Terfenadine - Wikipedia
Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition ... Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst ... "Status of Terfenadine-Containing Drugs in Canada". Health Canada. 23 April 2004. Archived from the original on 13 July 2006. " ... In the United States, terfenadine as Seldane was brought to market in 1985 as the first non-sedating antihistamine for the ...
Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance
A normal amount of regular-strength grapefruit juice produced maximum single-dose effects on terfenadine and carboxylic acid ... Terfenadine plasma peak drug concentration (Cmax) was also higher. Terfenadine carboxylate area under the plasma drug ... No differences in the pharmacokinetics of terfenadine and terfenadine carboxylate were observed between the two strengths of ... Plasma concentrations of the cardiotoxic agent terfenadine and the active antihistaminic metabolite terfenadine carboxylate ...
Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid...
... use of solid-phase extraction allows the use of robotic or manual sample preparation for the efficient clean-up of terfenadine ... This work describes the methodology for the analysis of terfenadine and the acid metabolite of terfenadine in plasma using high ... Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid ... This work describes the methodology for the analysis of terfenadine and the acid metabolite of terfenadine in plasma using high ...
Terfenadine: Uses, Interactions, Mechanism of Action | DrugBank Online
Terfenadine is an antihistamine for the treatment of allergy symptoms. ... Terfenadine is an antihistamine for the treatment of allergy symptoms.. Generic Name. Terfenadine. DrugBank Accession Number. ... On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at ... The active metabolite of terfenadine is fexofenadine.. Mechanism of action. Terfenadine competes with histamine for binding at ...
Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites.<...
Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites. Proceeding ... Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites. In ... Kenworthy, K. E., Bloomer, J., Clarke, S. E., & Houston, B. (1999). Inhibition of terfenadine metabolism by CYP3A4: evidence ... Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites. / Kenworthy ...
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Appendix -- Characteristics of Available Antiretroviral Drugs
DLV is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); sedative-hypnotics (e.g., ... Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ...
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Clarithromycin by Pro Doc Limitée: Clarithromycin belongs to the group of medications called macrolide antibiotics. It is used to treat infections caused by certain bacteria. It works by killing or stopping the growth of bacteria that can cause certain infections. Clarithromycin may be prescribed for people with bacterial throat infections, sinus infections, ear infections, bronchitis, pneumonia, and skin infections such as impetigo and cellulitis.
Torsade de Pointes: Overview, Pathophysiology, Etiology of Torsade
Astemizole and terfenadine, in high dosages or when used in combination with the azole antifungal drugs or the macrolide ... Drug interactions with the antihistamines astemizole (recalled from US market) and terfenadine (recalled from US market) can ... of these antihistamines as well as other drugs and to prolong the QT interval in patients taking astemizole or terfenadine. ...
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DailyMed - MONTELUKAST SODIUM tablet, film coated
Oral Contraceptives, Terfenadine, Digoxin, and Warfarin: In drug interaction studies, the recommended clinical dose of ... terfenadine, digoxin, and warfarin. Montelukast at doses of ≥ 100 mg daily dosed to pharmacokinetic steady state did not ... and did not prolong the QTc interval following coadministration with terfenadine 60 mg twice daily; did not change the ... terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti- ...
Long QT Syndrome: Practice Essentials, Background, Etiopathophysiology
Antihistamines (eg, diphenhydramine; terfenadine and astemizole [both recalled from the US market]) ...
Flavonoids | Linus Pauling Institute | Oregon State University
Appendix -- Characteristics of Available Antiretroviral Drugs
DLV is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); sedative-hypnotics (e.g., ... Indinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Nelfinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ... Saquinavir is not recommended for concurrent use with antihistamines (e.g., astemizole or terfenadine); cisapride; ergot ...
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ITRACAP - MyDr.com.au
terfenadine, astemizole or mizolastine (used for allergy or hay fever);. *bepridril felodipine, lercanidipine, ivabradine, ... terfenadine, astemizole or mizolastine (used for allergy or hay fever);. *bepridil, felodipine, nisoldipine, lercanidipine, ...
Fexofenadine hydrochloride 180mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc)
However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore ... The carcinogenic potential of fexofenadine hydrochloride was assessed using terfenadine studies with supporting pharmacokinetic ... No evidence of carcinogenicity was observed in rats and mice given terfenadine (up to 150 mg/kg/day). ...