"Topotecan". Drug Information Portal. U.S. National Library of Medicine. "Topotecan hydrochloride". Drug Information Portal. U.S ... Topotecan unsilences the paternal UBE2A allele by reducing the transcription of an antisense transcript. Topotecan inhibits ... In physiological environments, topotecan is in equilibrium with its inactive carboxylate form. Topotecans active lactone form ... "FDA Approval for Topotecan Hydrochloride". National Cancer Institute. "FDA approves topotecan hydrochloride (hycamtin) in ...

Topotecan: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking topotecan,. *tell your doctor and pharmacist if you are allergic to topotecan, any other medications, or any of ... If you become pregnant while taking topotecan, call your doctor immediately. Topotecan may harm the fetus. ... Topotecan comes as a capsule to take by mouth. It may be taken with or without food. It is usually taken once a day for 5 days ...

Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after ... Topotecan belongs to the group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are ... Some effects may occur after treatment with topotecan has been stopped. This medicine is to be given only by or under the ...

This patient-friendly article is about chemotherapy drug, Topotecan (Hycamptin) which is a chemotherapy drug primarily used to ... Topotecan is administered through a drip intravenously.. Side effects can include: fatigue, greater risk of infections, anaemia ...

For treating cancer. Generic Name: Topotecan.

IT administration of topotecan was tolerable on this dose and schedule. The majority of adverse events were mild to moderate, ... Conclusion: IT administration of topotecan was tolerable on this dose and schedule. The majority of adverse events were mild to ... Patients and methods: Patients received age-adjusted IT topotecan (0.4 mg/dose for patients ,3 years of age) administered twice ... Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: a Childrens Oncology ...

... topotecan), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... topotecan intravenous TOPOTECAN - INJECTION (TOE-poe-TEE-kan) COMMON BRAND NAME(S): Hycamtin WARNING: Topotecan decreases bone ... encoded search term (topotecan (Hycamtin)) and topotecan (Hycamtin) What to Read Next on Medscape ... You should not become pregnant while using topotecan. Topotecan may harm an unborn baby. Women using this medication should ask ...

Topotecan is a novel topoisomerase I inhibitor that may have a role in the adjuvant chemotherapy of several solid tumors, ... Neither short-term nor long-term topotecan toxicity was blocked by ectopic expression ofbcl-2 or wild-type p53. Transfer of a ... High micromolar concentrations of topotecan, which are unlikely to be achieved in plasma in human patients in vivo, were ... These data suggest that topotecan needs to be administered in high concentrations, such as an intratumoral polymer, to limit ...

Patients receive ZD9331 as in arm I and topotecan IV over 30 minutes on days 1-5. All arms:. Treatment repeats every 21 days in ... OBJECTIVES: I. Compare the efficacy of ZD9331 with or without topotecan in patients with. refractory or recurrent ovarian ... or in Combination With Topotecan, in Patients With Ovarian Cancer Refractory or Recurrent After Failing Platinum and Paclitaxel ... or in Combination With Topotecan, in Patients With Ovarian Cancer Refractory or Recurrent After Failing Platinum and Paclitaxel ...

Topotecan and carboplatin were chosen for a three-drug combination with melphalan because they have been used successfully as ... In the three-drug therapy, dose ranges were 2.5-7.5 mg for melphalan, 0.3-0.6 mg for topotecan, and 25-50 mg for carboplatin, ... There were a total of 61 three-drug (melphalan, carboplatin, and topotecan) infusion sessions. The mean number of three-drug ... To avoid systemic toxicity and maximise intraocular response, we have used SIAC in which melphalan is combined with topotecan ...

Diffuse alveolar damage after a single dose of topotecan in a patient with pulmonary fibrosis and small cell lung cancer. Lung ...

... but the mechanism of topotecan action on the PWS/AS locus is unknown. Here, we demonstrate that topotecan treatment stabilizes ... R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. ... These results demonstrate that the AS candidate drug topotecan acts predominantly through stabilizing R loops and chromatin ... Interestingly, topoisomerase inhibitors, including topotecan, were recently identified in an unbiased drug screen for compounds ...

Cyclophosphamide and topotecan as first-line salvage therapy in patients with relapsed ewing sarcoma at a single institution. J ... "Topotecan" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Topotecan" by people in this website by year, and whether " ... Camptothecin and Topotecan, Inhibitors of Transcription Factor Fli-1 and Topoisomerase, Markedly Ameliorate Lupus Nephritis in ...

Topotecan is indicated for the treatment of:. • metastatic carcinoma of the ovary after failure of initial or subsequent ... Topotecan in combination with cisplatin is indicated for the treatment of:. • stage IV-B, recurrent, or persistent carcinoma of ... Recommended Dosage: The recommended dose of Topotecan is 0.75 mg/m² by intravenous infusion over 30 minutes daily on days 1, 2 ... Recommended Dosage: The recommended dose of Topotecan is 1.5 mg/m² by intravenous infusion over 30 minutes daily for 5 ...

Find information on Topotecan (Hycamtin) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "Topotecan." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. Medicine Central, im.unboundmedicine.com/medicine/view/ ... Davis-Drug-Guide/51756/6/topotecan. Vallerand AHA, Sanoski CAC, Quiring CC. Topotecan. Daviss Drug Guide. F.A. Davis Company; ... Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2023). Topotecan. In Daviss Drug Guide (18th ed.). F.A. Davis Company. https ...

Find information on Topotecan (Hycamtin) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... www.drugguide.com/ddo/view/Davis-Drug-Guide/51756/10.0/topotecan. Vallerand AHA, Sanoski CAC, Quiring CC. Topotecan. Daviss ... Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2023). Topotecan. In Daviss Drug Guide (18th ed.). F.A. Davis Company. https ... TY - ELEC T1 - topotecan ID - 51756 A1 - Sanoski,Cynthia A, AU - Vallerand,April Hazard, AU - Quiring,Courtney, BT - Daviss ...

Topotecan, ifosfamide, and paclitaxel also have significant activity in this setting. The combination of topotecan and ... Topotecan inhibits topoisomerase I, inhibiting DNA replication. It acts in the S phase of the cell cycle. Patients who have ... Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology ...

... both genistein and topotecan induce cellular death in LNCaP cells, ii) topotecan-genistein combination was significantly more ... both genistein and topotecan induce cellular death in LNCaP cells, ii) topotecan-genistein combination was significantly more ... Anticancer ativities of topotecan-genistein combination in prostate cancer cells. 29 views. 6 downloads ... Anticancer ativities of topotecan-genistein combination in prostate cancer cells. Download pdf , Full Screen View ...

Topotecan Hydrochloride for Injection by Pfizer Canada ULC - This medication may be available under multiple brand names and/or ... Each single dose vial of solution contains topotecan HCL equivalent to 4 mg of topotecan as free base in 4 mL of Sterile Water ... Topotecan is used to treat metastatic cancer of the ovary after other treatment(s) have failed. It is also used to treat small ... Anemia: Topotecan may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) ...

Compound: Topotecan Drug Target: TOP1 Drug Target pathway: DNA replication Dataset. GDSC2. ...

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TagsClinical Trial, Glioblastoma, Glioma, Topotecan. Post navigation. Previous PostPrevious The V2 segment of the vertebral ... Regression of Recurrent Malignant Gliomas With Convection-Enhanced Delivery of Topotecan. Neurosurgery 69:1272-1280, 2011 DOI: ... CONCLUSION: Topotecan by convection-enhanced delivery has significant antitumor activity at concentrations that are nontoxic to ... METHODS: We performed a prospective, dose-escalation phase Ib study of the topoisomerase- I inhibitor topotecan given by ...

BRENDA - The Comprehensive Enzyme Information System

topotecan. Anti-tumor antibiotics. These drugs differ from antibiotics for treating infections. They work by causing DNA ...

Global Topotecan Industry Research Report, Growth Trends and Competitive Analysis 2023-2029 ... 12 Topotecan Market Dynamics. 12.1 Topotecan Market Trends. 12.2 Topotecan Market Drivers. 12.3 Topotecan Market Challenges. ... Topotecan Market Trends. Table 109. Topotecan Market Drivers. Table 110. Topotecan Market Challenges. Table 111. Topotecan ... 2.5 Global Top Topotecan Countries Ranking by Market Size. 3 Topotecan Competitive by Company. 3.1 Global Topotecan Revenue by ...

Topotecan continued to keep the disease stable so far. I had very little side effects from it. My hands would get hot and the ... I was on Topotecan after Taxol. I took 2 rounds of 6 treatments that were administered weekly. I had a 3 week break in between ... I used topotecan as part of a clinical trial, along with radiation Tx, 2 times/day for three weeks. After that, and four rounds ... Bottom line (in my opinion) is that I think Topotecan did do some good for Jim but the brain met was not able to be tackled at ...

Sometimes, topotecan is given by itself.. This type of treatment can help some patients, but it can cause severe side effects, ...

Irinotecan and Topotecan. GENISTEIN. In a cell culture study, genistein was used in combination with either irinotecan or ... When genistein and daidzein were used in combination with cisplatin and topotecan in five different ovarian cancer cell lines, ... When genistein and daidzein were used in combination with cisplatin and topotecan in five different ovarian cancer cell lines, ... In a cell culture study, genistein was used in combination with either irinotecan or topotecan. Genistein enhanced the ...

Detailed drug Information for Bacillus of calmette and guerin vaccine, live (Intradermal). Includes common brand names, drug descriptions, warnings, side effects and dosing information.

Topotecan. In a randomized trial of 784 patients, the combination of oral topotecan given with cisplatin for 5 days was not ... 7% for topotecan alone) and thrombocytopenia (41% for the combination arm vs. 28% for topotecan alone).[17][Level of evidence ... Topotecan. Evidence (topotecan and other chemotherapy agents):. *A randomized comparison of second-line treatment with either ... A randomized phase III trial (CWRU-SKF-1598 [NCT00003917]) of 304 patients assessed the use of oral topotecan (2.3 mg/m2/day ...