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*  Terf2ip MGI Mouse Gene Detail - MGI:1929871 - telomeric repeat binding factor 2, interacting protein
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus. ... Terf2ip interacts with 233 markers (Mir7-1, Mir7-2, Mir7b, ...) View All ... Protein Ontology. PR:000016237 telomeric repeat-binding factor 2-interacting protein 1 ...
  http://www.informatics.jax.org/marker/MGI:1929871
*  anti-TRF1 antibody [3H11] | GeneTex
... telomeric repeat binding factor (NIMA-interacting) 1) for ELISA, ICC/IF, WB. Anti-TRF1 mAb (GTX80331) is tested in Human ... Telomeric protein Pin2/TRF1, Telomeric repeat binding factor (NIMA interacting) 1,. Cellular Localization. Colocalizes with ... telomeric repeat binding factor (NIMA-interacting) 1. Background. The TRF1 gene encodes a telomere specific protein which is a ... The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two ...
  http://www.genetex.com/TRF1-antibody-3H11-GTX80331.html
*  Terf2ip - Telomeric repeat-binding factor 2-interacting protein 1 - Mus musculus (Mouse) - Terf2ip gene & protein
Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. ... Telomeric repeat-binding factor 2-interacting protein 1Add BLAST. 392. Amino acid modifications. Feature key. Position(s). ... sp,Q91VL8,TE2IP_MOUSE Telomeric repeat-binding factor 2-interacting protein 1 OS=Mus musculus GN=Terf2ip PE=1 SV=1 ... phosphatase binding Source: MGI. *telomeric DNA binding Source: BHF-UCL ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a ...
  http://www.uniprot.org/uniprot/Q91VL8
*  Terf1 - Telomeric repeat-binding factor 1 - Mus musculus (Mouse) - Terf1 gene & protein
Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; ... repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin ... Telomeric repeat-binding factor 1Add BLAST. 420. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... binding domain present within the protein.,p>,a href='/help/dna_bind' target='_top'>More...,/a>,/p>DNA bindingi. 390 - 415. H-T ...
  http://www.uniprot.org/uniprot/P70371
*  DiVA - Search result
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity ... belongs to the G-protein super-family and possesses all structural motifs characterizing proteins in this family. eEF2 binds to ... belongs to the G-protein super-family and possesses all structural motifs characterizing proteins in this family. eEF2 binds to ... After GTP hydrolysis and translocation, it leaves the ribosome bound to GDP. The rate of protein synthesis in the cell can be ...
  http://www.diva-portal.org/smash/resultList.jsf?dswid=0&searchType=SUBJECT&language=en&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211552%22%7D%5D%5D
*  DiVA - Søkeresultat
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity ... The otr region is known to be heterochromatic and bound by the Swi6 protein whereas the central core region contains an unusual ... Antibodies Biotinylated Using a Synthetic Z-domain from Protein A Provide Stringent In Situ Protein Detection2013Inngår i: ... Peptides of Mover have been reported in proteomics screens for self-interacting proteins, phosphorylated proteins, and synaptic ...
  http://www.diva-portal.org/smash/resultList.jsf?searchType=SUBJECT&language=no&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211552%22%7D%5D%5D
*  Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental...
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity ... In presence of growth signals CGGBP1 is retained in the nuclei and exhibits enhanced Alu binding thus inhibiting RNA Polymerase ... This profile was enriched for previously defined H3K27-tri-methylated genes, targets of the Polycomb group (PcG) proteins in ... We also show that itregulates Alu transcription in cis by binding to Alu promoter. Our results also indicate thatpotential ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:757411
*  Free energy profiles for binding of TRF1 and TRF2 to te | Open-i
Free energy profiles for binding of TRF1 and TRF2 to telomeric DNA.Dashed green lines show the boundaries between the three ... telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a ... Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1 and TRF2 ... Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1 and TRF2 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3935891_pone.0089460.g002&req=4
*  Titia de Lange - Wikipedia
In 1995, she identified and purified the Telomeric-repeat binding factor protein 1 (TRF1). With the assistance of Bas van ... In 2005, de Lange came to the crucial realization that six telomeric proteins form a dynamic protein complex, that she named ... Shelterin subunits are not the only proteins that associate with telomeres but they differ from other proteins by meeting the ... A human telomeric protein. Science 270: 1663-1667. Retrieved from doi: 10.1126/science.270.5242.1663 B. van Steensel and T. de ...
  https://en.wikipedia.org/wiki/Titia_de_Lange
*  Reactome | TERF2IP [nucleoplasm]
Telomeric repeat-binding factor 2-interacting protein 1 [nucleoplasm] Inferred From. TERF2IP [nucleoplasm] (Homo sapiens) ... Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure ...
  https://reactome.org/content/detail/R-MMU-174873
*  hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic...
Expression of hTR and telomeric-associated proteins TEP1, TRF1, TRF2, tankyrase and PinX1 was high in the majority of CP and AP ... its regulators and several telomeric-associated proteins. Quantitative real-time-polymerase chain reaction (PCR) was used to ... Telomeric Repeat Binding Protein 2, Transcription, Genetic, Tumor Suppressor Proteins ... Adolescent, Adult, Aged, Antigens, CD34, Benzamides, Carrier Proteins, DNA-Binding Proteins, Disease Progression, Down- ...
  https://www.rdm.ox.ac.uk/publications/246227
*  Plus it
Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic ... Expression of telomeric repeat binding factor-1 in astroglial brain tumors. Neurosurgery 2005;56:802-10. ... Gene expression for suppressors of telomerase activity (telomeric-repeat binding factors) in breast cancer. Jpn J Cancer Res ... Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Anticancer Res 2002; ...
  http://clincancerres.aacrjournals.org/content/12/19/5720
*  Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres | Science
Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor-1), a negative regulator of telomere length ... ADP-ribosylation of TRF1 diminished its ability to bind to telomeric DNA in vitro, suggesting that telomere function in human ... Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase ( ... Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1. Recombinant ...
  http://science.sciencemag.org/content/282/5393/1484
*  Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. - PubMed - NCBI
Telomeric Repeat Binding Protein 1/genetics. Substances. *Telomeric Repeat Binding Protein 1 ... Long telomeric repeats have less efficient DNA repair compared to chromosomal DNA with a similar amount of DNA damage. (A) ... Expansion of γH2AX in long telomeric repeats. (A) Quantification of co-localization between γH2AX and KR-TRF1 signals. Error ... By fusing the KillerRed chromophore with the telomere repeat binding factor 1, TRF1, we developed a novel approach to generate ...
  https://www.ncbi.nlm.nih.gov/pubmed/26082495
*  Prod is a novel DNA-binding protein that binds to the 1.686 g/cm(3) 10 bp satellite repeat of Drosophila melanogaster. -...
Footprinting experiments show that the protein interacts with a 5-8 bp target sequence in each 10 bp repeat and suggest that it ... We have examined the binding of the Prod protein to DNA in vitro. Co-immunoprecipitation experiments demonstrate that Prod is a ... DNA-binding protein that specifically recognizes the 10 bp AGAATAACAT satellite repeat of D.melanogaster. ... Gel retardation experiments indicate that Prod does not have a well defined DNA-binding domain and it binds the satellite in a ...
  https://www.semanticscholar.org/paper/Prod-is-a-novel-DNA-binding-protein-that-binds-to-T%C3%B6r%C3%B6k-Gorj%C3%A1n%C3%A1cz/a6315086ffbb7e4e840ed60dab82cb083d9ca036
*  List of MeSH codes (D12.776.660) - Wikipedia
... telomeric repeat binding protein 1 MeSH D12.776.660.235.700.875 -- telomeric repeat binding protein 2 MeSH D12.776.660.352. ... hmgb proteins MeSH D12.776.660.235.400.600.300 -- hmgb1 protein MeSH D12.776.660.235.400.600.600 -- hmgb2 protein MeSH D12.776. ... hmgn1 protein MeSH D12.776.660.235.400.400.300 -- hmgn2 protein MeSH D12.776.660.235.400.500 -- hmga proteins MeSH D12.776. ... hmga1b protein MeSH D12.776.660.235.400.500.400 -- hmga1c protein MeSH D12.776.660.235.400.500.600 -- hmga2 protein MeSH ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.660)
*  RAP1 at the Yeast Telomere
... these proteins can bind to the telomeric repeats of vertebrates in vitro. It is shown here that telomeric repeats from S. ... these proteins can bind to the telomeric repeats of vertebrates in vitro. It is shown here that telomeric repeats from S. ... cytogenetik, DNA-binding, Saccharomyces, yeast, telomeric repeat, telomere, RAP1, repressor activator protein 1, Genetics, ... Binding analyses revealed that the scas- and sdaiRAP1 proteins bind to telomeric sequences in a similar manner as scerRap1p. ...
  https://lup.lub.lu.se/search/publication/464700
*  Telomere-binding protein - Wikipedia
... function to bind telomeric DNA in various species. In particular, telomere-binding protein refers to TTAGGG repeat binding ... Telomere-binding proteins function to generate a T-loop, which is a specialized loop structure to cap the telomeric ends. ... There include: TRF1 TRF2 POT1 TIN2 RAP1 TPP1 Both TRF1 and TRF2 bind the telomeric repeat sequences in the duplex region of the ... It has homology to the Myb transcription factors as the protein-DNA complex requires both Myb repeats. TRF1 binds near the N- ...
  https://en.wikipedia.org/wiki/Telomere-binding_protein
*  TERF2 (telomeric repeat binding factor 2)
... telomeric repeat binding factor 2), Authors: Molly L Bristol, Claire P Bailey, Lynne W Elmore. Published in: Atlas Genet ... DNA binding double-stranded telomeric DNA binding double-stranded telomeric DNA binding telomerase activity protein binding ... DNA binding double-stranded telomeric DNA binding double-stranded telomeric DNA binding telomerase activity protein binding ... the Telomeric Repeat binding Factor domain, the RAP1 binding motif of telomere repeat binding factor, and the 'SWI3, ADA2, N- ...
  http://atlasgeneticsoncology.org/Genes/TERF2ID42522ch16q22.html
*  RCSB PDB - 1PGZ: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6...
... isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures ... Classification: DNA BINDING PROTEIN / DNA * Deposited: 2003-05-28 Released: 2003-11-11 ... Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta- ...
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1PGZ
*  TERF2IP - Wikipedia
Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene. TERF2IP has ... "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein". O'Connor, Matthew S; Safari Amin; Liu Dan; Qin ... 2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
  https://en.wikipedia.org/wiki/TERF2IP
*  TERF1 - Wikipedia
... the protein has a molecular function of binding telomeric DNA and the double-stranded telomeric DNA. The telomeric repeat- ... These functions include the binding of the protein, facilitation in the activity of protein homodimerization, the binding of ... contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding ... Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. The human TERF1 gene is located in ...
  https://en.wikipedia.org/wiki/TERF1
*  ZBTB48 is both a Telomere-binding Protein Limiting Telomere Length and a Transcriptional Activator [image] | EurekAlert!...
... as well as subtelomeric variant repeats (TTGGG/TCAGGG, grey), which represent the protective caps at the end of chromosomes. In ... addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, ... ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) ... ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) as well as subtelomeric variant ...
  https://eurekalert.org/multimedia/pub/143103.php
*  TERF2IP Gene - GeneCards | TE2IP Protein | TE2IP Antibody
Protein Coding), TERF2 Interacting Protein, including: function, proteins, disorders, pathways, orthologs, and expression. ... Protein Symbol:. Q9NYB0-TE2IP_HUMAN. Recommended name:. Telomeric repeat-binding factor 2-interacting protein 1 Protein ... Does not bind DNA directly: recruited to telomeric double-stranded 5-TTAGGG-3 repeats via its interaction with TERF2. ... Does not bind DNA directly: recruited to telomeric double-stranded 5-TTAGGG-3 repeats via its interaction with TERF2. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=TERF2IP
*  MDM2 negatively regulates the human telomerase RNA gene promoter | BMC Cancer | Full Text
Using an Sp1 binding site mutation construct we showed that mdm2 repression did not absolutely require Sp1 binding sites in the ... Here we show using chromatin immunoprecipitation that mdm2 specifically binds the hTR promoter in vivo. Transient co- ... Chromatin immunoprecipitation was used to determine binding of mdm2 to the hTR promoter. Transfection and luciferase assays ... with a template domain for telomeric DNA synthesis and of a catalytic protein, hTERT, with reverse transcriptase activity. ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-5-6