Tryptophan synthase - Wikipedia
The active sites of tryptophan synthase are allosterically coupled. Subunits: Tryptophan synthase typically exists as an α-ββ-α ... "Tryptophan synthase: Identification of Pasteurella multocida tryptophan synthase B-subunit by antisera against strain PI059". ... Tryptophan synthase or tryptophan synthetase is an enzyme (EC 4.2.1.20) that catalyses the final two steps in the biosynthesis ... Lyase Synthase Tryptophan synthase (indole-salvaging) Dunn MF, Niks D, Ngo H, Barends TR, Schlichting I (June 2008). " ...
A Thermodynamic Investigation of Reactions Catalyzed by Tryptophan Synthase | NIST
A Thermodynamic Investigation of Reactions Catalyzed by Tryptophan Synthase, Biophysical Chemistry (Accessed December 5, 2023) ... Le Chateliers principle provides an explanation as to why, in the metabolic pathway leading to the synthesis of l-tryptophan, ... have been used to conduct a thermodynamic investigation of the following reactions catalyzed by the tryptophan synthase [alpha] ... 2[Beta]2 complex (EC 4.2.1.20) and its subunits:indole(aq) + L-serine(aq) = L-tryptophan(aq) + H2O(1),L-serine(aq) = pyruvate( ...
WikiGenes - trpB - tryptophan synthase subunit beta
Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint - University of Regensburg...
The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric ... The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric ... Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint ...
MexAM1 META1p4890 6829683 tryptophan synthase alpha subunit (RefSeq) | Syntrophy Portal
PDB 6EQN | Chain SULFOLOBUS SOLFATARICUS TRYPTOPHAN SYNTHASE B2O | 6EQN B | 3D Structure | canSARS
The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics | Nature Reviews Chemistry
Finally, 52 and its metabolite conferred mutations in TrpAB (tryptophan synthase) in residues spread throughout the protein ... anthranilate synthase), which converts chorismite to anthranilate, the first step in the tryptophan biosynthesis pathway. The ... which is incorporated in the tryptophan biosynthetic pathway to produce toxic tryptophan metabolite (4-amino-l-Trp; 53). h, The ... Host CD4 T cells (involved in the immune response) manage Mtb growth by starving it of tryptophan; however, Mtb can subvert ...
1c9d.1 | SWISS-MODEL Template Library
CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXY-4- ... CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXY-4- ... Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. ... TRYPTOPHAN SYNTHASE (ALPHA CHAIN): AC. TRYPTOPHAN SYNTHASE (BETA CHAIN): BD. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
6wx3.1 | SWISS-MODEL Template Library
High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 inhibitor in the alpha- ... High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 inhibitor in the alpha- ... Hilario, E. et al., High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 ... Tryptophan synthase alpha chain: AC. Tryptophan synthase beta chain: BD. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
Non-Thermal Radio Frequency Stimulation Inhibits the Tryptophan Synthase Beta Subunit in the Algae Chlamydomonas reinhardtii
We inhibited the synthesis of the enzyme tryptophan synthase beta subunit (MAA7) by applying the signal derived from a ... because less 5-Fluoroin-dole can be converted to the toxic 5-Fluoro-L-tryptophan (5-FT). We find a 24% (±5%) increase of growth ... We inhibited the synthesis of the enzyme tryptophan synthase beta subunit (MAA7) by applying the signal derived from a ... Butters, B.M., Vogeli, G. and Figueroa, X.A. (2017) Non- Thermal Radio Frequency Stimulation In- hibits the Tryptophan Synthase ...
Highly efficient preparation of active S-phenyl-L-cysteine with tryptophan synthase using a chemoenzymatic method | BMC...
Through this approach, S-phenyl-L-cysteine was chemoenzymatically synthesized using tryptophan synthase from thiophenol and L- ... and then hydrolysis and enzymatic synthesis using tryptophan synthase. ... active S-phenyl-L-cysteine was prepared in a highly efficient manner from inexpensive bromobenzene using tryptophan synthase ... The activity of tryptophan synthase was determined by the conversion rate of S-phenyl-L-cysteine. Tryptophan synthase was ...
Overexpression of Arabidopsis tryptophan synthase beta 1 (AtTSB1) in Arabidopsis and tomato confers tolerance to cadmium stress...
SCOPe 2.08: Domain d1wq5a : 1wq5 A
PDB Compounds: (A:) tryptophan synthase alpha chain. SCOPe Domain Sequences for d1wq5a_:. Sequence, based on SEQRES records: ( ... PDB Description: Crystal structure of tryptophan synthase alpha-subunit from Escherichia coli ... Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins). *. Protein automated matches [190053] (10 species). not a ...
SCOPe 2.08: Domain d2clfa : 2clf A
PDB Compounds: (A:) tryptophan synthase alpha chain. SCOPe Domain Sequences for d2clfa_:. Sequence, based on SEQRES records: ( ... PDB Description: tryptophan synthase in complex with n-(4-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - highf6 ... Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins). *. Protein automated matches [190053] (10 species). not a ...
Tools to kill: Genome of one of the most destructive plant pathogenic fungi Macrophomina phaseolina | BMC Genomics | Full Text
Dimethylallyl tryptophan synthase. EST:. Expressed sequence tag. EVM:. EVidenceModeler. GH:. Glycoside hydrolase ... chitin synthase and β-1,3-glucan synthase) as well as cell wall degradation (e.g., cutinase and β-1,4-endoglucanase) are ... Böhnert HU, Fudal I, Dioh W, Tharreau D, Notteghem JL, Lebrun MH: A putative polyketide synthase/peptide synthetase from ... Beck J, Ripka S, Siegner A, Schiltz E, Schweizer E: The multifunctional 6-methylsalicylic acid synthase gene of Penicillium ...
Overview: trpA, Pseudomonas aeruginosa PAO1
Neurotransmitters - Proteopedia, life in 3D
The tryptophan synthase alpha 2 beta 2 complex. Cleavage of a flexible loop in the alpha subunit alters allosteric properties. ... The tryptophan synthase alpha 2 beta 2 complex. Cleavage of a flexible loop in the alpha subunit alters allosteric properties. ... Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in ...
Explore | Applied Biological Materials (abm) | UK & Europe Distribution
tryptophan synthase subunit beta. NP_227953. 15642912. pMH2T7. 896993. TM0156. alkaline phosphatase. NP_227971. 15642930. ... folylpolyglutamate synthase/dihydrofolate synthase. NP_227981. 15642940. pMH2T7. 896818. TM0009. hypothetical protein. NP_ ... tRNA pseudouridine synthase ACD. NP_229374. 15644322. pMH1. 898065. TM1411. helicase-related protein. NP_229212. 15644163. pMH1 ... flagellum-specific ATP synthase. NP_228033. 15642991. pMH1. 897265. TM0322. ABC transporter substrate-binding protein. NP_ ...
Dr Verena Kriechbaumer - Oxford Brookes University
It catalyzes the tryptophan synthase α-reaction (cleavage of IGP), and forms a tryptophan synthase complex with ZmTSB1 in vitro ... A 160 kD tryptophan synthase complex was partially purified from maize leaves and ZmTSA was identified as native α- subunit of ... There is some evidence for a tryptophan synthase (TS) complex in Arabidopsis. On the other hand maize (Zea mays) expresses the ... ZmTSAlike, BX1, and IGL were not detectable in the native tryptophan synthase complex in leaves.. ...
De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and...
Tryptamine of tryptophan metabolic pathway via strictosidine synthase (STR; EC 4.3.3.2) catalysis forms strictosidine [34], and ... Tryptophan decarboxylase (TDC; EC 4.1.1.28), a pyridoxal dependent enzyme converts tryptophan to tryptamine. Isopentenyl ... tryptophan decarboxylase, EC:4.1.1.28; STR: strictosidine synthase, EC:4.3.3.2; P450: cytochrome P450, EC:1.14.-.-. ... Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of ...
ExplorEnz: EC 4.2.1.20
tryptophan synthase. Reaction:. L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate ... L-tryptophan synthetase; indoleglycerol phosphate aldolase; tryptophan desmolase; tryptophan synthetase; L-serine hydro-lyase ( ... Hyde, C.C., Ahmed, S.A., Padlan, E.A., Miles, E.W. and Davies, D.R. Three-dimensional structure of the tryptophan synthase α2β2 ... Woehl, E. and Dunn, M.F. Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase α-, β-, and αβ- ...
Predicting Phenotype and Emerging Strains among Chlamydia trachomatis Infections - Volume 15, Number 9-September 2009 -...
Caldwell HD, Wood H, Crane D, Bailey R, Jones RB, Mabey D, Polymorphisms in Chlamydia trachomatis tryptophan synthase genes ... Additionally, tryptophan synthase genes and cytotoxin loci are located within the 50-kb plasticity zone of the chromosome, a ... A frame-shift mutation in 1 of the tryptophan synthase genes, trpA, was associated with trachoma strains when compared with all ... tRNA synthases); iv) genes without similarity to human genes; and v) no genes under diversifying selection. ...
Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts
2012Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthaseBiochim Biophys Acta - Bioenerg. ... The oxidized ATP synthase might be degraded by mitochondrial FtsH homologs, m-AAA and i-AAA proteases, which have an essential ... Here, we characterized oxidative modification of tryptophan (Trp) residues in the PSII core, and hypothesize that the oxidation ... 2015Tripping up Trp: Modification of protein tryptophan residues by reactive oxygen species, modes of detection, and biological ...
CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures | PLOS Computational Biology
Genome sequence and spore germination-associated transcriptome analysis of Corynespora cassiicola from cucumber | BMC...
... polyketone synthase (PKS), PKS-like, dimethylallyl tryptophan synthase (DMAT), excluding hybrid PKS-NRPS enzyme (HYBRID), but ... NRPS, non-ribosomal peptide synthetase; PKS, polyketide synthetase; DMAT, dimethylallyl tryptophan synthase; HYBRID, hybrid PKS ... a fumagillin-associated transcription factor and polyketide synthase, ATP synthase, binding immunoglobulin protein (Bip), and ... a A maximum likelihood tree of ketoacyl CoA synthase (KS) domain sequences of PKS in selected fungi. b Domain analysis of these ...
iTRAQ-based comparative proteome analyses of different growth stages revealing the regulatory role of reactive oxygen species...
The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is regulated by the cross-pathway control system.. Molecular ... Besides, the mutant of tryptophan synthase-encoding gene trpB or the histidine biosynthesis gene hisB leads to loss of ... Sexual development of Aspergillus nidulans in tryptophan auxotrophic strains.. Archives of Microbiology 172:157-166 ... In PR vs MF, the DAPs were enriched in pathways of phenylalanine, tyrosine and tryptophan biosynthesis(map00400, map00350), ...