*  Dihydrofolate reductase - Wikipedia
Miszta H, Dabrowski Z, Lanotte M (November 1988). "In vitro patterns of enzymic tetrahydrofolate dehydrogenase (EC 1.5.1.3) ... Found in all organisms, DHFR has a critical role in regulating the amount of tetrahydrofolate in the cell. Tetrahydrofolate and ... Because tetrahydrofolate, the product of this reaction, is the active form of folate in humans, inhibition of DHFR can cause ... DHFR is responsible for the levels of tetrahydrofolate in a cell, and the inhibition of DHFR can limit the growth and ...
  https://en.wikipedia.org/wiki/Dihydrofolate_reductase
*  Center for Theoretical & Mathematical Sciences » People
Tetrahydrofolate DehydrogenaseTetrahydrofolates • Thymidine Monophosphate • Thymidylate Synthase • Time Factors • Tissue ... Formate-Tetrahydrofolate Ligase • Gene Expression • Gene Expression Profiling • Gene Expression Regulation • Gene Expression ...
  http://fds.duke.edu/db/aas/math/ctms/faculty/hfn
*  FOLD4 - Bifunctional protein FolD 4, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - FOLD4 gene & protein
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.Curated. ,p>UniProtKB Keywords constitute a ,a href="http ... tetrahydrofolate interconversion. This protein is involved in the pathway tetrahydrofolate interconversion, which is part of ... View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One- ...
  http://www.uniprot.org/uniprot/O65271
*  Search: All Pfam signatures | InterPro | EMBL-EBI
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain (IPR020630) Pfam signature: PF00763 Argininosuccinate synthase ... Short-chain dehydrogenase/reductase SDR (IPR002347) Pfam signature: PF00106 Alcohol dehydrogenase, C-terminal (IPR013149) Pfam ... IMP dehydrogenase/GMP reductase (IPR001093) Pfam signature: PF00478 Glucose-6-phosphate dehydrogenase, NAD-binding (IPR022674) ... Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA (IPR001670) Pfam signature: PF00465 Ribosomal protein L10P ( ...
  http://www.ebi.ac.uk/interpro/member-database/Pfam
*  On the ancestral carbon fixation pathway | Philosophical Transactions of the Royal Society B: Biological Sciences
10-methylene-tetrahydrofolate dehydrogenase; GlyA, serine hydroxymethyltransferase; CODH, carbon monoxide dehydrogenase; ACS, ... 2004 The quinoprotein dehydrogenases for methanol and glucose. Arch. Biochem. Biophys. 428, 2-9. doi:10.1016/j.abb.2004.03.038 ... 2005 MtdC, a novel class of methylene tetrahydromethanopterin dehydrogenases. J. Bacteriol. 187, 6069-6074. doi:10.1128/JB. ... 2000 Tetrahydrofolate and tetrahydromethanopterin compared: functionally distinct carriers in C1-metabolism. Biochem. J. 350, ...
  http://rstb.royalsocietypublishing.org/content/368/1622/20120258
*  folD - Bifunctional protein FolD - Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) - folD gene & protein
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation. ,p>Manual validated information which ... tetrahydrofolate interconversion. This protein is involved in the pathway tetrahydrofolate interconversion, which is part of ... Methylenetetrahydrofolate dehydrogenaseUniRule annotation. ,p>Manual validated information which has been generated by the ... View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One- ...
  http://www.uniprot.org/uniprot/Q0AB42
*  folD - Bifunctional protein FolD - Treponema pallidum (strain Nichols) - folD gene & protein
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation. ,p>Manual validated information which ... tetrahydrofolate interconversion. This protein is involved in the pathway tetrahydrofolate interconversion, which is part of ... Methylenetetrahydrofolate dehydrogenaseUniRule annotation. ,p>Manual validated information which has been generated by the ... View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One- ...
  http://www.uniprot.org/uniprot/O83714
*  folD - Bifunctional protein FolD - Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) -...
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation. ,p>Manual validated information which ... tetrahydrofolate interconversion. This protein is involved in the pathway tetrahydrofolate interconversion, which is part of ... Methylenetetrahydrofolate dehydrogenaseUniRule annotation. ,p>Manual validated information which has been generated by the ... View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One- ...
  http://www.uniprot.org/uniprot/Q8PZQ1
*  Anti-MTHFD1L antibody (ab116615) | Abcam
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.. In the C-terminal section; ... This monofunctional enzyme consists of two major domains: an N-terminal inactive methylene-THF dehydrogenase and cyclohydrolase ...
  http://www.abcam.com/mthfd1l-antibody-ab116615.html
*  Cerebral Toxoplasmosis Summary Report | CureHunter
Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 06/01/1993 - "The clinical efficacy of trimetrexate, a ...
  http://www.curehunter.com/public/keywordSummaryD016781-Cerebral-Toxoplasmosis.do
*  Does Our Gut Microbiome Predict Cardiovascular Risk? | Circulation: Genomic and Precision Medicine
... methylene-tetrahydrofolate dehydrogenase (EC 1.5.1.5); MTHFR, methylene-tetrahydrofolate reductase (EC 1.5.1.20); PD, ... choline dehydrogenase (EC 1.1.99.1); CK, creatine kinase (EC 2.7.3.2); can, creatininase (EC 3.5.2.10); DMA, dimethylamine; ... 34 Choline can also undergo metabolism to betaine via a 2-step process involving choline dehydrogenase (EC 1.1.99.1; Figure). ... sarcosine dehydrogenase (EC 1.5.99.1); TMA, trimethylamine; and TMAO, trimethylamine-N-oxide. ...
  http://circgenetics.ahajournals.org/content/8/1/187
*  Mthfd1l - Monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor - Mus musculus (Mouse) - Mthfd1l gene & protein
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.Curated ... tetrahydrofolate interconversion. This protein is involved in the pathway tetrahydrofolate interconversion, which is part of ... Monofunctional C1-tetrahydrofolate synthase, mitochondrialAdd BLAST. 946. Amino acid modifications. Feature key. Position(s). ... Methylenetetrahydrofolate dehydrogenase and cyclohydrolaseAdd BLAST. 316. ,p>This subsection of the 'Family and Domains' ...
  http://www.uniprot.org/uniprot/Q3V3R1
*  SMART: Secondary literature for Ala racemase C domain
One of them, YKR400, encodes an NAD-dependent 5,10-methylene-tetrahydrofolate dehydrogenase. YKR404, YKR405 and YKR406 ... A putative binding site of the CoA cofactor was assigned, and implications for the cooperation with threonine dehydrogenase ... It acts in concert with threonine dehydrogenase and converts 2-amino-3-ketobutyrate, the product of threonine dehydrogenation ... The enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the Gram-negative denitrifying bacterial species Alcaligenes ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Ala_racemase_C
*  "Chromosomal Organization of the Human Dihydrofolate Reductase Genes: D" by Nicholas P. Anagnou, Stephen J. O'Brien et al.
8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) gene family includes a functional gene (hDHFR) and at least four ... The human dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5 ...
  https://nsuworks.nova.edu/cnso_bio_facarticles/246/
*  MTHFD2 - Wikipedia
"Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase". Nucleic Acids Res. 17 ... Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by ... This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and ... Yang XM, MacKenzie RE (Nov 1993). "NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate ...
  https://en.wikipedia.org/wiki/MTHFD2
*  MTHFD1 - Wikipedia
"Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase". Nucleic Acids Res. 17 ... C-1-tetrahydrofolate synthase, cytoplasmic also known as C1-THF synthase is an enzyme that in humans is encoded by the MTHFD1 ( ... Allaire M, Li Y, MacKenzie RE, Cygler M (1998). "The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase ... 2006). "Evaluation of a methylenetetrahydrofolate-dehydrogenase 1958G>A polymorphism for neural tube defect risk". J. Hum. ...
  https://en.wikipedia.org/wiki/MTHFD1
*  Roman, L. J.<...
Tetrahydrofolate Dehydrogenase Research Output 1986 2017 * 4631 Citations * 36 h-Index * 139 Article ...
  https://uthscsa.influuent.utsystem.edu/en/persons/linda-j-roman
*  Plus it
For example, the covalent binding of APAP to N-10-formyl-tetrahydrofolate dehydrogenase led to a decrease in its catalytic ... Halmes NC, Hinson JA, Martin BM, and Pumford NR (1996) Glutamate dehydrogenase covalently binds to a reactive metabolite of ... and aldehyde dehydrogenase (Landin et al., 1996), respectively, although the content of each protein was not evaluated in those ... Covalent binding of acetaminophen to N-1-formyltetrahydrofolate dehydrogenase in mice. J Pharmacol Exp Ther 280: 501-505. ...
  http://jpet.aspetjournals.org/content/317/1/202
*  Frontiers | Folate-related gene variants in Irish families affected by neural tube defects | Genetics
Methylene tetrahydrofolate dehydrogenase 1 (MTHFD1) acts in folate metabolism and DNA synthesis, and the 1958G,A variant ... 2002). A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate ... Methylene tetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism. The 677 T allele results in reduced ...
  https://www.frontiersin.org/articles/10.3389/fgene.2013.00223/full
*  AtREG502
tetrahydrofolate dehydrogenase/cyclohydrolase, putative; FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: folic acid and ... tetrahydrofolate dehydrogenase/cyclohydrolase, putative (TAIR:AT4G00620.1); Has 7113 Blast hits to 7108 proteins in 1554 ... Tetrahydrofolate dehydrogenase/cyclohydrolase (InterPro:IPR000672), NAD(P)-binding (InterPro:IPR016040); BEST Arabidopsis ...
  http://ppdb.agr.gifu-u.ac.jp/ppdb/cgi-bin/tag_list.cgi?organism=At&tag=AtREG502
*  MTHFD2L - Wikipedia
MTHFD2L is a member of the tetrahydrofolate dehydrogenase/cyclohydrolase family. This enzyme is expressed in all adult tissues ... In the final step of this pathway, the NADP+-dependent CH2-THF dehydrogenase/CH+-THF cyclohydrolase activity of bifunctional ... NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (MTHFD2L), also known as bifunctional ... This gene encodes a 340-residue protein that is homologous to the mitochondrial bifunctional dehydrogenase/cyclohydrolase ( ...
  https://en.wikipedia.org/wiki/MTHFD2L
*  MPI 5004 - AdisInsight
Mechanism of Action Tetrahydrofolate dehydrogenase inhibitors * Orphan Drug Status Orphan designation is assigned by a ...
  http://adisinsight.springer.com/drugs/800006659?error=cookies_not_supported&code=d57686a5-a9fa-4af9-9cfb-8cfc2349883c
*  Search Results
BL00766C-E, which encompass tetrahydrofolate dehydrogenase sequences,. e.g. FOLD_ECOLI.. ProDom Summary: Protein Domain Search ... Cog name: 5,10-methylene-tetrahydrofolate dehydrogenase. Functional class: H. BeTs to -hg-c-yu. Number of proteins in this ... C family which is described as Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain (PF02882). PDB Hit:. gi, ... methylenetetrahydrofolate dehydrogenase. Gene Start:. 382856. Gene Stop:. 383665. Gene Length:. 810. Molecular Weight*:. 31594 ...
  http://stdgen.northwestern.edu/cgi-bin/gene_id_search.cgi?dbname=uure&gene_id=UU337
*  JCI - Volume 127, Issue 5
The folate cycle, through transfer of a carbon unit between tetrahydrofolate and its derivatives in the cytoplasmic and ... We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role ...
  https://hzyouma.com.www.mobile.jci.org/127/5