Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). ... Rönnstrand L (October 2004). "Signal transduction via the stem cell factor receptor/c-Kit". Cell. Mol. Life Sci. 61 (19-20): ... Rönnstrand L (2004). "Signal transduction via the stem cell factor receptor/c-Kit". Cell. Mol. Life Sci. 61 (19-20): 2535-48. ... SCF may serve as guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in ...
Here, we identified and characterized a stem cell population from adult murine submandibular glands. Of the different cells ... Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry ... is highly expressed in Lin-CD24+c-Kit+Sca1+ stem cells. Furthermore, GDNF expression was upregulated upon radiation therapy in ... Serial transplantations of this stem cell population into the submandibular gland of irradiated mice successfully restored ...
... depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and ... another angiogenic cell type that plays an important role during the neovascularization. MSCs derived from placental tissues ( ... we identified several novel candidates for EPC migration enhancing factor in PL-MSCs secretome that could be used to enhance ... studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells ...
No risk factors of hospital stay prolongation were determined. We conclude that in spite of rapid engraftment, non- ... the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem ... cell transplantation (PBSCT), we performed this retrospective analysis. One hundred patients (receiving 123 conditioning ... Factors that influence collection and engraftment of autologous peripheral-blood stem cells J Clin Oncol 1995 13: 2547-2555 ...
... World J Stem Cells ... Mesenchymal stem cells, Differentiation, Osteogenic, Chondrogenic, Literature review. Core Tip: Mesenchymal stem cells (MSCs) ... Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells ... Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating ...
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.. Return to Grants ... Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal ... Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the ... Stem Cell Basics *Stem Cell Key Terms. *Creating New Types of Stem Cells ...
Swiss Blood Stem Cell Transplantation Group), Haematopoietic stem cell transplantation: activity in Switzerland compared with ... Prognostic factors for survival in lymphoma patients after autologous stem cell transplantation *Panagiotis Samaras ... Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell ... Prognostic factors for survival after high-dose therapy and autologous stem cell transplantation for patients with relapsing ...
Research in these fields has broad implications in the areas of cell therapies and neurodegeneration. ... Transcription factors have crucial roles in stem cell biology and differentiation. ... Governing the Fate of Stem Cells With Transcription Factors. Stem cells are unique due to their ability to limitlessly self- ... Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell vol. 131,5 (2007): 861-72. doi: ...
... and impairment of cell-mediated immunity (CMI) and humoral immunity. This impairment leads to an immunocompromised state, ... Stem cell source contributes to the risk of infection. Compared with stem cells from bone marrow, peripheral blood stem cells ... The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. The stem cell source may be bone ... encoded search term (Infections After Hematopoietic Stem Cell Transplantation) and Infections After Hematopoietic Stem Cell ...
... stem cells, plant stem cells and other related technologies. ... up the confusion about the differences between growth factors, ... Plant Stem Cells. Many companies offer plant stem cells, but they are not like human stem cells and do not provide any of the ... This is known as induced pluripotent stem cells (IPS). Stem cells can also be encouraged to grow skin-targeted growth factors ... However, there remains a great deal of confusion about the differences between growth factors, stem cells, plant stem cells and ...
Hydrogel Delivery of Neural Growth Factors and Stem Cells for the Treatment of Spinal Cord Injuries 12:00 pm - 12:00 pm ...
Leukemia Inhibitory Factor Is Essential for Subventricular Zone Neural Stem Cell and Progenitor Homeostasis as Revealed by a ... Bauer S, Patterson PH: Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci 2006;26 ... 2E1, E2). However, none of the flat cells were O4+. These large flat cells persisted even after 10 days of growth factor ... Maric D, Maric I, Chang YH, Barker JL: Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial ...
Mobilization of human mesenchymal stem cells through different cytokines and growth factors after their immobilization by ... Mesenchymal stem cells (MSC) are known to play an important role in wound healing. Moreover, it is also known that patients ... Material & methods: Mesenchymal stem cells (MSC) were isolated from femoral heads of healthy donors. They were cultured for ... with chronic wound healing diseases have compromised mesenchymal stem cell functionality. Based on these observations and the ...
... and quantitative RT-PCR of cardiac side population stem cells. Adult cardiac side population stem cells (CSPCs) were isolated ... Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor ... Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential ... Embryonic stem cells facilitate the isolation of persistent clonal cardiovascular progenitor cell lines and leukemia inhibitor ...
Thus, this cell and growth-factor combination may be the ideal choice for cell-based intervertebral disc (IVD)-regeneration ... Both bone marrow-derived (BM) mesenchymal stem cells (MSCs) and adipose-derived MSCs (AD-MSCs) are proposed as suitable cells ... However, currently no consensus exists as to the optimum growth factor needed to drive differentiation to a nucleus pulposus ( ... The aim of this study was to investigate the effect of growth differentiation factor-6 (GDF6), compared with other transforming ...
While the inflammatory transcription factor nuclear factor of activated T-cells 2 (NFAT2, NFATC1) is overexpressed in AML, it ... FLT3ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. ... We find that NFATC1 governs FLT3ITD-driven precursor cell expansion and transformation, causing a fully penetrant lethal AML. ... in which tamoxifen-inducible Cre-recombinase targets expression of a constitutively nuclear transcription factor NFATC1 to ...
... reduce apoptotic cell death. In conclusion, we suggest that factors released from ES cells with and without TGF-B2 treatment ... Effects of conditioned medium (CM) prepared from mouse embryonic stem (ES) cells on H2O2 induced apoptosis and necrosis in ... Further studies are needed to determine potential additional benefits of the · released factors from TGF-B2 primed ES cells. ... Additionally, effects of CM from ES cells primed with TGF-b2 on stress-induced apoptosis and necrosis in H9c2 cells have not ...
Genomic risk factors and biomarkers as predictors of GvHD after haematopoietic stem cell transplantation. Lookup NU author(s): ... Genetic factors could improve the goodness of fit of a model when viewed alongside a clinical risk score, however, we were ... Results: In a cohort consisting of 442 HLA-matched sibling patient and donor pairs where the transplants were non T cell ... As an alternative to genetic factors, biomarkers could, however, be used as additional predictors. Further work is under way to ...
... nuclear factor-kB, and indoleamine, among other signaling pathways. Classic growth factors and cytokines-such as VEGF, CNTF, ... The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be ... Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, ... Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. Recently, trophic ...
AnteAGE® Sun Safety , Bone Marrow Stem Cell Derived Protein Molecules Influence Skin Protection. ...
... Stem cells are unspecialised cells, defined by their ... Methods to study cell-cell communication from single-cell sequencing data This feature on cell-cell communication is adapted ... Loss of transcription factor alters chromatin accessibility Researchers have discovered that chromatin accessibility is heavily ... Japanese Study Identifies 35 Genetic Risk Factors for Atrial Fibrillation In a new study published in Nature, researchers have ...
SCF / Stem Cell Factor. Target Synonyms. KITLG; MGF; SF; KL1; Kitl; FPH2; Kit-Ligand; Steel Factor; Mast Cell Growth Factor; ... Human Stem Cell Factor (SCF) ELISA Kit, Cat#EKU11610. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars (average) ... Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Mini Samples Stem Cell Factor (SCF ... Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Mini Samples Stem Cell Factor (SCF ...
This study suggests that the protein expression of embryonic stem cell reprogramming factors is enriched in benign as well as ... Background: The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a ... Methods: In this study, the expression levels of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, Sox2, and Klf4 ... Table 2. Percentage of tumors with positive antigenicity for embryonic stem cell reprogramming factors Protein. Normal. Benign ...
... neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells ... neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells ...
Growth Factors-They are the biggest buzz words in the skin care world today- but are they actually benefiting you? On the ... subject, Dr John Layke had this to say, Specific peptides and growth factors will be the next generation of improving the ... What are Peptides, Stem Cells and Growth Factors?. Stem Cells: are biological cells that can divide and have the unique ability ... Growth Factors: are cultured in a laboratory setting from stem cells that assign specific functions to stem cells in the body. ...
Nomenclature for factors of the HLA system, 2004. Marsh SGE., Albert ED., Bodmer WF., Bontrop RE., Dupont B., Erlich HA., ...
Mesenchymal Stem Cells: Intrinsic/Extrinsic Factors Regulating Stemness, Growth, and Differentiation Mesenchymal Stem Cells: ... Mesenchymal stem/stromal cells (MSCs) are adult stem cells with the capability of self-renewal and multilineage differentiation ... www.mdpi.com/journal/cells/special_issues/Mesenchymal_Stem_Cells_Stemness_Growth_Differentiation ... Approximately 50 years have passed since MSC-like cells were first discovered, and many studies have been carried out to ...
We and others now work with human stem cells, which have proven to be far more prolific at creating growth factors. The cells ... Further, stem cell science has advanced with the discovery of IPS (induced pluripotency). We now know that adult stem cells can ... Jon Bon Jovi on Do you know that fat stem cells and bone marrow stem cells are really, really different? ... drgeorge on Do you know that fat stem cells and bone marrow stem cells are really, really different? ...
We also readily detected off-target alterations induced by four out of six RGNs targeted to endogenous loci in human cells by ... Here, we use a human cell-based reporter assay to characterize off-target cleavage of CRISPR-associated (Cas)9-based RGNs. We ... Our work demonstrates that RGNs can be highly active even with imperfectly matched RNA-DNA interfaces in human cells, a finding ... Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction *Shengzhou Shan ...
... this stem cell renewal is dependent on a newly described stem cell self-renewal factor known as DOT1L. ... Additionally, the activity of the animals spermatogonial stem cells was reduced in half after these treated stem cells were ... Identifying this essential factor not only helps us understand the biology of adult germline stem cells but could also allow us ... "These transcription factors probably contribute to the stem cell self-renewal process. Finding out the details of that is a ...