*  Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling | Cell...
Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry ... and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs) (37). TIMPs are a family of four ... Woessner JF Jr. That impish TIMP: the tissue inhibitor of metalloproteinases-3. J Clin Invest 108: 799-800, 2001. ... Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. Lamis ...
  http://ajpcell.physiology.org/content/296/4/C735
*  TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA - Rabbit Polyclonal Antibody IHC-P, IF, FC - Buy Now! ...
Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA, Rabbit Polyclonal Antibody validated in IHC-P, IF, FC (AH10767 ... TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the ... Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3. Format 200ug/ml of Ab purified from rabbit anti-serum by Protein A. ... Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody - ...
  http://www.abgent.com/products/AH10767-TIMP-3-Tissue-Inhibitor-of-Metalloproteinase-3-Antibody-Without-BSA
*  TIMP3 - tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases ... SFD; K222TA2; HSMRK222; K222 expressed in degenerative retinas; Tissue inhibitor of metalloproteinase-3. ... The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases ... Graff JR Methylation-associated silencing of the tissue inhibitor ofmetalloproteinase-3 gene suggest a suppressor role in ...
  http://www.urogene.org/kgdb/gene/28.html
*  Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus...
Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus ... Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus ... A transient COS-7 cell expression system was used to investigate the functional domain arrangement of tissue inhibitor of ... ECM bound MMP inhibitor, whereas a chimeric TIMP molecule, consisting of the NH2-terminal domain of TIMP-2 fused to the COOH- ...
  http://eprints.whiterose.ac.uk/440/
*  Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is...
The tissue inhibitors of metalloproteinases (TIMPs) are a family of four secreted inhibitors of matrix metalloproteinases (MMPs ... Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is ... Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is ... Furthermore, a point mutation at residue 1 of TIMP-3 totally abolished MMP-inhibitory activity of TIMP-3 and also failed to ...
  http://eprints.gla.ac.uk/17091/
*  Timp3 - tissue inhibitor of metalloproteinase 3 | International Mouse Phenotyping Consortium
Expression No Expression No Tissue Available Ambiguous Show Wildtype Expression. Anatomy. #HET Specimens HOM Images? WT Expr ... Expression No Expression No Tissue Available Ambiguous Anatomy. #HET Specimens WT Expr Mutant Expr. Images ...
  https://www.mousephenotype.org/data/genes/MGI:98754
*  Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not...
... is a dual inhibitor of the matrix metalloproteinases (MMPs) and some adamalysins, two families of extracellular and cell ... The mutant proteins are also effective inhibitors of tumor necrosis factor alpha (TNF-alpha) release from phorbol ester- ... stimulated cells, indicating that they provide a lead for engineering TACE-specific inhibitors that may reduce side effects ... surface metalloproteinases that function in extracellular matrix turnover and the shedding of cell surface proteins. The ...
  https://www.ndorms.ox.ac.uk/publications/226931
*  Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor...
Tissue inhibitors of metalloproteinases (TIMPs) are natural MMP inhibitors and impede the proteolytic activity of MMPs by ... Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. ... Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and ... The micrographs show tissue inhibitor of metalloproteinases (TIMP)-3 in the cytoplasm of a lobular carcinoma (a), both the ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1607
*  Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor...
Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... IntroductionOur aim was to study the expression pattern of tissue inhibitor of metalloproteinases TIMP-3 protein in invasive ...
  http://libros.duhnnae.com/2017/jul7/150134619652-Expression-of-tissue-inhibitor-of-matrix-metalloproteinases-TIMP-3-protein-in-invasive-breast-carcinoma-Relation-to-tumor-phenotype-and-clinical-outc.php
*  Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the...
Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... of cone mosaic is restored and cone outer segments are protected at later stages with Tissue Inhibitor of Metalloproteinase 1 ( ...
  https://iovs.arvojournals.org/article.aspx?articleid=2559862
*  CADM1 | Cancer Genetics Web
Tissue Inhibitor of Metalloproteinase-3. *Non-Small Cell Lung Cancer. *Apoptosis. *Cell Proliferation ... The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, ... Furthermore, in tumor tissues obtained from gastric cancer patients, the expression of miR-126 was negatively correlated with ... Furthermore, in tumor tissues obtained from liver cancer patients, the expression of miR-1246 was negatively correlated with ...
  http://www.cancerindex.org/geneweb/CADM1.htm
*  Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment | SpringerLink
Anand-Apte B, Bao L, Smith R, Iwata K, Olsen BR, Zetter B, Apte SS (1996) A review of tissue inhibitor of metalloproteinases-3 ... A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding ... Anti-angiogenesis Clinical trials Combination therapy Epi-drugs Histone deacetylase inhibitors DNA methyltransferase inhibitors ... Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in ...
  https://link.springer.com/article/10.1007/s10456-017-9551-z?no-access=true
*  Differentiation of the Mammary Epithelial Cell during Involution: Implications for Breast Cancer | Springer for Research &...
tissue-inhibitor of metalloproteinase 3. TMEM4/CNPY2. MIR-interacting saposin-like protein or canopy 2 homolog or transmembrane ... matrix metalloproteinase. MMTV-Neu. expression of the Neu oncogene (HER2/ErbB2) using the mouse mammary tumor virus LTR ... ECM degrading proteases and tissue remodelling in the mammary gland. Bioessays. 2005;27(9):894-903. doi: 10.1002/bies.20281. ... An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. ...
  https://rd.springer.com/article/10.1007/s10911-009-9121-0
*  TIMP3 Gene - GeneCards | TIMP3 Protein | TIMP3 Antibody
TIMP Metallopeptidase Inhibitor 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like ... matrix metalloproteinase,tissue inhibitor 3,expressed in retinal pigment epithelium,placenta,localized in extracellular matrix ... Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to ...
  https://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=7078
*  Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human...
... and highly accurate method for characterization of the transcriptome of specific cell/tissue types. Using this method, it ... TIMP3 encodes tissue inhibitor of metalloproteinase 3. Mutations in this gene have been associated with the autosomal dominant ... Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature. 1985, 318 ... HPRT1 is expressed at low levels in various cell lines and tissue types, with fewer than 8 to 15 serial analysis of gene ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2008-9-1-r3
*  Cancers | Free Full-Text | The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis...
Many inhibitors of DNA methylation as well as of histone methylation, have been successfully tested in preclinical studies and ... either as cytostatic molecules-reducing the proliferation of cancerous cells-or as tumor angiogenesis inhibitors. In this ... while at the same time display minimal toxic side effects to healthy tissues. Bevacizumab (Avastin)-a humanized monoclonal anti ... For example, the tissue inhibitor of metalloproteinases (TIMP-2) is suppressed in several types of cancers due to ...
  https://www.mdpi.com/2072-6694/10/8/268/htm
*  MicroRNA - Wikipedia
MiR-712 targets tissue inhibitor of metalloproteinases 3 (TIMP3). TIMPs normally regulate activity of matrix metalloproteinases ... miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in ... Let-7 accumulates in human tissues during the course of aging. When let-7 was ectopically overexpressed to mimic accelerated ... HMGA expression is almost undetectable in differentiated adult tissues, but is elevated in many cancers. HMGA proteins are ...
  https://en.wikipedia.org/wiki/MicroRNA
*  TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver...
The tissue inhibitor of metalloproteinase (TIMP)3, a stromal protein that restrains the activity of proteases and receptors, is ... Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation. J ... Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1. Endocrinology 2009;150:1697-1704pmid: ... Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in mice does not affect adipogenesis or adipose ...
  http://diabetes.diabetesjournals.org/content/61/2/454?with-ds=yes
*  Frontiers | Drugs and Targets in Fibrosis | Pharmacology
Tissue inhibitor of metalloproteinases (TIMPs) work as the inhibitors of MMPs. The balance of MMPs and TIMPs modulates the ... Shenlong Decoction on mRNA expressions of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in lung tissue ... 2010). Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am. J. Pathol ... Wang, H., Lafdil, F., Wang, L., Yin, S., Feng, D., and Gao, B. (2011). Tissue inhibitor of metalloproteinase 1 (TIMP-1) ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00855/full?utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Pharmacology&id=306391
*  astrocytic tumor spinal cord 2005:2010[pubdate] *count=100 - BioMedLibâ„¢ search engine
Tissue Inhibitor of Metalloproteinase-3 / metabolism. *[Email] Email this result item Email the results to the following email ... Tissue Inhibitor of Metalloproteinase-3; 0 / Von Willebrand antigen; 0 / von Willebrand Factor; EC 3.4.24.- / ADAM Proteins; EC ... Ten human brains at different developmental stages and 118 cases of nervous system tumor tissues were examined by ... Tumor Necrosis Factor-alpha / antagonists & inhibitors. Tumor Necrosis Factor-alpha / metabolism. *Hazardous Substances Data ...
  http://www.bmlsearch.com/?kwr=astrocytic+tumor+spinal+cord+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Gene Expression sub-cluster 37
Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by Porphyromonas ... ... proteases and their inhibitors, the tissue inhibitor of metalloproteinases (TIMPs). Here, we report that TIMP-2, MMP-2, and MT1 ... Tissue inhibitors of matrix metalloproteinases (TIMPs) regulate the activity of MMPs. We investigated the expression of MMP-2 ... Production of tissue inhibitors of matrix metalloproteinases (TIMPs), a family of secreted proteins with inhibitory actions on ...
  http://www.biomedsearch.com/cluster/10/Gene-Expression/sub-37-p12.html
*  TIMP3 - Wikipedia
1995). "Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human ... 1996). "The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites ... This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are ... Apte SS, Olsen BR, Murphy G (1995). "The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory ...
  https://en.wikipedia.org/wiki/TIMP3
*  Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. Cancer Res. ... Cell Culture and Tissue Samples. Normal human Schwann cells (NHSCs) were cultured from trauma victims (Casella et al. 1996) and ... Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol. ... Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2809821/
*  TIMP-3 Antibody | Abbiotec
Tissue inhibitor of metalloproteinases 3) is a secreted extracellular matrix protein, metalloprotease inhibitor. It forms ... Tissue inhibitor of metalloproteinases 3; TIMP-3; Protein MIG-5; TIMP3 ... It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, ... the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues ...
  http://abbiotec.com/antibodies/timp-3-antibody-1
*  Plus it
Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol ... These findings are in concordance with other findings in cancer tissues compared with normal tissues. ... Tissue DNA was extracted using the Puregene DNA Purification Kit (Gentra Systems). One microgram of DNA extracted from fresh ... A total of 119 tissue samples analyzed by Infinium array or methylation-sensitive high-resolution melting (MS-HRM; Table 1) ...
  http://clincancerres.aacrjournals.org/content/17/17/5582