*  Terf2ip MGI Mouse Gene Detail - MGI:1929871 - telomeric repeat binding factor 2, interacting protein
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus. ... Terf2ip interacts with 233 markers (Mir7-1, Mir7-2, Mir7b, ...) View All ... Protein Ontology. PR:000016237 telomeric repeat-binding factor 2-interacting protein 1 ...
  http://www.informatics.jax.org/marker/MGI:1929871
*  Terf2ip - Telomeric repeat-binding factor 2-interacting protein 1 - Mus musculus (Mouse) - Terf2ip gene & protein
Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. ... Telomeric repeat-binding factor 2-interacting protein 1Add BLAST. 392. Amino acid modifications. Feature key. Position(s). ... sp,Q91VL8,TE2IP_MOUSE Telomeric repeat-binding factor 2-interacting protein 1 OS=Mus musculus GN=Terf2ip PE=1 SV=1 ... phosphatase binding Source: MGI. *telomeric DNA binding Source: BHF-UCL ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a ...
  http://www.uniprot.org/uniprot/Q91VL8
*  Terf1 - Telomeric repeat-binding factor 1 - Mus musculus (Mouse) - Terf1 gene & protein
Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; ... repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin ... Telomeric repeat-binding factor 1Add BLAST. 420. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... binding domain present within the protein.,p>,a href='/help/dna_bind' target='_top'>More...,/a>,/p>DNA bindingi. 390 - 415. H-T ...
  http://www.uniprot.org/uniprot/P70371
*  DiVA - Search result
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity ... belongs to the G-protein super-family and possesses all structural motifs characterizing proteins in this family. eEF2 binds to ... belongs to the G-protein super-family and possesses all structural motifs characterizing proteins in this family. eEF2 binds to ... After GTP hydrolysis and translocation, it leaves the ribosome bound to GDP. The rate of protein synthesis in the cell can be ...
  http://www.diva-portal.org/smash/resultList.jsf?dswid=0&searchType=SUBJECT&language=en&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211552%22%7D%5D%5D
*  Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental...
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity ... In presence of growth signals CGGBP1 is retained in the nuclei and exhibits enhanced Alu binding thus inhibiting RNA Polymerase ... This profile was enriched for previously defined H3K27-tri-methylated genes, targets of the Polycomb group (PcG) proteins in ... We also show that itregulates Alu transcription in cis by binding to Alu promoter. Our results also indicate thatpotential ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:757411
*  Titia de Lange - Wikipedia
In 1995, she identified and purified the Telomeric-repeat binding factor protein 1 (TRF1). With the assistance of Bas van ... In 2005, de Lange came to the crucial realization that six telomeric proteins form a dynamic protein complex, that she named ... Shelterin subunits are not the only proteins that associate with telomeres but they differ from other proteins by meeting the ... A human telomeric protein. Science 270: 1663-1667. Retrieved from doi: 10.1126/science.270.5242.1663 B. van Steensel and T. de ...
  https://en.wikipedia.org/wiki/Titia_de_Lange
*  Free energy profiles for binding of TRF1 and TRF2 to te | Open-i
Free energy profiles for binding of TRF1 and TRF2 to telomeric DNA.Dashed green lines show the boundaries between the three ... telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a ... Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1 and TRF2 ... Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1 and TRF2 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3935891_pone.0089460.g002&req=4
*  List of MeSH codes (D12.776.660) - Wikipedia
... telomeric repeat binding protein 1 MeSH D12.776.660.235.700.875 -- telomeric repeat binding protein 2 MeSH D12.776.660.352. ... hmgb proteins MeSH D12.776.660.235.400.600.300 -- hmgb1 protein MeSH D12.776.660.235.400.600.600 -- hmgb2 protein MeSH D12.776. ... hmgn1 protein MeSH D12.776.660.235.400.400.300 -- hmgn2 protein MeSH D12.776.660.235.400.500 -- hmga proteins MeSH D12.776. ... hmga1b protein MeSH D12.776.660.235.400.500.400 -- hmga1c protein MeSH D12.776.660.235.400.500.600 -- hmga2 protein MeSH ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.660)
*  Plus it
Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic ... Expression of telomeric repeat binding factor-1 in astroglial brain tumors. Neurosurgery 2005;56:802-10. ... Gene expression for suppressors of telomerase activity (telomeric-repeat binding factors) in breast cancer. Jpn J Cancer Res ... Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Anticancer Res 2002; ...
  http://clincancerres.aacrjournals.org/content/12/19/5720
*  Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres | Science
Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor-1), a negative regulator of telomere length ... ADP-ribosylation of TRF1 diminished its ability to bind to telomeric DNA in vitro, suggesting that telomere function in human ... Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase ( ... Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1. Recombinant ...
  http://science.sciencemag.org/content/282/5393/1484
*  Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. - PubMed - NCBI
Telomeric Repeat Binding Protein 1/genetics. Substances. *Telomeric Repeat Binding Protein 1 ... Long telomeric repeats have less efficient DNA repair compared to chromosomal DNA with a similar amount of DNA damage. (A) ... Expansion of γH2AX in long telomeric repeats. (A) Quantification of co-localization between γH2AX and KR-TRF1 signals. Error ... By fusing the KillerRed chromophore with the telomere repeat binding factor 1, TRF1, we developed a novel approach to generate ...
  https://www.ncbi.nlm.nih.gov/pubmed/26082495
*  Prod is a novel DNA-binding protein that binds to the 1.686 g/cm(3) 10 bp satellite repeat of Drosophila melanogaster. -...
Footprinting experiments show that the protein interacts with a 5-8 bp target sequence in each 10 bp repeat and suggest that it ... We have examined the binding of the Prod protein to DNA in vitro. Co-immunoprecipitation experiments demonstrate that Prod is a ... DNA-binding protein that specifically recognizes the 10 bp AGAATAACAT satellite repeat of D.melanogaster. ... Gel retardation experiments indicate that Prod does not have a well defined DNA-binding domain and it binds the satellite in a ...
  https://www.semanticscholar.org/paper/Prod-is-a-novel-DNA-binding-protein-that-binds-to-T%C3%B6r%C3%B6k-Gorj%C3%A1n%C3%A1cz/a6315086ffbb7e4e840ed60dab82cb083d9ca036
*  RAP1 at the Yeast Telomere
... these proteins can bind to the telomeric repeats of vertebrates in vitro. It is shown here that telomeric repeats from S. ... these proteins can bind to the telomeric repeats of vertebrates in vitro. It is shown here that telomeric repeats from S. ... cytogenetik, DNA-binding, Saccharomyces, yeast, telomeric repeat, telomere, RAP1, repressor activator protein 1, Genetics, ... Binding analyses revealed that the scas- and sdaiRAP1 proteins bind to telomeric sequences in a similar manner as scerRap1p. ...
  https://lup.lub.lu.se/search/publication/464700
*  TERF2 (telomeric repeat binding factor 2)
... telomeric repeat binding factor 2), Authors: Molly L Bristol, Claire P Bailey, Lynne W Elmore. Published in: Atlas Genet ... DNA binding double-stranded telomeric DNA binding double-stranded telomeric DNA binding telomerase activity protein binding ... DNA binding double-stranded telomeric DNA binding double-stranded telomeric DNA binding telomerase activity protein binding ... the Telomeric Repeat binding Factor domain, the RAP1 binding motif of telomere repeat binding factor, and the 'SWI3, ADA2, N- ...
  http://atlasgeneticsoncology.org/Genes/TERF2ID42522ch16q22.html
*  TERF2IP - Wikipedia
Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene. TERF2IP has ... "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein". O'Connor, Matthew S; Safari Amin; Liu Dan; Qin ... 2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
  https://en.wikipedia.org/wiki/TERF2IP
*  TERF1 - Wikipedia
... the protein has a molecular function of binding telomeric DNA and the double-stranded telomeric DNA. The telomeric repeat- ... These functions include the binding of the protein, facilitation in the activity of protein homodimerization, the binding of ... contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding ... Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. The human TERF1 gene is located in ...
  https://en.wikipedia.org/wiki/TERF1
*  RCSB PDB - 1PGZ: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6...
... isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures ... Classification: DNA BINDING PROTEIN / DNA * Deposited: 2003-05-28 Released: 2003-11-11 ... Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta- ...
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1PGZ
*  Telomere-binding protein - Wikipedia
... function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat binding ... Telomere-binding proteins function to generate a T-loop, which is a specialized loop structure to cap the telomeric ends. ... There include: TRF1 TRF2 POT1 TIN2 RAP1 TPP1 Both TRF1 and TRF2 bind the telomeric repeat sequences in the duplex region of the ... It has homology to the Myb transcription factors as the protein-DNA complex requires both Myb repeats. TRF1 binds near the N- ...
  https://en.wikipedia.org/wiki/Telomere-binding_protein
*  ZBTB48 is both a Telomere-binding Protein Limiting Telomere Length and a Transcriptional Activator [image] | EurekAlert!...
... as well as subtelomeric variant repeats (TTGGG/TCAGGG, grey), which represent the protective caps at the end of chromosomes. In ... addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, ... ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) ... ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) as well as subtelomeric variant ...
  https://eurekalert.org/multimedia/pub/143103.php
*  TERF2IP Gene - GeneCards | TE2IP Protein | TE2IP Antibody
Protein Coding), TERF2 Interacting Protein, including: function, proteins, disorders, pathways, orthologs, and expression. ... Protein Symbol:. Q9NYB0-TE2IP_HUMAN. Recommended name:. Telomeric repeat-binding factor 2-interacting protein 1 Protein ... Does not bind DNA directly: recruited to telomeric double-stranded 5-TTAGGG-3 repeats via its interaction with TERF2. ... Does not bind DNA directly: recruited to telomeric double-stranded 5-TTAGGG-3 repeats via its interaction with TERF2. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=TERF2IP
*  Plus it
To date, six proteins, including telomeric repeat binding factor 1 and 2 (TRF1 and TRF2), human TRF2-interacting telomeric ... POT1 is known to bind specifically to telomeric overhangs and regulates the access of telomerase to the repeats that affect ... a newly identified telomeric protein, was identified as a regulator of POT1 for telomeric targeting (36). However, the exact ... Control of telomere length by the human telomeric protein TRF1. Nature 1997;385:740-743pmid:9034193. ...
  http://diabetes.diabetesjournals.org/content/61/11/2998
*  SUBSTITUTED 2-ALKYL QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS - Patent application
... homologues to the cytoskeletal protein ankyrin. The ANK domain interacts with a telomeric protein, Telomere Repeat binding ... binding proteins, TRF-1 and TRF-2. TRF-2 protects chromosome ends, and TRF-1 regulates telomere length. ADP-ribosylation ... glutamate may bind and hence finding an effective mix of antagonists or universal antagonist to prevent binding of glutamate to ... and expression of the protein starting from human liver cDNA. Information concerning the used protein sequence of the PARP-1 ...
  http://www.patentsencyclopedia.com/app/20110077245
*  Recombinant Human TRF1 protein (ab116406) | Abcam
Ab116406 is a full length protein produced in Escherichia coli and has been validated in WB, ELISA, SDS-PAGE, MS. Abcam… ... Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the ... The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.. The ... ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.. Ubiquitinated by RLIM/RNF12, leading to ...
  http://www.abcam.com/recombinant-human-trf1-protein-ab116406.html
*  Protein (Weighted) Links for PubMed (Select 20622869) - Protein - NCBI
telomeric repeat binding factor 2, interacting protein, isoform CRA_c, partial [Mus musculus] ... telomeric repeat binding factor 2, interacting protein, isoform CRA_b, partial [Mus musculus] ... telomeric repeat binding factor 2, interacting protein, isoform CRA_a [Mus musculus] ... telomeric repeat binding factor 2, interacting protein, isoform CRA_a [Homo sapiens] ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein_weighted&from_uid=20622869
*  Welcome to LibAge, the ageing reference resource
Telomeric Repeat Binding Protein 1/deficiency/genetics/metabolism *Tumor Suppressor Protein p53/metabolism ... 2008) "Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone ... 2007) "A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2." Am. J. Hum. Genet. ... 1998) "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular ...
  http://libage.ageing-map.org/entries/tags/495/