*  Steroid Delta-isomerase - Wikipedia
... steroid isomerase, Δ5-ketosteroid isomerase, Δ5(or Δ4)-3-keto steroid isomerase, Δ5-steroid isomerase, 3-oxosteroid isomerase, ... In enzymology, a steroid Δ5-isomerase (EC 5.3.3.1) is an enzyme that catalyzes the chemical reaction a 3-oxo-Δ5-steroid ⇌ {\ ... isomerase and 3α- and 3β-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot". The Journal of Steroid ... Δ5-3-keto steroid isomerase, and Δ5-3-oxosteroid isomerase. KSI has been studied extensively from the bacteria Comamonas ...
  https://en.wikipedia.org/wiki/Steroid_Delta-isomerase
*  Azasteroid - Wikipedia
DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase". Journal of Medicinal Chemistry. 37 (15): 2352-60. doi:10.1021 ... An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a ... Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase". Journal of Medicinal Chemistry. 36 (26): 4313-5. doi: ...
  https://en.wikipedia.org/wiki/Azasteroid
*  GSTA3 - Wikipedia
2005). "Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase ... Johansson AS, Mannervik B (2002). "Active-site residues governing high steroid isomerase activity in human glutathione ... a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones". J. Biol. Chem. 276 ( ... effects on xenobiotic metabolism and steroid biosynthesis". Pharmacogenetics. 14 (10): 657-63. doi:10.1097/00008571-200410000- ...
  https://en.wikipedia.org/wiki/GSTA3
*  HSD3B2 - Wikipedia
... isomerase type II or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2. It is expressed principally ... HSD3B2 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2". Pelletier G, Dupont E, Simard J, Luu-The ... 1991). "Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ ... 1992). "Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal ...
  https://en.wikipedia.org/wiki/HSD3B2
*  HSD3B1 - Wikipedia
... isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. While it can carry out the ... HSD3B1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1". Researchers Identify Genetic Mutation ... 1991). "Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ ... 1989). "Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase". Mol. ...
  https://en.wikipedia.org/wiki/HSD3B1
*  List of MeSH codes (D08) - Wikipedia
... steroid isomerases MeSH D08.811.399.475.800 --- sulfur-sulfur bond isomerases MeSH D08.811.399.475.800.550 --- protein ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16- ... steroid 11-beta-hydroxylase MeSH D08.811.682.690.708.170.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... triose-phosphate isomerase MeSH D08.811.399.475.400 --- carbon-carbon double bond isomerases MeSH D08.811.399.475.400.700 --- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase - Wikipedia
The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 or HSD3B7 ... 3-beta-HSD Wikvall K (April 1981). "Purification and properties of a 3 β-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit ... This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. ... steroid oxidoreductase is mutated in progressive intrahepatic cholestasis". J. Clin. Invest. 106 (9): 1175-84. doi:10.1172/ ...
  https://en.wikipedia.org/wiki/Cholest-5-ene-3beta,7alpha-diol_3beta-dehydrogenase
*  Cholestenol Delta-isomerase - Wikipedia
This enzyme participates in biosynthesis of steroids. Wilton DC, Rahimtula AD, Akhtar M (1969). "The reversibility of the ... In enzymology, a cholestenol Delta-isomerase (EC 5.3.3.5) is an enzyme that catalyzes the chemical reaction 5alpha-cholest-7-en ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The ... delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis". Biochem. J. 114 (1): 71-3. PMC 1184797 ...
  https://en.wikipedia.org/wiki/Cholestenol_Delta-isomerase
*  Cycloeucalenol cycloisomerase - Wikipedia
... obtusifoliol isomerase. This enzyme participates in biosynthesis of steroids. Heintz R, Benveniste P (1974). "Plant sterol ... This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this ...
  https://en.wikipedia.org/wiki/Cycloeucalenol_cycloisomerase
*  Peptidylprolyl isomerase D - Wikipedia
... a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization ... Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on ... The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the ... PPID peptidylprolyl isomerase D (cyclophilin D)". Kazui T, Inoue N, Yamada O, Komatsu S (Jan 1992). "Selective cerebral ...
  https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase_D
*  Isopentenyl-diphosphate Delta-isomerase - Wikipedia
... and isopentenylpyrophosphate isomerase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis. As of ... Other names in common use include isopentenylpyrophosphate Delta-isomerase, methylbutenylpyrophosphate isomerase, ... Isopentenyl pyrophosphate isomerase". J. Biol. Chem. 235: 326-32. PMID 13792054. Molecular and Cellular Biology portal. ... Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001). "An unusual isopentenyl diphosphate isomerase found in the ...
  https://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase
*  Cyproterone acetate - Wikipedia
"Distribution and percentages of non-protein bound contraceptive steroids in human serum". Journal of Steroid Biochemistry. 17 ( ... Stalvey JR (July 2002). "Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of ... CPA is also reportedly the most potent of the steroidal antiandrogens, out of hundreds of other steroids. CPA is a potent ... However, unlike many other steroid esters, CPA is not extensively hydrolyzed, and much of the pharmacological activity of the ...
  https://en.wikipedia.org/wiki/Cyproterone_acetate
*  3β-Hydroxysteroid dehydrogenase - Wikipedia
Δ5-C27-steroid dehydrogenase/isomerase 3β-hydroxy-Δ5-C27-steroid oxidoreductase 3β-hydroxy-5-ene-steroid oxidoreductase steroid ... 3β-HSD catalysis,catalyzes the chemical reaction: a 3β-hydroxy-Δ5-steroid + NAD+ ⇌ a 3-oxo-Δ5-steroid + NADH + H+ Thus, the two ... reductase Δ5-3β-hydroxysteroid dehydrogenase 3β-hydroxy-5-ene steroid dehydrogenase 3β-hydroxy steroid dehydrogenase/isomerase ... 3β-HSD is also known as delta Δ5-4-isomerase, which catalyzes the oxidative conversion of Δ5-3β-hydroxysteroids to the Δ4-3- ...
  https://en.wikipedia.org/wiki/3%CE%B2-Hydroxysteroid_dehydrogenase
*  Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency - Wikipedia
3β-HSD II mediates three parallel dehydrogenase/isomerase reactions in the adrenals that convert Δ4 to Δ5 steroids: ... The sex steroid consequences of severe 3β-HSD CAH are unique among the congenital adrenal hyperplasias: it is the only form of ... Measurement of the other affected steroids distinguishes the two. Second, 3β-HSD I can convert enough DHEA to testosterone to ... Inborn errors of steroid metabolism Congenital adrenal hyperplasia Adrenal insufficiency Disorders of sexual development ...
  https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_3%CE%B2-hydroxysteroid_dehydrogenase_deficiency
*  Medroxyprogesterone acetate - Wikipedia
Steroids. 71 (9): 792-8. doi:10.1016/j.steroids.2006.05.009. PMID 16784762. Wikström A, Green B, Johansson ED (1984). "The ... MPA has been identified as a competitive inhibitor of human 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase II (3β-HSDII). This ... As an agonist of the GR, MPA has glucocorticoid activity, and as a result can cause symptoms of Cushing's syndrome, steroid ... MPA is a synthetic pregnane (C21) steroid and a derivative of 17α-hydroxyprogesterone. Specifically, it is the 17α-acetate ...
  https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate
*  Pregnenolone - Wikipedia
Steroids. 70 (3): 179-83. doi:10.1016/j.steroids.2004.12.007. PMID 15763596. Piper T, Schlug C, Mareck U, Schänzer W (2011). " ... The critical enzyme step is two-fold using a 3β-hydroxysteroid dehydrogenase and a Δ5-4 isomerase. The latter transfers the ... is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including ... Pregnenolone undergoes further steroid metabolism in one of several ways: Pregnenolone can be converted into progesterone. ...
  https://en.wikipedia.org/wiki/Pregnenolone
*  16-hydroxysteroid epimerase - Wikipedia
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on other compounds. The ... Dahm K, Lindlau M, Breuer H (1968). "[Steroid epimerase--a new enzyme of estrogen metabolism]". Biochim. Biophys. Acta. 159 (2 ...
  https://en.wikipedia.org/wiki/16-hydroxysteroid_epimerase
*  Prostacyclin synthase - Wikipedia
This enzyme belongs to the family of cytochrome P450 isomerases. This gene encodes a member of the cytochrome P450 superfamily ... steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of ... The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase. ...
  https://en.wikipedia.org/wiki/Prostacyclin_synthase
*  List of EC numbers (EC 5) - Wikipedia
... steroid D-isomerase EC 5.3.3.2: isopentenyl-diphosphate D-isomerase EC 5.3.3.3: vinylacetyl-CoA D-isomerase EC 5.3.3.4: ... arabinose isomerase EC 5.3.1.4: L-arabinose isomerase EC 5.3.1.5: xylose isomerase EC 5.3.1.6: ribose-5-phosphate isomerase EC ... furylfuramide isomerase EC 5.2.1.7: retinol isomerase EC 5.2.1.8: peptidylprolyl isomerase EC 5.2.1.9: farnesol 2-isomerase EC ... maleate isomerase EC 5.2.1.2: maleylacetoacetate isomerase EC 5.2.1.3: retinal isomerase EC 5.2.1.4: maleylpyruvate isomerase ...
  https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_5)
*  Cycloartenol synthase - Wikipedia
This enzyme participates in biosynthesis of steroids. Rees HH, Goad LJ, Goodwin TW (1969). "2,3-oxidosqualene cycloartenol ... This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The ...
  https://en.wikipedia.org/wiki/Cycloartenol_synthase
*  PHB2 - Wikipedia
1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): ... Martini PG, Katzenellenbogen BS (2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid ... Steroid Biochem. Mol. Biol. England. 85 (2-5): 117-22. doi:10.1016/S0960-0760(03)00207-3. ISSN 0960-0760. PMID 12943695. ...
  https://en.wikipedia.org/wiki/PHB2
*  FKBP52 - Wikipedia
This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high ... Davies TH, Ning YM, Sánchez ER (February 2002). "A new first step in activation of steroid receptors: hormone-induced switching ... Galigniana MD, Radanyi C, Renoir JM, Housley PR, Pratt WB (May 2001). "Evidence that the peptidylprolyl isomerase domain of the ... Sanchez ER, Faber LE, Henzel WJ, Pratt WB (May 1990). "The 56-59-kilodalton protein identified in untransformed steroid ...
  https://en.wikipedia.org/wiki/FKBP52
*  FKBP5 - Wikipedia
This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to ... Davies TH, Ning YM, Sánchez ER (2002). "A new first step in activation of steroid receptors: hormone-induced switching of ... Pirkl F, Buchner J (2001). "Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, ... Steroid Biochem. Mol. Biol. 56 (1-6 Spec No): 31-7. doi:10.1016/0960-0760(95)00221-9. PMID 8603045. Nair SC, Rimerman RA, Toran ...
  https://en.wikipedia.org/wiki/FKBP5
*  Progesterone - Wikipedia
Steroids. 68 (10-13): 891-905. doi:10.1016/j.steroids.2003.08.008. PMID 14667981. Attardi BJ, Zeleznik A, Simhan H, Chiao JP, ... This reaction is catalyzed by 3β-hydroxysteroid dehydrogenase/δ5-4-isomerase. Progesterone in turn is the precursor of the ... The key step of the synthesis is the π-cation cyclization of 13 in which the B-, C-, and D-rings of the steroid are ... It contains a steroid called diosgenin that is taken from the plant and is converted into progesterone. Diosgenin and ...
  https://en.wikipedia.org/wiki/Progesterone
*  Steroidogenic enzyme - Wikipedia
... steroid synthesis Steroid sulfotransferase (SULT1A1, 1E1, 2A1, 2B1a, 2B1b) - steroid metabolism, neurosteroid synthesis Steroid ... and neurosteroid synthesis and metabolism 3β-Hydroxysteroid dehydrogenase/Δ5-4-isomerase (1, 2) - androgen, progestogen, and ... Steroidogenic enzymes, or steroid-metabolizing enzymes, are enzymes that are involved in steroidogenesis and steroid metabolism ... Steroid desmolases Cholesterol side-chain cleavage enzyme (20,22-desmolase) - steroid synthesis 17,20-Lyase (17,20-desmolase ...
  https://en.wikipedia.org/wiki/Steroidogenic_enzyme