Stearoyl-CoA 9-desaturase - Wikipedia
Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen- ... Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in stearoyl-CoA ... Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the ... "Entrez Gene: Stearoyl-CoA desaturase (delta-9-desaturase)". Retrieved 2011-09-29. Paton, Chad M.; Ntambi, James M. (2017-03-08 ...
Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase - PubMed
... is a membrane-embedded metalloenzyme that catalyzes the formation of a double bond on a saturated acyl-CoA. SCD1 has a diiron ... Increasing peak of oleoyl-CoA and simultaneous decreasing peak of stearoyl-CoA confirmed stearoyl-CoA to oleoyl-CoA conversion ... Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase Jiemin Shen 1 , Gang Wu 2 , Ah-Lim Tsai ... Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase Jiemin Shen et al. J Mol Biol. 2020. . ...
Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death | Cancer Research | American Association...
Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death Lia Tesfay; Lia Tesfay ... Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis ... A commentary has been published: Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic ... Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives ...
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1...
Stearoyl CoA desaturase 1 (SCD1) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids (MUFAs). ... Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 ... Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 ...
One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in...
Regulation of stearoyl-CoA desaturase expression. Ntambi JM, Miyazaki M, Dobrzyn A. Ntambi JM, et al. Lipids. 2004 Nov;39(11): ... Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat ... Plasma stearoyl-CoA desaturase indices: association with lifestyle, diet, and body composition. Vinknes KJ, Elshorbagy AK, Nurk ... Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes. Malodobra- ...
Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase<...
"Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase",. abstract = "Mammalian Δ9 stearoyl-CoA ... N2 - Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ... AB - Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ... Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ...
Metabolic Dysfunction Under Reduced Estrogen Levels
Decreases in Circulating Estrogens Leads to Increased Hepatic Stearoyl CoA Desaturase Activity. Although we did not find large ... is regulated enzymatically by the enzyme stearoyl CoA desaturase (SCD-1). In addition, we found a significant increase in the ... Sedentary OVX animals exhibited significant increases in hepatic stearoyl CoA desaturase (SCD-1) content compared with all ... Sedentary OVX animals exhibited significant increases in hepatic stearoyl CoA desaturase (SCD-1) content compared with all ...
Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase<...
Kakuma, T., Lee, Y. H., & Unger, R. H. (2002). Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. ... Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. / Kakuma, Tetsuya; Lee, Young H; Unger, Roger H. ... Kakuma, T, Lee, YH & Unger, RH 2002, Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase, Biochemical ... Kakuma, Tetsuya ; Lee, Young H ; Unger, Roger H. / Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase ...
Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the - TAM Receptor Signaling in Immune Homeostasis
Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the. Stearoyl-CoA desaturase (SCD) is conserved in ... We modeled a stearoyl-CoA molecule into this density although we were unable to distinguish between oleoyl-CoA and stearoyl-CoA ... are strongly conserved among known stearoyl-CoA desaturases including human SCD1 but not among stearoyl-lipid desaturases ( ... This tunnel is usually sharply kinked where it binds to C9 and C10 on stearoyl-CoA the atoms involved in formation of the has a ...
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer...
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99. :11482-11486, PMID: ... stearoyl-CoA desaturase; SREBP-1c, sterol regulatory element binding protein-1c. * p. ,. 0.05. ; # One-way ANOVA for all groups ... aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose ...
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | Nature Medicine
Long non‑coding RNAs, lipid metabolism and cancer (Review)
... including stearoyl CoA desaturase-1 and FA synthase, which in turn reduce PA levels and promote GC cell growth and metastasis. ... stearoyl-CoA desaturase 5; SLC25A21-AS1, SLC25A21 antisense RNA 1; SPRY4IT-1, SPRY4 intronic transcript 1; SYBU, syntabulin; TG ... Long-chain acyl CoA synthetase 4 (ACSL4), a member of the acyl CoA synthetase 4 family, is a key regulator of lipid metabolism ... Acetyl-CoA also synthesizes FAs and palmitic acid is an FA that produces diglycerides, which may be interconverted with ...
Frontiers | Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche...
An intriguing example is the enzyme Stearoyl-CoA Desaturase 5. SCD5 is not present in rodents (Wang et al., 2005). We found a ... 2005). Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem. Biophys. Res. Commun. 332 ... encoding a primate-specific isoform of Stearoyl-CoA Desaturase (Wang et al., 2005), and the microtubule-associated protein ... Sinner, D. I., Kim, G. J., Henderson, G. C., and Igal, R. A. (2012). StearoylCoA desaturase-5: a novel regulator of neuronal ...
Biomarkers Search
1. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by ... 2. Stearoyl-CoA desaturase and tumorigenesis.. Kikuchi K; Tsukamoto H. Chem Biol Interact; 2020 Jan; 316():108917. PubMed ID: ... Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target ...
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Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer | Nature Reviews Cardiology
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NIAAA Directors Report on Institute Activities to the 135th Meeting of the National Advisory Council on Alcohol Abuse and...
IJMS | Free Full-Text | Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations...
JCI - ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. Am J Pathol. 2013;183(3):735-744 ... Peroxisome proliferator-activated nuclear receptor alpha (PPARA), acyl-coA dehydrogenase medium chain (ACADM), and acyl-coA ... Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA ...
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Molecular Vision: Androgen regulation of gene expression in human meibomian gland and conjunctival epithelial cells
Testosterone enhances stearoyl-CoA desaturase mRNA levels in mouse male and female meibomian glands [27,28], and the targeted ... and stearoyl-CoA desaturase, an iron-containing enzyme that catalyzes the synthesis of unsaturated fatty acids. ... Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of ...
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Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice | Diabetes | American Diabetes...
Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS, Parimoo S: Scd3-a novel gene of the stearoyl-CoA desaturase family with ... Miller CW, Ntambi JM: Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci ... Kurebayashi S, Hirose T, Miyashita Y, Kasayama S, Kishimoto T: Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene ... Scd1 (stearoyl-coenzyme A desaturase) NM_009127 Lipid desaturase TGF-β, Insulin, PPAR-γ ...
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Is hepatic lipid metabolism of beef cattle influenced by breed and dietary silage level? | BMC Veterinary Research | Full Text
... whereas genes encoding for desaturases, such as FADS1, appear to be modulated by dietary silage level. Our results indicate ... Fatty acid indices of stearoyl Co-A desaturase activity do not reflect actual stearoyl Co-A desaturase enzyme activity in ... Chung KY, Lunt DK, Kawachi H, Yano H, Smith SB: Lipogenesis and stearoyl-CoA desaturase gene expression and enzyme activity in ... Chang JHP, Lunt DK, Smith SB: Fatty acid composition and fatty acid elongase and stearoyl-CoA desaturase activities in tissues ...