact, a weakened immune system is just what the scientists are looking for to increase the potency and 'effectiveness' of ... scientists say that breastfeeding should be halted to improve vaccine effects (which include negative effects).. The advisory ...http://sweetremedyfilm.blogspot.com/2012/01/scientists-say-delay-breastfeeding-to.html
Nasal swine flu vaccine recalled over potency
AP) -- Drugmaker Medimmune is recalling nearly 5 million doses of swine flu vaccine because the nasal spray appears to lose ... Nasal swine flu vaccine recalled over potency. December 22, 2009 (AP) -- Drugmaker Medimmune is recalling nearly 5 million ... Agency officials say the vaccine met potency specifications when it was distributed in October and November. ... Last week, another vaccine maker recalled swine flu shots for children because tests indicated those doses lost some strength. ...https://medicalxpress.com/news/2009-12-nasal-swine-flu-vaccine-recalled.html
Development of a flow cytometric bead immunoassay and its assessment as a possible aid to potency evaluation of enterotoxaemia...
The vaccine is prepared by deriving a toxoid from the bacterial culture filtrate and the potency of the vaccine is tested with ... The potency of C. perfringens type D vaccines is measured in terms of their ability to induce antitoxins against the epsilon ... Of the two in vitro assays, the I-ELISA could discriminate differences in the potency of the vaccines to a greater extent than ... Levings, R.L., Henderson, L.M. & Metz, C.A., 1993, 'In vitro potency assays for nonreplicating veterinary vaccines: Comparison ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282014000100008&lang=en
Improved potency assay of rubella vaccine: parameters for plaq...
Parameters for plaque formation by rubella vaccine strains licensed in Japan were s ... Improved potency assay of rubella vaccine: parameters for plaque formation.: ... Improved potency assay of rubella vaccine: parameters for plaque formation.. Authors * Umino, Y ... The number of plaques formed by vaccine strains decreased at 37 degrees C. Vaccine strains other than MEQ11 and TCRB19 formed ...https://www.mysciencework.com/publication/show/improved-potency-assay-rubella-vaccine-parameters-plaque-formation-b517c9b1
Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with foot-and-mouth disease virus of O...
However, in sheep the recommended vaccine dose is half of the cattle dose (1 ml) and most vaccines have not been potency tested ... Potency tests for commercial oil-adjuvanted foot-and-mouth disease (FMD) vaccines are usually carried out in cattle, using a ... To determine the efficacy of a high potency (,6PD50) FMD virus (FMDV) O1Manisa vaccine in sheep, we carried out a study using a ... Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with foot-and-mouth disease virus of O/ ...https://repository.up.ac.za/handle/2263/62149
Assessment of in vitro potency of inactivated Newcastle disease oil adjuvanted vaccines using hemagglutination test and...
... oil-adjuvanted vaccines using hemagglutination test (HA) and blocking ELISA (B-ELISA) based on polyclonal antibodies ... The present study was aimed to establish a protocol for the evaluation of the in vitro potency of commercial inactivated ... Minor, P. (2015) Assaying the potency of influenza vaccines. Vaccines, 3: 90-104. [Crossref] [PubMed] [PMC] ... Keywords: blocking ELISA, inactivated vaccines, in vitro, Newcastle disease virus, vaccine potency. ...http://www.veterinaryworld.org/Vol.11/September-2018/4.html
Low Density Microarrays for Vaccine Related Protein Quanitification, Potency Determination and Efficacy Evaluation - Patent...
... determination of influenza vaccine potency would streamline vaccine production by reduction of "wait time" for new reference ... Quantification of Influenza HA Using Universal Capture Agent(s) for Influenza Vaccine Potency Determination  As ... Quantification of Influenza HA Using Strain-Specific Capture Antibodies for Influenza Vaccine Potency Determination  In ... 0046] This ratio may be a more direct measurement of vaccine potency, as a theoretical quantitative value can be determined ...http://www.patentsencyclopedia.com/app/20120316079
Evaluation of Whole Cell Vaccine-induced humoral antibody responses in the Pertussis Serological Potency Test in relation to...
Evaluation of Whole Cell Vaccine-induced humoral antibody responses in the Pertussis Serological Potency Test in relation to ... Evaluation of Whole Cell Vaccine-induced humoral antibody responses in the Pertussis Serological Potency Test in relation to ... Evaluation of Whole Cell Vaccine-induced humoral antibody responses in the Pertussis Serological Potency Test in relation to ... The Pertussis Serological Potency Test (PSPT) has been developed as an alternative for the current MPT. The PSPT is based on in ...https://rivm.openrepository.com/rivm/handle/10029/10208
Lyophilization USA : Pharmaceuticals : North America
Can controlled nucleation impart consistency whilst maintaining vaccine potency?. *Impact on cycle time, consistency and ... In his career to date, Tim has worked with small molecules, vaccines and proteins in both aqueous and co solvent systems. Tim ... In his career to date, Tim has worked with small molecules, vaccines and proteins in both aqueous and co solvent systems. Tim ... In his career to date, Tim has worked with small molecules, vaccines and proteins in both aqueous and co solvent systems. Tim ...http://www.smi-online.co.uk/pharmaceuticals/northamerica/conference/Lyophilisation-USA?o=login&dl=cc&p1=5324&p2=892
Vaccines | Free Full-Text | Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene...
While skin electroporation offers an exciting and novel future methodology for the delivery of DNA vaccines in the clinic, ... Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 2004, 22, 2489-2493. [Google Scholar] [ ... Vaccine 2008, 26, 5073-5074. [Google Scholar] [CrossRef]. *Donnelly, J.J.; Ulmer, J.B.; Liu, M.A. DNA vaccines. Life Sci. 1997 ... Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ ...http://mdpi.com/2076-393X/1/3/384/htm
Novel organic metal hybrids that will revolutionize materials science and chemical e... ( A novel class of hybrid materials ma...
Novel molecules developed at UB can boost vaccine potency. 6. Novel small molecule therapy shows benefit for anemic patients ... Novel vaccine concept developed by scientists at the Wistar Institute. 8. Tibotec Pharmaceuticals a Respectful Partner to HIV ...http://www.bio-medicine.org/medicine-news-1/Novel-organic-metal-hybrids-that-will-revolutionize-materials-science-and-chemical-engineering-12133-1/
Library System/Howard University
Enhancement of protein vaccine potency by in vivo electroporation mediated intramuscular injection. Vaccine, In Press, ...http://www.howard.edu/apps/keyword/huauthors.cfm?yearrange2=0&bysubject=Display%20Publications&department=Dentistry&bylastletter=&oneyear=0&yearrange1=0&yeartype=All&format=&letteroflastname=&Page=12
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. ... Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. ... Here, we assessed the mechanisms that control the potency of CD8 T cell responses in murine models following vaccination with ... Recombinant adenoviral vectors (rAds) are lead vaccine candidates for protection against a variety of pathogens, including ...https://www.jci.org/125/3
Mucosal vaccination--an old but still vital strategy. - Semantic Scholar
Particular attention was focused on the mode of simple but efficacious delivery of vaccine antigens to mucosal surfaces. A few ... trials to generate potential mucosal vaccines against toxoplasmosis introduced by nasal or oral routes to experimental animals ... The basic premise of vaccinology is to achieve strong protective immunity against defined infectious agents by a vaccine ... Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells. *Ali Azizi, Ashok Kumar, Francisco Diaz-Mitoma, Jiri Mestecky ...https://www.semanticscholar.org/paper/Mucosal-vaccination-an-old-but-still-vital-strateg-D%C5%82ugo%C5%84ska-Grzybowski/8e18c643c9d709a16b78d069b8561b9a0758345a
WHO | World Health Organization
... and the development and availability of vaccine potency reagents.. Selection of vaccine viruses *Vaccine virus selection has ... Vaccine potency reagents. *Reference antigen and sheep antisera are developed by ERLs in collaboration with vaccine ... Candidate vaccine viruses and potency testing reagents for use in specific influenza seasons. For the southern hemisphere 2018 ... Zoonotic influenza candidate vaccine viruses and potency testing reagents. * Influenza A(H5N1) ...http://who.int/influenza/vaccines/virus/en/
Toxins | Free Full-Text | Vaccines against Botulism | HTML
However, this formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was losing potency and was discontinued. This article ... These vaccines include DNA-based, viral vector-based, and recombinant protein-based vaccines. DNA-based vaccines include ... There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational ... Among the potential recombinant protein vaccines reviewed are HC, light chain-heavy chain translocation domain, and chemically ...http://www.mdpi.com/2072-6651/9/9/268/htm
Potency assays for novel T-cell-inducing vaccines against malaria. - Northumbria Research Link
Potency assays for novel T-cell-inducing vaccines against malaria. Current Opinion in Molecular Therapeutics, 11 (1). pp. 72-80 ... Therefore, traditional potency assays, such as the highly sensitive ex vivo and cultured ELISPOT, are being complemented by ... Induction of cytotoxic T-cells or those producing IFNgamma has become a major goal for T-cell-inducing vaccines, and the liver ... T-cells can effectively be primed by several vaccine strategies, including recombinant vectors. A wide range of such vectors is ...http://nrl.northumbria.ac.uk/205/
IAC Express: Issue 1128
... vaccine recommendations, and vaccination resources from ACIP, CDC, FDA, WHO, and more. ... Proper storage and handling help ensure vaccine potency and safety. Vaccines are fragile, and storage and handling errors are ... IAC recently posted the following new Vaccine Information Statement (VIS) translations. *Td Vaccine VIS (released 2/4/2014) in ... Updates on page 2 include facts related to new influenza vaccine products such as the recombinant influenza vaccine, and ...http://www.immunize.org/express/issue1128.asp
Judicial Watch tears into Gardasil... | Scarleteen
... the vaccine's potency significantly declines. The long-term value of the vaccine has yet to be determined; if it wears off ... Any time you ask your immune system to work a little harder (which is what all vaccines do), you do run a risk of having a ... There is no attempt on the part of ANYBODY to try to determine any kind of actual correlation or CAUSALITY between the vaccine ... The most controversial point about Gardasil is it is a vaccine against a sexually-transmitted virus, and it is supposed to be ...http://www.scarleteen.com/blog/susie/2007/10/11/judicial_watch_tears_into_gardasil?page=5
Table of Contents - May 01, 2001, 166 (9) | The Journal of Immunology
Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen Chien-Fu Hung, Wen- ... Prime-Boost Immunization with DNA Vaccine: Mucosal Route of Administration Changes the Rules Seong Kug Eo, Malgorzata Gierynska ... Flanking Spacers and Enhanced Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine ...http://www.jimmunol.org/content/166/9
Marcus W. Bosenberg, MD, PhD > Yale Cancer Center | Yale School of...
Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology. 2014 Nov; 2014 Dec 15 ...http://yalecancercenter.org/patient/programs/melanoma/members/marcus_bosenberg-2.profile
Cold chain legal definition of Cold chain
Live viral vaccine potency: an index for assessing the cold chain system.. Yellow Fever Vaccine ... FAO and MLFI have been working hard to re-establish the central cold chain in order to get the vaccines to all parts of South ...http://legal-dictionary.thefreedictionary.com/Cold+chain