Th17 Cell Plasticity and Functions in Cancer Immunity
M. A. Munegowda, Y. Deng, S. J. Mulligan, and J. Xiang, "Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17- ... H. Liu, A. T. Cao, T. Feng et al., "TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression," European ... R. Du, H. Zhao, F. Yan, and H. Li, "IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and ... P. Muranski, Z. A. Borman, S. P. Kerkar et al., "Th17 cells are long lived and retain a stem cell-like molecular signature," ...https://www.hindawi.com/journals/bmri/2015/314620/ref/
"Playing Nice": Transcription Factors in TH17 Cells | Science Translational...
"Playing Nice": Transcription Factors in TH17 Cells Message Subject. (Your Name) has forwarded a page to you from Science ... Ciofani et al. aimed to define how TH17-cell TFs work together to determine cell lineage and function. To do this, the authors ... M. Ciofani et al., A validated regulatory network for TH17 cell specification. Cell 151, 289-303 (2012). [Abstract] ... which is produced by TH17 cells, but little is known about how these TFs govern TH17 specification and cell function. ...http://stm.sciencemag.org/content/4/158/158ec198
Abstract 2867: TH17 cells promote early pancreatic tumorigenesis. | Cancer Research
We have found that TH17 cells, a subtype of CD4+ T-helper cells known to play an active role in other models of inflammation- ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ...http://cancerres.aacrjournals.org/content/73/8_Supplement/2867
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. | Broad Institute
Th17 Cells. Abstract. TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are ... These data demonstrate that SGK1 has a critical role in the induction of pathogenic TH17 cells and provide a molecular insight ... SGK1 is critical for regulating IL-23R expression and stabilizing the TH17 cell phenotype by deactivation of mouse Foxo1, a ... Here we used transcriptional profiling of developing TH17 cells to construct a model of their signalling network and nominate ...https://www.broadinstitute.org/publications/broad4831
IFN-β Inhibits Human Th17 Cell Differentiation | The Journal of Immunology
IFN-β-1a directly inhibits Th17 cell differentiation. A direct effect of IFN-β-1a on Th17 cell differentiation was investigated ... cells cultured in Th17-polarizing conditions. Two × 106 negatively selected CD4+CD45RA+ cells were cultured as above in Th17- ... and the Th17 cell surface marker IL-23R. The IFN-β-1a-mediated suppression of Th17 cell differentiation is also supported by ... the differentiation of Th17 cells is orchestrated by cytokines secreted by APCs. Although TGF-β and IL-6 induce Th17 cell ...http://www.jimmunol.org/content/183/8/5418?ijkey=7ddbecc251ce7249d4f5f8fcd06fdb702cf45964&keytype2=tf_ipsecsha
MINK1: The missing link between ROS and its inhibition of Th17 cells | JEM
... leads to increased ROS that negatively affect Th17 cell generation. Moreover, the DCA inhibitory effect on Th17 cell generation ... Mink1 deficiency results not only in a T cell-intrinsic enhanced Th17 cell commitment, but also in an increase in activated/ ... which in turn leads to enhanced Th17 cell generation in WT cells. This study demonstrated that Mink1 is the molecular mechanism ... MINK1: The missing link between ROS and its inhibition of Th17 cells. View ORCID ProfileGustavo J. Martinez ...http://jem.rupress.org/content/214/5/1205.long
TGF-β in Th17 cell development: the truth is out there.
2011) demonstrate in this issue of Immunity that autocrine TGF-β cytokine promotes Th17 cell development and maintenance. ... As Th17 cell developmental requirements continue to be studied, Gutcher et al. ( ... As Th17 cell developmental requirements continue to be studied, Gutcher et al. (2011) demonstrate in this issue of Immunity ...http://www.biomedsearch.com/nih/TGF-in-Th17-Cell-Development/21435582.html
JCI - miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, ... miR-146a-deficient 2D2 T cells induced more severe EAE and were more prone to differentiate into Th17 cells. Microarray ... miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ- ... miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. ...https://jci.org/articles/view/94012/figure/1
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis. | Sigma-Aldrich
... activity of Th17 cells from children with LN and suggest that therapeutic modulation of the Akt activity may inhibit Th17 cell ... Th17 cells infiltrate the kidneys of patients with lupus nephritis (LN) and are critical for the pathogenesis of this disease. ... Th17 cells from children with LN exhibit high Akt activity and enhanced migratory capacity. Inhibition of the Akt signaling ... effector T cells from children with LN correlates with increased frequencies of IL-17-producing cells within these T cell ...https://www.sigmaaldrich.com/catalog/papers/25339666
Human Th17 cells | Arthritis Research & Therapy | Full Text
Th17 cells produce IL-26 , whose exact role in the Th17 response is not yet established (Figure 2). Murine Th17 cells are ... cell into a Foxp3+ T regulatory (Treg) cell. IL-23 produced by DCs allows the expansion and/or survival of Th17 cells. Th17 ... Discovery of murine Th17 cells and their origin. *Properties of murine Th17 cells and their role in protection and ... Th17 CellExperimental Autoimmune EncephalomyelitisTreg CellTh17 DifferentiationDevelopmental Relationship. Introduction. The ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar2392
Protocol for the Differentiation and Characterization of Human Th17 Cells: R&D Systems
Flow Cytometric Analysis, single and Multi-analyte Assay of Cell Supernatants. ... Protocol for the Differentiation and Characterization of Human Th17 Cells. ... In vitro differentiation of Th17 cells from the larger CD4+ T cell population provides increased numbers of Th17 cells to ... Verify successful Th17 cell differentiation by analysis of the cells with flow cytometry and analysis of the cell culture media ...https://www.rndsystems.com/resources/protocols/protocol-differentiation-and-characterization-human-th17-cells
Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi. | Sigma-Aldrich
Th17 cells are a subset of CD4+ T cells known to play a central role in the pathogenesis of many autoimmune diseases, as well ... Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi.. [Catherine W Cai, Jennifer ... Mechanistically, Th17 cells can directly protect infected cells through the IL-17A-dependent induction of NADPH oxidase, ... Th17 cells confer significantly stronger protection against T. cruzi-related mortality than even Th1 cells, traditionally ...https://www.sigmaaldrich.com/catalog/papers/27695083
Vaccines | Free Full-Text | Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
While Th1/Tc1 cells are traditionally used for their potent anti-tumor responses, mounting evidence suggests Th17/Tc17 cells ... IL-17 producing T-cells (Th17/Tc17) play an important role in autoimmune diseases, but their function in cancer is more ... The induction of polarized T-cell responses can be regulated by dendritic cells (DCs). DCs are key regulators of the immune ... The type of T-cell response generated (e.g., Th1 or Th2) will determine the efficacy of the therapy, and it is generally ...http://www.mdpi.com/2076-393X/1/4/527
Increased serum interleukin-17 and peripheral Th17 cells in children with acute Henoch-Schönlein purpura - Jen - 2011 -...
Increased serum interleukin-17 and peripheral Th17 cells in children with acute Henoch-Schönlein purpura. ... Increased serum interleukin-17 and peripheral Th17 cells in children with acute Henoch-Schönlein purpura. Pediatric Allergy and ...http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3038.2011.01198.x/references?globalMessage=0
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1...
B. Diabetes incidence when sorted Th17 cells from A) were injected into NOD.scid mice. C. Lymph node and spleen cells recovered ... Shown are cells gated on CD4+. C. Averages of the percentage of IL-17 or IFN-γ positive cells gated from the CD4+Tcr-β+ cells ( ... Numbers represent millions of cells. D. Photograph of pancreas of NOD.scid mice that received Th17 cells sections. Tissues were ... A. Lymph node and spleen cells recovered from diabetic NOD.scid that received Th17 cells, were activated for 5 hours with ...https://www.ncbi.nlm.nih.gov/pubmed/19130584?access_num=19130584&link_type=MED&dopt=Abstract
Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis | The Journal of Immunology
Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis. Siva Karthik Varanasi, Siddheshvar Bhela ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ...http://www.jimmunol.org/content/196/1_Supplement/147.8
The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells | Science Translational Medicine
Moreover, ICOS promoted the robust expansion of IL-17+IFN-γ+ human T cells, and the antitumor activity of these cells after ... The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells ... Human cord blood contained a subset of CD161+CD4+ T cells that were recent emigrants from the thymus, expressed ICOS ... These findings reveal a vital role for ICOS signaling in the generation and maintenance of human TH17 cells and suggest that ...http://stm.sciencemag.org/content/2/55/55ra78.short
Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation | Protocol (Translated to Hindi)
Romagnani, S., Maggi, E., Liotta, F., Cosmi, L., Annunziato, F. Properties and origin of human Th17 cells. Mol Immunol. 47, (1 ... Escobar, T. M., et al. miR-155 Activates Cytokine Gene Expression in Th17 Cells by Regulating the DNA-Binding Protein Jarid2 to ... Korn, T., Bettelli, E., Oukka, M., Kuchroo, V. K. IL-17 and Th17 Cells. Ann Rev Immunol. 27, (1), 485-517 (2009). ... Annunziato, F., et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 204, (8), 1849-1861 (2007). ...https://www.jove.com/video/55546/-electroporation-th17-?language=Hindi
γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell...
... biological response modifiers and the family of cell adhesion-promoting molecules. ... T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires ... The aim of this study was to evaluate the effect of GSI on Th17 cell differentiation in a mouse model of allergic asthma. OVA ... GSI also significantly suppressed Th17-cell responses in spleen and reduced IL-17 levels in serum. These findings suggest that ...https://www.hindawi.com/journals/mi/2015/258168/abs/
IJMS | Free Full-Text | Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid...
... pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly- ... Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising ... Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains ... PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. ...http://www.mdpi.com/1422-0067/15/2/1927/htm
JCI Insight - Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Th17 cells, lymphoid tissue inducer cells [LTi cells], and invariant NK T cells [iNKT cells] ; refs. 1, 10), whose development ... For Th17 cell differentiation assays, CD4+ cells were seeded at 5 x 104 cells/well in 96-well flat-bottom plates and stimulated ... Isolation of rat CD4+ T cells and Th17 cell polarization assay. CD4+ T cells from male Lewis rats were obtained from ... A validated regulatory network for Th17 cell specification. Cell. 2012;151(2):289-303.. View this article via: PubMed CrossRef ...https://insight.jci.org/articles/view/91127
Th17 cell cytokine secretion profile in host defense and autoimmunity | Springer for Research & Development
Objective and design The goal of this review is to examine the effector functions of Th17 cells in host defense and ... Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases ... IL-9 induces differentiation of TH17 cells and enhances function of FoxP3 + natural regulatory T cells. Proc Natl Acad Sci USA ... Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. Clin Immunol ...https://rd.springer.com/article/10.1007/s00011-011-0419-1
IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis | Science Translational Medicine
IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis ... IL-29 secretion by these cells was dependent on NFAT and c-Jun N-terminal kinase and was inhibited by IL-4. These data suggest ... We identified T helper 17 (TH17) cells as IL-29 producers and demonstrated their ability to increase the antiviral competence ... IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis ...http://stm.sciencemag.org/content/5/204/204ra129
Cutting Edge: Loss of α4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells | The Journal of Immunology
Itga4 is expressed at higher levels in Th1 cells compared with Th17 cells. Th cell subsets express distinct chemokine receptors ... The other possibility is that uncommitted cells from the pool of naive donor cells may have differentiated into Th17 cells and ... for Th1 cells or IL-6 (30 ng/ml), TGF-β (5 ng/ml), and anti-IFN-γ (10 μg/ml) for Th17 cells. After 3 d, 50 × 106 cells were ... Th1 cells and Th17 cells (2-5).. Trafficking of autoreactive CD4+ T cells from the systemic compartment into the CNS are ...http://www.jimmunol.org/content/187/12/6176
Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab...
... and Th17 cells (P = 0.019) while inflammatory Th17 cells expressing the CXCR3 marker, and called Th17/Th1 in the article, did ... cells were activated with 2 μg/mL anti-CD3 (Bio X Cell) and anti-CD28 (Bio X Cell) as effector cells and cocultured with or ... D, evolution (D0, D15, D30, and D60) of Th17 cell frequency in the blood of a patient with an induction or a decrease of Th17 ... In the 25 mCRC patients, we did not observe any change in the frequency of Th1, Th2, and Th17/Th1. For Treg and Th17 cells, we ...http://cancerres.aacrjournals.org/content/76/18/5241.long