PIT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Transcription+Factor+Pit-1 at the ... is a transcription factor for growth hormone. PIT1 is a pituitary-specific transcription factor responsible for pituitary ... Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. doi: ... "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387-8. doi:10.1016/ ...

59] The tumor cells are focally immunoreactive for ER-α, and diffusely immunoreactive for the transcription factor PIT-1. [49] ... In addition, the adenomas show diffuse immunoreactivity for the transcription factor PIT-1. [49] At the ultrastructural level, ... Bottom right: A strong immunostain for transcription factor PIT-1 (pituitary-specific positive transcription factor 1) is ... Bottom right: A strong immunostain for transcription factor PIT-1 (pituitary-specific positive transcription factor 1) is ...

Adenomas driven by the transcription factor Pit-1 include lactotroph, somatotroph, mixed somato-lactotroph, mammosomatotroph, ... Transcription Factor. Adenoma Subtype. Pituitary transcription factor 1 (Pit-1). Lactotroph (densely and sparsely granulated). ... A third transcription factor, pituitary cell-restricted T box factor (Tpit), drives corticotroph adenomas but its antibody is ... Antibodies directed against the transcription factors steroidogenic factor 1 (SF1) and transcription factor 1 (Pit-1) are ...

Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human ... Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human ... The latter region contains three DNA sequences homologous to a pituitary-specific transcription factor, Pit-1/GHF-1, DNA- ... Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.. ...

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell. 55: 519-29. PMID 2902928 ... Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 347: 528-33 ... TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of ... Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. The Embo Journal. ...

It was shown that this group of proteins control the transcription of the growth hormone (GH), the prolactin (PRL), the thyroid ... Pit-1 is a member of the POU domain containing proteins, a group of transcriptional regulators with a critical role in cell ... The allelic frequencies at Pit-1/TaqI locus were 0.76 (G) and 0.24 (A), while those at Pit-1/HinfI locus were 0.70 (B) and 0.30 ... In this study, the Pit-1/HinfI and Pit-1/TaqI loci were investigated using PCR-RFLP approach in a sample of 104 Podolica cattle ...

1B). This can reveal insight into other factors that cobind with the transcription factor that was mapped. ER was one of the ... Visualization of Pit-1 transcription factor interactions in the living cell nucleus by fluorescence resonance energy transfer ... An indirect, but powerful method for finding transcription factors that associate with a factor of interest is by ... Methods for mapping transcription factor binding sites, such as ChIP-seq, are relatively standard tools for many laboratories. ...

... a member of the POU domain family of transcription factors, characterized by a bipartite DNA-binding domain, serves critical ... PROTEIN PIT-1. C [auth A],. D [auth B]. 146. Rattus norvegicus. Mutation(s): 2 Gene Names: Pit-1, Pou1f1, Ghf-1, Pit1. ... Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.. Jacobson, E.M., Li, P., Leon- ... Here we report a high resolution X-ray analysis of the Pit-1 POU domain bound to a DNA element as a homodimer. This analysis ...

Mutations in pituitary transcription factors can cause multiple pituitary hormone deficiencies (MPHD) or, less commonly, an ... 4, 5] (ie, prophet of Pit-1) were the first mutations shown to cause MPHD. Mutations in the PIT1 gene produce a phenotype ... Regulation of the development of the mammalian anterior pituitary gland by transcription factors. Following, inductive signals ... Regulation of the development of the mammalian anterior pituitary gland by transcription factors. Following, inductive signals ...

Human pituitary-derived growth hormone More than 40 years have elapsed since human pituitary-derived growth hormone (pit-hGH) ... The PIT1 gene, located on chromosome 3, is a member of a large family of transcription factor genes responsible for the ... As a result, pit-hGH therapy was often discontinued when girls attained a height of 60 inches and when boys attained a height ... Insulinlike growth factors. Insulinlike growth factors (IGFs) are a family of peptides that partially depend on GH and that ...

Transcription Factor Pit-2 Related Concept UI. M0177775. Registry Number. 0. Terms. Transcription Factor Pit-2 Preferred Term ... Transcription Factor Pit-2 Registry Number. 0. Public MeSH Note. 2006; TRANSCRIPTION FACTOR PIT-1 was indexed under DNA-BINDING ... POU Domain Factors [D12.776.260.655] * Octamer Transcription Factors [D12.776.260.655.500] * Transcription Factor Brn-3 [ ... POU Domain Factors [D12.776.930.710] * Octamer Transcription Factors [D12.776.930.710.500] * Transcription Factor Brn-3 [ ...

... is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins ... Pituitary-specific positive transcription factor 1 (P28069) (SMART). OMIM:173110: Pituitary hormone deficiency, combined. ... TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE ... POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The ...

Transcription Factor Pit-1 / genetics ... The fibroblast growth factor 2 gene is associated with ... Association of bovine fibroblast growth factor 2 (FGF2) gene with milk fat and productive life: An example of the ability of ... Fibroblast Growth Factor 2 / genetics; Genotype; Least-Squares Analysis; Male; Polymorphism, Single Nucleotide; Pregnancy; ... Fibroblast Growth Factor 2 / genetics; Israel; Lactation / genetics; Milk / chemistry; Milk / cytology; Milk / standards; ...

T-Box Transcription Factor 19. ... etx-pit-ch28-fig11. Published February 1, 2023. at 1231 × 1096 ... PC 1/3 - Prohormone Convertase 1/3, POMC - Pro-opiomelanocortin, TBX19 - ...

Expression of growth hormone and its transcription factor, Pit‐1, in early bovine development. Molecular Reproduction and ... Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and ... Insulin-like growth factors in the development of the pancreas. Experimental and Clinical Endocrinology and Diabetes. 145-153. ... Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese ...

Mutations in pituitary transcription factor genes (e.g. HESX-1, PIT-1, LHX-4) can result in isolated or multiple anterior ...

... prevalence 1:125,000) characterised by broad thumbs and halluces, facial dysmorphism, psychomotor development delay, skeletal ... Arnold Chiari malformation type 1, double syringomyelic cavity and a novel CREBBP mutation (c.3546insCC). We hypothesize that ... Novel function of the transactivation domain of a pituitary-specific transcription factor, Pit-1. J Biol Chem. 2002, 277: 45141 ... mutant mice showed that selective loss of the CREB transcription factor in all the brain except pituitary resulted in reduced ...

CONCLUSIONS: The likelihood of CSI differed by transcription factor expression; PIT-1-expressing tumors had a higher ... There were 64 pituitary transcription factor-1 (PIT-1)-expressing, 62 steroidogenic factor-1 (SF-1)-expressing, 38 T-box ... transcription factor (TPIT)-expressing, and 5 nonstaining PTs. The gold standard for cavernous sinus invasion (CSI) was based ... Factors associated with STR were retrosellar (P = 0.04), subfrontal (P = 0.02), Knosp 3,4 cavernous sinus extension (P = 0.03 ...

Characterization of Transactivation Domain and Developmental Expression of Pituitary Specific Transcription Factor, Pit-1 of ... Cloning and Characterization of Insulin-Like Growth Factor I cDNA from Black Seabream (Acathopagrus schlegeli). Chen, MH; Lin, ... Cloning and characterization of insulin-like growth factor I cDNA from black seabream (Acathopagrus schlegeli).. Chen, MHC; Lin ... Comparison of cofilin-1 and Twist-1 protein expression in human non-small cell lung cancer tissues.. Chang, CY; Chang, SL; Leu ...

USMLE Step 1 M14 Notes *Knowing the difference between bacterial conjugation, transduction, and transformation *It is th... ... a transcription factor? GH,prolactin,TSH Pit-1 is a home domain protein thats required for transcription of these hormones * ... factor V b)factor VII c)factor XII d)factor XIII Answer: factor XII *Intramembranous deposits are seen in which type of ... Others are transcription factors and RNA polymerase, which all bind to DNA. *The enzyme inhibited by mycophenolate mofetil and ...

Time Factors. *Tissue Distribution. *Trans-Activators. *Transcription Factor Pit-1. *Transcription Factors ...

... pituitary-specific transcription factor 1) antibody syndrome is a novel clinical entity that presents an acquired combined ... Circulating anti-PIT-1 antibody along with various autoantibodies are detected with multiple endocrine organopathy, meeting the ... Key words: PIT-1, Hypopituitarism, Autoimmune polyglandular syndromes, Cytotoxic T lymphocytes, Autoantibody, Anti-PIT-1 ... Mechanistically, cytotoxic T lymphocytes that specifically react with PIT-1 protein play an important role in the development ...

The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that is involved in the pathogenesis ... NeuroD1 mRNA was widely expressed in PA (82%), with measurable levels found especially in those derived from Pit-1 independent ... Among the transcription factors involved in pituitary ontogenesis and physiology, basic helix-loop-helix (bHLH) have been ... Depletion of this transcription factor from lung cancer cells by antisense oligonucleotides results in a significant decrease ...

... that p30II is a multifunctional regulator that differentially modulates CREB and Tax-responsive element-mediated transcription ... HTLV-1 pX ORF II encodes two proteins, p13II and p30II whose roles are beginning to be defined in the virus life cycle. ... Human T-lymphotropic virus type-1 (HTLV-1) is a complex retrovirus that causes adult T-cell leukemia/lymphoma (ATL) and is ... These new findings suggest that HTLV-1, which is associated with lymphoproliferative diseases, uses p30II to selectively ...

... a homeodomain transcription factor. It regulates the activity of Six3 in the developing mouse retina, by binding to ... Pituitary PRL is controlled by the Pit-1 transcription factor and ultimately dopamine, extrapituitary PRL is controlled by a ... Main articles: Gene transcriptions/Promoters and Promoters. A promoter is a region of DNA that facilitates the transcription of ... a Steroidogenic Cell-Specific Transcription Factor, to Regulation of the Human CYP11A and Bovine CYP11B Genes through Their ...

We analyzed the expression of the transcription factors AP-2α (TFAP2α) and PAX6, the graded expression of which defines the ... and to highlight the entire GnRH migratory scaffold from the olfactory pit to the medial septal area (Fueshko and Wray, 1994). ... Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to ... to form simple olfactory pits (Fig. 1A,B). An invagination of the medial olfactory placode gives rise to the presumptive ...

POU Domain Factors. A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as ... The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, ... It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in ... Time Factors. Elements of limited time intervals, contributing to particular results or situations.. ...

... a pituitary transcription factor whose loss results in concomitant deficiencies of GH, PRL, and thyroid-stimulating hormone ( ... Additional genetic causes of disease include mutations in pit-1, ... Approximately 1 to 2% of adenomas secrete 2 or more hormones, ... The most common genetic disorder to affect the pituitary is multiple endocrine neoplasia-1 (MEN-1), characterized by neoplasms ... Pituitary adenomas are arbitrarily classified as microadenomas (, 1 cm) or macroadenomas (, 1 cm). Macroadenomas, when large, ...

Casar-Borota O et al., Immunohistochemistry for transcription factor T-Pit as a tool in diagnostics of corticotroph pituitary ... Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor ...