Trophoblast - Wikipedia
The invasion of a specific type of trophoblast (extravillous trophoblast) into the maternal uterus is a vital stage in the ... cytotrophoblasts in the tips of villi can differentiate into another type of trophoblast called the extravillous trophoblast. ... Trophoblast stem cells (TSCs) are cells that can regenerate and they are similar to embryonic stem cells (ESCs) in the fact ... Failure of the trophoblast to invade sufficiently is important in the development of some cases of pre-eclampsia. Invasion of ...
Decreased junctional adhesion molecule 3 expression induces reactive oxygen species production and apoptosis in trophoblasts†
JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M ... our results show that JAM3 may not only be a structural component of trophoblast cell junctions but also regulates trophoblast ... Using trophoblasts as an in vitro model, we observed that forskolin and JAM3 knockdown significantly reduced JAM3 expression ... Furthermore, H2O2-induced oxidative stress reduced JAM3 expression in trophoblasts and cell culture supernatants. H2O2 ...
The human trophoblast cells - The Human Protein Atlas
Trophoblast cells. The trophoblast cell-specific proteomeThe trophoblast cell transcriptomeCytotrophoblastsSyncytiotrophoblasts ... Extravillous trophoblasts. As shown in Table 1, 679 genes are elevated in Extravillous trophoblasts compared to other cell ... Trophoblast cell function. The placenta is made up of various kinds of cells, mainly stemming from trophoblasts. Upon ... The trophoblast cell-specific proteome. The main cellular components of the highly vascularized placenta are trophoblasts, ...
NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation
... abnormal pregnancies containing hypertrophic vesicular trophoblast but no embryo. BiHM trophoblasts display abnormal DNA ... NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation Hum Mol Genet. 2014 ... abnormal pregnancies containing hypertrophic vesicular trophoblast but no embryo. BiHM trophoblasts display abnormal DNA ... Reduced NLRP7 levels alter DNA methylation and accelerate trophoblast lineage differentiation. NLRP7 thus appears to function ...
A distinct pattern in the DNA ploidy histograms of hydatidiform moles and nonmolar abortuses is caused by accumulation of...
Trophoblast invasion and spiral artery transformation in placenta accreta | ADC Fetal & Neonatal Edition
Trophoblast giant cells and SA transformation are reduced in accreta areas with no decidua. Our results emphasise the crucial ... Decidua is, at least focally, defective and abnormal uterine invasion by extravillous trophoblast (EVT) has been proposed. ... Invasive EVT and multinucleate trophoblast giant cells (MTGC) were quantified and confluent EVT (,5 opposed EVTs) assessed semi ... role of decidua in control of trophoblast invasion and SA transformation. The presence of decidua in focal accretas may help ...
COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in...
It is widely accepted that preeclampsia is caused by shallow invasion of trophoblasts. The failure of trophoblast invasion to ... Tolcapone repressed cell invasion in HTR8/SVneo trophoblast cell line. HTR8/SVneo trophoblast cells were exposed to different ... Tolcapone inhibited the invasion of placental trophoblast to maternal decidua in mice. The invasion of trophoblast from ... de: decidua, gc: trophoblast giant cell. I. Ratio of areas of labyrinth zone over junction zone of placentas. J. Maternal ...
BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a DeltaNp63+ cytotrophoblast stem...
BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a DeltaNp63+ cytotrophoblast stem ... Little is known about early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model system. ... We also establish that, similar to in vivo events, hESC differentiation into trophoblast is characterized by a p63+/KRT7+ CTB ... Taken together, our results establish that BMP4-treated hESCs are an excellent model of human trophoblast differentiation, ...
Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin...
Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ... Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ... decreases amino acid uptake in primary human trophoblast (PHT) cells by activation of Nedd4-2, which increases transporter ... acid transfer is critically dependent on the expression of specific transporters in the plasma membrane of the trophoblast, the ...
The Gabrielle Rizzuto Lab: The immunology of trophoblast tumors | Gerstner Sloan Kettering Graduate School of Biomedical...
View the Gabrielle Rizzuto Lab page for The immunology of trophoblast tumors. ... Gestational trophoblast-derived tumors are relatively rare cancers that can arise post-pregnancy. The most common subtype, ... Choriocarcinoma most often arises after a non-viable "molar" pregnancy where the trophoblast cells contain only paternal DNA. ... Then, we will use our immunologic tools (antigen tetramers, etc) to interrogate host immune responses to trophoblast tumor ...
Wnt3a Activates the WNT-YAP/TAZ Pathway to Sustain CDX2 Expression in Bovine Trophoblast Stem Cells. | StemBook
Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX...
Hypoxia potentiates trophoblast column outgrowth. To test the effect of exposure to differing levels of oxygen on trophoblast ... DCT, distal column trophoblast; MC, mesenchymal core; PCT, proximal column trophoblast. Scale bars: 100 µm. ... DCT, distal column trophoblast; MC, mesenchymal core; PCT, proximal column trophoblast. Scale bars: 100 µm. ... Shown are annotations of trophoblast/placental subtypes: CTB, cytotrophoblast; DCT; distal column trophoblast; MC, mesenchymal ...
Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice<...
Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice. / Watkins, Adam J; Lucas, Emma S; Marfy- ... Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice. In: Reproduction. 2015 ; Vol. 149. pp. ... Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice. Reproduction. 2015 Jun 1;149:563-575. ... Watkins, AJ, Lucas, ES, Marfy-Smith, S, Bates, N, Kimber, SJ & Fleming, TP 2015, Maternal nutrition modifies trophoblast giant ...
Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation | Journal of Cell Biology |...
During implantation the embryo attaches to the endometrial surface and trophoblast traverses the uterine epithelium, anchoring ... When trophoblast cells were lysed with NH(4)OH on day 8, it was apparent that the area underneath the trophoblast outgrowth had ... Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation RH Glass, RH Glass ... RH Glass, J Aggeler, A Spindle, RA Pederson, Z Werb; Degradation of extracellular matrix by mouse trophoblast outgrowths: a ...
How To Isolate Trophoblasts
... : A Step-by-Step Guide. Trophoblasts are a crucial component of the placenta, playing a vital role ... Q: What are trophoblasts?. A: Trophoblasts are specialized cells that form the outer layer of the blastocyst, which later ... Step 4: Trophoblast Culture. Once isolated, trophoblasts can be cultured in a suitable medium to maintain their viability and ... Q: What are the challenges in isolating trophoblasts?. A: Isolating trophoblasts can be challenging due to their complex ...
Senescence In Genotoxic Amniocytes And Stressed Trophoblasts | ISPR
Senescence In Genotoxic Amniocytes And Stressed Trophoblasts Home ‹ 2012 Abstracts ‹ Senescence In Genotoxic Amniocytes And ... We also assessed the presence of SAHF in trophoblasts from pregnancies complicated by IUGR (n=12) and from pregnancies ... Conclusion: Increased SAHF formation in amniocytes and in trophoblasts that were previously found to express shorter telomeres ... We studied senescence in amniocytes and placentas from aneuploidic fetuses, in trophoblasts from IUGR fetuses, and from ...
Trophoblast Stem Cells<...
Trophoblast Stem Cells. / Oda, Mayumi; Shiota, Kunio; Tanaka, Satoshi. In: Methods in Enzymology, Vol. 419, 2006, p. 387-400.. ... In the trophoblast cell lineage, a subset of the trophectoderm cells maintains the capacity to proliferate and contribute to ... In the trophoblast cell lineage, a subset of the trophectoderm cells maintains the capacity to proliferate and contribute to ... In the trophoblast cell lineage, a subset of the trophectoderm cells maintains the capacity to proliferate and contribute to ...
Complete human day 14 post-implantation embryo models from naive ES cells | Nature
... and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. This SEM platform will probably enable ... the extra-embryonic mesoderm and the trophoblast layer surrounding the latter compartments. These human complete SEMs ... the chorionic sac and the surrounding trophoblast layer) remain lacking1,2. Mouse naive embryonic stem cells have recently ... Trophoblast Giant Cells (TGC) progenitors, parietal trophoblast giant cells (pTGC), spiral artery associated trophoblast giant ...
External weblinks | Centre for Trophoblast Research
Spatial multiomics map of trophoblast development in early pregnancy.
4 and trophoblast stem cells5. We define the transcriptomes of the final cell states of trophoblast invasion: placental bed ... Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries ... Defects in trophoblast invasion and arterial transformation established during early pregnancy underlie common pregnancy ... Together, our data provide a comprehensive analysis of postimplantation trophoblast differentiation that can be used to inform ...
Expression of TAP1 by human trophoblast. - Radcliffe Department of Medicine
This pattern could result from HLA-G being shed from the surface of the trophoblast, a process which may play a central role in ... We have determined their expression by trophoblast in relation to HLA-G, using immunohistochemistry. Anti-transporter protein ... Successful placentation in the human is dependent on the trophoblast evading recognition and destruction by the maternal immune ... This pattern could result from HLA-G being shed from the surface of the trophoblast, a process which may play a central role in ...
Quantifying the syncytialisation of human placental trophoblast BeWo cells grown in vitro - Nuffield Department of Women's &...
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells | Development |...
... the dataset contains cells within the trophoblast lineage between pre-implantation trophoblast and second trimester trophoblast ... Our human trophoblast atlas provides a powerful analytical resource to delineate trophoblast cell fate acquisition, to ... A molecular atlas of human trophoblast development to mid-gestation. To track trophoblast lineage specification during human ... where yij is the expression of a gene i in a cell j along the trophoblast trajectory, μij and σij are the mean and standard ...
Reprogramming roadmap reveals route to human induced trophoblast stem cells
Springbok (Antidorcas marsupialis) | IVIS
The pigmented trophoblast below the chorion, in trophoblast. 6) Umbilical Cord. Although the cord of this specimen was ... 9) Trophoblast External to Barrier. It is unlikely that this species has trophoblast externally, in endo/myometrium since its ... There was none of the subchorionic pigmentation but many trophoblast cells had pigmented cytoplasm. In addition, there was no ... The intercotyledonary membranes are covered with trophoblast that lack binucleate cells in my specimen. There is an extensive ...
Dorcas gazelle (Gazella dorcas) | IVIS
9) Trophoblast external to barrier. There is none.. 10) Endometrium. True decidual transformation of the endometrium does not ... Note the prominent trophoblast beneath the vascular chorionic plate. 6) Umbilical cord. The umbilical cord contains 4 large ... A small amount of pigment, typical of the pigment of the "hematophagous organ" can be found in foci of trophoblast beneath the ... Occasional binucleate cells interrupt the cuboidal trophoblast of the villous surface. The fetal capillaries protrude ...
Curcumin induces apoptosis in trophoblast model cell line | Medical Journal of Indonesia
Methods: In this in vitro study, trophoblast cells were divided into six groups, the control group (trophoblast cells were ... Curcumin induces apoptosis in trophoblast model cell line * Tatit Nurseta Department of Obstetric and Gynecology, Faculty of ... Keywords: apoptosis, curcumin, eNOS, hydatidiform mole, trophoblast Abstract. Background: Several studies have reported that ... Curcumin induces apoptosis in trophoblast model cell line. Med J Indones [Internet]. 2018Sep.9 [cited 2023Dec.5];27(2):87â 93. ...
"PALMITIC ACID IMPEDES EXTRAVILLOUS TROPHOBLAST ACTIVITY BY INCREASING " by Yunali V. Ashar
Normal function of placental extravillous trophoblasts (EVT), which are responsible for uteroplacental vascular remodeling, is ... Ashar, Yunali V., "PALMITIC ACID IMPEDES EXTRAVILLOUS TROPHOBLAST ACTIVITY BY INCREASING MRP1 EXPRESSION AND FUNCTION" (2022). ... Normal function of placental extravillous trophoblasts (EVT), which are responsible for uteroplacental vascular remodeling, is ... PALMITIC ACID IMPEDES EXTRAVILLOUS TROPHOBLAST ACTIVITY BY INCREASING MRP1 EXPRESSION AND FUNCTION ...
Altered protein O‑GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast...
Altered protein O‑GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast ... Altered protein O‑GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast ... Altered protein O‑GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast ... Altered protein O‑GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast ...