*  Plus it
Until now the substrate specificity of UGT8 has never been broadly investigated. We found that UGT8 had restricted substrate ... We identified the novel sugar specificities and substrate profiles of the two members of the UGT3A family: UGT3A1 uses UDP-N- ... To date other substrates for this UGT have not been identified and there has been no suggestion that UGT8 is involved in ... Human UGT8 activities were assayed as in Materials and Methods with 0.2 mM of the listed substrate and 1 mM UDP-Gal or UDP-Glc ...
  http://molpharm.aspetjournals.org/content/87/3/442
*  Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological...
Although the substrate sequence specificities of numerous proteases have been established, 'topological specificities,' whereby ... Substrate topology modulated the affinity and sequence specificity of ADAMTS-4 with K(m) values indicating a preference for ... In the present study, the topological substrate specificity of ADAMTS-4 (aggrecanase-1) was examined using triple-helical or ... that topological specificity may be a guiding principle for protease behavior and can be utilized to design specific substrates ...
  https://oacentre.kennedy.ox.ac.uk/publications/226928
*  Biochemistry- Enzymes - Flashcards in University Biology
Different enzymes show a different degree of specificity. Some are specific to one substrate, whilst others aren't. Give an ... i.e. substrate binding at one site can affect substrate binding at the next. 2. Small change in [I] can cause a large change in ... has a structure similar to the substrate, and hence occupies the active site instead of the substrate, taking the free enzyme ... It decreases i.e. there is an apparent increase in affinity of substrate to enzyme (but actually substrate release is just ...
  https://getrevising.co.uk/revision-tests/biochemistry_enzymes?game_type=flashcards
*  Determinants for Substrate Specificity of Protein Phosphatase 2A
... Andrew M. Slupe, Ronald A. Merrill, and Stefan Strack ... Andrew M. Slupe, Ronald A. Merrill, and Stefan Strack, "Determinants for Substrate Specificity of Protein Phosphatase 2A," ...
  https://www.hindawi.com/journals/er/2011/398751/cta/
*  Analysis of AtZDP substrate specificity
... Valsecchi, Isabel Uppsala University, Disciplinary Domain of Medicine and Pharmacy, ... All substrates were dephosphorylated by AtZDP, assuming that this enzyme could potentially be involved in double-strand DNA ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:172212
*  Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... peptides within the library which are substrates for the kinase are converted to phosphopeptides and the phosphopeptides are ... When the substrate is a substrate for a protein-serine/threonine kinase, Xaa5 is Ser or Thr, whereas whenthe substrate is a ... This invention pertains to the substrate specificity of protein kinases and to peptides which are substrates for protein ...
  http://www.patentgenius.com/patent/5532167.html
*  Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants
... Laadan, B. ... resulting in Adh1p-variants with different substrate specificities. ... Kinetic characterization with both aldehydes and the in vivo primary substrate acetaldehyde also enabled to correlate the ... of both native and mutated ADH1 genes was performed in order to identify the key amino acids involved in this substrate shift, ...
  http://www.diva-portal.org/smash/record.jsf?pid=diva2:738158
*  Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
  https://www.jstage.jst.go.jp/article/bpb/35/6/35_b212001/_article
*  Chemoenzymatic synthesis of prodigiosin analogues-exploring the substrate specificity of PigC - Chemical Communications (RSC...
analogues-exploring the substrate specificity of PigC Suresh R. Chawrai,a Neil R. Williamson,b George P. C. Salmond*b and ... analogues-exploring the substrate specificity of PigC S. R. Chawrai, N. R. Williamson, G. P. C. Salmond and F. J. Leeper, Chem ...
  http://pubs.rsc.org/en/Content/ArticleLanding/2008/CC/b719353j
*  Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase | SpringerLink
Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase. ... Daubner S.C., Melendez J., Fitzpatrick P.F. (2002) Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of ... These substrate specificities are determined by the C domains (11). The goal of the experiments described here was to identify ... these enzymes differ in their substrate specificities. PheH is very specific for phenylalanine; although it can hydroxylate ...
  https://link.springer.com/chapter/10.1007/978-1-4615-0945-5_21
*  The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis | Biochemical Journal
The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis Message Subject (Your Name) has forwarded a ... The substrate specificity of the tyrosine decarboxylase of Streptococcus faecalis. G. H. Sloane-Stanley ...
  http://www.biochemj.org/content/44/3/373
*  Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase - Featured Articles - Elsevier
Highlights • The origin of specificity of the LeuRS editing domain was until now unresolved. • Ground-state binding does not... ... Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase. ... Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase ... Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase ...
  https://www.journals.elsevier.com/journal-of-molecular-biology/featured-articles/kinetic-origin-of-substrate-specificity-in-post-transfer-edi
*  Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains (Journal Article) | DOE...
... and modulate substrate specificity. Two amino acid differences at the domain interface alter the substrate binding specificity ... To avoid cleavage of unintended substrates, these enzymes have very selective substrate specificities. Our biochemical and ... Title: Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains ... Accepted Manuscript: Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains ...
  https://www.osti.gov/pages/biblio/1233189-insights-substrate-specificity-nlpc-p60-cell-wall-hydrolases-containing-bacterial-sh3-domains
*  Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum. | Plant Physiology
Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum.. Se-Young Jun, Alexander M ... Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum. ...
  http://www.plantphysiol.org/content/early/2017/06/12/pp.17.00576/tab-figures-data
*  Substrate Specificity for the Synthesis of Cyclic Fatty Acids by a Flaxseed Extract | Plant Physiology
Substrate Specificity for the Synthesis of Cyclic Fatty Acids by a Flaxseed Extract. Brady A. Vick, Don C. Zimmerman ... Substrate specificity studies showed that n-3,6,9 unsaturation was an absolute requirement for conversion of polyunsaturated ... Substrate Specificity for the Synthesis of Cyclic Fatty Acids by a Flaxseed Extract ... Substrate Specificity for the Synthesis of Cyclic Fatty Acids by a Flaxseed Extract ...
  http://www.plantphysiol.org/content/63/3/490
*  Characterization of HIV-1 Reverse Transcriptase substrate specificity by conformationally sensitive fluorescence
... ... In doing so, we define the role of induced-fit in nucleotide specificity and mismatch discrimination. Additionally, we have ... but provides a signal to monitor changes in enzyme structure that result from conformational changes induced by substrate ... characterized the kinetics governing the specificity and discrimination of several widely administered Nucleotide Reverse ...
  https://repositories.lib.utexas.edu/handle/2152/ETD-UT-2010-12-2154
*  Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease | HKMJ
1. Substrate-specificity of the main protease of SARS coronavirus was systematically profiled at P5 to P3' positions, which ... Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease ... Substrate preferences at P5 to P3 positions were important in enhancing the main protease activity. 'Super-reactive' substrate ...
  http://www.hkmj.org/abstracts/v20n4s4/18.htm
*  Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas...
To investigate the fundamental differences in substrate specificity between BMO and MMO, single amino acid substitutions were ... Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas ...
  https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/02870z43h
*  Molecules | Free Full-Text | A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para...
Screening of a small library of VAO and EUGO active-site variants for alterations in their substrate specificity led to the ... Here, we present the development of a screening assay for the substrate specificity of para-phenol oxidases based on the ... This assay provides a quick and efficient method to screen the substrate specificity of para-phenol oxidases, facilitating the ... The assay was used to screen the activity of VAO and EUGO towards a set of twenty-four potential substrates. This led to the ...
  http://mdpi.com/1420-3049/23/1/164
*  Structure Cluster - 1JT2: STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OF THE FERUL DOMAIN OF THE CELLULOSOMAL...
Structural basis for the substrate specificity of the feruloyl esterase domain of the cellulosomal xylanase Z from Clostridium ... STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OF THE FERUL DOMAIN OF THE CELLULOSOMAL XYLANASE Z FROM C. THERMOCELLUM. ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1JT2
*  Structural Comparison, Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present...
Structural Comparison, Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present ... Substrate Specificity, and Inhibitor Binding of AGPase Small Subunit from Monocot and Dicot: Present Insight and Future ...
  https://www.hindawi.com/journals/bmri/2014/583606/cta/
*  DIGITAL.CSIC: The white-rot fungus Pleurotus ostreatus secretes laccase isozymes with different substrate specificities
The white-rot fungus Pleurotus ostreatus secretes laccase isozymes with different substrate specificities. ... When staining with ABTS and guaiacol in native polyacrilamide gels, different specificities were observed for LCC1/LCC2 and ...
  https://digital.csic.es/handle/10261/97404
*  JAIRO | Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium...
Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans.. ... Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans. ... Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans.. ...
  http://jairo.nii.ac.jp/0083/00250294/en
*  Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes | Journal of Pharmacology and...
Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... Substrate Specificity of Organic Cation/H+ Exchange in Avian Renal Brush-Border Membranes. A. R. Villalobos and E. J. Braun ... In summary, the substrate specificity of the renal luminal OC/H+ exchanger for a battery of test OCs was evaluated in membranes ...
  http://jpet.aspetjournals.org/content/287/3/944
*  Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells | Cancer Research
Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells. Yasumasa Honjo ... In light of the fact that mutations in Pgp derived from drug selection have been shown to alter substrate specificity (11) , ... Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells ... Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells ...
  http://cancerres.aacrjournals.org/content/61/18/6635