*  Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis | Journal...
Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis ... Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis ... Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis ... Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis ...
  http://jcs.biologists.org/content/128/14/2454.long
*  Essential role for the TRF2 telomere protein in adult skin homeostasis.
TRF2 is essential for telomere capping owing to its roles in suppressing an ATM-dependent DNA damage response (DDR) at ... Essential role for the TRF2 telomere protein in adult skin homeostasis.. aging. cancer. senescence. stem cell. telomerase ... Telomere Science Library Publications, Presentations, and Videos about the Nobel-Prize Winning Science of Telomere Biology ... Copyright © 2017 Telomere Science Library. All Rights Reserved. All trademarks used are the properties of their respective ...
  http://www.telomerescience.com/essential-role-for-the-trf2-telomere-protein-in-adult-skin-homeostasis-24725274.html
*  Genomic Instability Induced by Mutations in Saccharomyces cerevisiae POL1 | Genetics
2000 The function of DNA polymerase α at telomeric G tails is important for telomere homeostasis. Mol. Cell. Biol. 20: 786-796 ... and telomere homeostasis maintenance (Diede and Gottschling 1999; Adams-Martinet al. 2000; Dahlenet al. 2003). ... 1999 Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerase α and δ. Cell 99: 723-733. ... 2003 Replication proteins influence the maintenance of telomere length and telomerase protein stability. Mol. Cell. Biol. 23: ...
  http://www.genetics.org/content/165/1/65
*  Tethering Est1 to telomeres promotes efficient telomere | Open-i
A) Telomere length analysis by Southern blot of XhoI-digested DNA isol ... Tethering Est1 to telomeres promotes efficient telomere elongation in Ku mutant strains. ( ... fig3: Tethering Est1 to telomeres promotes efficient telomere elongation in Ku mutant strains. (A) Telomere length analysis by ... fig3: Tethering Est1 to telomeres promotes efficient telomere elongation in Ku mutant strains. (A) Telomere length analysis by ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4125388_1123fig3&req=4
*  Lennon, A. M.<...
Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors. ...
  https://jhu.pure.elsevier.com/en/persons/anne-marie-obroin-lennon
*  Identify Genes Involved in hTERT Induction | Thermo Fisher Scientific - AR
This is the preferred pathway to maintain telomere homeostasis in human cancer cells. Because telomere length controls cellular ... telomeres get shortened as the cell divides until the cell reaches telomere dependent senescence. Telomerase is a cellular, ... The Role of Telomerase Telomeres are regions of repetitive DNA at the ends of eukaryotic chromosomes that have functions that ... ribonucleoprotein reverse transcriptase that can maintain the length of telomeres by using its integral RNA component as a ...
  http://www.thermofisher.com/ar/es/home/references/ambion-tech-support/microrna-studies/tech-notes/functional-screen-to-identify-genes-involved-in-htert-induction.html
*  Erica D Smith, PhD: Faculty Profile: Feinberg School of Medicine: Northwestern University
... paying particular attention to regeneration and tissue homeostasis. We are also investigating telomere homeostasis and it's ...
  http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=17848
*  Interactive Fly, Drosophila
Elg1 is required for efficient S phase progression and telomere homeostasis in yeast. Elg1 interacts physically with the PCNA ... Unlike pol30-8, the pol30-6 and pol30-79 mutants partially reduce gene silencing at telomeres and the HMR and synergistically ... In the absence of CAF-1, the expression of genes near the telomeres is variegated in a population of cells. It is suggested ... In yeast, deletion of any genes encoding CAF-1 subunits (CAC1, 2 and 3) results in partial loss of silencing at telomeres and ...
  http://www.sdbonline.org/sites/fly/polycomb/pcna2a.htm
*  Steven Artandi | Stanford Medicine Profiles
... pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. Short telomeres, a ... Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo PROCEEDINGS ... Loss of telomere capping function brought about by telomerase deficiency and gradual erosion of telomere ends or by ... Critical telomere shortening and loss of the protective telomere capping function in cell culture initiates senescence and ...
  https://med.stanford.edu/profiles/steven-artandi
*  Telomere length shows no association with BRCA1 and BRCA2 mutation status - Danish National Research Database-Den Danske...
Telomere; Telomere Homeostasis Main Research Area: Medical science Publication Status: Published Review type: Peer Review ... This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of ... We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. ...
  http://www.forskningsdatabasen.dk/catalog/259984191
*  Telomeres: virtue stands in the middle | Philosophical Transactions of the Royal Society B: Biological Sciences
... telomere homeostasis' [4,6].. These and other data show that perturbations in telomere equilibrium, either to shorter or longer ... 2009 Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms. J. Pathol. 217 ... However, it is not just critically eroded telomeres that may harbour defects in telomere integrity; long telomeres can also be ... and to increased telomere fragility [44,45]. Indeed, the DDR itself is critical to telomere length homeostasis, and ataxia- ...
  http://rstb.royalsocietypublishing.org/content/373/1741/20160444
*  Protocols and Video Articles Authored by Yuji Mishina (Translated to Hindi)
Jun, 2014 , Pubmed ID: 24747911 Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis, and mitosis, offering ... To study how SHP-2 regulates tissue homeostasis in normal adults, we used a conditional SHP-2 mouse mutant in which loss of ... Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for ... Here we report that the BMP-Smad1 pathway, which is essential for embryonic development and tissue homeostasis, has an ...
  https://www.jove.com/author/Yuji_Mishina?language=Hindi
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Transplantation-related factors should be taken into consideration because of their impacts on telomere homeostasis. As ... Telomeres are specific nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeres and telomere-associated ... Significantly shortened telomeres, activation of telomerase, and altered expression of telomere-associated proteins are common ... In this review, the characteristics and roles of telomeres and telomerase both in hematologic malignancies and in HSCT will be ...
  https://www.jove.com/visualize?author=Xing+Zhang
*  Marius Wernig | Stanford Medicine Profiles
... pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. Short telomeres, a ... Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells NATURE Batista, L. F., ... Extended culture of DKC1-mutant iPSCs leads to progressive telomere shortening and eventual loss of self-renewal, indicating ... yet the ability of telomerase to lengthen telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli ...
  https://med.stanford.edu/profiles/marius-wernig
*  Most recent papers with the keyword shelterin | Read by QxMD
Telomere length homeostasis is achieved via a balance between telomere lengthening by telomerase, and erosion over successive ... How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis. ... Ag-np altered the telomere dynamics by disrupting the shelterin complex located at the telomeres and telomere lengths... ... read/29663033/how-long-does-telomerase-extend-telomeres-regulation-of-telomerase-release-and-telomere-length-homeostasis ...
  https://www.readbyqxmd.com/keyword/46482
*  UW Genome Sciences: past GS Seminars
Finding the right balance: Mechanisms of telomere length homeostasis in yeast' May 14 - Dr. Gerald Rubin. Howard Hughes Medical ... Regulation of Telomere Replication in Yeast' Wed., October 24. Seminar will be held in Kane Hall, Rm. 130 Leland Hartwell, Ph.D ... Centromeres impersonating telomeres, and other forms of deception at the chromosome end'. flier ...
  http://www.gs.washington.edu/news/pastseminars.htm
*  The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation | Journal of...
Transplantation-related factors should be taken into consideration because of their impacts on telomere homeostasis. As ... Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and ... Significantly shortened telomeres, activation of telomerase, and altered expression of telomere-associated proteins are common ... In this review, the characteristics and roles of telomeres and telomerase both in hematologic malignancies and in HSCT will be ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-014-0061-9
*  The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis | Genetics
2004 Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117: ... In Saccharomyces cerevisiae, Ndj1 is a meiotic telomere-associated protein required for physically attaching telomeres to ... and is involved in telomere silencing and regulation of telomere length (Wotton and Shore 1997; Teixeira et al. 2004). Esc8 is ... 2008 Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell ...
  http://www.genetics.org/content/206/3/1319
*  A Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women | Diabetes
... the exact mechanistic functions by which these proteins interact in telomere homeostasis remain unknown, though mutually ... a constitutive component of telomeres (27). Mutations in these telomere-regulating proteins may disrupt telomere structure, ... We identified genes coding for proteins involved in telomere regulation, including those directly associated with telomere ... 107 kb of telomere sequence in the 1× telomere standard. The standard curve of 36B4 contained 100 pg of the 36B4 75-oligomer ...
  http://diabetes.diabetesjournals.org/content/61/11/2998
*  Frontiers | Evolution of TERT-interacting lncRNAs: expanding the regulatory landscape of telomerase | Genetics
... and how such RNAs may facilitate telomerase regulation and off-telomere functions. ... and how such RNAs may facilitate telomerase regulation and off-telomere functions. ... TER works in concert with the telomerase reverse transcriptase (TERT) to maintain telomeres. Here we discuss recent findings ... TER works in concert with the telomerase reverse transcriptase (TERT) to maintain telomeres. Here we discuss recent findings ...
  https://www.frontiersin.org/articles/10.3389/fgene.2015.00277/full
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The universally conserved Kae1/Qri7/YgjD and Sua5/YrdC protein families have been implicated in growth, telomere homeostasis, ... The partial complementation of telomere maintenance by Qri7 hints that KEOPS has evolved novel functions in higher organisms. ... to restore ER homeostasis. In mice, IRE1? inactivity leads to embryonic death and IRE1? plays an essential role in ... telomere maintenance. These observations suggest that Kae1 provides a core essential function that other subunits within KEOPS ...
  https://www.jove.com/visualize?author=Yuan+Fang
*  Dyskeratosis Congenita Publications and Abstracts | PubFacts.com
Defects in lymphocyte telomere homeostasis contribute to cellular immune phenotype in patients with cartilage-hair hypoplasia. ... Telomere shortening is proposed to be a primary molecular cause of aging. Short telomeres block the proliferative capacity of ... Dyskeratosis congenita (DC) is a rare inherited disease in which the telomere complex cannot be maintained. Shortened telomeres ... and play an important role in telomere homeostasis. They participate in several fundamental cellular processes by contributing ...
  https://www.pubfacts.com/search/Dyskeratosis+Congenita
*  Anti-p53 抗体 [PAb 240] (ab26) 使用論文 | アブカム
Petti E et al. Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice. Cell Cycle 14: ... Gu BW et al. A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere ... Chen J et al. Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis. Oncotarget 8:7301-7314 (2017 ... Gazzaniga FS & Blackburn EH An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or ...
  http://www.abcam.co.jp/p53-antibody-pab-240-ab26-references.html
*  More Light Is Cast on Epigenetics and Design
... the telomeres, to form a powerful protein scaffold required for telomere homeostasis." Cells are glad to have these seemingly ... In a study published today in Cell, they elucidated how sequence repeats in telomeres help stabilize these regions and prevent ...
  http://healthimpactnews.com/2013/more-light-is-cast-on-epigenetics-and-design/