Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study - pdf...
Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study. . ... neoangiogenic endothelial cells and myofibroblasts. uPAR expression in tumor-associated stromal cells and neoplastic cells and ... Within the tumor microenvironment uPAR is expressed by malignant cells as well as tumor-associated stromal cells. However, the ... This study compares the association of uPAR expression in both colorectal tumor-associated stromal cells and neoplastic cells ...http://libros.duhnnae.com/2017/jul/149887326813-Expression-of-uPAR-in-tumor-associated-stromal-cells-is-associated-with-colorectal-cancer-patient-prognosis-a-TMA-study.php
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS - Full Text View - ClinicalTrials.gov
... expressed on CD34+ cells and other leukocytes. This inhibition interferes with the binding of stromal cell derived factor-1 ( ... SDF-1), which is constitutively expressed on bone marrow stromal cells and appears to cause direct and indirect cellular ... A drug called Mozobil has been approved for use in combination with G-CSF to increase the number of stem cells that can be ... Excessive function of this gene causes mature neutrophils (part of white blood cells) to be retained within the bone marrow ...https://clinicaltrials.gov/show/NCT00967785
AID 44634 - HSF produced by bone marrow-derived stromal cell lines C6.4 on stimulation with the compound at (1000 ng/mL) was...
HSF produced by bone marrow-derived stromal cell lines C6.4 on stimulation with the compound at (1000 ng/mL) was determined in ...https://pubchem.ncbi.nlm.nih.gov/bioassay/44634
Stromal Cells May Be Involved in Development of Breast Carcinoma | Cancer Network | The Oncology Journal
researchers to isolate cancer cells from normal cells and to separate. epithelial cells from stromal cells. The laser beam can ... 69% of the neoplastic epithelial cells showed LOH, as did 17% to 61% of the. surrounding stromal cells. The higher frequency of ... of tumor comprising a mixture of cells and examining the "mixed bag". of cells for gene alterations," Dr. Eng told ONI. ... "We used to think that the surrounding structure of the cancer cell was. just a silent bystander in the process of ...http://www.cancernetwork.com/articles/stromal-cells-may-be-involved-development-breast-carcinoma
As a consequence, transcripts expressed by cancer cells can be distinguished from stromal transcripts by their species of ... leukocytes and endothelial cells. Stromal scores were found to correlate with poor CRC prognosis and resistance of rectal ... To stratify CRC based on cancer cell-intrinsic transcriptional features, we performed class discovery on a human-specific gene ... In PDX models, after engraftment, the stromal components are contributed by the mouse host. ...http://clincancerres.aacrjournals.org/content/22/16_Supplement/IA09
Theradigm, Inc. - Gene/Cell Therapy; Stem Cells - Maryland
Theradigm's technology platform is based on Bone Marrow Stromal Cells (BMSC) and Neural Stem Cells (NSCs). It uses BMSCs for ... Stem Cells - Theradigm, Inc. is engaged in developing cell-based therapies for the treatment of the central nervous system (CNS ... Preclinical data have shown recovery from stroke and traumatic brain injury upon IV infusion of BMSC cells and early ... of new human NSC lines and development of methods to improve the growth rate and expansion potential of these cells to obtain ...http://www.communitywalk.com/location/theradigm_inc/baltimore/md/genecell_therapy_stem_cells/10599117
Primary Human Prostate Stromal Cells | Creative Bioarray
PRODUCTS Cells. Probe. BioBank. Tissue Array SERVICES Cell Services. Cell-Based Drug Discovery Services. Histology Services. ... Primary Human Prostate Stromal Cells are available in limited quantities, please inquire for additional information. ... Tissue samples, tissue arrays, cells, microorganisms, probes and services for your research. ...https://www.creative-bioarray.com/Primary-Human-Prostate-Stromal-Cells-CSC-C4362X-item-2105.htm
"The Effect of αCT-1 Peptide on Bone Marrow Stromal Cells Following Inj" by Adam Clay Vandergriff
Live cell imaging showed an increase in migration for the first seven hours followed by a breakdown in cell to cell contact. ... Scratch assays were performed on rat bone marrow stromal cells treated with the peptide and were then analyzed using qPCR, ... migration and morphology of the cells were similar to that of cells undergoing EMT. This study provides a beginning look into ... western blotting, confocal microscopy, and live cell imaging. The gene expression analysis showed up-regulation of F11r and ...https://scholarcommons.sc.edu/etd/2305/
USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERS | SBIR.gov
Substantial in vitro data indicates that these stromal cells differentiate into cells biochemically and morphologically similar ... In Phase I of this SBIR, we tested the hypothesis that human adipose tissue-derived stromal cells are capable of osteoblast ... Specific Aim 1 examines the ability of human adipose tissue-derived stromal cells to form ectopic bone in hydroxyapatite ... Specific Aim 3 will determine if these modified bone morphogenetic protein receptor expressing stromal cells form bone more ...https://www.sbir.gov/sbirsearch/detail/97773
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation. - Radcliffe Department of Medicine
We documented a WNT/β-catenin activation signature in CD34+ cells from advanced cases of MDS, where it associated with adverse ... Constitutive activation of β-catenin in hematopoietic cells yielded lethal myeloid disease in a NUP98-HOXD13 mouse model of MDS ... This result was confirmed in an independent set of sorted, primary MDS-derived mesenchymal cells. ... In this study, we conducted a DNA methylome analysis of bone marrow-derived stromal cells from myelodysplastic syndrome (MDS) ...https://www.rdm.ox.ac.uk/publications/707949
SILAC Analysis of Two Bone Marrow Stromal Cell Lines
... to analyze proteomic differences in HS5 and HS27a cells. ... used stable isotope labeling with amino acids in cell culture ( ... stromal cells help support hematopoietic cells and inflammatory processes. Two major types of stromal cells related to early ... helpful in studying tumor cell growth and stromal interactions by deciphering crosstalk between stromal cells and clonal cells ... SILAC Analysis of Two Bone Marrow Stromal Cell Lines. By Emily Humphreys 01.10.2017 Within the bone marrow, ...https://www.thermofisher.com/blog/proteomics/silac-analysis-of-two-bone-marrow-stromal-cell-lines/
In this study, we conducted a DNA methylome analysis of bone marrow-derived stromal cells from myelodysplastic syndrome (MDS) ... We documented a WNT/ß-catenin activation signature in CD34+ cells from advanced cases of MDS where it associated with adverse ... Constitutive activation of ß-catenin in hematopoietic cells yielded lethal myeloid disease in a NUP98-HOXD13 mouse model of MDS ... This result was confirmed in an independent set of sorted, primary MDS-derived mesenchymal cells. ...http://cancerres.aacrjournals.org/content/early/2017/07/06/0008-5472.CAN-17-0282
Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells. - Petrakis...
Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.. ... Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells. ...http://onlinelibrary.wiley.com/doi/10.1002/biot.201100471/references
Adipose stromal cells repair pressure ulcers in both young and elderly mice: potential role of adipogenesis in skin repair. |...
Stem cells translational medicine 2015-4-23 Adipose stromal cells repair pressure ulcers in both young and elderly mice: ... Adipose-derived stromal/stem cells (ASCs) promote the healing of pressure ulcer wounds in both young and old mice. ASCs enhance ... The current study uses a murine model to address the hypothesis that adipose-derived stromal/stem cell (ASC) treatment would ... Relative to phosphate-buffered saline-treated controls, ASC-treated mice displayed a cell concentration-dependent acceleration ...https://www.sigmaaldrich.com/catalog/papers/25900728
Synthesis of calbindin-D28K during mineralization in human bone marrow stromal cells | Biochemical Journal
Synthesis of calbindin-D28K during mineralization in human bone marrow stromal cells. Corinne FAUCHEUX, Reine BAREILLE, Joëlle ... The human bone marrow stromal cells (HBMSC) described in this paper developed a calcified matrix, expressed osteocalcin (OC), ... Synthesis of calbindin-D28K during mineralization in human bone marrow stromal cells ... Synthesis of calbindin-D28K during mineralization in human bone marrow stromal cells ...http://www.biochemj.org/content/333/3/817
Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in...
We show that: i) lymph-node mesenchymal stromal cells of non-Hodgkin lymphoma inhibit NKG2D-mediated lymphoid cell killing, but ... aminobiphosphonate-treated mesenchymal stromal cells drive Vδ2 T lymphocyte differentiation into effector memory T cells, ... pre-treatment of mesenchymal stromal cells with the aminobisphosphonates pamidronate or zoledronate can rescue lymphoma cell ... In this study, we analyzed the influence of mesenchymal stromal cells derived from lymph nodes of non-Hodgkin lymphomas, on ...http://www.haematologica.org/content/early/2013/10/21/haematol.2013.097311
The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs. - PubMed -...
Neoplastic Stem Cells/pathology*. *Stromal Cells/pathology*. *Tumor Microenvironment*. Grant support. *P30 CA016672-35/CA/NCI ... TGFα produced by colon tumor cells binds to the myofibroblast EGFR, which respond by entering the cell cycle and increasing ... This signaling is mediated by the EGFR that is expressed on both cell populations. Tumor cells express VEGFA that reinforces ... Colon cancer cells produce TGFα that acts in an autocrine manner to promote tumor growth and in a paracrine fashion to activate ...https://www.ncbi.nlm.nih.gov/pubmed/21365651?access_num=21365651&link_type=MED&dopt=Abstract
Stromal cell - Wikipedia
Fibroblasts and pericytes are among the most common types of stromal cells. The interaction between stromal cells and tumor ... bone marrow stromal cells have been described to be involved in human haematopoiesis and inflammatory processes. Stromal cells ... Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow ... cannot spread throughout the body because the cancer cells require nearby stromal cells to continue their division. The loss of ...https://en.wikipedia.org/wiki/Stromal_cell
Mesenchymal Stromal Cell Therapy of Stroke | SpringerLink
Bone marrow stromal cells and bone marrow-derived mononuclear cells: which are suitable as cell source of transplantation for ... Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell ... Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 2000;164(2):247-56.PubMedCrossRefGoogle ... Human bone marrow stromal cell: coexpression of markers specific for multiple mesenchymal cell lineages. Blood Cells Mol Dis. ...https://link.springer.com/chapter/10.1007/978-3-319-66679-2_11
Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... Among these, cell therapy is regarded as one of the best candidates. In particular, mesenchymal stromal cells (MSCs) have great ... Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough. Benoît Usunier, Marc Benderitter, Radia Tamarat, and Alain ...https://www.hindawi.com/journals/sci/2014/340257/abs/
Immunomodulatory Effects of Mesenchymal Stromal Cells in Crohn's Disease
... such as dendritic cells (DC), naïve and effector T cells, and natural killer (NK) cells. Recently published papers attribute ... Immunomodulatory Effects of Mesenchymal Stromal Cells in Crohn's Disease. Ilse Molendijk,1 Marjolijn Duijvestein,1 Andrea E. ... The ability of mesenchymal stromal cells (MSCs) to suppress immune responses combined with their potential to actively ... Multiple studies have shown that MSCs suppress a range of immune cells, ...https://www.hindawi.com/journals/ja/2012/187408/abs/
Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... dendritic cells, macrophages, and B lymphocytes), and NK cells via direct cell-to-cell contact or production of soluble factors ... Mesenchymal stromal cells (MSCs) are multipotent and self-renewable cells that reside in almost all postnatal tissues. In ...https://www.hindawi.com/journals/sci/2015/989473/abs/
Labeling and tracking of mesenchymal stromal cells with EdU. - PubMed - NCBI
Labeling and tracking of mesenchymal stromal cells with EdU.. Lin G1, Huang YC, Shindel AW, Banie L, Wang G, Lue TF, Lin CS. ... for labeling and tracking of mesenchymal stromal cells (MSC), specifically adipose tissue-derived stem cells (ADSC).. ... The labeled cells can also be tracked when transplanted into a suitable host. In the present study we tested a new thymidine ... Cell labeling with EdU in culture or living animals can be performed easily. The detection of EdU label requires no harsh ...https://www.ncbi.nlm.nih.gov/pubmed/19903099
Immunohistochemical and electron microscopical characterization of stromal cells in nasopharyngeal angiofibromas | SpringerLink
Twenty-eight cases of nasopharyngeal angiofibroma were studied immunohistochemically for cytoskeletal phenotyping of stromal ... cells. Electron microscopy was also used to study the ultrastructure of... ... Ultrastructurally, most of these cells appeared to be exclusively fibroblasts. However, in some areas stromal cells were seen ... All typical stromal cells showed intensive immunostaining for vimentin, but were negative for smooth muscle actin and desmin. ...https://link.springer.com/article/10.1007/BF00879273
Cefazolin Irreversibly Inhibits Proliferation and Migration of Human Mesenchymal Stromal Cells
Compared to untreated cells (7.29 × 105 cells), MSCs treated with 250 μg/mL (3.90 × 105 cells, ), 500 μg/mL (1.83 × 105 cells, ... the number of cells treated for 24 h with 500 μg/mL (3.57 × 105 cells, ) and 1000 μg/mL cefazolin (2.91 × 105 cells, ) was ... Proliferation curves showing that the cell count of mesenchymal stromal cells (. ) treated with cefazolin is significantly ... Bar charts showing (a) the proportion of mesenchymal stromal cells that migrated towards SDF-1 and (b) number of cells after 24 ...https://www.hindawi.com/journals/bmri/2016/2042687/