Genes | Free Full-Text | Solving the Telomere Replication Problem
This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can ... Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at ... In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity ... Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. ...http://www.mdpi.com/2073-4425/8/2/55
Telomere shortening in smokers with and without COPD | European Respiratory Society
Telomere length shortens with age in all replicating somatic cells. It has been shown that tobacco smoking enhances telomere ... Telomere shortening in smokers with and without COPD. M. Morlá, X. Busquets, J. Pons, J. Sauleda, W. MacNee, A. G. N. Agustí ... Telomere shortening in smokers with and without COPD Message Subject (Your Name) has sent you a message from European ... Telomere length was determined by fluorescence in situ hybridisation in circulating lymphocytes harvested from 26 never-smokers ...http://erj.ersjournals.com/content/27/3/525.short
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication...
Potts PR, Yu H (2007) The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere‐binding ... Figure 3. Conservative DNA replication at telomeres and telomere function in ALT cells are dependent on PolD3 and PolD4. *. ... Nabetani A, Ishikawa F (2011) Alternative lengthening of telomeres pathway: recombination‐mediated telomere maintenance ... In addition, we excluded from our analysis telomeres that exhibited telomeric SCEs (T‐SCEs) . Telomeres with T‐SCEs ...http://embor.embopress.org/content/17/12/1731.share
Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins |...
Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins. ... Telomere repeat binding factors (TRFs) 1 and 2 bind to telomere double-stranded DNA and function to regulate telomere length ... Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins ... stranded telomere DNA and regulate telomere length by controlling the access of telomerase to telomeres . In addition, ...http://circleofdocs.com/do-telomeres-adapt-to-physiological-stress-exploring-the-effect-of-exercise-on-telomere-length-and-telomere-related-proteins/
Terf2ip - Telomeric repeat-binding factor 2-interacting protein 1 - Mus musculus (Mouse) - Terf2ip gene & protein
... it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end- ... Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to ... Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' ... Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair ...http://www.uniprot.org/uniprot/Q91VL8
The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation | Journal of...
Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and ... Significantly shortened telomeres, activation of telomerase, and altered expression of telomere-associated proteins are common ... In this review, the characteristics and roles of telomeres and telomerase both in hematologic malignancies and in HSCT will be ... In normal somatic cells, the length of the telomeres gradually becomes shortened with cell division. In tumor cells, the ...https://jhoonline.biomedcentral.com/articles/10.1186/s13045-014-0061-9
Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine | Cancer Discovery
Critically short telomeres, or impaired telomere-protective proteins in the shelterin complex, can lead to "uncapped" telomere ... These telomere-associated DNA-damage signals are referred to as telomere dysfunction-induced foci (TIF). TIFs can be visualized ... Red dots show DNA damage (53BP1), green dots show telomeres, and yellow dots show TIF (DNA damage on telomeres) in merged ... S1). In addition, these cell lines had a variety of telomere lengths, but cell killing was independent of initial telomere ...http://cancerdiscovery.aacrjournals.org/content/5/1/82
Telomere length : dynamics and role as a biological marker in malignancy
4. Blood cell telomere length is a dynamic feature. Open this publication in new window or tab ,,Blood cell telomere length is ... Telomere shortening can be prevented in the presence of the telomere--‐elongating enzyme telomerase. Telomerase is expressed ... Telomeres are repetitive structures located at chromosome ends. Previous studies have indicated that blood cell telomeres may ... Furthermore, we analyzed telomere length in tumor samples and corresponding kidney cortex. Relative telomere length (RTL) was ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:570563
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication...
Potts PR, Yu H (2007) The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere‐binding ... telomere length regulation. Introduction. One of the factors limiting indefinite proliferation of somatic cells is telomere ... Figure 3. Conservative DNA replication at telomeres and telomere function in ALT cells are dependent on PolD3 and PolD4. *. ... Nabetani A, Ishikawa F (2011) Alternative lengthening of telomeres pathway: recombination‐mediated telomere maintenance ...http://embor.embopress.org/content/early/2016/10/19/embr.201643169
YKU70 - ATP-dependent DNA helicase II subunit 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - YKU70...
Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere ... Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 ... Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for ... Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. ...http://www.uniprot.org/uniprot/P32807
Brunel University Research Archive: Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic...
... using known telomere length assays. We measured telomere lengths using: Telomere Restriction Fragment length (TRF), absolute ... Background: Telomere length dysregulation plays a major role in cancer development and aging. Telomeres are maintained by a ... The increase in telomere lengths was consistently observed when various telomere length methods were used. Conclusions: Further ... Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic modifying drug. ...http://bura.brunel.ac.uk/handle/2438/14059
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end | The EMBO Journal
TIFs without telomere fusions. The effects of lowered POT1 and POT1-55 levels on telomere protection were determined using ... A transient postmitotic telomere damage signal. Cells with diminished POT1 accumulate γ‐H2AX and 53BP1 at telomeres, indicating ... As telomere fusions are a pervasive signature of telomere dysfunction, metaphase chromosomes were examined for this defect. In ... The hallmarks of telomere dysfunction in mammals are reduced telomeric 3′ overhangs, telomere fusions, and cell cycle arrest ...http://emboj.embopress.org/content/24/14/2667.share
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length ... A critically short telomere will trigger the cell to enter a state of cellular senescence or to apoptose. The rate of telomere ... 1. Telomeres and the brain: an investigation into the relationships of leukocyte telomere length with functional and structural ... In Paper I, telomere length was shown to be longer among non-demented carriers of the apolipoprotein E (APOE) ε4 allele, a well ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:516681
The Role of Stn1p in Saccharomyces cerevisiae Telomere Capping Can Be Separated From Its Interaction With Cdc13p | Genetics
Teng, S.C., and V. A. Zakian, 1999 Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in ... Telomerase and telomere length are critical for stn1-186t and stn1-281t viability:. To determine whether the telomere ... First, the single-stranded telomere DNA in the stn1-186t and stn1-281t strains is present as internal gaps within the telomere ... Diploids inherit elongated telomeres through mating with stn1-186t strains. (A) Southern blot showing telomere lengths in ...http://www.genetics.org/content/177/3/1459
Leicester Research Archive: Investigation of epigenetic alterations related to telomere maintenance in human cells
Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere repeats, or by the ... No relationship between telomere length and DNA methylation at XpYp was found in telomerase positive cells. Additionally, ... In marked contrast to mouse models, no relationship was found between the level of any of these modifications and telomere ... This may indicate that the role such marks play at telomeres differs between humans and mice. Additionally, the level of ...https://lra.le.ac.uk/handle/2381/10324
Neuro Adrenal Panel(HOR14) |Regenerus Laboratories
What does Telomere Testing measure? Telomeres are sections of genetic material at the end of each chromosome whose primary ... The Patient Telomere Score is calculated based on the patient's average telomere length in peripheral whole blood cells. This ... SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age. ... SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age. ...https://regeneruslab.odoo.com/shop/product/neuro-adrenal-panel-hor14-611
The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized ...http://www.uniprot.org/locations/SL-0276
Telomere Research Positions
... Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Wed Sep 25 10:36:35 EST 1996 *Previous ... the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. MCB 16: 2483- ... that appears to combine elements of intrachromatid recombination and pairing of non-homologous telomeres to regulate telomere ... POSTDOCTORAL POSITIONS AVAILABLE TO STUDY TELOMERE SIZE REGULATION AND TELOMERIC SILENCING IN SACCHAROMYCES CEREVISIAE. I am ...http://www.bio.net/bionet/mm/yeast/1996-September/005803.html
Telomeres - Scientific American
... although telomere shortening may play a role in limiting cellular life span, there is no evidence that telomere shortening ... long-lived species often have shorter telomeres than do short-lived species, indicating that telomere length probably does not ... 56Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Commun. ... Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460. 54Vaziri H, Dragowska W, Allsopp RC, Thomas TE, ...https://www.scientificamerican.com/article/telomeres/
Vitamin D Council| telomere length
Tag Archives: telomere length. New research explores the relationship between telomere length and vitamin D status. A study ... investigated whether low vitamin D status is associated with short telomeres, since both are linked to risk of chronic health ...https://www.vitamindcouncil.org/tag/telomere-length/
telomeres Archives - ExtremeTech
Telomeres and Telomerase | SpringerLink
... rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere ... Cancer progression Cell growth Chromatin Genomics Model systems Protein interaction networks Proteomics Telomere DNA Telomere ... Telomeres and Telomerase: Methods and Protocols, Second Edition builds upon the telomerase assays featured in the popular first ... Authoritative and practical, Telomeres and Telomerase: Methods and Protocols, Second Edition serves as an ideal, up-to-date ...https://link.springer.com/book/10.1007/978-1-61779-092-8
telomeres | NextBigFuture.com
telomeres Archive antiaging100 years ago the world absolute poverty rate was as bad as the poorest country today. No Comments ...https://www.nextbigfuture.com/tag/telomeres
telomeres at Tulane
Postdoctoral position to study telomere structure and function. A postdoctoral position is available to investigate telomere ... telomeres at Tulane. Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Mon Mar 10 09:14:06 EST 1997 *Previous message: THE ... We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) ... The mechanisms of nucleation and inheritance of telomeric silencing (e.g. MCB 16: 2843); and 2) the mechanism of telomere size ...http://www.bio.net/bionet/mm/biochrom/1997-March/001446.html
Accelerated telomere shortening in response to life stress | PNAS
... and telomere length implies that stress preceded telomere shortening, because telomere length cannot have influenced the number ... A) Average telomere length and SE are shown. The high-stress group had shorter telomeres even after controlling for age and BMI ... Therefore, in translating telomere shortening to years of aging, we based our estimates on studies averaging telomere ... Telomeres are DNA-protein complexes that cap chromosomal ends, promoting chromosomal stability. When cells divide, the telomere ...http://www.pnas.org/content/101/49/17312.long