Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function
... whereas tumor suppressor protein p53 impedes proliferation of cells with genomic damage. Whether there is a direct link between ... Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function J Biol Chem. 2006 Apr 14;281(15 ... Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes ... Knocking down p53 and ERalpha by small interfering RNA elicits opposite effects on p53-target gene expression and cell cycle ...
Recombinant Human Tumor suppressor p53-binding protein 1 (TP53BP1), partial - Cusabio
Purchase Recombinant Human Tumor suppressor p53-binding protein 1 (TP53BP1), partial. It is produced in Yeast. High purity. ... Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; Tumor ... Recombinant Human Tumor suppressor p53-binding protein 1 (TP53BP1), partial. Recombinant Human Tumor suppressor p53-binding ... 53 BP1; 53BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53-binding protein 1; p53BP1; TP53 BP1; TP53B_HUMAN ...
Stability of p53 protein is not necessary for its tumor suppressor effect
p53 is one of the most important tumor suppressor genes, and more than half of cancer patients carry mutations in the p53 gene. ... Stability of p53 protein is not necessary for its tumor suppressor effect. ... Stability of p53 protein is not necessary for its tumor suppressor effect. p53 is one of the most important tumor suppressor ... Stability of p53 protein is not necessary for its tumor suppressor effect. 3 years ago ...
Aflatoxin B1 - Wikipedia
us), National Center for Biotechnology Information (1998-01-01). The p53 tumor suppressor protein. National Center for ... These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... TA transversion at codon 249 of p53, a characteristic mutation seen with this toxin. Prevalence of hepatocellular carcinoma in ... "Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation". Liver International. 31 (4 ...
The activity of the p53 tumor suppressor protein and the c-Jun - DNA Ligase Inhibitors with Broad-Spectrum Activity
The activity of the p53 tumor suppressor protein and the c-Jun. The activity of the p53 tumor suppressor protein and the c-Jun ... GST-p53 was used at a concentration of 50 ng and GST-PIASx at 250 ng. p53 was recognized by immunoblotting by using an anti-p53 ... To further examine whether the SUMO ligase activity of PIAS proteins is BGJ398 enzyme inhibitor restricted to p53, we tested ... Fig.44translated p53 (translated 35S-labeled PIASx with GST-Ubc9, GST-p53 like a positive control, and GST as a negative ...
Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53
Tumor Suppressor Protein p53 * Superoxide Dismutase * superoxide dismutase 2 Grants and funding * P01 AG005119/AG/NIA NIH HHS/ ... Furthermore, because of the known interaction between SOD2 and p53 protein, this study seeks to clarify the impact that the ... Keywords: MnSOD; p53; RRID:AB_10618757; RRID:AB_10850321; RRID:AB_1840351; RRID:AB_2049199; RRID:AB_2256876; RRID:AB_476744; ... their potential role in the maintenance of the cellular redox homeostasis in the presence of changes of SOD2 and/or p53 protein ...
Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis - Fingerprint -...
The ART of Reproductive Medicine | OHSU
Porokeratosis: Background, Pathophysiology, Etiology
Overexpression of p53 tumor suppressor protein in porokeratosis. Arch Dermatol. 1994 Feb. 130(2):187-90. [QxMD MEDLINE Link]. ... Urano Y, Sasaki S, Ninomiya Y, Oura H, Arase S. Immunohistochemical detection of p53 tumor suppressor protein in porokeratosis ... p53 alterations in porokeratosis. J Cutan Pathol. 2003 Aug. 30(7):455-8. [QxMD MEDLINE Link]. ... Ninomiya Y, Urano Y, Yoshimoto K, Iwahana H, Sasaki S, Arase S. p53 gene mutation analysis in porokeratosis and porokeratosis- ...
Microreactor Array Device | Scientific Reports
... cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein ... The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion ... Some cancer patients produce autoantibodies against p53, a tumor suppressor protein18. These autoantibodies can be detected in ... A bitmap image rendered in fluorescently labeled p53 protein expressed in microreactors from plasmid DNA for the p53 gene is ...
Divya Ramalingam Iyer, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Tumor Suppressor Protein p53. 1. 2021. 2936. 0.100. Why? Cell Cycle Proteins. 1. 2022. 3467. 0.100. Why? ...
Biblio | Linus Pauling Institute | Oregon State University
Biblio | Page 4 | Linus Pauling Institute | Oregon State University
Tumor Suppressor Protein p53. Chimploy K, G Díaz D, Li Q, Carter O, Dashwood W-M, Mathews CK, Williams DE, Bailey GS, Dashwood ... Cell Line, Tumor. Chimploy K, G Díaz D, Li Q, Carter O, Dashwood W-M, Mathews CK, Williams DE, Bailey GS, Dashwood RH. 2009. ...
WTS database | WHO FCTC
Frontiers | Wildland fire, air pollution and cardiovascular health: is it time to focus on the microvasculature as a risk...
Pfaff, M. J., Mukhopadhyay, S., Hoofnagle, M., Chabasse, C., and Sarkar, R. (2018). Tumor suppressor protein p53 negatively ... oxidized low density protein, ox-LDL) (Jiang, 2016). An overactivation of tumor suppressor protein 53 (TP53) in the endothelium ... PM2.5 exposure can also slow down the process of autophagy and increase activity of the tumor suppressor gene p53 (TP53) in ... 2007). FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323. ...
Protein data bank archives 50,000th molecule | Scientific Computing World
The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego ( ... p53 tumor suppressor, a protein often implicated in cancer; anthrax toxin, the disease-causing protein made by anthrax; and ... Proteins, one of the main building blocks for living organisms, come in a variety of shapes, with the form of a protein ... The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego ( ...
Newswise Expert | Antonio Giordano, Sbarro Health Research Organization (SHRO)
Drug reactivates p53 tumor suppressor protein and increases chemotherapy effectiveness in potential glioblastoma breakthrough. ... Decoy Damaged DNA Discovers New Gene Repair Protein. A synthetic DNA structure was used as bait to capture nuclear proteins, ... demonstrating the importance of cell cycle proteins in the functioning of DNA tumor viruses. The transforming gene products of ... A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors.. 2023. ...
How Elephants Defend Against Cancer | National Institutes of Health (NIH)
TP53 codes for the protein p53, a crucial tumor suppressor that stops cells with damaged DNA from dividing. People have 2 ... Both are known p53-mediated responses to DNA damage. Cells obtained from people with Li-Fraumeni syndrome had significantly ... These results suggest that elephants may have evolved to resist cancer by triggering apoptosis through p53 to efficiently ...
VCV000133282.3 - ClinVar - NCBI
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution ... Protein change. - Other names. -. Canonical SPDI NC_000017.11:7675152:GGGCGGGGGTGTGG:GG. Functional consequence. -. Global ... This variant, c.448_459del, results in the deletion of 4 amino acid(s) of the TP53 protein (p.Thr150_Pro153del), but otherwise ... This variant, c.448_459del, results in the deletion of 4 amino acid(s) of the TP53 protein (p.Thr150_Pro153del), but otherwise ...
Mutant p53 as a novel target for cancer | MUTP53 Project | Results in brief | FP6 | CORDIS | European Commission
Mutations in the p53 tumour suppressor protein are among the most frequent genetic alterations found in cancer. Scientists in ... Mutant p53 as a novel target for cancer. Mutations in the p53 tumour suppressor protein are among the most frequent genetic ... p53 tumour suppressor activity by abrogating the gain of function or reactivating the wild type properties of the protein. To ... a p53 mutation detection array and small molecules that restore wild type function to mutant p53. Experimental work produced a ...
Targeting the ubiquitin-proteasome system and ubiquitin-like protein conjugation pathways for non-genotoxic therapy of cancer |...
The tumour suppressor p53 protein, ""the guardian of the genome"", has an overarching role in protecting the organism from ... The restoration of the impaired function of the single gene, p53, by disrupting the Mdm2- p53/Mdmx-p53 interactions, offers a ... cancer-related protein-protein interactions in the ubiquitin-proteasome system (UPS) and ubiquitin-like protein (UBL) ... The UPS and UBL proteins studied by us are: the oncogenic E3 ligase Mdm2, which regulates levels of p53, the deubiquitinating ...
Chemistry Tree - Search results
p53 tumour suppressor protein. jandh. 2014‑05‑08. Orville Samuel Privett (Info). UMN. Biochemistry. Vigyaanik. 2021‑10‑31. ... Theoretical Chemistry, Protein Bioinformatics, Computational Biology. srr10. 2015‑08‑25. Kyun-Il Rah (Info). McGill. Physical ... Chemistry, self-assembly, DNA nanotechnology, protein engineering. navakyan. 2020‑05‑19. Sandra Meija Avendano (Info). McGill. ... protein polymers, biomedical engineering, bioengineering, biophotonics, bioelectronics. aarat. 2020‑10‑23. Patanjali ...
Myles W. Jackson to Confront Questions of Genes, Patents, and Race in Debut IAS Public Lecture - Press Release | Institute for...
Tumor-suppressor protein dynamics determine if tissues survive radiation | ScienceDaily
A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 ... In vulnerable tissues, p53 levels go up and remain high, leading to cell death. In tissues that tend to survive radiation ... Scientists have known these differences involve the protein p53, a well-studied tumor-suppressor protein that initiates a ... The protein is also a famous tumor suppressor -- around half of human cancers have p53 mutations that render it defective or ...
2 Million NIH MIRA Grant Will Support Trailblazing Research in UMass Amherst Lab : UMass Amherst
... of tumor suppressor protein p53. "The MIRA award enables us to continue working on several central problems regarding the study ... and their derivatives interact with the p53 gene, a tumor suppressor and the most important protein involved in cancer. ... They make up about one-third of proteins that human bodies make, Chen explains, and two-thirds of cancer-associated proteins ... But about two decades ago, Chen explains, IDPs were recognized as a new class of proteins that rely on a lack of stable ...
Update on Epstein-Barr virus and gastric cancer (Review)
PML is a tumor suppressor protein that is associated with p53 activation. They showed that by repressing PML, EBNA-1 impaired ... Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of ... In addition, excessive methylation may lead to repressing tumor suppressor genes, which ultimately could give rise to ... Similar to oncogenes and tumor suppressor genes, miRNAs associated with carcinogenesis are called oncomiRs and anti-oncomiRs. ...
Current Trend and Pro-survival Approaches for Augmenting Stem Cell Viability | Bentham Science
Bálint, E.E.; Vousden, K.H. Activation and activities of the p53 tumour suppressor protein. Br. J. Cancer, 2001, 85(12), 1813- ... Strikoudis, A.; Guillamot, M.; Aifantis, I. Regulation of stem cell function by protein ubiquitylation. EMBO Rep., 2014, 15(4 ... Fan, G.C. Role of heat shock proteins in stem cell behavior.[Internet]. In: Progress in Molecular Biology and Translational ... Shaik, S.; Hayes, D.; Gimble, J.; Devireddy, R. Inducing heat shock proteins enhances the stemness of frozen- thawed adipose ...
Sari Tojkander - Publikationer - Helsingfors universitet
Regulation of tumor suppressor protein p53 in cellular stress and tumorigenesis. Tojkander, S., 2007, [Laukkoski]: [S. ... TRPV Protein Family-From Mechanosensing to Cancer Invasion. Karki, T. & Tojkander, S., juli 2021, I: Biomolecules. 11, 7, 23 s. ... Analysis of Contractility and Invasion Potential of Two Canine Mammary Tumor Cell Lines. Rajakylä, K., Krishnan, R. & Tojkander ...
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... focused on developing and commercializing novel cancer therapeutics that reactivate the mutant tumor suppressor protein p53. ... p53 is the protein expressed from the TP53 gene, the most commonly mutated gene in cancer. We believe that mutant p53 is an ... focused on developing and commercializing novel cancer therapeutics that reactivate the mutant p53 tumor suppressor protein. ... p53 is the protein expressed from the TP53 gene, the most commonly mutated gene in cancer. The Company began principal ...
Splicing News, Research - Page 13
Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from ... Why Should We Weigh Every Protein in the Human Body? Our mission is to advance the measurement of human proteins with greater ... Protein changes essential for normal adult muscle function Researchers at Baylor College of Medicine have shed light on the ... MUSC researchers show how non-coding RNA promotes tumor formation A mechanism that pushes a certain gene to produce a non- ...