Tryptases Grants and funding * AI 09728/AI/NIAID NIH HHS/United States ...
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only ... Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. ... Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. GRCh38 ... 2000). "Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene ...
nowiki,hidrolasa; 加水分解酵素; Hidrolasa; Hidrolase; Hydrolase; Hydrolase; hydrolase; هیدرولاز; Хидролаза; Hydrolase; Hidrolază; 加水分解酵素; Hydroláza; Idrolasa; 水解酶; 가수 분해 효소; Гидролазалар; Hydrolase; hydroláza; நீராற்பகுப்பி; idrolasi; hydrolase; Гідралязы; hidrolasa; Hidrolaze; 水解酶; Hidrolase; Hydrolaser; Hidrolaza; hidrolase; Hidrolaz; гідролази; hydrolase; Hidrolazės; hidrolaza; Hydrolaasit; Hidrolase; hydrolase; hydrolazy; hydrolase; hydrolaser; Hidrolaza; Гідралазы; Հիդրոլազներ; hydrolas; Hüdrolaasid; hydrolase; هيدروليز; Гидролазы; hidrolizazo; 加水分解反応の触媒として作用する酵素; protéine; enzim que catalitza la hidròlisi dun enllaç químic; Protein; 효소의 종류; enzyme family; proteinë; класс ферментов; Clase
Tryptases (Tryptase) 4. Thromboplastin (Tissue Factor) 5. GTP-Binding Proteins (G-Protein) ...
Tryptases.. All the above proteins belong to family S1 in the classification of peptidases [ (PUBMED:7845208) ] and originate ...
Clinical studies have demonstrated that tryptases are released in patients with irritable bowel syndrome and they can directly ...
... degeneration and release of MC-restricted tetramer tryptases (TTs) in the IVDs. TTs were found to regulate the expression of ...
Busso-Lopes, A. F., Neves, L. X., Câmara, G. A., Granato, D. C., Pretti, M. A. M., Heberle, H., Patroni, F. M. S., Sá, J., Yokoo, S., Rivera, C., Domingues, R. R., Normando, A. G. C., De Rossi, T., Mello, B. P., Galdino, N. A. L., Pauletti, B. A., Lacerda, P. A., Rodrigues, A. A. N., Casarim, A. L. M., de Lima-Souza, R. A., y 13 otrosDamas, I. I., Mariano, F. V., Gollob, K. J., Medina, T. S., Cervigne, N. K., Prado-Ribeiro, A. C., Brandão, T. B., Villa, L. L., Uno, M., Boroni, M., Kowalski, L. P., González-Arriagada, W. A. & Paes Leme, A. F., dic. 2022, En: Nature Communications. 13, 1, p. 6725 6725.. Producción científica: Contribución a una revista › Artículo › revisión exhaustiva ...
TY - JOUR. T1 - Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia. T2 - Implications for optimal dosing. AU - Klion, Amy D.. AU - Robyn, Jamie. AU - Maric, Irina. AU - Fu, Weiming. AU - Schmid, Laura. AU - Lemery, Steven. AU - Noel, Pierre. AU - Law, Melissa A.. AU - Hartsell, Marilyn. AU - Talar-Williams, Cheryl. AU - Fay, Michael P.. AU - Dunbar, Cynthia E.. AU - Nutman, Thomas B.. PY - 2007/11/15. Y1 - 2007/11/15. N2 - Although imatinib is clearly the treatment of choice for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia (CEL), little is known about optimal dosing, duration of treatment, and the possibility of cure in this disorder. To address these questions, 5 patients with FIP1L1/PDGFRA positive CEL with documented clinical, hematologic, and molecular remission on imatinib (400 mg daily) and without evidence of cardiac involvement were enrolled in a dose de-escalation trial. The imatinib dose was tapered slowly ...
Tryptases Medicine & Life Sciences 10% * Skin Medicine & Life Sciences 8% * Immunoglobulin E Medicine & Life Sciences 7% ...
Roos, F. J. M., van Tienderen, G. S., Wu, H., Bordeu, I., Vinke, D., Albarinos, L. M., Monfils, K., Niesten, S., Smits, R., Willemse, J., Rosmark, O., Westergren-Thorsson, G., Kunz, D. J., de Wit, M., French, P. J., Vallier, L., IJzermans, J. N. M., Bartfai, R., Marks, H., Simons, B. D., & 3 othersvan Royen, M. E., Verstegen, M. M. A. & van der Laan, L. J. W., 2022, In: Cell Stem Cell. 29, 5, p. 776-794.e13. Research output: Contribution to journal › Article › peer-review ...
Tryptases Medicine & Life Sciences 100% * Permeability Medicine & Life Sciences 65% * Epithelial Cells Medicine & Life Sciences ...
Tryptases Medicine & Life Sciences 27% * Cell Marker Chemical Compounds 19% View full fingerprint ...
Tryptases Medicine & Life Sciences 53% * Prostaglandin D2 Medicine & Life Sciences 36% * Chymases Medicine & Life Sciences 29% ...
Tryptases are resistant to inhibition by most natural trypsin inhibitors and display some affinity for heparin. The existence ... Although in vivo substrates have not been positively identified, tryptases cleave a limited number of potential physiological ... Tryptases are trypsin-like enzymes found in mast cell granules. ... Tryptases are trypsin-like enzymes found in mast cell granules ... Tryptases are resistant to inhibition by most natural trypsin inhibitors and display some affinity for heparin. The existence ...
Because tryptases are specific to mast cells and are their most abundant products, the study of tryptase gene regulation ... In addition, the search for novel tryptases may lead to the identification of new enzymes with important functions in lung and ... Except for small amounts expressed in basophils, known tryptases are exclusive to mast cells. They are of special interest in ... Recent discoveries in the Principal Investigators laboratory reveal the existence of multiple copies of known tryptases in the ...
In this concept cloud, the sizes of the concepts are based not only on the number of corresponding publications, but also how relevant the concepts are to the overall topics of the publications, how long ago the publications were written, whether the person was the first or senior author, and how many other people have written about the same topic. The largest concepts are those that are most unique to this person ...
The results show that tetramer-forming tryptases initiated aggrecanolysis by proteolytically activating the latent proenzyme ... Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix ...
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only ... Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. ... Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. ... This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount ...
BACKGROUND: Tryptases are serine peptidases stored in mast cell granules. Rodents express 2 soluble tryptases, mast cell ... BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. Tryptase gene ... Human mast cell tryptases vary strikingly in secretion, catalytic competence, and inheritance. To explore the basis of ... Although delta-tryptases are nearly inactive in humans, they are active and dominant in monkeys. ...
Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense. J Biol Chem. 2007 Jul 20; 282(29): ... The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are ... Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix ...
2021, August 13; Clinical relevance of inherited genetic differences in human tryptases: Hereditary alpha-tryptasemia and ... 2021, December; Clinical relevance of inherited genetic differences in human tryptases: Hereditary alpha-tryptasemia and beyond ...
Her project will focus on Mast cell-induced allergic inflammation: the role of tryptases. ...
FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokine, tryptases, chemokine, and ...
FLONASE products act on multiple inflammatory substances, including histamine, prostaglandins, cytokines, tryptases, chemokines ...
FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and ... FLONASE nasal sprays acts on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and ...
Allergy-Rf™ acts inhibits tryptases from creating the physiological reactions that release histamines and cause the full-blown ... Upon allergen inhalation, tryptases stimulate the release of histamines - the natural compound released by the immune system as ... Many allergens such as pollen, mold, animal dander and house dust mites contain specific enzymatic proteins known as tryptases ...
Tryptases, Interleukins). These are chemical-immune messengers and they drive a powerful inflammatory response throughout your ...