SCOPe 2.05: Protein: Telomeric repeat binding factor 2, TRF2
DNA-binding domain of telomeric protein. Timeline for Protein Telomeric repeat binding factor 2, TRF2 from a.4.1.4: DNA-binding ... DNA-binding domain of telomeric protein appears in SCOPe 2.04. *Protein Telomeric repeat binding factor 2, TRF2 from a.4.1.4: ... DNA-binding domain of telomeric protein appears in SCOPe 2.06. *Protein Telomeric repeat binding factor 2, TRF2 from a.4.1.4: ... DNA-binding domain of telomeric protein first appeared in SCOP 1.71. *Protein Telomeric repeat binding factor 2, TRF2 from a. ...
Telomeric repeat-binding factor 1 - Wikipedia
... the protein has a molecular function of binding telomeric DNA and the double-stranded telomeric DNA. The telomeric repeat- ... Telomeric Repeat Factor 1 (TRF1) is a protein that binds at telomere ends. The protein has the ultimate use of functioning as ... the telomeric repeat-binding factor 1 protein has most of its functions related to the binding of components and regulation of ... Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. The human TERF1 gene is located in ...
Inhibition of the Alternative Lengthening of Telomeres (ALT) Pathway
The processes that maintain telomeres employ replication protein A (RPA), a single-stranded DNA binding protein. Dr. Zou and ... This process is facilitated by a type of RNA called telomeric repeat-containing RNA (TERRA). Levels of TERRA fluctuate during ... Terra Controls Single-Stranded DNA Binding Protein RPA. In a paper published in Science in January 2015,2 Dr. Zou and his team ... Then the persistent binding of RPA promotes recombination and the activation of the ALT pathway, allowing the cancer to ...
In Vivo Cell Reprogramming to Pluripotency | SpringerLink
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer. 2011;11(3):161-76. doi: ... A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in tetrahymena. J Mol Biol. 1978;120(1 ... Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009;4(6):472- ...
DeCS
DNA-Binding Proteins (1998-2002). Public MeSH Note:. 2003; TRF2 PROTEIN (now TELOMERIC REPEAT BINDING PROTEIN 2) was indexed ... Telomeric Repeat Binding Protein 2 - Preferred Concept UI. M0282405. Scope note. A ubiquitously expressed telomere-binding ... It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues. ... It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues. ...
CTBP1 and TERF2 Interaction - Wiki-Pi
It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... C-terminal binding protein 1. telomeric repeat binding factor 2 ... Protein-Protein Interactions. 83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 ... homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric ...
TERF2IP and AIMP2 Interaction - Wiki-Pi
It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... telomeric repeat binding factor 2, interacting protein. ... Protein-Protein Interactions. 125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP ...
Werner syndrome. Medical search
Telomeric Repeat Binding Protein 2. A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout ... DNA-Binding Proteins. Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded ... Protein Binding. The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein ... It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues. ...
Pesquisa | Prevenção e Controle de Câncer
Telomeric repeat-binding factor 2 (TRF2) is a critical telomere protection protein. Emerging evidence indicates that TRF2 may ... qRT-PCR and Western blotting were carried out to analyze the mRNA and protein expression levels after TRF2 depletion on ... However, the serum/plasma/CSF iron levels and serum/plasma ferritin, transferrin, total iron-binding capacity (TIBC) did not ... total iron-binding capacityï¼ TIBCï¼ in CSF sample or serum/plasma sample (from Jan 2010 to Sep 2022 to filter these inaccurate ...
Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications
... a protein complex composed of six proteins including TERF telomeric repeat binding factor 1 (TRF1)[56], TERF telomeric repeat ... Through binding telomeric DNA at the chromosome ends, Shelterin protects telomeric DNA from being recognized as DNA damage by ... Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting ... telomeric repeat-binding factor 2-interacting protein 1 [TERF2IP, or repressor/activator protein 1 (RAP1)][58], the protection ...
YRC Public Data Repository - Protein Overview - csx1 / SPAC17A2.09c
The experimental data is in the form of mass spectrometry, yeast two-hybrid, protein structure prediction, light microscopy and ... The YRC PDR provides for the searching of millions of protein descriptions from many databases to find proteins and public ... experimental data describing those proteins produced by the YRC. ... A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta- ... Polypyrimidine tract-binding protein 3. View Details. [372..488]. deduced N/A No confident structure predictions are available ...
Titia de Lange - Heineken Prizes
De Lange and her group identified the first two proteins within the complex, Telomeric Repeat binding Factor (TRF) 1 and 2. She ... De Lange was the first to suggest that telomeres are shielded from the cell machinery by a protein complex. Her ideas turned ... They showed that the shelterin protein TRF2 helps in forming these loops.. Telomeres play a major role in healthy and sick ... She played a major role in identifying the protein complex that protects the telomeres - a shield that she has named the ...
Welcome to PDBbind-CN database
The aim of the PDBbind database is to provide a comprehensive collection of the experimentally measured binding affinity data ... for all types of biomolecular complexes deposited in the Protein Data Bank (PDB). It thus provides an essential linkage between ... PROTEIN-DNA COMPLEX, UP1, HUMAN TELOMERIC REPEAT, HTR, TR2- KEYWDS 2 G(10)NEB, RRM, RNA RECOGNITION MOTIF, PRN, NEBULARINE, ... HELIX-DESTABILIZING PROTEIN, SINGLE-STRAND COMPND 9 BINDING PROTEIN, HNRNP CORE PROTEIN A1; COMPND 10 ENGINEERED: YES SOURCE ...
Telomeres are essential for maintaining the integrity of the genome through - Factor VIII inhibitors in hemophilia A
Keywords: telomere ageing shelterin repressor/activator protein 1 telomeric repeat factor CORIN 2 human being dermal ... The POT1 protein is found in the 3′ end of the G-rich strand bound to the single-stranded TTAGGG repeats (15). TPP1 is required ... telomere ageing shelterin repressor/activator protein 1 telomeric repeat factor CORIN ... telomeric repeat element 2 (TRF2) decreased significantly. By contrast the levels of one of its binding partners repressor/ ...
Telomere Lengthening and Other Functions of Telomerase - Rubtsova - Acta Naturae
The proteins TRF1, TRF2 (te-lomeric repeat binding factor 1 and 2) and POT1 (protection of telomeres protein 1) are bound to ... RNA containing telomeric repeats (TERRA - Telomeric Repeat containing RNA), or telomeric RNA - TelRNA, which is formed as a ... ACA-proteins are bound to the 3-terminal stem-loop of hTER; the second complex of H/ACA-proteins with the GAR1 protein ... One telomeric repeat is added after the substrate binding. The resulting product can either dissociate from the enzymes active ...
G-qaudruplexes - AGINGSCIENCES™ - Anti-Aging Firewalls™
By James P Watson with editorial help and selected contributions by Vince Giuliano Image source Human telomeric G-quadruplex ... 2014 DNA and RNA quadruplex-binding proteins. 2011 Structure of long human telomeric RNA (TERRA): G-quadruplexes formed by four ... forms RNA G-quadruplexes and that the TERRA RNA G-quadruplex binds to telomere repeat binding factor 2 (TRF2). Here is an ... In addition to a well characterized group of proteins which bind specifically to telomeric DNA, we have further classified ...
NIOSHTIC-2 Search Results - Full View
The telomeric repeat-binding factor 1 (Trf1) and 2 (Trf2), and the protection of telomere 1 (Pot1) are involved in telomere ... Double- and single-stranded telomere DNA-binding proteins Trf1/Trf2 and Pot1, as well as telomeric DNA damage foci LambdaH2AX ... Single-stranded binding protein Pot1, initially up-regulated at 12 wk in the WF+REG group, was later down-regulated in liver ... Telomeric DNA and shelterin proteins prevent loss of essential genetic information during cell division. Telomere attrition ...
SMART: SANT domain annotation
Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain. ... STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES. 1ign. DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE ... hTRF2 DNA-binding domain in complex with telomeric DNA.. 1wgx. Solution structure of RSGI RUH-022, a myb DNA-binding domain in ... MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3. 1mse. SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH ...
CoP: Co-expressed Biological Processes
DNA-binding protein, putative. Encodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to ... transducin family protein / WD-40 repeat family protein. F:nucleotide binding;P:unknown;C:cellular_component unknown;MFOBPAV. O ... Ran GTPase binding / chromatin binding / zinc ion binding. F:chromatin binding, zinc ion binding, Ran GTPase binding;P:unknown; ... DNA-binding protein, putative. F:nucleoside-triphosphatase activity, DNA binding, nucleotide binding, ATP binding;P:unknown;C: ...
DAZ Family Proteins, Key Players for Germ Cell Development
G-rich RNA sequence binding factor 1, GRSF1), a TATA box-binding protein (TBP)-like (Telomeric repeats binding site 2, Trf2). ... DAZ family proteins interact with several types of proteins including DAZ associated protein (DAZAP), poly(A)-binding proteins ... DAZ family proteins are central RNA binding proteins in this process. These proteins appear to be associated with common ... DAZL protein increases the translation of the mRNA of both proteins. In vitro, DAZL protein directly binds to the 3-UTR of ...
TZAP mediated BTR localization to telomeres | NIH Research Festival
This protein binds specifically to telomeric repeat but shows preferential binding to long telomeres. Upon binding TZAP ... A critical factor involved in telomere length homeostasis is TZAP (telomeric zinc finger–associated protein). ... The TZAP-mediated generation of ECTR is dependent on a protein complex called Bloom (BLM)-Topoisomerase lll α-RMI1-RMI2 (BTR ... Additionally, we demonstrate that TZAP can recruit BLM to telomeres independently of PML (promyelocytic leukemia protein), a ...
GSE339 CD4POS VS CD4CD8DN DC UP
TATA-box binding protein associated.... TERF2. 7014. TERF2. telomeric repeat binding factor 2 [.... ... GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP LI_PBMC_MENACTRA_AGE_18_45YO_ ... GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP GSE9006_TYPE_1_DIABETES_AT_DX ...
TERF2 and BANP Interaction - Wiki-Pi
It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... telomeric repeat binding factor 2. BTG3 associated nuclear ... Protein-Protein Interactions. 55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A ... homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric ...
CATALOGUE - Protein Alternatives
Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis-GST tagged €69,00. - €2.170,00. ... Human TERF1 (Telomeric repeat-binding factor 1) recombinant protein 6xHis tagged €69,00. - €2.170,00. ... Human EDIL3 (EGF-like repeat and discoidin I-like domain-containing protein 3) recombinant protein €69,00. - €2.170,00. ... Human GABPB1 (GA-binding protein subunit beta-1) recombinant protein €69,00. - €2.170,00. ...
CoP: Co-expressed Biological Processes
DNA-binding protein, putative. Encodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to ... interact with double-stranded telomeric repeats.. -. -. -. C.G.. S.X.. Please select. ath TAIR (integral). ath,osa KEGG ( ... DNA-binding family protein / histone H1/H5 family protein. C.G.. S.X.. Please select. ... harpin-induced family protein / HIN1 family protein / harpin-responsive family protein. S.X.. H.G.. Please select. ...
Page 3: Mgr. Martina Dvořáčková, Ph.D. - Publications | Faculty of Science MU
Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase PROCHÁZKOVÁ ... AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association ... Loss of telomeric and rDNA repeats in fas x rad51B double mutant Arabidopsis thaliana plants MUCHOVÁ Veronika DVOŘÁČKOVÁ ... Chromatin assembly - instability of rDNA and telomeric repeats in Arabidopsis thaliana MUCHOVÁ Veronika MOZGOVÁ Iva DVOŘÁČKOVÁ ...
KnowledgeBase Articles Archive - JASCO
Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 ( ... Telomeric Repeat-Binding Factor 2 (TRF2) Protein−Protein Interaction in the Shelterin Complex ... TRF2) Protein−Protein Interaction in the Shelterin Complex. 2016 / Journal of Medicinal Chemistry ... Shelterin, a six-protein complex, plays a fundamental role in protecting both the length and the stability of telomeres. ...
Home
We plan to examine genes coding for telomere-regulation proteins, including telomeric repeat binding factor 1 and 2 (TRF1 and ... human TRF2-interacting telomeric protein (hRAP1), TRF1-interacting nuclear factor 2 (TIN2), and TIN2- and POT1-organizing ... Telomere length is regulated by telomerase and telomere-associated proteins, including TRF1, TRF2, POT1, TIN2, RAP1, and TPP1, ... We hypothesize that SNPs in those genes may affect their protein structures and functions and thereby accelerate telomere ...
Genome Integrity Discussion Group Meeting (4) | The New York Academy of Sciences
Recruitment is DNA sequence specific and determined in part by sequence motifs that may be bound by recruiter proteins. ... In particular she is studying shelterin, the six-subunit complex that coats telomere repeats and tankyrase 1, a poly(ADP-ribose ... cell cycle regulation and non-telomeric functions of tankyrase 1 and 5) overlapping and/or distinct roles of tankyrase 2. In ... Others are protein modification enzymes that can change the properties of many proteins at once to elicit changes in favor of ...
Telomeric 22q13 deletions resulting from rings, simple deletions, and translocations: cytogenetic, molecular, and clinical...
... n repeats could result from their ability to bind the hsRad51 recombinase protein preferentially,38,39 or to form Z-DNA.40 The ... In addition, we did not observe any telomeric repeat on the ring chromosomes using the specific probe PNA-(CCCTAA)3 (data not ... Biet E, Sun J, Dutreix M. Conserved sequence preference in DNA binding among recombination proteins: an effect of ssDNA ... Human satellite I sequences include a male specific 2.47 kb tandemly repeated unit containing one Alu family member per repeat ...