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*  Expression analysis of candidate breast tumour suppressor genes on chromosome 16q | Breast Cancer Research | Full Text
An opposing view on WWOX protein function as a tumor suppressor. Cancer Res. 2003, 63: 8629-8633.PubMedGoogle Scholar. ... Mao JH, Perez-losada J, Wu D, DelRosario R, Tsunematsu R, Nakayama K, Brown K, Bryson S, Balmain A: Fbxw7/Cdc4 is a p53- ... Berx G, Cleton-Jansen AM, Nollet F, De Leeuw WJ, d van V, Cornelisse C, Van Roy F: E-cadherin is a tumour/invasion suppressor ... Indeed, the selection of candidate tumour suppressor genes in previous studies is driven by the exact location of a gene in the ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1337
*  Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine | Genome Biology |...
... encoding tumor protein p53), were always subclonal, and thus probably involved in ccRCC progression. Selection for mutations in ... In fact, inactivating mutations in the Von Hippel-Lindau tumor suppressor gene and loss of heterozygosity at chromosome 3p were ... Tumor A shows a linear evolution pattern; tumors B and C display a branched pattern. Single snapshots of Tumors B and C may ... Branched tumor evolution has been found in many tumor types, including breast [12], ovarian [13], prostate [14], pancreatic [15 ...
  https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0453-8
*  Frontiers | DNA Damage Response and Immune Defense: Links and Mechanisms | Genetics
... is a tumor-suppressive mechanism arresting cells at risk for malignant transformation mediated by the tumor suppressor p53 upon ... Initiation and maintenance of cytokine signaling required the DDR proteins ATM, NBS1, and CHK2 but was independent of p53 ( ... Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumour suppressor. ... For instance, oxidative DNA damage occurring in tumor-suppressor genes, oncogenes and key regulators of cell proliferation can ...
  https://www.frontiersin.org/articles/10.3389/fgene.2016.00147/full
*  Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein |...
... the biology of the PIDDosome multiprotein complex and recent advances that link PIDDosome-dependent CASP2 activation to p53 ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ...
  http://jcs.biologists.org/content/early/2016/05/12/jcs.184846
*  "P38 Phoshporylates RB On SER567 By A Novel, Cell Cycle-Independent Mec" by Rachel Delston
... and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. ... The stress-regulated mitogen activated protein kinase: MAPK) p38 also phosphorylates Rb, but it does so in a cell cycle- ... The retinoblastoma protein: Rb) inhibits both cell division and apoptosis, but the mechanism by which Rb alternatively ... and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. ...
  https://openscholarship.wustl.edu/etd/86/
*  Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 | Springer for Research & Development
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations ... on the tetrameric structure of tumor suppressor protein p53, which plays ... and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53 ... Quantitative Analysis for p53 Tetramerization Domain Mutants Reveals a Low Threshold for Tumor Suppressor Inactivation ...
  https://rd.springer.com/book/10.1007/978-4-431-54135-6
*  481044: p53 Tumor Suppressor Gene Protein,... | LabCorp
Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst. ... p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block. TEST: 481044 Test number copied ... Alterations of the p53 tumor suppressor gene have been shown to serve as an independent prognostic marker in a wide variety of ... Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J ...
  https://www.labcorp.com/test-menu/32621/p53-tumor-suppressor-gene-protein-immunohistochemical-paraffin-block
*  DNA and p53 Tumor Suppressor Protein - Stock Image - G200/0097 - Science Photo Library
Protein p53 is an important checkpoint in the cell cycle, ensuring the integrity of DNA replication. ... Shown here are the DNA-binding regions of the p53 tumor suppressor protein, bound to DNA. ... Shown here are the DNA-binding regions of the p53 tumor suppressor protein, bound to DNA. Protein p53 is an important ...
  https://www.sciencephoto.com/media/210735/view
*  Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of ... Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration. These ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
*  The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity - White Rose Research Online
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete ... The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity ... 5 more authors) (2006) The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity. EMBO ... which enables the protein to bind variably spaced DNA target sequences, essential for p53 transactivation and tumour suppressor ...
  http://eprints.whiterose.ac.uk/6065/
*  p53 Tumor Suppressor Protein Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone BP53-12 ] WB, IHC-P, IF, FC -...
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone BP53-12 ] validated in WB, IHC- ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide p53 Tumor Suppressor Protein Antibody - Without BSA and Azide. ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10775-p53-Tumor-Suppressor-Protein-Antibody-Without-BSA-and-Azide
*  p53 Tumor Suppressor Protein Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, FC, IP, E - Buy Now! ...
p53 Tumor Suppressor Protein Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, FC, IP, E ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide p53 Tumor Suppressor Protein Antibody - With BSA and Azide. Purified ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10154-p53-Antibody-Clone-DO-7
*  Apoptosis - Springer
Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival Rosi Bissinger, Elisabeth Lang, Irene ...
  https://link.springer.com/journal/10495
*  Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... tumor suppressor protein p53, phosphatase and tensin homolog (PTEN), p16INK4a gene, cytochrome c oxidase (CcO), phospholipid ... Molecular signatures associated with tumor aggressiveness as well as with disease progression and their relation to differences ... and 7 transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), vascular endothelial growth factor (VEGF), ... the most common primary brain tumor, has few available therapies providing significant improvement in survival. ...
  http://www.mdpi.com/2072-6694/5/3/1103/htm
*  Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/72123/Sorafenib-With-Irinotecan-in-Metastatic-Colorectal-Cancer-mCRC-and-K-RAS-Mutation.html
*  A Study of OSI-906 and Irinotecan in Patients With Advanced Cancer With Expanded Cohorts of Patients With KRAS Mutant...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/70653/A-Study-of-OSI-906-and-Irinotecan-in-Patients-With-Advanced-Cancer.html
*  Duet TRS Used in Pulmonary Resections
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... The study goal is to collect blood samples from individuals at risk for lung cancer in order to identify protein markers for ...
  https://www.bioportfolio.com/resources/trial/70163/Duet-TRS-Used-in-Pulmonary-Resections.html
*  A Study of Bevacizumab Plus Carboplatin and Paclitaxel in Subjects With Advanced, Previously Untreated, Squamous Non-Small Cell...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine ... Influences the Sensitivity of Non-Small Cell Lung Cancer to Paclitaxel by Regulating NF-κB Pathway and Its Downstream Proteins. ...
  https://www.bioportfolio.com/resources/trial/107993/A-Study-of-Bevacizumab-Plus-Carboplatin-and-Paclitaxel-in-Subjects-With-Advanced.html
*  Soblidotin in Treating Patients With Progressive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Drugs used in chemotherapy such as soblidotin use different ways to stop tumor cells from dividing so they stop ... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Determine the objective tumor response rate and duration of response in patients with progressive locally advanced or ...
  https://www.bioportfolio.com/resources/trial/121591/Soblidotin-in-Treating-Patients-With-Progressive-Locally-Advanced-or-Metastatic-Non-Small.html
*  Oltipraz in the Prevention of Lung Cancer in People Who Smoke
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... The study goal is to collect blood samples from individuals at risk for lung cancer in order to identify protein markers for ... The immune checkpoint-blockade (ICB) tumor therapy has led to striking improvement of long-term survival for some lung cancer ...
  https://www.bioportfolio.com/resources/trial/124351/Oltipraz-in-the-Prevention-of-Lung-Cancer-in-People-Who-Smoke.html
*  Sonography After Thoracic Surgery (SATS)
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/63399/Sonography-After-Thoracic-Surgery-SATS.html
*  Cisplatin, Etoposide & Bevacizumab in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer
... work in different ways to stop tumor cells from div... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by ... the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein ... Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or deliver tumor-killing ... Giving chemotherapy with a monoclonal antibody may kill more tumor cells.. PURPOSE: This phase II trial is studying how well ...
  https://www.bioportfolio.com/resources/trial/120723/Cisplatin-Etoposide-Bevacizumab-in-Treating-Patients-With-Previously-Untreated-Extensive-Stage-Small.html
*  ZD0473 in Treating Patients With Progressive or Relapsed Non-Small Lung Cancer
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PUR... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. ...
  https://www.bioportfolio.com/resources/trial/123626/ZD0473-in-Treating-Patients-With-Progressive-or-Relapsed-Non-Small-Lung-Cancer.html
*  Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Angiostatin may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: This ... ... whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8... ...
  https://www.bioportfolio.com/resources/trial/120823/Captopril-in-Treating-Patients-With-Non-Small-Cell-Lung-Cancer-or-Limited.html
*  Evaluation of a New Anti-cancer Vaccine for Patients With Non-small Cell Lung Cancer, After Tumor Removal by Surgery
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Tumor-specific T Cells in Lung Cancer. Non-small cell lung cancer is characterized by aggressive growth and treatment ... Mixed-lineage leukemia protein 2 (MLL2 or KMT2D) is a histone methyltransferase whose mutation has been associated with a poor ...
  https://www.bioportfolio.com/resources/trial/62995/Evaluation-of-a-New-Anti-cancer-Vaccine-for-Patients-With-Non-small.html