The active sites of tryptophan synthase are allosterically coupled. Subunits: Tryptophan synthase typically exists as an α-ββ-α ... "Tryptophan synthase: Identification of Pasteurella multocida tryptophan synthase B-subunit by antisera against strain PI059". ... Tryptophan synthase or tryptophan synthetase is an enzyme (EC 4.2.1.20) that catalyses the final two steps in the biosynthesis ... Lyase Synthase Tryptophan synthase (indole-salvaging) Dunn MF, Niks D, Ngo H, Barends TR, Schlichting I (June 2008). " ...
A Thermodynamic Investigation of Reactions Catalyzed by Tryptophan Synthase, Biophysical Chemistry (Accessed December 5, 2023) ... Le Chateliers principle provides an explanation as to why, in the metabolic pathway leading to the synthesis of l-tryptophan, ... have been used to conduct a thermodynamic investigation of the following reactions catalyzed by the tryptophan synthase [alpha] ... 2[Beta]2 complex (EC 4.2.1.20) and its subunits:indole(aq) + L-serine(aq) = L-tryptophan(aq) + H2O(1),L-serine(aq) = pyruvate( ...
Synechocystis PCC 6803 contains a single gene for the beta subunit of tryptophan synthase with strong homology to the trpB ...
The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric ... The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric ... Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint ...
E) COG159 , Tryptophan synthase alpha chain (4.2.1.20, 4.1.2.8) Tryptophan synthase., (4.2.1.20, 4.1.2.8) Indole-3-glycerol- ... MexAM1_META1p4890 6829683 tryptophan synthase alpha subunit (RefSeq). × Error message. *Unable to create CTools CSS cache ...
SULFOLOBUS SOLFATARICUS TRYPTOPHAN SYNTHASE B2O - 6EQN , canSARS ...
Finally, 52 and its metabolite conferred mutations in TrpAB (tryptophan synthase) in residues spread throughout the protein ... anthranilate synthase), which converts chorismite to anthranilate, the first step in the tryptophan biosynthesis pathway. The ... which is incorporated in the tryptophan biosynthetic pathway to produce toxic tryptophan metabolite (4-amino-l-Trp; 53). h, The ... Host CD4 T cells (involved in the immune response) manage Mtb growth by starving it of tryptophan; however, Mtb can subvert ...
CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXY-4- ... CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXY-4- ... Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. ... TRYPTOPHAN SYNTHASE (ALPHA CHAIN): AC. TRYPTOPHAN SYNTHASE (BETA CHAIN): BD. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 inhibitor in the alpha- ... High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 inhibitor in the alpha- ... Hilario, E. et al., High resolution Tryptophan Synthase crystal structure from Salmonella typhimurium in complex with F9 ... Tryptophan synthase alpha chain: AC. Tryptophan synthase beta chain: BD. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ...
We inhibited the synthesis of the enzyme tryptophan synthase beta subunit (MAA7) by applying the signal derived from a ... because less 5-Fluoroin-dole can be converted to the toxic 5-Fluoro-L-tryptophan (5-FT). We find a 24% (±5%) increase of growth ... We inhibited the synthesis of the enzyme tryptophan synthase beta subunit (MAA7) by applying the signal derived from a ... Butters, B.M., Vogeli, G. and Figueroa, X.A. (2017) Non- Thermal Radio Frequency Stimulation In- hibits the Tryptophan Synthase ...
Through this approach, S-phenyl-L-cysteine was chemoenzymatically synthesized using tryptophan synthase from thiophenol and L- ... and then hydrolysis and enzymatic synthesis using tryptophan synthase. ... active S-phenyl-L-cysteine was prepared in a highly efficient manner from inexpensive bromobenzene using tryptophan synthase ... The activity of tryptophan synthase was determined by the conversion rate of S-phenyl-L-cysteine. Tryptophan synthase was ...
Overexpression of Arabidopsis tryptophan synthase beta 1 (AtTSB1) in Arabidopsis and tomato confers tolerance to cadmium stress ... Overexpression of Arabidopsis tryptophan synthase beta 1 (AtTSB1) in Arabidopsis and tomato confers tolerance to cadmium stress ...
PDB Compounds: (A:) tryptophan synthase alpha chain. SCOPe Domain Sequences for d1wq5a_:. Sequence, based on SEQRES records: ( ... PDB Description: Crystal structure of tryptophan synthase alpha-subunit from Escherichia coli ... Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins). *. Protein automated matches [190053] (10 species). not a ...
PDB Compounds: (A:) tryptophan synthase alpha chain. SCOPe Domain Sequences for d2clfa_:. Sequence, based on SEQRES records: ( ... PDB Description: tryptophan synthase in complex with n-(4-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - highf6 ... Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins). *. Protein automated matches [190053] (10 species). not a ...
Dimethylallyl tryptophan synthase. EST:. Expressed sequence tag. EVM:. EVidenceModeler. GH:. Glycoside hydrolase ... chitin synthase and β-1,3-glucan synthase) as well as cell wall degradation (e.g., cutinase and β-1,4-endoglucanase) are ... Böhnert HU, Fudal I, Dioh W, Tharreau D, Notteghem JL, Lebrun MH: A putative polyketide synthase/peptide synthetase from ... Beck J, Ripka S, Siegner A, Schiltz E, Schweizer E: The multifunctional 6-methylsalicylic acid synthase gene of Penicillium ...
Nucleotide sequence of the genes for tryptophan synthase in Pseudomonas aeruginosa. Hadero A, Crawford IP ...
The tryptophan synthase alpha 2 beta 2 complex. Cleavage of a flexible loop in the alpha subunit alters allosteric properties. ... The tryptophan synthase alpha 2 beta 2 complex. Cleavage of a flexible loop in the alpha subunit alters allosteric properties. ... Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in ...
tryptophan synthase subunit beta. NP_227953. 15642912. pMH2T7. 896993. TM0156. alkaline phosphatase. NP_227971. 15642930. ... folylpolyglutamate synthase/dihydrofolate synthase. NP_227981. 15642940. pMH2T7. 896818. TM0009. hypothetical protein. NP_ ... tRNA pseudouridine synthase ACD. NP_229374. 15644322. pMH1. 898065. TM1411. helicase-related protein. NP_229212. 15644163. pMH1 ... flagellum-specific ATP synthase. NP_228033. 15642991. pMH1. 897265. TM0322. ABC transporter substrate-binding protein. NP_ ...
It catalyzes the tryptophan synthase α-reaction (cleavage of IGP), and forms a tryptophan synthase complex with ZmTSB1 in vitro ... A 160 kD tryptophan synthase complex was partially purified from maize leaves and ZmTSA was identified as native α- subunit of ... There is some evidence for a tryptophan synthase (TS) complex in Arabidopsis. On the other hand maize (Zea mays) expresses the ... ZmTSAlike, BX1, and IGL were not detectable in the native tryptophan synthase complex in leaves.. ...
Tryptamine of tryptophan metabolic pathway via strictosidine synthase (STR; EC 4.3.3.2) catalysis forms strictosidine [34], and ... Tryptophan decarboxylase (TDC; EC 4.1.1.28), a pyridoxal dependent enzyme converts tryptophan to tryptamine. Isopentenyl ... tryptophan decarboxylase, EC:4.1.1.28; STR: strictosidine synthase, EC:4.3.3.2; P450: cytochrome P450, EC:1.14.-.-. ... Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of ...
tryptophan synthase. Reaction:. L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate ... L-tryptophan synthetase; indoleglycerol phosphate aldolase; tryptophan desmolase; tryptophan synthetase; L-serine hydro-lyase ( ... Hyde, C.C., Ahmed, S.A., Padlan, E.A., Miles, E.W. and Davies, D.R. Three-dimensional structure of the tryptophan synthase α2β2 ... Woehl, E. and Dunn, M.F. Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase α-, β-, and αβ- ...
Caldwell HD, Wood H, Crane D, Bailey R, Jones RB, Mabey D, Polymorphisms in Chlamydia trachomatis tryptophan synthase genes ... Additionally, tryptophan synthase genes and cytotoxin loci are located within the 50-kb plasticity zone of the chromosome, a ... A frame-shift mutation in 1 of the tryptophan synthase genes, trpA, was associated with trachoma strains when compared with all ... tRNA synthases); iv) genes without similarity to human genes; and v) no genes under diversifying selection. ...
2012Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthaseBiochim Biophys Acta - Bioenerg. ... The oxidized ATP synthase might be degraded by mitochondrial FtsH homologs, m-AAA and i-AAA proteases, which have an essential ... Here, we characterized oxidative modification of tryptophan (Trp) residues in the PSII core, and hypothesize that the oxidation ... 2015Tripping up Trp: Modification of protein tryptophan residues by reactive oxygen species, modes of detection, and biological ...
Hyde CC, Ahmed SA, Padlan EA, Miles EW, Davies DR (1988) Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 ... Teplyakov A, Obmolova G, Badet B, Badet-Denisot MA (2001) Channeling of ammonia in glucosamine-6-phosphate synthase. J Mol Biol ...
... polyketone synthase (PKS), PKS-like, dimethylallyl tryptophan synthase (DMAT), excluding hybrid PKS-NRPS enzyme (HYBRID), but ... NRPS, non-ribosomal peptide synthetase; PKS, polyketide synthetase; DMAT, dimethylallyl tryptophan synthase; HYBRID, hybrid PKS ... a fumagillin-associated transcription factor and polyketide synthase, ATP synthase, binding immunoglobulin protein (Bip), and ... a A maximum likelihood tree of ketoacyl CoA synthase (KS) domain sequences of PKS in selected fungi. b Domain analysis of these ...
The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is regulated by the cross-pathway control system.. Molecular ... Besides, the mutant of tryptophan synthase-encoding gene trpB or the histidine biosynthesis gene hisB leads to loss of ... Sexual development of Aspergillus nidulans in tryptophan auxotrophic strains.. Archives of Microbiology 172:157-166 ... In PR vs MF, the DAPs were enriched in pathways of phenylalanine, tyrosine and tryptophan biosynthesis(map00400, map00350), ...
changes in regulating activity of α-subunit of tryptophan synthase.. C. Chang, D.D. Boehr, Y. Bosken ...
... found in a group of proteins of the PLP-dependent enzymes superfamily represented by the beta subunit of tryptophan synthase ... PUBMED:10673430) ]. It is a group of diverse proteins, including threonine dehydratase, cysteine synthase, pyridoxal phosphate- ...