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Miller, F. G. and H. Brody (2003). "A Critique of Clinical Equipoise: Therapeutic Misconception in the Ethics of Clinical ... Djulbegovic, B. (2009). "The Paradox of Equipoise: The Principle That Drives and Limits Therapeutic Discoveries in Clinical ... Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves ... Freedman proposed a different approach to this ethical dilemma called clinical equipoise. Clinical equipoise occurs "if there ...

Lay publics understanding of equipoise and randomisation in randomised controlled trials. Health Technol Assess. 2005 Mar;9(8 ... Therapeutic misconception. All participants. Figure 2 shows the participants responses related to therapeutic misconceptions. ... Suggestions for countering therapeutic misconception have focused on being more explicit about procedures unique to research (e ... Expression of therapeutic misconception amongst Egyptians: a qualitative pilot study. BMC Med Ethics. 2009;10:7. PMID:19563683 ...

We are in a state of clinical equipoise regarding the role of HTS in moderate bronchiolitis. Placebo-controlled (except 0.9% ... the therapeutic value of HTS in acute bronchiolitis remains unclear. ...

For therapeutic trials, this must include a discussion of why there is clinical equipoise and how the results will impact ... Applications submitted to this FOA may propose either therapeutic or mechanistic clinical trials. A therapeutic trial has a ... For therapeutic trials, this must include consideration of translation and dissemination steps needed, if applicable, ...

... therapeutic value assessments. Equipoise cannot be ignored when it is inconvenient to ones conclusions. ... 2) No attempt to estimate therapeutic utility values in U.S. terms. The assumption that comparative unmet need, criteria for ... in terms of unmet medical need offers more compelling metrics for therapeutic value. ... significant therapeutic value, and related critical indicators are similar across borders and regulatory regimes is absurd. ...

Methadone: is there therapeutic equipoise?. Romero, J., Baldinger, S. H., Goodman-Meza, D., Engstrom, K., Valencia, C. R., ...

Ideally, this equipoise is also present in patient-participants. In pediatrics, data on equipoise are lacking. We hypothesize ... Furthermore, a therapeutic misconception endangers correct assessment of participation, making parents inaccurately attribute ... Conclusions Lack of equipoise during enrolment did not reduce study recruitment, mainly due to the fact that preferred ... In our study, lack of equipoise during trial-participation did not reduce retention in those assigned to a less favoured option ...

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Therapeutic Equipoise (MeSH) * Treatment Outcome (MeSH) published in * Journal of Medical Ethics Journal ... Equipoise is the key ethical concept in determining which research studies are justified. However, there is a good deal of ... Position statement on ethics, equipoise and research on charged particle radiation therapy Journal Articles ...

That its therapeutic. And they foster what Appelbaum called the "therapeutic misconception." Its still research. Its still ... Its still in what we call "equipoise." And equipoise is this ethical phrase we use to say were in the middle, equally ... If people are getting benefits and its therapeutic, their insurance should cover it. The sponsoring company should cover it. ...

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Less than half of the respondents (44.3%, n = 82) "routinely" prescribed therapeutic anticoagulation for SpVT. A clinical trial ... Respondents indicate that a position of equipoise exists to justify randomized evaluation. ...

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Therapeutic restabilization corrects cellular contractile and metabolic phenotypes and may limit these adverse clinical ... Conclusions: Myosin conformations establish work-energy equipoise that is essential for life-long cellular homeostasis and ... Conclusions: Myosin conformations establish work-energy equipoise that is essential for life-long cellular homeostasis and ... Therapeutic restabilization corrects cellular contractile and metabolic phenotypes and may limit these adverse clinical ...

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... clinical equipoise is applicable to CRTs. Clinical equipoise is used to argue that control groups receiving only usual care are ... Finally, clinical equipoise provides research ethics committees with formal and procedural guidelines that form an important ... This paper addresses the third of the questions posed, namely, does clinical equipoise apply to CRTs in health research? The ... Here we argue that clinical equipoise may be usefully grounded in a trust relationship between the state and research subjects ...

The intellectual challenges and emotional consequences of equipoise contributed to the fragility of recruitment in six ... training strategies are required that orientate staff towards perceiving recruitment as ethical and rational given therapeutic ... they should understand the need for the study and the need for randomisation in conditions of clinical equipoise, given that ...

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STS and EACTS approach this evidence with scheduled follow-up to 10 years from a position of scientific and clinical equipoise ... as outstanding therapeutic options for patients with aortic stenosis. TAVI has proven to be an excellent innovation, ... we feel that some of the statements made were appropriately weighted with equipoise, but some were not. ...

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STS and EACTS approach this evidence with scheduled follow-up to 10 years from a position of scientific and clinical equipoise ... as outstanding therapeutic options for patients with aortic stenosis. TAVI has proven to be an excellent innovation, ... we feel that some of the statements made were appropriately weighted with equipoise, but some were not. ...

Discussions are provided on e.g. clinical equipoise, social value, health economical decision making, number of study arms, and ... If there is clinical equipoise among two (or more) treatments, physicians who are researchers do not violate their therapeutic ... Clinical equipoise (2a). It has been argued that there should be "genuine uncertainty in the expert medical community about the ... Although clinical equipoise and social value are ethical requirements for both designs, the content of these requirements may ...

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