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*  Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases ...
It is a high affinity thrombin receptor that converts thrombin into a protein C activator. Activated protein C then functions ... Biological activity is the ability to act as a receptor for thrombin, increase the activation of protein C, or other biological ...
  http://www.patentsencyclopedia.com/app/20090123440
*  Primed to Understand Fibrinogen in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
... fibrinogen to support high-affinity nonsubstrate binding of thrombin.22-24 Although fibrin-bound thrombin resists heparin- ... Inhibition of thrombin generation in plasma by fibrin formation (Antithrombin I). Thromb Haemost. 2002;88:253-258. ... Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ′. J Thromb ... Note on the adsorption of thrombin on fibrin. Science. 1945;101:520-521. doi: 10.1126/science.101.2629.520. ...
  http://atvb.ahajournals.org/content/36/1/4
*  Thrombin generation in different cohorts : Evaluation of the haemostatic potential
... endogenous thrombin potential (ETP, total thrombin concentration), peak (maximum thrombin concentration) and time to peak ( ... The total amount of thrombin generated was not related to diagnosis. The prolonged thrombin generation noted in controls and FV ... The great over-lap in thrombin generation between patients with and without recurrences though, makes the use of thrombin ... Additionally, we study the correlation between thrombin generation at the time of an acute VTE and thrombin generation measured ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:660831
*  Heparin cofactor II deficiency
Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of ... Heparin cofactor II (HCF2; {142360}) rapidly inhibits thrombin in plasma in the presence of dermatan sulfate or heparin. ...
  http://diseaseinfosearch.org/Heparin+cofactor+II+deficiency/8506
*  Aniara: MEASUREMENT OF HEPARIN COFACTOR II
... and measurement of residual thrombin by its amidolytic activity on a thrombin specific chromogenic substrate (SIIa-01). pNA is ... The amount of pNA released is directly related to the residual thrombin activity. There is an inverse relationship between the ... TEST PRINCIPLE: Heparin Cofactor II is an anticoagulant protein which inhibits specifically thrombin. This inhibition is highly ... The BIOPHEN H-CoII assay is a chromogenic method based on the inhibition of a constant and in excess amount of thrombin, by the ...
  http://www.aniara.com/mm5/merchant.mvc?Store_Code=ANIA&Screen=CTGY&Category_Code=HEPARINCOFACTORII
*  Aggregated Low-Density Lipoprotein Uptake Induces Membrane Tissue Factor Procoagulant Activity and Microparticle Release in...
... initiating blood coagulation and leading to the focal production of thrombin via the successive activation of factor IX, factor ...
  http://circ.ahajournals.org/content/110/4/452
*  Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational...
Parameters relating to thrombin generation, from emergency room (ER) admission until day 7. Endogenous thrombin potential was ... Each well was calibrated to a parallel well with a thrombin calibrator (Thrombin calibrator TS 20.0, Thrombinoscope BV). ... The following parameters were recorded: lag time, peak thrombin generation, time to peak, and endogenous thrombin potential ( ... and between thrombin potential and thrombin inhibition potential. This balance may have been impaired in the FC-PCC group, ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc13982
*  P104 Coagulation proteins in liver fibrosis: a role for tissue factor and fibrin/fibrinogen | Gut
... but with the exception of thrombin the expression and role of individual coagulation proteins in the pathogenesis of liver ...
  http://gut.bmj.com/content/60/Suppl_2/A48.2
*  Factor xa inhibitors - Eliquis copay card
Direct Thrombin Inhibitors and Factor Xa Inhibitors in. Initial identification of fXa inhibitors relied on high-throughput ... bind directly to thrombin and do not require a cofactor such as antithrombin to exert their effect.. List of Factor Xa ... direct thrombin inhibitors and factor Xa inhibitors are likely to replace warfarin for long-term anticoagulation in selected ... a coagulation factor at a critical juncture in the blood coagulation pathway leading to thrombin generation. ...
  http://www.valleystamp.com/wepe/factor-xa-inhibitors-1598.php
*  Thrombin Receptor Agonist Peptide | Abbiotec
Thrombin Receptor Agonist Peptide; TRAP; Proteinase-activated receptor 1; PAR-1; Thrombin receptor; Coagulation factor II ... respectively corresponding to aa42-47 and aa42-55 of the human thrombin receptor were found to be as effective as thrombin for ... Thrombin signaling of platelets is mediated by a G protein-coupled protease-activated receptor (PAR). The PAR is activated ... Synthetic thrombin receptor agonist peptides (TRAP) of 6 residues (SFLLRN) and 14 residues (SFLLRNPNDKYEPF), ...
  http://abbiotec.com/peptides/thrombin-receptor-agonist-peptide
*  Antifactor Xa Monitoring in Patients on IV Unfractionated Heparin
Of these, thrombin and factor Xa are most responsive, and thrombin's sensitivity to inhibition is approximately 10 times ... Heparin prohibits fibrin formation by inactivating thrombin and limits thrombin-induced activation of factors V and VIII. Once ... This leads to a conformational change that accelerates thrombin inhibition. The heparin-antithrombin complex binds to the ... Molecular weight dependency of the heparin potentiated inhibition of thrombin and activated factor X. Effect of heparin ...
  https://www.uspharmacist.com/article/antifactor-xa-monitoring-in-patients-on-iv-unfractionated-heparin
*  "Evaluation of Activated Partial Thromboplastin Time (aPTT) Reagents fo" by Magdalena Dudek, Leanne F. Harris et al.
Performance was assessed by measurement of the clotting time (CT) as evidenced by the onset of thrombin formation using a ... chromogenic thrombin substrate in plasma samples activated with these formulations. Results: Reagents in all of the three forms ... as evidenced by the onset of thrombin formation using a chromogenic thrombin substrate in plasma samples activated with these ...
  https://arrow.dit.ie/scschbioart/152/
*  LDL Increases Inactive Tissue Factor on Vascular Smooth Muscle Cell Surfaces | Circulation
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin ... Various agents, including serum, thrombin, angiotensin II, and platelet-derived growth factor have been shown to induce tissue ... In acute coronary syndrome, increased thrombin could promote coagulation after plaque rupture; in restenosis or atherosclerosis ... 1 3 4 5 and it has been proposed that the resulting increase in local thrombin production could play a pivotal role in the ...
  http://circ.ahajournals.org/content/99/13/1753
*  Heparin cofactor II - Wikipedia
2004). "Molecular mapping of the thrombin-heparin cofactor II complex". J. Biol. Chem. 279 (41): 43237-44. doi:10.1074/jbc. ... Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state. GRCh38: Ensembl release ... 2003). "Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular ... 2002). "Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism". Proc ...
  https://en.wikipedia.org/wiki/Heparin_cofactor_II
*  Argatroban - Wikipedia
This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared). Argatroban is used as an ... Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food ... Direct thrombin inhibitors. N Engl J Med 2005;353:1028-40. PMID 16148288 http://www.pharmatimes.com/Article/12-07-03/UK_launch_ ...
  https://en.wikipedia.org/wiki/Argatroban
*  Thrombin - Wikipedia
E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. ... Thrombin is sold under the brand name Fibrimex for use as a binding agent for meat. The thrombin in Fibrimex derives from ... Thrombin interacts with thrombomodulin. As part of its activity in the coagulation cascade, thrombin also promotes platelet ... Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The thrombin cleavage site (Leu-Val-Pro-Arg- ...
  https://en.wikipedia.org/wiki/Thrombin
*  Willems1991 - Simulating thrombin generation
Simulations of the effect of hirudin indicate that factor V is predominantly activated by thrombin and not by factor Xa. The ... A simulation model for the production of thrombin in plasma is presented. Values of the reaction rate constants as determined ... The dependence of this threshold value on different negative feedback reactions, e.g. the inactivation of thrombin and factor ... SBML L2V4 representation of Willems1991 - Simulating thrombin generation. 55.36 KB. Preview , Download. ...
  http://www.ebi.ac.uk/biomodels/MODEL1807240002
*  THROMBIN TIME
Home : For health professionals : Refer a patient : Laboratory Services : Test Table : THROMBIN TIME ... Heparin, Direct Thrombin Inhibitors (Lepirudin, Argatroban, Dabigatran, etc.), Fibrin/fibrinogen degradation products may cause ... prolongation of the Thrombin Time. Other interferences include: Hemoglobin (,500 mg/dL), Triglycerides (1,000 mg/dL), Bilirubin ...
  http://www.legacyhealth.org/for-health-professionals/refer-a-patient/laboratory-services/test-table/thrombin-time.aspx
*  thrombin cleavage
... stephen goodwin goodwin at BINAH.CC.BRANDEIS.EDU Thu Oct 10 06:42:16 EST 1996 *Previous message: Looking for ... Hi folks Does anyone know of any bead technology that exists that allows efficient removal of thrombin protease after cleavage ...
  http://www.bio.net/bionet/mm/dros/1996-October/002429.html
*  thrombin antibodies?
... Ding Ming ming at mbcrr.harvard.edu Fri Mar 24 12:35:13 EST 1995 *Previous message: MW of IgG? ... I would appreciate if you can tell me who produce the thrombin antibodies and what their telephone numbers. Thanks in advance. ...
  http://www.bio.net/bionet/mm/methods/1995-March/026418.html
*  Thrombin Sawai - Drugs.com
A list of US medications equivalent to Thrombin Sawai is available on the Drugs.com website. ... Thrombin Sawai is a medicine available in a number of countries worldwide. ... Thrombin Sawai may be available in the countries listed below.. Ingredient matches for Thrombin Sawai. Thrombin. Thrombin is ...
  https://www.drugs.com/international/thrombin-sawai.html
*  STA THROMBIN 10
Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium.,medicine, ... Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium. ...
  http://www.bio-medicine.org/medicine-products/STA-THROMBIN-10-20319-1/
*  THROMBIN PROJECT
Kinetic analyses of thrombin activities are routinely used to monitor changes in thrombin reactivity. Computer modeling of ... THROMBIN RESEARCH PROJECT. My main interest of research, which has been funded by Research Corporation and the NIH, involves ... and the production of rabbit antibody fragments recognizing thrombin. ... determining structural features of the bovine clotting enzyme thrombin which control its reactivity with other clotting factors ...
  http://employees.csbsju.edu/hjakubowski/images/research/clot.html
*  3PO1: Thrombin In Complex With Benzothiazole Guanidine
THROMBIN HEAVY CHAINTHROMBIN LIGHT CHAINTHROMBIN PEPTIDEAcetate IonEthyl [(2z)-2-(Carbamimidoylimino)-6-Hydroxy-1,3- ...
  https://www.ncbi.nlm.nih.gov/Structure/pdb/3PO1
*  Recothrom (Thrombin (Topical)) Information - Drugs.com
Thrombin (Topical)). Includes indications, proper use, special instructions, precautions, and possible side effects. ... Thrombin-JMI Epistaxis Kit, Thrombin-JMI Pump Spray Kit, Thrombin-JMI Syringe Spray Kit ... Generic Name: Thrombin (Topical) (THROM bin, TOP i kal). Brand Name: Evithrom, Recothrom, Recothrom Spray Kit, Thrombi-Gel, ... If you have an allergy to thrombin or any other part of Recothrom (thrombin (topical)). ...
  https://www.drugs.com/cdi/recothrom-thrombin-topical.html