*  Genes | Free Full-Text | Solving the Telomere Replication Problem
This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can ... Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at ... In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity ... Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. ...
  http://www.mdpi.com/2073-4425/8/2/55
*  MPIDR - Telomere length and mortality: a study of leukocytes in elderly Danish twins
Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human ... and it grew stronger with increasing intrapair difference in all telomere parameters. Leukocyte telomere dynamics might help ... Telomere length and mortality: a study of leukocytes in elderly Danish twins Kimura, M., Hjelmborg, J. v.B., Gardner, J., ... The proportions derived from the intrapair comparisons indicated that the shorter telomeres predicted the death of the first co ...
  http://www.demogr.mpg.de/de/projekte_publikationen/publikationen_1904/zeitschriftenartikel/telomere_length_and_mortality_a_study_of_leukocytes_in_elderly_danish_twins_3279.htm
*  Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication...
Potts PR, Yu H (2007) The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere‐binding ... Figure 3. Conservative DNA replication at telomeres and telomere function in ALT cells are dependent on PolD3 and PolD4. *. ... Nabetani A, Ishikawa F (2011) Alternative lengthening of telomeres pathway: recombination‐mediated telomere maintenance ... In addition, we excluded from our analysis telomeres that exhibited telomeric SCEs (T‐SCEs) [46]. Telomeres with T‐SCEs ...
  http://embor.embopress.org/content/17/12/1731.share
*  Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins |...
Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins. ... Telomere repeat binding factors (TRFs) 1 and 2 bind to telomere double-stranded DNA and function to regulate telomere length ... Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins ... stranded telomere DNA and regulate telomere length by controlling the access of telomerase to telomeres [36]. In addition, ...
  http://circleofdocs.com/do-telomeres-adapt-to-physiological-stress-exploring-the-effect-of-exercise-on-telomere-length-and-telomere-related-proteins/
*  Terf2ip - Telomeric repeat-binding factor 2-interacting protein 1 - Mus musculus (Mouse) - Terf2ip gene & protein
... it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end- ... Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to ... Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' ... Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair ...
  http://www.uniprot.org/uniprot/Q91VL8
*  Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine | Cancer Discovery
Critically short telomeres, or impaired telomere-protective proteins in the shelterin complex, can lead to "uncapped" telomere ... These telomere-associated DNA-damage signals are referred to as telomere dysfunction-induced foci (TIF). TIFs can be visualized ... Red dots show DNA damage (53BP1), green dots show telomeres, and yellow dots show TIF (DNA damage on telomeres) in merged ... S1). In addition, these cell lines had a variety of telomere lengths, but cell killing was independent of initial telomere ...
  http://cancerdiscovery.aacrjournals.org/content/5/1/82
*  Telomere length : dynamics and role as a biological marker in malignancy
4. Blood cell telomere length is a dynamic feature. Open this publication in new window or tab ,,Blood cell telomere length is ... Telomere shortening can be prevented in the presence of the telomere--‐elongating enzyme telomerase. Telomerase is expressed ... Telomeres are repetitive structures located at chromosome ends. Previous studies have indicated that blood cell telomeres may ... Furthermore, we analyzed telomere length in tumor samples and corresponding kidney cortex. Relative telomere length (RTL) was ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:570563
*  YKU70 - ATP-dependent DNA helicase II subunit 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - YKU70...
Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere ... Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 ... Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for ... Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. ...
  http://www.uniprot.org/uniprot/P32807
*  Brunel University Research Archive: Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic...
... using known telomere length assays. We measured telomere lengths using: Telomere Restriction Fragment length (TRF), absolute ... Background: Telomere length dysregulation plays a major role in cancer development and aging. Telomeres are maintained by a ... The increase in telomere lengths was consistently observed when various telomere length methods were used. Conclusions: Further ... Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic modifying drug. ...
  http://bura.brunel.ac.uk/handle/2438/14059
*  POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end | The EMBO Journal
TIFs without telomere fusions. The effects of lowered POT1 and POT1-55 levels on telomere protection were determined using ... A transient postmitotic telomere damage signal. Cells with diminished POT1 accumulate γ‐H2AX and 53BP1 at telomeres, indicating ... As telomere fusions are a pervasive signature of telomere dysfunction, metaphase chromosomes were examined for this defect. In ... The hallmarks of telomere dysfunction in mammals are reduced telomeric 3′ overhangs, telomere fusions, and cell cycle arrest ...
  http://emboj.embopress.org/content/24/14/2667.share
*  Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length ... A critically short telomere will trigger the cell to enter a state of cellular senescence or to apoptose. The rate of telomere ... 1. Telomeres and the brain: an investigation into the relationships of leukocyte telomere length with functional and structural ... In Paper I, telomere length was shown to be longer among non-demented carriers of the apolipoprotein E (APOE) ε4 allele, a well ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:516681
*  The Role of Stn1p in Saccharomyces cerevisiae Telomere Capping Can Be Separated From Its Interaction With Cdc13p | Genetics
Teng, S.C., and V. A. Zakian, 1999 Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in ... Telomerase and telomere length are critical for stn1-186t and stn1-281t viability:. To determine whether the telomere ... First, the single-stranded telomere DNA in the stn1-186t and stn1-281t strains is present as internal gaps within the telomere ... Diploids inherit elongated telomeres through mating with stn1-186t strains. (A) Southern blot showing telomere lengths in ...
  http://www.genetics.org/content/177/3/1459
*  Neuro Adrenal Panel(HOR14) |Regenerus Laboratories
What does Telomere Testing measure? Telomeres are sections of genetic material at the end of each chromosome whose primary ... The Patient Telomere Score is calculated based on the patient's average telomere length in peripheral whole blood cells. This ... SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age. ... SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age. ...
  https://regeneruslab.odoo.com/shop/product/neuro-adrenal-panel-hor14-611
*  telomere
The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized ...
  http://www.uniprot.org/locations/SL-0276
*  Telomere Research Positions
... Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Wed Sep 25 10:36:35 EST 1996 *Previous ... the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. MCB 16: 2483- ... that appears to combine elements of intrachromatid recombination and pairing of non-homologous telomeres to regulate telomere ... POSTDOCTORAL POSITIONS AVAILABLE TO STUDY TELOMERE SIZE REGULATION AND TELOMERIC SILENCING IN SACCHAROMYCES CEREVISIAE. I am ...
  http://www.bio.net/bionet/mm/yeast/1996-September/005803.html
*  Vitamin D Council| telomere length
Tag Archives: telomere length. New research explores the relationship between telomere length and vitamin D status. A study ... investigated whether low vitamin D status is associated with short telomeres, since both are linked to risk of chronic health ...
  https://www.vitamindcouncil.org/tag/telomere-length/
*  telomeres Archives - ExtremeTech
This newsletter may contain advertising, deals, or affiliate links. Subscribing to a newsletter indicates your consent to our Terms of Use and Privacy Policy. You may unsubscribe from the newsletter at any time ...
  https://www.extremetech.com/tag/telomeres
*  telomeres | NextBigFuture.com
telomeres Archive antiaging100 years ago the world absolute poverty rate was as bad as the poorest country today. No Comments ...
  https://www.nextbigfuture.com/tag/telomeres
*  telomeres at Tulane
Postdoctoral position to study telomere structure and function. A postdoctoral position is available to investigate telomere ... telomeres at Tulane. Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Mon Mar 10 09:14:06 EST 1997 *Previous message: THE ... We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) ... The mechanisms of nucleation and inheritance of telomeric silencing (e.g. MCB 16: 2843); and 2) the mechanism of telomere size ...
  http://www.bio.net/bionet/mm/biochrom/1997-March/001446.html
*  Hsp90 levels affect telomere length in yeast | SpringerLink
Shortening of telomeres was also observed in wild-type cells upon overexpression of HSC82, or of its temperature-inducible ... The stn1-13 mutation induces dramatic telomere elongation which is telomerase dependent, as shown here. Additional mutants for ...
  https://link.springer.com/article/10.1007%2Fs004380000398
*  Can You Repair a Telomere? - Sharecare
Telomeres (strings of DNA that protect chromosomes) shorten due to stress. the enzyme telomerase can lengthen them again. In ... The telomere length is actually not a one way street. When you examine the cell in culture, you find that well, the telomere ... Can You Repair a Telomere? (1:20) Telomeres (strings of DNA that protect chromosomes) shorten due to stress. the enzyme ... Telomeres is a very high and can cause cancer cells go on and on dividing. So we know Telomeres is a double edged sword, if ...
  https://www.sharecare.com/video/sharecare-experts/elissa-epel/can-you-repair-a-telomere
*  Telomere Length Affects Colorectal Cancer Risk
Home , Telomere Length Affects Colorectal Cancer Risk. Telomere Length Affects Colorectal Cancer Risk. • Telomeres of some ... If the telomeres shorten, then cells age. Shortened telomeres have been associated with an increased risk of cancer development ... They were surprised, however, to find a group with longer telomeres.. "Even for people their age, their telomeres were longer ... Patients with the longest telomeres - those patients in the 95th percentile of telomere length - were 30 percent more likely to ...
  https://www.mdtmag.com/print/news/2010/10/telomere-length-affects-colorectal-cancer-risk
*  Telomeres and Atherosclerosis | Hypertension
Schematic overview depicting either (A) shorter inherited telomere length (TL), or (B) accelerated telomere attrition (ΔTL), as ... telomeres versus (2) higher telomere attrition rates (Figure). The study provides evidence supporting the first hypothesis. In ... Telomeres and Atherosclerosis. The Intricate Pursuit of Mechanistic Insight Through Epidemiology. Tim De Meyer, Marc L. De ... These studies demonstrated that telomeres-typically measured in the DNA isolated from blood cells-clearly shorten with age. On ...
  http://hyper.ahajournals.org/content/70/2/243
*  Telomere Length Influences Cancer Cell Differentiation
Researchers from the Japanese Foundation for Cancer Research in Tokyo have discovered that forced elongation of telomeres ( ... Cancer cells have shorter telomeres compared to healthy cells, but they guard their immortality by maintaining these telomeres ... Telomeres are protective extensions on the ends of chromosomes, which shorten as cells age, like an hourglass running down. ... In the study, the forced elongation of cancer cells' telomeres suppressed a number of genes and proteins that appear to be ...
  https://www.asm.org/index.php/asm-newsroom/journal-tip-sheets/88-news-room/journal-tipsheets/91725-telomere-length-influences-cancer-cell-differentiation
*  telomere | iHealthTube.com
2017 iHealthTube. All rights reserved.. Use of the website signifies your agreement to the Terms of Use and Privacy Policy.Notice: Users should note that this site is not a medical site and cannot replace advice from your physician or health care provider. Individual results may vary. iHealthTube encourages users to seek the advice of a qualified professional for any health concern, including supplemental nutrition.. Questions: help@ihealthtube.com We try our best not to make mistakes; however, if typographical errors appear in our site, we cannot be held responsible.. ...
  https://www.ihealthtube.com/tags/telomere