*  Morphological and Functional Evaluation of Buttock Lipoatrophy Treatment With Macrolane - Study Results - ClinicalTrials.gov

Outcome Measures Hide All Outcome Measures 1. Primary: Change From 6 Months to Baseline in Visual Analogue Scale (VAS) Pain ... 6 months after treatment compared to baseline Population Description Explanation of how the number of participants for analysis ... 12 months after treatment Population Description Explanation of how the number of participants for analysis was determined. ... One month and up to 18 months after treatment Population Description Explanation of how the number of participants for analysis ...
https://clinicaltrials.gov/ct2/show/results/NCT00931268?sect=X0125&view=results

*  Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To...

Show Outcome Measure 2 3. Secondary: Time to Treatment Failure [ Time Frame: Time from date of radomization to the earliest ... Show Outcome Measure 3 4. Secondary: Overall Survival (OS) [ Time Frame: time from the date of randomization to the date of ... Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To ... Allocation: Randomized; Intervention Model: Parallel Assignment; Masking: None (Open Label); Primary Purpose: Treatment. ...
https://clinicaltrials.gov/ct2/show/results/NCT00751036?term=nilotinib

*  A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid Arthritis - Study Results -...

Outcome Measures Show All Outcome Measures 1. Primary: Percentage of Participants Achieving American College of Rheumatology 20 ... Show Outcome Measure 23 24. Secondary: Medical Outcome Study Sleep Scale (MOS-SS) at Baseline and Month 3 [ Time Frame: ... Show Outcome Measure 24 25. Secondary: Number of Participants With Optimal Sleep Assessed Using Medical Outcomes Study Sleep ... Show Outcome Measure 26 27. Secondary: Number of Participants With Optimal Sleep Assessed Using Medical Outcomes Study Sleep ...
https://clinicaltrials.gov/ct2/show/results/NCT00814307?sect=X0156_04&view=results

*  Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate - Study...

Outcome Measures Show All Outcome Measures 1. Primary: Number of Participants Who Meet the Definition of Treatment Success ... Show Outcome Measure 13 14. Secondary: Changes in Early Treatment Diabetic Retinopathy Study (ETDRS) Best-corrected Visual ... Show Outcome Measure 14 15. Secondary: Changes in Early Treatment Diabetic Retinopathy Study (ETDRS) Best-corrected Visual ... Show Outcome Measure 15 16. Secondary: Changes in Early Treatment Diabetic Retinopathy Study (ETDRS) Best-corrected Visual ...
https://clinicaltrials.gov/ct2/show/results/NCT01314417

*  Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation - Study Results - ClinicalTrials.gov

Outcome Measures 1. Primary: Off-medication/On-stimulation Motor Function Score of the Unified Parkinson's Disease Rating Scale ... Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation (CSP#468F). This study has been completed. ...
https://clinicaltrials.gov/ct2/show/results/NCT01022073

*  Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients - Full Text View -...

Treatment Outcome. Quality of Life. Additional relevant MeSH terms: HIV Infections. Sarcoma. Sarcoma, Kaposi. Lentivirus ... regardless of treatment group. For patients with documented progressive disease (treatment failure), the treatment assignment ... Primary Purpose: Treatment. Official Title:. A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for ... For treatment failures in the IM862 group, IM862 is stopped and the patient is allowed other therapy options. ...
https://clinicaltrials.gov/show/NCT00002445?order=170

*  Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of Paclitaxel From Baker Norton...

Treatment Outcome. Antineoplastic Agents, Phytogenic. Additional relevant MeSH terms: HIV Infections. Sarcoma. Sarcoma, Kaposi ... Primary Purpose: Treatment. Official Title:. Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of ...
https://clinicaltrials.gov/show/NCT00002189?order=161

*  Lithium Treatment for Patients With Spinocerebellar Ataxia Type I - Full Text View - ClinicalTrials.gov

Primary Outcome Measures: *Incidence of side effects, side effect profile, and number of falls.. ... Lithium treatment Start treatment and remain in hospital until the blood level of the drug is stabilized; continue treatment at ... Primary Purpose: Treatment. Official Title:. Pilot Study of Tolerability of Lithium Therapy in Patients With Spinocerebellar ... Lithium Treatment for Patients With Spinocerebellar Ataxia Type I. This study has been completed. ...
https://clinicaltrials.gov/ct2/show/NCT00683943

*  Clinical Evaluation of Efficacy of 99mTC -Ethambutol in Tubercular Lesion Imaging : Table 1

Treatment history. Outcome. Male/40. Pulmonary TB. Lungs. Active pulmonary tuberculosis. True positive. ...
https://hindawi.com/journals/trt/2010/618051/tab1/

*  Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes : Table 2

Primary treatment. IB Mo. Metastatic site. Metastatic treatment. OS Mo. Special aspects. ... No active lesion within primary, BM occurred 24 months s/p treatment. ...
https://hindawi.com/journals/sarcoma/2014/475175/tab2/

*  Comparing of percutaneous coronary intervention and coronary artery bypass graft surgery in treating single and multi-vessel...

Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery are two types of revascularization procedures done in patients with single and multi-vessel coronary disease. The purpose of this review of the literature was to determine whether either of these revascularization procedures had a better outcome than the other in treating single and multi-vessel coronary artery disease. Initially, PCI consist of balloon angioplasty then progressed to include the use of coronary bare-metal stents and drug-eluting stents. CABG surgery can involve an on-pump procedure which requires cardiac arrest and rerouting the blood during the procedure or off-pump procedures which takes place in the beating heart. The risk of restenosis, thrombosis, graft failure, cognitive decline and repeat revascularization and other post-procedure complications can take place with these two revascularization procedures. The administrations of antiplatelets drugs with the procedures have decrease ...
content.library.ccsu.edu/cdm/singleitem/collection/ccsutheses/id/1607/rec/8

*  Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus...

BACKGROUND: Although many believe that platelet glycoprotein IIb/IIIa inhibitors should be used only in acute coronary syndrome patients undergoing percutaneous coronary intervention, supporting data from randomized clinical trials are tenuous. The a
biomedsearch.com/nih/Differential-treatment-benefit-platelet-glycoprotein/14769687.html

*  Clinical Outcomes Following Transcatheter Aortic Valve Replacement in Asian Population | JACC: Cardiovascular Interventions

This is the first large-scale study to evaluate the safety, efficacy, and clinical outcomes of Asian patients who underwent TAVR by using Sapien and CoreValve prostheses. The main findings included acceptable clinical outcomes of TAVR in Asian patients despite anatomical features of concern and Sapien and CoreValve demonstrated similar mortality rates, although different device-specific complications were observed. The present study also evaluated Asian patient characteristics, including small stature. Body mass indexes, annulus dimensions, and iliofemoral arteries are smaller in Asian patients than in Western patients. All these anatomical features raise concerns about an increased risk of major complications and poorer long-term outcomes. There have been no comparable studies that adequately assessed the clinical outcomes of TAVR, using the Sapien and CoreValve devices.. Among the 848 patients in our present study cohort who underwent ...
interventions.onlinejacc.org/content/9/9/926

*  Prompt Recognition and Percutaneous Coronary Intervention Leads to Favorable Myocardial Recovery After ST-Segment Elevation...

Acute myocardial infarction (AMI) is extremely rare in children, and unlike the adult disease, the etiology of the infarction is rarely due to atherosclerotic coronary disease. This unique reported case involved a 15-year-old boy with severe chest pain who presented with an ST-segment-elevation myocardial infarction secondary to in situ thrombus formation in the left anterior descending (LAD) coronary artery. The initial electrocardiogram (ECG) had a Q-wave pattern in V6 and ST depression in the inferior leads with ST-segment elevation in reciprocal leads. The cardiac enzymes and routine labs showed evidence of myocardial damage. The boy was urgently taken to the cardiac catheterization laboratory for percutaneous coronary intervention, where complete occlusion of the LAD was found and successfully stented. Eventually, a peripheral blood smear showed pancytopenia with 38Â % hypergranular blast-like cells consistent with acute myeloid leukemia (AML), and chemotherapy with all-transretinoic acid ...
connection.ebscohost.com/c/case-studies/91907480/prompt-recognition-percutaneous-coronary-intervention-leads-favorable-myocardial-recovery-after-st-segment-elevation-myocardial-infarction-secondary-acute-promyelocytic-leukemia-pediatric-case-report

*  Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European...

PURPOSE: Patients with chronic lymphocytic leukemia (CLL) and 17p deletion (17p-) have a poor prognosis. Although allogeneic hematopoietic stem-cell transplantation (HCT) has the potential to cure patients with advanced CLL, it is not known whether this holds true for patients with 17p-CLL. PATIENTS AND METHODS: Baseline data from patients, for whom information on the presence of 17p-CLL was available, were downloaded from the European Group for Blood and Marrow Transplantation database. Additional information on the course of CLL and follow-up was collected with a questionnaire. RESULTS: A total of 44 patients with 17p-CLL received allogeneic HCT between March 1995 and July 2006 from a matched sibling (n = 24) or an alternative donor (n = 20). 17p-CLL had been diagnosed by fluorescent in situ hybridization in 82% of patients and by conventional banding in 18% of patients. The median age was 54 years. Before HCT, a median of three lines of chemotherapy had been administered. At HCT, 53% of ...
repository.ubn.ru.nl/handle/2066/69689

*  "Single Stage Oncologic Resection and Reconstruction: A Step toward Dev" by Haroon Ur Rashid, Kashif Abbas et al.

ABSTRACT: Tumor free-margin surgical resection remains the single most important treatment in the curative therapy of musculoskeletal tumor of limbs. Refinements in surgical techniques have led to increased function preservation and limb salvage. Patients and Methods: The records of patients (n = 24) who underwent microsurgical soft tissue reconstruction subsequent to resection of limb tumour during the period 2006 to 2011 were reviewed. Primary outcome i.e. uptake of the flap was evaluated. Perioperative morbidities were also noted including donor as well as recipient site complications. Assessment of Functional outcome (Musculoskeletal Tumor Society score, MSTS) local recurrence, free survival, and disease-specific survival was also made. Results: Twenty four patients (age range: 7 - 72 years) who have undergone tumor resection followed by flap coverage were identified. Lower limb reconstruction outnumbered upper limb by 6:1. Complications included, one ...
ecommons.aku.edu/pakistan_fhs_mc_surg_orthop/21/

*  Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial. - The...

PURPOSE: Lapatinib is an orally reversible inhibitor of epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER-2) tyrosine kinases with demonstrated activity in patients with HER-2-positive breast cancer. In the current phase III open-label trial, lapatinib was compared with hormone therapy (HT) in patients with advanced renal cell carcinoma (RCC) that express EGFR and/or HER-2. PATIENTS AND METHODS: Patients with advanced RCC who had experienced disease progression through first-line cytokine therapy--stratified by Karnofsky performance status and number of metastatic sites--were randomly assigned to lapatinib 1,250 mg daily or HT. The primary end point was time to progression (TTP); secondary end points included overall survival (OS), safety, and biomarker analyses. RESULTS: Four hundred sixteen patients were enrolled onto the study. Median TTP was 15.3 weeks for lapatinib versus 15.4 weeks for HT (hazard ratio [HR] = 0.94; P = .60), and median OS was 46.9 weeks ...
christie.openrepository.com/christie/handle/10541/66158

*  Mechanical Thrombectomy for Acute Ischemic Stroke | JACC: Journal of the American College of Cardiology

In this meta-analysis of 9 randomized trials with 2,410 patients with acute ischemic stroke caused by large artery occlusion who presented within 4.5 h of symptom onset, mechanical thrombectomy after usual care was associated with improved recanalization rates, better functional outcomes, and a similar risk of sICH compared with usual care alone (i.e., intravenous thrombolysis). In particular, mechanical thrombectomy after usual care was associated with a 45% higher relative likelihood and a 13% higher absolute likelihood of achieving a good functional outcome at 90 days (mRS 0 to 2) compared with usual care alone administered within the recommended ischemic window (number needed to treat = 8) (Central Illustration). The metaregression analysis demonstrated that outcomes were improved in the more recent studies (i.e., those that used stent retrievers). In addition, there was a trend for reduced all-cause mortality with mechanical thrombectomy.. All studies ...
onlinejacc.org/content/66/22/2498

*  Abstract T P96: Short-term and Mid-term Results of Carotid Artery Revascularization as Carotid Artery Stenting for First-line...

Objective: Penetration ratio of carotid artery stenting (CAS) in carotid revascularization caught up that of carotid endarterectomy (CEA) in 2005, exceeding more than 60% in recent years after CREST in Japan. We choose CAS for first-line treatment, while CEA is applied to CAS high-risk patients dependent on factors including accessibility, plaque diagnosis, and symptom. The aim of this study is to evaluate short-term and mid-term results of single center experience of 266 consecutive cases with CAS / CEA.. Materials / Methods: This is a retrospective analysis of 227 CAS and 39 CEA during January 2009 to March 2013. The primary outcome measures (short-term results) were any periprocedural (within 30 days after procedure) death, stroke, and acute coronary syndrome, and the rate of postoperative positive lesion in diffusion weighted imaging (DWI) on MRI. The mid-term results include death, stroke, and restenosis requiring retreatment during the follow-up ...
stroke.ahajournals.org/content/45/Suppl_1/ATP96

*  Pharyngeal electrical stimulation for treatment of poststroke dysphagia: individual patient data meta-analysis of randomised...

Background. Dysphagia after stroke is common, associated independently with poor outcome, and has limited treatment options. Pharyngeal electrical stimulation (PES) is a novel treatment being evaluated for treatment of poststroke dysphagia. Methods. We searched electronically for randomised controlled trials of PES in dysphagic patients within 3 months of stroke. Individual patient data were analysed using regression, adjusted for trial, age, severity, and baseline score. The coprimary outcomes were radiological aspiration (penetration aspiration score, PAS) and clinical dysphagia (dysphagia severity rating scale, DSRS) at 2 weeks; secondary outcomes included functional outcome, death, and length of stay in hospital. Results. Three completed trials were identified: 73 patients, age 72 (12) years, severity (NIHSS) 11 (6), DSRS 6.7 (4.3), mean PAS 4.3 (1.8). Compared with no/sham stimulation, ...
eprints.nottingham.ac.uk/37305/

*  High-dose rate brachytherapy in localized penile cancer: short-term clinical outcome analysis | Radiation Oncology | Full Text

The median time to onset of loco-regional recurrence in our study was 7.7 months [6-9.4]. Similar data are reported in the literature with the notion that most of loco-regional recurrences occur in the first two years after treatment [18]. However, De Crevoisier et al. [14] observed 10-year local, inguinal and metastatic recurrence rates of 20%, 11% and 6% respectively. Moreover, Solsona et al. [19] reported a late recurrence rate of 2.5%. It is therefore necessary to recommend a prolonged surveillance and provide education to patients to detect these late local, lymph node and metastatic relapses.. The only series of HDR brachytherapy for penile cancers has been published by Petera et al. [10]. The authors reported the results of a cohort of 10 patients with squamous cell carcinoma of the penile. Eight pts were classified as T1N0M0, 1 pt TisN0M0 and 1 pt T1N1M0. Ninety percent of the tumors were localized to the glans. With a median follow up of 20 months [3.4 - 90.6], the authors reported ...
ro-journal.biomedcentral.com.preview-live.oscarjournals.springer.com/articles/10.1186/1748-717X-9-142

*  Transcatheter Aortic Valve Implantation | JACC: Cardiovascular Interventions

The PARTNER trial investigated the efficacy and safety of TAVI in otherwise inoperable patients with severe symptomatic AS and further strengthened the momentum toward TAVI in high-risk surgical patients. Continued advancements in delivery systems, valve durability, smaller sheath sizes, and operator experience will continue to make TAVI a viable option for patients with severe AS and prohibitive surgical risk. A second randomized trial from the PARTNER study (PARTNER II) investigating TAVI use with the new 18-F device in patients with high but not prohibitive surgical risk is currently ongoing and offers to shed light on TAVI use in surgical candidates. Further evaluation of transfemoral, transaxillary, and transapical approaches to TAVI in addition to newer devices, including the Medtronic Core Valve system (Medtronic, Minneapolis, Minnesota), might broaden the suitability of TAVI for a wider range of patients.. The exclusion of patients with coronary stenoses requiring revascularization, left ...
interventions.onlinejacc.org/content/4/1/132

*  Randomized, Two-arm, Non-inferiority Study Comparing Endeavor-Resolute Stent With Abbot Xience-V Stent - Full Text View -...

The RESOLUTE-III Allcomers trial is a prospective, multicenter, randomized, two-arm, international, non-inferiority, open-label study with 2300 patients at 15-20 centers. The study is a 'real world, all comers' study.. Primary objective: to compare the Medtronic Endeavor-Resolute (Zotarolimus-Eluting stent) system with the Abbott XIENCE V (Everolimus-Eluting stent) system with respect to cardiac death, myocardial infarction (not clearly attributable to a non-target vessel), Target Lesion Revascularization at 1 year in a 'real world' patient population.. Study hypothesis: To determine whether the Zotarolimus-Eluting stent (Medtronic Endeavor-Resolute) is non-inferior to the Everolimus-eluting stent (Abbott XIENCE V) in terms of the primary endpoint at 12 months after stent implantation. ...
https://clinicaltrials.gov/ct2/show/NCT00617084

*  Totally arterial off-pump coronary artery bypass grafting after pneumonectomy.

We report the case of an 82-year-old man who underwent triple coronary artery bypass grafting with arterial grafts, who 20 years previously underwent left pneumonectomy for lung cancer. Computed tomography (CT) presented a marked shift of the heart a
biomedsearch.com/nih/Totally-Arterial-Off-pump-Coronary/21697802.html

*  Prognostic factors affecting local control of hepatic tumors treated by stereotactic body radiation therapy | Radiation...

One of the first prospective studies using stereotactic radiotherapy as a single fraction with doses of 14-26 Gy for the treatment of hepatic tumors, including HCC and metastases, was conducted by Herfarth et al.[13]. The actuarial local control rates were 75%, 71%, and 67% at six-, 12-, and 18-months respectively. Updating these results yielded a local control rate of 66% at 18 months after a single fraction of 22 Gy[14]. The authors showed that the reduction in tumor volume may be delayed after a single irradiation dose; eight of the 17 patients with stable disease at the first evaluation achieved a complete or partial response at last follow-up. More recently, Ambrosino et al. published their preliminary results of SBRT by CyberKnife for unresectable hepatic lesions in 27 patients[1]. They obtained disease control in 74.1% of cases. The latest study to our knowledge was by Van der Pool et al.[4], reporting a local control rate of 74% at two years, with the Body Frame system, after three ...
ro-journal.biomedcentral.com.preview-live.oscarjournals.springer.com/articles/10.1186/1748-717X-7-166

*  Predictors of outcome in neck pain patients undergoing chiropractic care: comparison of acute and chronic patients - Zurich...

BACKGROUND: Neck pain is a common complaint in patients presenting for chiropractic treatment. The few studies on predictors for improvement in patients while undergoing treatment identify duration of symptoms, neck stiffness and number of previous episodes as the strong predictor variables. The purpose of this study is to continue the research for predictors of a positive outcome in neck pain patients undergoing chiropractic treatment. METHODS: Acute (, 4 weeks) (n = 274) and chronic (, 3 months) (n = 255) neck pain patients with no chiropractic or manual therapy in the prior 3 months were included. Patients completed the numerical pain rating scale (NRS) and Bournemouth questionnaire (BQ) at baseline prior to treatment. At 1 week, 1 month and 3 months after start of treatment the NRS and BQ were completed along with the Patient Global Impression of Change (PGIC) scale. Demographic information was provided ...
zora.uzh.ch/id/eprint/73802/

*  Abstract T P353: Positive Fluid Balance Predicts Poor Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage | Stroke

Background and Purpose: Strict maintenance of normovolemia is standard of care in treatment of aneurysmal subarachnoid hemorrhage (aSAH) and induced hypervolemia is used to treat delayed cerebral ischemia (DCI) from vasospasm. Fluid-related complications are not uncommon. We tested the hypothesis that fluid balance affected clinical outcomes in aSAH.. Methods: We reviewed 307 patients with aSAH admitted to the Neuroscience Intensive Care Unit (NICU) from October 2001 to June 2011. We collected data on fluid balance during NICU stay, clinical and radiographic evidence of vasospasm, cardiopulmonary complications, and functional outcomes by modified Rankin scale (mRS) upon follow-up (mean 8 ± 8 months). Poor functional outcome was defined as mRS 3-6. Associations of variables of interest with outcome were assessed using univariable and multivariable logistic regression. Propensity scores were estimated to account for imbalances ...
stroke.ahajournals.org/content/45/Suppl_1/ATP353

*  Austin Health Research Online: Apneic oxygenation versus low-tidal-volume ventilation in anesthetized cardiac surgical patients...

OBJECTIVES: To compare the physiology of apneic oxygenation with low-tidal-volume (VT) ventilation during harvesting of the left internal mammary artery. DESIGN: Prospective, single-center, randomized trial. SETTING: Single-center teaching hospital. PARTICIPANTS: The study comprised 24 patients who underwent elective coronary artery bypass grafting surgery. INTERVENTIONS: Apneic oxygenation (apneic group: 12 participants) and low-VT ventilation (low-VT group: 12 participants) (2.5 mL/kg ideal body weight) for 15 minutes during harvesting of the left internal mammary artery. MEASUREMENT AND MAIN RESULTS: The primary endpoint was an absolute change in partial pressure of arterial carbon dioxide (PaCO2). Secondary endpoints were changes in arterial pH, pulmonary artery pressures (PAP), cardiac index, and pulmonary artery acceleration time and ease of surgical access. The mean (standard deviation) absolute increase in PaCO2 was 31.8 mmHg (7.6) in the apneic group and 17.6 mmHg (8.2) in the low-VT ...
https://ahro.austin.org.au/austinjspui/handle/1/16613

*  Oral Skin Lightening - All About Skin Lightening

Multiple studies indicate that oral intake of tranexamic acid can benefit individuals with melasma. Since melasma is rooted in hormonal imbalances, tranexamic acid is a viable treatment option since it decreases the alpha-MSH (Melanocyte Stimulating Hormone) through its antiplasmin activity.. One particular study published in Aesthetics Plastic Surgery, revealed that 6 months of consuming tranexamic acid at a dosage of 250 mg, twice a day, resulted in mark reductions in epidermal and mixed (epidermal and dermal) melasma lesions. A small amount (9.5%) of subjects in this study reported a recurrence of melasma after discontinuance.. Oral intake of tranexamic acid has a very small side effect profile and is generally well-tolerated by most individuals. However, a small amount of subjects in the above study reported gastrointestinal discomfort (5.4% out of 74 subjects) and hypomenorrhea (8.1% out of 74 subjects). No severe side effects have been reported in regards to the systemic intake of ...
allaboutskinlightening.net/2016/03/oral-skin-lightening.html

*  HKU Scholars Hub: Evidence of a novel anti-apoptotic factor: Role of Id-1 in anticancer drug-induced apoptosis

Id-1 (inhibitor of differentiation or DNA binding), a member of the basic helix-loop-helix (HLH) transcription factor family, is upregulated in many types of human cancer and its expression levels are correlated with poor treatment outcome and shorter survival. To study if Id-1 plays a positive role in protecting cancer cells from programmed cell death, we studied the role of Id-1 on five cancer cell lines derived from nasopharyngeal carcinoma (CNE1), cervical carcinoma (HeLa), breast cancer (MCF7), hepatocarcinoma (Huh7) and prostate cancer (PC3), all of which have been shown overexpression of Id-1 in clinical specimens. Nine commonly used anticancer drugs including two DNA damaging agents (cisplatin, mechlorethamine), one antibiotic (mitomycin C), two topoisomerase II inhibitors (doxorubicin, etoposide), one anti-metabolite (methotrexate), two microtubule disrupting agents (taxol, vincristine), and a green tea extract, epigallocatechin gallate (EGCG), were used to examine ...
hub.hku.hk/handle/10722/95384

*  Effectiveness of Intracoronary Injection of Eptifibatide in Primary Coronary Intervention in STEMI Patients - Full Text View -...

The achievement of high local concentration of Eptifibatide, a GP 2b3a inhibitor,via direct intracoronary injection, promotes (in vitro) clot disaggregation. It remains unclear if it is of superior benefit than the routine intravenous administration of these agents.. In patients presenting with acute myocardial infarction, and undergoing primary coronary intervention, intracoronary administration of Eptifibatide may increase local drug concentration by several orders of magnitude and promote clot disaggregation with a minimal increase in systemic drug concentration, and in that way enhancing myocardial perfusion and survival. ...
https://clinicaltrials.gov/ct2/show/NCT00945308

*  OC-109 Endoscopic papillectomy: feasibility, safety and efficacy data from a single uk centre | Gut

Results A total of thirty-five patients were referred for papillectomy but only twenty-two patients (13 female, median age 72 years) underwent a total of 24 papillectomies. En-bloc resection was achieved in 17 patients (77%) with lesion sizes ranging from 8-25 mm (Median 16 mm). Pancreatic stent placement was successful in 82% of all papillectomies. Three patients experienced complications (12.5%); 2 bleeding and 1 acute pancreatitis. There was no procedure related deaths and no one required emergency surgery. There were no local recurrences in 77% of patients. Two patients required 2 attempts to achieve complete clearance of their adenomas. Histology of the resected lesions revealed low grade dysplasia (54.6%), high grade dysplasia (27.2%), cancer (9%), gangliocytic paraganglioma (4.6%), and neuroendocrine tumour (4.6%). Of the two patients who were found to have invasive cancer, the first patient went on to have a pancreaticoduodenectomy and subsequently died of post-operative complications ...
gut.bmj.com/content/64/Suppl_1/A54.2

*  Exercise Therapy Versus Arthroscopic Partial Meniscectomy for Degenerative Meniscal Tear in Middle Aged Patients - Sociedad...

Patient reported outcomes are prone to placebo effects.[31] Although placebo effects are greater after invasive interventions such as surgery,[31,32] they are also present from non-invasive passive treatments such as inactive ultrasonography and inert gel.[33] In exercise studies, where the patient, not the therapist, performs the intervention, placebo effects are less obvious, although attention effects cannot be excluded. Objective outcomes are less prone to placebo effects,[31] and a valuable addition for interpretation of clinical trials comparing surgical interventions with non-surgical interventions. Although we found no significant differences between treatments when evaluated using patient reported outcomes, muscle strength was significantly more improved in the supervised exercise group, directly after the intervention at both three months and 12 months. We cannot exclude the possibility that the greater placebo ...
sogacot.org/exercise-therapy-versus-arthroscopic-partial-meniscectomy-for-degenerative-meniscal-tear-in-middle-aged-patients/

*  Towards a framework of advanced nursing practice for the clinical research nurse in cancer care - University of Huddersfield...

Background: The Nursing and Midwifery Council (NMC), the regulatory body in the UK, is in the process of opening a new part of the register for Advanced Nurse Practitioners. This presents a potential opportunity for clinical research nurses within cancer care.. Objectives: To explore the role of the clinical research nurse in cancer care whilst considering whether the role can be performed at a level that could be considered advanced practice. Consequently, a developmental model to enable the clinical research nurse to work towards an advanced level of practice is explored.. Method: A literature review of the clinical research role in cancer care and analysis of published frameworks of advancing practice in nursing.. Discussion: Advanced practice is not defined by the role but by the level of skill to which it is performed. There is scope within the role of the clinical research nurse to practice at a level beyond initial registration. A framework for development towards advanced practice within ...
eprints.hud.ac.uk/id/eprint/5851/

*  Reply | JACC: Journal of the American College of Cardiology

We thank Drs. Zahger and Wolak for their interest in our paper (1) and for the observation about the role of grade of ischemia on surface electrocardiography (ECG) in the prediction of no-reflow. Many ECG-derived indexes including the QRS score (number of Q waves) (2) and the QRS duration (3) along with terminal distortion of the QRS, known as grade of ischemia (4), have been used in the assessment of no-reflow risk. In our review (1), we mentioned the QRS score because it is the most widely used ECG index in the triage of ST-segment elevation myocardial infarction patients. We acknowledge that other indexes including grade of ischemia may be useful in risk stratification before primary percutaneous coronary intervention. Interestingly, in a previous study performed by Wolak et al. (4), grade of ischemia was associated with infarct size, thrombus burden, and admission glycemia, which may all contribute to the multifactorial pathogenesis of no-reflow. We agree with Drs. Zahger and Wolak that, in ...
onlinejacc.org/content/55/3/265.1