Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism
Studies have demonstrated the role mechanical stress plays in regulating osteoblastic functions, such as cellular proliferation ... such as fluid shear stress (9-11) and hydrostatic pressure (12,13). Studies have also shown that mechanical stimuli regulate ... The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. J Biol Chem. 289: ... the following points also imply the close correlation of mechanical stress, mTOR signals and energy metabolism: i) tensile ...https://spandidos-publications.com/ijmm/36/4/947
Cytosolic Alkalinization of Vascular Endothelial Cells Produced by an Abrupt Reduction in Fluid Shear Stress | Circulation...
Mechanical stress mechanisms and the cell: an endothelial paradigm. Circ Res. 1993;72:239-245. ... Fluid shear stress was then abruptly reduced by rapidly decreasing flow from 1.6 to 0.2 mL/min. Shear stress was calculated by ... Cells were exposed to 20 mmol/L NH4Cl in bicarbonate buffer for 4 minutes at a fluid shear stress of 2.7 dyne/cm2. Shear stress ... After the 30-minute period at a shear stress of 2.7 dyne/cm2, shear stress was abruptly decreased to 0.3 dyne/cm2. After the ...http://circres.ahajournals.org/content/82/7/803
Faculty Collaboration Database - Revealing the role of phosphatidylserine in shear stress-mediated protection in endothelial...
Stress, Mechanical. Tumor Necrosis Factor-alpha. View this publication's entry at the Pubmed website PMID: 18663626 ... Revealing the role of phosphatidylserine in shear stress-mediated protection in endothelial cells. Endothelium 2008 Jul-Aug;15( ... Previous studies have demonstrated that endothelial cells exposed to laminar shear stress are protected from apoptotic stimuli ... endothelial cells exposed to laminar shear stress were unable to protect against TNF-alpha-induced apoptosis, in contrast to ...https://fcd.mcw.edu/?module=search&func=showPublication&id=93186
Cyclic Strain Increases Protease-Activated Receptor-1 Expression in Vascular Smooth Muscle Cells | Hypertension
Hu Y, Bock G, Wick G, Xu Q. Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress. FASEB J. ... an understanding of the PAR-1 gene regulation by the mechanical forces of cyclic strain and shear stress may offer insight into ... mechanical forces regulate the PAR-1 gene differently, depending on the balance of mechanical forces to which the cells are ... Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF. J Cell Biol. 1993; 123: 741-747. ...http://hyper.ahajournals.org/content/38/5/1038
Enhanced interstitial flow as a contributing factor in neointima formation: (shear) stressing vascular wall cell types other...
This concept may have clinical ramifications given that factors which enhance interstitial flow (i.e., chemical or mechanical ... from shear stress and are most responsive to hemodynamic-imposed stretch, the influences of shear stress would seem to be of ... resulting in a propagation of shear stress effects to the entire vessel wall. To illustrate this point, changes in shear stress ... Interestingly, the magnitudes of shear stress are in the range of 0.05 to 0.36 dyn/cm, which is 100 lower than those used in ...https://www.semanticscholar.org/paper/Enhanced-interstitial-flow-as-a-contributing-facto-Rizzo/5463fb930f4efbb860ca95e6162745f55d15a75f
Abstract 588: Cap Inflammation Leads to Large Plaque Cap Stress Decrease and Strain Increase: MRI-PET/CT-Based FSI Modeling |...
Introduction: Recent studies indicated that plaque rupture may be associated with: a) extreme mechanical stress/strain ... Results: Mean plaque cap stress (PC-Stress), strain (PC-Strain) and flow shear stress (PC-FSS) are reported in Table 1. Roughly ... The goal of this paper is to investigate possible impact of cap inflammation on plaque stress/strain and flow shear stress ... Abstract 588: Cap Inflammation Leads to Large Plaque Cap Stress Decrease and Strain Increase: MRI-PET/CT-Based FSI Modeling. ...http://atvb.ahajournals.org/content/35/Suppl_1/A588
Tests to Evaluate the Mechanical Properties of the Ureter
ureter, mechanical property, tension test, stress, tension, elongation, expansion, yield point, leak point, tissue damage--> ... ureter, mechanical property, tension test, stress, tension, elongation, expansion, yield point, leak point, tissue damage ... The maximum tensile stress of the ureter was higher than that of the bladder, which was previously reported in another paper. ... Tensile strength and maximum tensile stress in the transverse direction of the ureter were weaker than those in the ...https://www.astm.org/DIGITAL_LIBRARY/STP/PAGES/STP18111S.htm
Mechanical stress modulates bone remodeling signals | SpringerLink
Mechanical stress plays an essential role in bone homeostasis. Although mechanotransduction-induced de novo gene expression is ... mechanical stress JNK/p38 MAP kinase bone remodeling Fn14 MCP-3 This is a preview of subscription content, log in to check ... Mechanical stress plays an essential role in bone homeostasis. Although mechanotransduction-induced de novo gene expression is ... 2010) Mechanical stress modulates bone remodeling signals. In: Sasano T., Suzuki O. (eds) Interface Oral Health Science 2009. ...https://link.springer.com/chapter/10.1007%2F978-4-431-99644-6_21
Mechanical stress is communicated between... & related info | Mendeley
Tissue remodeling often reflects alterations in local mechanical conditions and manifests as an integrated response among the ... We show that (i) mechanical stress can be communicated from stressed to unstressed cells to elicit a remodeling response, and ( ... might communicate a mechanical stress by using airway cells as a representative in vitro system. Normal stress is imposed on ... Mechanical stress is communicated between different cell types to elicit matrix remodeling.. *Swartz M ...https://www.mendeley.com/research-papers/mechanical-stress-communicated-between-different-cell-types-elicit-matrix-remodeling/
When mechanical stress alters developmental gene expression
When mechanical pressure is applied to the embryo, ß catenin enters the cell nucleus (on right), whereas to perform its role as ... But on applying mechanical pressure to the Drosophila embryo, Emmanuel Farge noted that the Twist gene was then expressed in ... Significantly, the Twist gene is not expressed in mutant embryos in which this mechanical pressure is absent. This is the first ... "Mechanical Induction of Twist in the Drosophila Foregut/Stomodeal Primordium" Emmanuel Farge Current biology (www.current- ...https://www.innovations-report.com/html/reports/life-sciences/report-21487.html
Fat Cells and Their Response to Mechanical Stress
How fat cells respond to mechanical loads can be studied now through a new method developed by researchers at the Tel Aviv ... Stress and the Gender Divide. Stress has become entwined in the current lifestyle of a young working couple and has resulted in ... Gefen, applying mechanical loads on tissues can affect many different cells within our bodies. He believes that, much like bone ... Gefen and his team of researchers can determine how much mechanical load can be tolerated by fat cells, and at what point the ...http://www.medindia.net/news/Fat-Cells-and-Their-Response-to-Mechanical-Stress-77169-1.htm
Endogenous patterns of mechanical stress are required for branching morphogenesis. - PubMed - NCBI
Arrows denote regions of high mechanical stress that branch, and asterisks denote regions of high mechanical stress that do not ... Mechanical stress profiles of tubules surrounded by matrices of different stiffness: (A) Ematrix = 680 Pa, (B) Ematrix = 860 Pa ... Mechanical stress profiles of tubules with increasing contractility: prestress (pt) that yields prestrain (ε0) of (A) 0.2 % (B) ... Endogenous patterns of mechanical stress are required for branching morphogenesis.. Gjorevski N1, Nelson CM. ...https://www.ncbi.nlm.nih.gov/pubmed/20717570?dopt=Abstract
Analysis on thermo-mechanical stress of thermoelectric module - IEEE Conference Publication
A heat cycle test was performed in order to analyze the thermo-mechanical ... This paper describes the thermo-mechanical performance of thermoelectric modules. ...http://ieeexplore.ieee.org/document/843396/?reload=true&arnumber=843396&contentType=Conference+Publications
Abstract 10698: Syndecan-4 Regulates Myofibroblast Differentiation Following Mechanical Stress | Circulation
Abstract 10698: Syndecan-4 Regulates Myofibroblast Differentiation Following Mechanical Stress. Kate M Herum, Ida G Lunde, Dina ... Mechanical stress caused by pressure overload of the heart leads to differentiation of cardiac fibroblasts into myofibroblasts ... Abstract 10698: Syndecan-4 Regulates Myofibroblast Differentiation Following Mechanical Stress. Kate M Herum, Ida G Lunde, Dina ... Abstract 10698: Syndecan-4 Regulates Myofibroblast Differentiation Following Mechanical Stress. Kate M Herum, Ida G Lunde, Dina ...http://circ.ahajournals.org/content/124/Suppl_21/A10698
Cells | Free Full-Text | Under Pressure: Mechanical Stress Management in the Nucleus
Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in ... Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback ... mechanical stress mechanotransduction; nucleoskeleton; lamina; lamin; LINC; nucleus; mechanical stress ... Belaadi, N.; Aureille, J.; Guilluy, C. Under Pressure: Mechanical Stress Management in the Nucleus. Cells 2016, 5, 27. ...http://www.mdpi.com/2073-4409/5/2/27
NIOSHTIC-2 Publications Search - 00181265 - Back injuries: mechanical stresses in the human spine.
The finite element models of lumbar motion segments were useful in analyzing internal stresses, given segment geometry, ...https://www.cdc.gov/niosh/nioshtic-2/00181265.html
Bone Strength and In-Flight Mechanical Stresses.
It was concluded that: (a) The ceramics used possessed adequate mechanical strength for use as femur sections in rhesus monkeys ... MECHANICAL PROPERTIES, STRESSES, CHEMICAL PROPERTIES, CRYSTALLOGRAPHY, BONES, LEGS ... It was concluded that: (a) The ceramics used possessed adequate mechanical strength for use as femur sections in rhesus monkeys ...http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0754982
Electrothermal mechanical stress reference design flow for printed circuit boards - The Engineer The Engineer
Electrothermal mechanical stress reference design flow for printed circuit boards. 4th December 2017 4:41 pm 4th December 2017 ... Electrothermal mechanical stress reference design flow for printed circuit boards. Contact Supplier ... This paper presents a reference design flow for solving the electrical, thermal and mechanical challenges of a printed circuit ... thermal and mechanical characteristics of the board - all using ANSYS tools. The multiphysics simulation yields power losses ...https://www.theengineer.co.uk/supplier-network/product/electrothermal-mechanical-stress-reference-design-flow-printed-circuit-boards/
Influence of photo-initiator concentration on residual mechanical stress in SU-8 thin films
... experimental results on the residual mechanical stress generated during the different steps of the photolithography process of ... The main aim is to investigate the causes and optimise the fabrication process in order to minimise the residual stresses. It ... Therefore, it is important to investigate each process step in relation to the internal stress formulation during the SU-8 ... during the fabrication process considerable internal stress is generated in SU-8 films, which causes the appearance of cracked ...http://www.nsti.org/procs/Nanotech2006v1/1/W60.611
Effects of dynamic mechanical stresses on mammalian cell metabolism
The cells were stressed at 0, 450 and 900 dynes/cm$\sp2$ at 37$\sp\circ$C for 5 min. Damage caused by the stresses was ... The effects of dynamic mechanical stresses on the arachidonic acid (AA) metabolism of human platelets and on the cell growth ... The cells were stressed by suspending them in laminar simple shear flows. Washed human platelet suspensions were stressed at 75 ... the results are in contrast to the accepted view that mechanical stresses developed in the circulation directly cause the ...https://scholarship.rice.edu/handle/1911/16477
Radial vs Axial Turbine, diff in mechanical stress | Physics Forums - The Fusion of Science and Community
Similar Discussions: Radial vs Axial Turbine, diff in mechanical stress * Centripetal vs radial? (Replies: 13) ... I have conducted a couple of experiments to demonstrate that there is less mechanical stress in the radial approach as compared ... someone out there please explain the basic math principles that show why an axial turbine will have more mechanical stresses ...https://www.physicsforums.com/threads/radial-vs-axial-turbine-diff-in-mechanical-stress.674726/
RecA Homology Search is Promoted by Mechanical Stress Along the Scanned Duplex DNA
... DSpace/Manakin Repository. * DASH Home ... RecA homology search is promoted by mechanical stress along the scanned duplex DNA. Nucleic Acids Research 40, no. 4: 1717-1727 ... RecA Homology Search is Promoted by Mechanical Stress Along the Scanned Duplex DNA. ... RecA Homology Search is Promoted by Mechanical Stress Along the Scanned Duplex DNA. ...https://dash.harvard.edu/handle/1/11210457
Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes - Full Text...
Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes (MediaSport). ... Impact and Consequences of Mechanical Stress on the Cardiovascular Adaptations of Peripheral Arterial Calcifications. ...https://clinicaltrials.gov/show/NCT01577576
Inventions | Free Full-Text | Influence of the Grinding Wheel Topography on the Thermo-Mechanical Stress Collective in Grinding
Therefore, the aim of the current research is an empirical-analytical model for the prediction of the thermo-mechanical stress ... The obtained results are summarized and are used to explain the thermo-mechanical stress collective as a function of the ... of the volumetric grinding wheel composition and the resulting grinding wheel topography on the thermo-mechanical stress ... For this purpose, a methodology is developed, which enables the prediction of the topography-dependent thermo-mechanical load ...http://www.mdpi.com/2411-5134/2/4/34
mechanical stress | Biology Open
Novel device for application of continuous mechanical tensile strain to mammalian cells Satoshi Wada, Hiroyuki Kanzaki, ...http://bio.biologists.org/keyword/mechanical-stress