*  RNA-binding protein 40
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes ... The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that ... Minor spliceosome components are predominantly localized in the nucleus.. 18482256. 2009. Protein microarray analysis ... The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct ...
  https://pharos.nih.gov/idg/targets/Q96LT9
*  Items where Subject is "bioinformatics | genomics and proteomics | genetics & nucleic acid processing | protein structure,...
Anczukow, O., Krainer, A. R. (2015) The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Med, 7 (1). p. 107 ... Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome ... Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A, 105 (25). pp. 8485-6. ... Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol, 16 (1). p. 119. ISSN ...
  http://repository.cshl.edu/view/subjects/spliceosome=5Fcomplex.html
*  PRPF8 defects cause missplicing in myeloid malignancies. - Radcliffe Department of Medicine
Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most ... Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most ...
  https://www.rdm.ox.ac.uk/publications/463348
*  Splicing together sister chromatids | The EMBO Journal
Bonnal S, Vigevani L, Valcarcel J (2012) The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discovery 11: 847- ... Wahl MC, Will CL, Luhrmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701-718. ... Hofmann JC, Husedzinovic A, Gruss OJ (2010) The function of spliceosome components in open mitosis. Nucleus 1: 447-459. ... Figure 1. The control of sororin levels by the spliceosome determines proper sister chromatid cohesion during mitosis. The ...
  http://emboj.embopress.org/content/early/2014/09/29/embj.201489988
*  Department Lührmann | Max Planck Institute for Biophysical Chemistry
Assembly of the spliceosome by the stepwise binding of the snRNPs to the pre-mRNA. In the early phase of spliceosome assembly, ... Assembly of the spliceosome by the stepwise binding of the snRNPs to the pre-mRNA. In the early phase of spliceosome assembly, ... Assembly of the spliceosome by the stepwise binding of the snRNPs to the pre-mRNA. In the early phase of spliceosome assembly, ... Spliceosomes do not exist in the cell nucleus as complete, pre-formed complexes. Rather, a new spliceosome is built up from its ...
  http://www.mpibpc.mpg.de/luehrmann/
*  8:43 pm
RNA and spliceosomes are pink, DNA and nucleosomes are yellow. This cell is producing antibodies, all steps of the process… ... RNA and spliceosomes are pink, DNA and nucleosomes are yellow. This cell is producing antibodies, all steps of the process are ...
  https://craftymcclever.wordpress.com/2012/12/03/infinity-imagined-the-interior-of-a-eukaryotic/
*  Mechanistic consequences of mutations in spliceosomal snRNAs - Richard Padgett
2014) Biochemical defects in minor spliceosome function in the developmental disorder MOPD I. RNA 20:1078-89 ...
  http://grantome.com/grant/NIH/R01-GM104059-02
*  Spliceosome RNA helicase DDX39B (F6U6E2) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
  https://www.ebi.ac.uk/interpro/protein/F6U6E2
*  DDX39B - Spliceosome RNA helicase DDX39B - Homo sapiens (Human) - DDX39B gene & protein
Spliceosome RNA helicase DDX39BImported. ,p>Information which has been imported from another database using automatic ... tr,F6UJC5,F6UJC5_HUMAN Spliceosome RNA helicase DDX39B (Fragment) OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1 ...
  http://www.uniprot.org/uniprot/F6UJC5
*  RCSB PDB - Protein Feature View - Spliceosome-associated protein CWC15 homolog - Q9P013 (CWC15 HUMAN)
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA ...
  http://www.rcsb.org/pdb/protein/Q9P013
*  Structure and function of the yeast spliceosome | JILA Science
Structure and function of the yeast spliceosome. Event Details. Event Dates: Wednesday, April 11, 2018 - 3:30pm ...
  https://jila.colorado.edu/events/2018/structure-and-function-yeast-spliceosome-0
*  Idea to determine order of assembly of spliceosome - Biology-Online
The thing is that the questions are made so that we will pretend that we don't know that much about the spliceosome as we ... If the spliceosome assembles stepwise, then wouldn't we be able to detect different masses at different points in time? ... Generaly there are five proteins in spliceosome, let's call them Spliceosome Protein1 - 5, but in actin is not present SP3, but ... The question is, how to discriminate those bound in spliceosome from others. One way could be specific binding to introns ( ...
  https://www.biology-online.org/biology-forum/viewtopic.php?t=25067&hilit=Extraction
*  Frontiers | The Spliceosome-Activating Complex: Molecular Mechanisms Underlying the Function of a Pleiotropic Regulator | Plant...
Thus, while mutations of single genes encoding essential spliceosome and NTC components lead to cell death in other organisms, ... Thus, while mutations of single genes encoding essential spliceosome and NTC components lead to cell death in other organisms, ... A compilation of mass spectrometry data available on the composition of NTC and spliceosome complexes purified from different ... A compilation of mass spectrometry data available on the composition of NTC and spliceosome complexes purified from different ...
  https://www.frontiersin.org/articles/10.3389/fpls.2012.00009/full
*  Spliceosome - Wikipedia
Only eukaryotes have spliceosomes and some organisms have a second spliceosome, the minor spliceosome. An analogy is a film ... The spliceosome is assembled from snRNAs and protein complexes. The spliceosome removes introns from a transcribed pre-mRNA, a ... A spliceosome is a large and complex molecular machine found primarily within the splicing speckles of the cell nucleus of ... Each spliceosome is composed of five small nuclear RNAs (snRNA) and a range of associated protein factors. When these small ...
  https://en.wikipedia.org/wiki/Spliceosome
*  Biology-Online • View topic - Idea to determine order of assembly of spliceosome
The thing is that the questions are made so that we will pretend that we don't know that much about the spliceosome as we ... If the spliceosome assembles stepwise, then wouldn't we be able to detect different masses at different points in time? ... Generaly there are five proteins in spliceosome, let's call them Spliceosome Protein1 - 5, but in actin is not present SP3, but ... Re: Idea to determine order of assembly of spliceosome. by nukeman » Tue May 29, 2012 12:29 pm ...
  http://www.biology-online.org/biology-forum/post-142701.html
*  Minor spliceosome - Wikipedia
Like major spliceosome, minor spliceosome had an early origin: several of its characteristic constituents are present in ... Minor spliceosome consists of U11, U12, U4atac, and U6atac, together with U5 and an unknown number of non-snRNP proteins. The ... Spliceosome RNA splicing Review papers: Turunen, J. J., Niemelä, E. H., Verma, B., & Frilander, M. J (January-February 2013). " ... The minor spliceosome is a ribonucleoprotein complex that catalyses the removal (splicing) of an atypical class of spliceosomal ...
  https://en.wikipedia.org/wiki/Minor_spliceosome
*  Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly. | Sigma-Aldrich
Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.. [X Wang, S ... PKG phosphorylates SF1 at Ser20, which inhibits the SF1-U2AF65 interaction leading to a block of pre-spliceosome assembly. ... pre-mRNA splicing by regulating in a phosphorylation-dependent manner the association of SF1 with U2AF65 and spliceosome ...
  https://www.sigmaaldrich.com/catalog/papers/10449420
*  Reactome | ATAC spliceosome mediated 3' splice site cleavage, exon ligation
ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus) ATAC spliceosome mediated 3' splice site cleavage ... ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa) ATAC spliceosome mediated 3' splice site cleavage ... ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Danio rerio) ATAC spliceosome mediated 3' splice site ... ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Oryza sativa) ATAC spliceosome mediated 3' splice site ...
  http://www.reactome.org/content/detail/R-HSA-75083
*  anti-CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) (Cwc27) antibody (Alexa Fluor 488) ABIN914592 from antibodies...
anti-CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) (Cwc27) antibody (Alexa Fluor 488) ABIN914592 from antibodies ... anti-CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) (Cwc27) antibody (Alexa Fluor 488) from antibodies-online. ... Itemanti-CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae) (Cwc27) antibody (Alexa Fluor 488) ...
  https://www.biocompare.com/9776-Antibodies/4069246-anti-CWC27-Spliceosome-Associated-Protein-Homolog-S-Cerevisiae-Cwc27-antibody-Alexa-Fluor-488/
*  Plus it
Recent studies indicate that E7107 inhibits activity of the spliceosome most likely by interacting with the spliceosome- ... Some spliceosome inhibitors that were developed and analyzed in preclinical studies, such as isoginkgetin, have not yet been ... The spliceosome as target for anticancer treatment. Br J Cancer 2009;100:228-32. ... This is the first clinical study that has been conducted with the spliceosome inhibitor E7107. Because it was a phase I study, ...
  http://clincancerres.aacrjournals.org/content/19/22/6296
*  Splicing and transcription touch base: co-transcriptional spliceosome assembly and function. | Physician's Weekly for Medical...
Emerging evidence that the catalytic spliceosome is physically close to Pol II in vivo implies that transcription and splicing ... Splicing and transcription touch base: co-transcriptional spliceosome assembly and function. by Physicians Weekly , Aug 7, 2017 ... This nascent RNA harbours introns that are removed by the spliceosome, which is a megadalton ribonucleoprotein complex that ... In this Review, we discuss aspects of spliceosome assembly, transcription elongation and other co-transcriptional events that ...
  https://www.physiciansweekly.com/splicing-and-transcription-touch-base-co-transcriptional-spliceosome-assembly-and-function/
*  Refractory anemia with ring sideroblasts and marked thrombocytosis (RARS-T) cases harbor mutations in SF3B1 or other...
... cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations ... cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations ... cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations ...
  http://www.haematologica.org/content/early/2015/01/12/haematol.2014.119032
*  Role of Pseudouridine in Stabilizing the Pre-mRNA Branch Site Helix of the Eukaryotic Splicosome
... mRNA in eukaryotes is catalyzed by the spliceosome, a ribonucleoprotein complex comprising recyclable small nuclear (sn)RNA and ... Role of Pseudouridine in Stabilizing the Pre-mRNA Branch Site Helix of the Eukaryotic Splicosome. Excision, or splicing, of ... noncoding regions (introns) from precursor (pre)-mRNA in eukaryotes is catalyzed by the spliceosome, a ribonucleoprotein ...
  http://www.jbsdonline.com/role-pseudouridine-stabilizing-pre-mrna-branch-site-helix-of-eukaryotic-splicosome-p11554.html
*  A 10S galectin-3-U1 snRNP complex assembles into active spliceosomes : Nucleic Acids Research - oi
... ternary complex is a functional E complex and that U1 snRNP is required to assemble galectin-3 onto an active spliceosome. ...
  http://oxfordindex.oup.com/view/10.1093/nar/gkw303?rskey=OboNZa&result=1