Identification and functional characterization of protein domains in the transcription factor TWIST Saethre-Chotzen syndrome is ... TWIST belongs to class B bHLH proteins which are known to form stable heterodimers with members of class A bHLH transcription ... The Ustilago maydis forkhead transcription factor Fox1 is involved in the regulation of genes required for the attenuation of ... This gene encodes for a bHLH transcription factor, which inhibits osteogenic differentiation by transcriptional control of ...

The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist. ... we identify the Hox transcription factor Ultrabithorax (Ubx) to be critical for the repression of the master regulator Twist. ... The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal ... function experiments using CRISPR-Cas9 and overexpression studies demonstrate that Ubx majorly impacts twist transcription. A ...

Twist transcription factor has been shown to interact with EP300, TCF3 and PCAF. Transcription factor TWIST2 GRCh38: Ensembl ... The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, ... Martin TA, Goyal A, Watkins G, Jiang WG (Jun 2005). "Expression of the transcription factors snail, slug, and twist and their ... GeneReviews/NCBI.NIH.UW entry on Saethre-Chotzen syndrome Twist+transcription+factor at the U.S. National Library of Medicine ...

twist family bHLH transcription factor 2. acts_upstream_of_or_within. ISO. MGI:3044412 (MGI:3831587,PMID:19090621). RGD. PMID: ... MAF bZIP transcription factor B. involved_in. ISO. (PMID:8620536). RGD. PMID:8620536. NCBI chr 3:148,998,111...149,000,031 ... KLF transcription factor 13. involved_in. ISO. (MGI:3796470,PMID:18285334). RGD. PMID:18285334. MGI:3796470. NCBI chr 1: ... RUNX family transcription factor 1. involved_in. ISO. (PMID:9199349). RGD. PMID:9199349. NCBI chr11:31,839,880...32,074,427 ...

... twist family bHLH transcription factor 1, matrix metallopeptidase (MMP) 2 and MMP9 compared with those in the control group ( ... and twist family bHLH transcription factor 1 (TWIST1), which are two transcriptional inhibitors of CDH1 (16). PPs, especially ... twist family bHLH transcription factor 1; MMP, matrix metallopeptidase. ... Since EMT-inducing transcription factors promote cancer metastasis, the present study examined whether PPII inhibited bladder ...

The results showed that lncRNA SNHG3 and TWIST were highly expressed in GC cell lines, while miR-326 was expressed to a low ... In addition, TWIST overexpression can reverse the inhibition of lncRNA SNHG3 knockdown or miR-326 overexpression on cell ... In conclusion, lncRNA SNHG3 may promote GC progression through the miR-326/TWIST axis, which may provide a new diagnostic and ... Western blotting was performed to detect the protein levels of TWIST and EMT-related genes. Luciferase reporter gene analysis ...

TGF-β, IGF-II, FGF, and EGF signaling promote EMT by activating transcription factors such as Snail, Twist, and ZEB, and they ... the transcription factors (TWIST and SNAIL) expressions are enhanced, promoting α-tubulin detyrosination. This further promotes ... Snail (transcription factor) induces the expression of αvβ3- integrin, which is localized in the invading front of cancer and ... The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer ...

TWIST and several other transcription factors (FOXC2, E47 (TFC3), KLF8, and PRRX1) also induce EMT. Although it is still ... Saxena M, Stephens MA, Pathak H and Rangarajan A (2011) Transcription factors that mediate epithelial-mesenchymal transition ... Agents that can be used to target the EMT may include extracellular inducers of EMT, the transcription factors that orchestrate ... EMT is classically driven by transcriptional repressors commonly referred to as EMT transcription factors (EMT-TF) including ...

Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 1996 Jun 7;272(5267):1476-80. ... Moreover, the 5-CATCTG-3 E-box sequence included in this X-ray structure is a TWIST-responsive element [2][3]. Although the C ... Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G. A twist code ... Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nat Genet. 1997 Jan;15(1):42-6. PMID:8988167 doi:10.1038/ng0197-42 ...

Among the abnormalities identified was up-regulation of the TWIST-1 transcription factor, which was shown to promote ... TWIST-1 is involved in the p53 tumor suppressor pathway as an inhibitor. [25] Genetic analysis of 62 cases of choroid plexus ... Platelet-derived growth factor receptor expression and activation in choroid plexus tumors. Am J Pathol. 2009 Oct. 175(4):1631- ... TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Cancer Res. ...

The VF domain, defined by the expression of two transcription factors Twist and Snail, is rectangular (around 18 cells along d- ... Leptin, M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 5, 1568-1576 ... a, bottom) The VF domain (green) consists of a ventral rectangle defined by the expression pattern of Twist and Snail. (b, top ... 1) We made the contracting VF domain less rectangular by extending the expression of Twist and Snail around the embryo ...

A group of embryonic EMT-inducing transcription factors, including Twist, Snail and Slug, are induced in carcinoma cells to ... These transcription factors mainly function during embryogenesis, and they are mostly silent in normal adult tissues. Since ... cells directly from fibroblasts by retroviral overexpression of the transcription factors Oct4, Sox2, c-myc and Klf4. In ... In this study, I propose to use the promoters of Twist, Snail and Slug to drive the expression of a novel EMT detection/ ...

... results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors ... Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/betacatenin ...

Among these transcription factors, we found that Twist was important. Four potential Twist protein binding sites, separately ... Twist is reportedly a main transcription factor associated with the EMT progress [23]. First, we used Patch software to ... The transcription factor Twist, a master regulator of embryonic morphogenesis, is closely related to many kinds of cancers and ... As a main VM-related proteins, twist is a member of the basic helix-loop-helix (bHLH) transcription factor family and ...

E.-J. Tan, S. Thuault, L. Caja, T. Carletti, C.-H. Heldin, and A. Moustakas, "Regulation of transcription factor twist ... HMGB1 interacts differentially with members of the REL family of transcription factors (RELA/P65, c-REL, RELB, P50/NF-κB1, and ... In the nucleus, HMGB proteins interact with a number of transcription factors, among them tumour suppressors like P53 [51-53] ... The transcription factor NRF2 in healthy cells senses the redox state and activates the expression of genes related to ...

It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist and Prrx, all activated by TGF-β ... Several recent studies have highlighted the involvement of splicing factors, including epitheli... ...

Martin TA, Goyal A, Watkins G and Jiang WG: Expression of the transcription factors snail, slug, and twist and their clinical ... Studies have shown that several transcription factors, including the Snail/Slug family (3), δEF1/ZEB1 (4) and SIP1 (5) have ... We hypothesized that Snail, as a transcription factor, may promote breast cancer metastasis through the regulation of RhoA ... Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J Cell Sci. 118 ...

Chromosomal deletion or mutation within the TWIST1 (twist family bHLH transcription factor 1) gene at 7p21.1 is observed in ... Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the ...

... a basic helix-loop-helix transcription factor, exists in at least two isoforms called Twist 1 and Twist 2. Twist proteins ... the zinc finger transcription factors (ZEB), Transforming growth factor beta (TGF-β), Twist and Slug. ... The zinc finger transcription factors ZEB1 and ZEB2 also make a pivotal contribution to this regulation. TGF-β, a major inducer ... As a key component of the JAK/STAT pathway, Signal Transducer and Activator of Transcription, an important transcription ...

An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. ... Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial- ... evolutionarily conserved DNA architecture which determines target specificity of the TWIST family bHLH transcription factors ... Risk factors for early epithelial to mesenchymal transition in renal grafts.. American journal of transplantation : official ...

An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. ... Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial- ... evolutionarily conserved DNA architecture which determines target specificity of the TWIST family bHLH transcription factors ... Insulin-like growth factor binding protein-related protein 1 is expressed in rheumatoid synovium and regulates synovial ...

... fibroblast transcription factor 1, which binds in the FSP1 promoter. Fibroblast transcription factor 1 also up-regulates Twist ... Twist is a basic helix-loop-helix transcription factor that was originally identified as a D. melanogaster EMT activator ( ... Both Twist and Goosecoid regulate FOXC2, which is a transcription factor of the FOX family of forkhead helix-turn-helix DNA- ... and increased production of the transcription factors such as Snail1 (Snail), Snail2 (Slug), Twist, EF1/ZEB1, SIP1/ZEB2, and/or ...

Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal ... Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal ... Journal Article] Risk factors of infectious complications after endobronchial ultrasound-guided transbronchial biopsy.2020. *. ... Journal Article] Feasibility of tissue re-biopsy in non-small cell lung cancers resistant to previous epidermal growth factor ...

Twist Transcription Factor Twist-Related Protein 1 E - Analytical, Diagnostic and Therapeutic Techniques and Equipment Changed ...

Twist Transcription Factor Twist-Related Protein 1 E - Analytical, Diagnostic and Therapeutic Techniques and Equipment Changed ...

Twist Transcription Factor Twist-Related Protein 1 E - Analytical, Diagnostic and Therapeutic Techniques and Equipment Changed ...

Twist Transcription Factor Twist-Related Protein 1 E - Analytical, Diagnostic and Therapeutic Techniques and Equipment Changed ...

twist family bHLH transcription factor 1 Transcription factor 559 0.397. 0.846. 0.34. 0.400. None 0.980. 149 0 2004. 2019. ... Transcription factor 2494 0.236. 0.962. 0.53. 0.600. None 0.936. 578 13 1991. 2020. ... vascular endothelial growth factor A Signaling 1899 0.266. 0.923. 2.4E-05. 0.400. None 0.976. 503 4 1994. 2020. ... transforming growth factor beta 1 Signaling 1558 0.287. 0.962. 3.7E-02. 0.400. None 0.982. 168 2 1994. 2020. ...

ACS3 , BPES2 , BPES3 , CRS , CRS1 , CSO , SCS , TWIST , bHLHa38. twist family bHLH transcription factor 1. 7p21.2. CV:GWASdb. ... transcription factor EC. 7q31.2. CV:PGCnp. 800. CALD1. CDM , H-CAD , HCAD , L-CAD , LCAD , NAG22. caldesmon 1. 7q33. CV:PGCnp. ... transcription factor 4. 18q21.1. CV:GWAScat. CV:GWASdb. CV:PGC128. CV:PGCnp. Expression. PMID:cooccur. CompositeSet. Darnell ... ELK3, ETS transcription factor. 12q23. CV:PGCnp. DMG:Jaffe_2016. PMID:cooccur. ...

twist homolog 2 (Drosophila) IDBP-812219 twist family bHLH transcription factor 2 ... The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, ... Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. ... Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a ...