*  Gene Silencing Shows Promise for Treating Two Fatal Neurological Disorders
In two studies of mice, researchers showed that a drug, engineered to combat the gene that causes spinocerebellar ataxia type 2 ... Pulst and other researchers discovered that mutations in the ataxin 2 gene cause spinocerebellar ataxia type 2, a fatal ... NIH-funded preclinical studies suggest designer drug may treat ALS and spinocerebellar ataxia 2. ... Antisense oligonucleotide therapy for spinocerebellar ataxia type 2. Nature, April 12, 2017 DOI: 10.1038/nature22044 ...
  http://trnds.org/gene-silencing-shows-promise-for-treating-two-fatal-neurological-disorders/
*  Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila ...
Spinocerebellar ataxia type 5 (SCA5). In The Cerebellum and its Disorders, M.U. Manto, M. Pandolfo, editors. Cambridge ... Spectrin mutations cause spinocerebellar ataxia type 5. Nat. Genet. 38:184-190. doi:10.1038/ng1728. ... Spinocerebellar ataxia type 5 (SCA5) is an autosomal dominant neurodegenerative disorder caused by mutations in the SPTBN2 gene ... Spinocerebellar ataxia type 5 (SCA5) is an autosomal dominant neurodegenerative disease that primarily affects the cerebellum. ...
  http://jcb.rupress.org/content/189/1/143.long
*  Spinocerebellar ataxia, autosomal recessive type 11 | definition of spinocerebellar ataxia, autosomal recessive type 11 by...
What is spinocerebellar ataxia, autosomal recessive type 11? Meaning of spinocerebellar ataxia, autosomal recessive type 11 ... What does spinocerebellar ataxia, autosomal recessive type 11 mean? ... Looking for online definition of spinocerebellar ataxia, autosomal recessive type 11 in the Medical Dictionary? spinocerebellar ... spinocerebellar ataxia, autosomal recessive type 11. spinocerebellar ataxia, autosomal recessive type 11. A form (OMIM:614229) ...
  http://medical-dictionary.thefreedictionary.com/spinocerebellar+ataxia%2C+autosomal+recessive+type+11
*  Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 : Sussex Research Online
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl ... Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 ... Gov't Spinocerebellar Ataxias/*genetics/*pathology. Schools and Departments:. School of Life Sciences. School of Life Sciences ... Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434 (7029). pp. 108-13. ...
  http://sro.sussex.ac.uk/955/
*  Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias - Full Text View - ClinicalTrials...
... spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 ... Spinocerebellar Ataxias. Spinocerebellar Degenerations. Ataxia. Cerebellar Ataxia. Dyskinesias. Neurologic Manifestations. ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 3 ... Trial record 4 of 116 for: 'infantile-onset spinocerebellar ataxia' OR 'Spinocerebellar Ataxias' ...
  https://clinicaltrials.gov/ct2/show/NCT00654251?cond=%22infantile-onset+spinocerebellar+ataxia%22+OR+%22Spinocerebellar+Ataxias%22&rank=4
*  Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias - Full Text View - ClinicalTrials...
... spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Dyskinesias. Neurologic Manifestations. ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 3 ... Spinocerebellar ataxias (SCA's) are relatively rare, inherited disorders of the cerebellum that cause inexorably progressive ...
  https://clinicaltrials.gov/ct2/show/NCT00654251
*  Spinocerebellar Ataxia
... , atau lebih sering disebut Ataxia memiliki gejala-gejala sebagai berikut : Elemen 1 pergerakan terhambat ... Spinocerebellar Ataxia memiliki nama lain Spinocerebellar Degeneration. Mungkin banyak orang menganggap ini adalah dua penyakit ... Spinocerebellar Ataxia memiliki nama lain Spinocerebellar Degeneration. Mungkin banyak orang menganggap ini adalah dua penyakit ... Spinocerebellar Ataxia, atau lebih sering disebut Ataxia memiliki gejala-gejala sebagai berikut : ...
  https://budayangeblog.wordpress.com/2009/09/15/spinocerebellar-ataxia/
*  Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6 | Journal of Medical Genetics
Autosomal dominant cerebellar ataxias, also known as spinocerebellar ataxias (SCA), are neurodegenerative diseases that are ... Estimation of the age at onset in spinocerebellar ataxia type 2 Cuban patients by survival analysis. Clin Genet 2010;78:169-74. ... Age at onset variance analysis in spinocerebellar ataxias: a study in a Dutch-French cohort. Ann Neurol 2005;57:505-12. ... Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6. Mov Disord 2008;23:2232-8. ...
  http://jmg.bmj.com/content/51/7/479
*  Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10 | Journal of Neurology, Neurosurgery &...
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant cerebellar degenerative disorder, variably associated with ... Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10 ... Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10 ... Gait ataxia started at 26 years of age followed by the development of complex partial seizures with occasional secondary ...
  http://jnnp.bmj.com/content/84/12/1409
*  Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias - Full Text View - ClinicalTrials...
Spinocerebellar ataxia type 1 Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 3 Spinocerebellar ataxia type 6 ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Dyskinesias. Neurologic Manifestations. ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 3 ... Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias. The safety and scientific ...
  https://clinicaltrials.gov/show/NCT00654251
*  Study to Determine the Safety and Tolerability of Varenicline (Chantix®) in Treating Spinocerebellar Ataxia Type 3 - Full Text...
... spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Cerebellar Diseases. Machado-Joseph Disease ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 3 ... Spinocerebellar ataxia (SCA) is a group of inherited disorders characterized by cerebellar degeneration leading to imbalance, ...
  https://clinicaltrials.gov/ct2/show/NCT00992771?term=Ataxias+and+Cerebellar+or+Spinocerebellar+Degeneration&rank=5
*  Spinocerebellar ataxia type 6 - Wikipedia
"Frequency of spinocerebellar ataxia types 1, 2, 3, 6, and 7 in Australian patients with spinocerebellar ataxia". Am J Med Genet ... of spinocerebellar ataxias. In Australia, SCA6 accounts for 30% of spinocerebellar ataxia cases while 11% in the Dutch. Calcium ... Spinocerebellar ataxia type 6 (SCA6) is a rare, late-onset, autosomal dominant disorder, which, like other types of SCA, is ... Alonso I, Barros J, Tuna A, Coelho J, Sequeiros J, Silveira I, Coutinho P (2003). "Phenotypes of spinocerebellar ataxia type 6 ...
  https://en.wikipedia.org/wiki/Spinocerebellar_ataxia_type_6
*  Spinal Cord Damage in Spinocerebellar Ataxia Type 1 | SpringerLink
... characterized by progressive cerebellar ataxia and pyramidal signs. Non-motor and... ... Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder caused by a CAG repeat expansion, ... Spinal cord MRI Ataxia Spinocerebellar ataxia type 1 Polyglutamine disorders Biomarker This is a preview of subscription ... Spinocerebellar ataxia types 1, 2, 3 and 6: the clinical spectrum of ataxia and morphometric brainstem and cerebellar findings ...
  https://link.springer.com/article/10.1007/s12311-017-0854-9?wt_mc=alerts.TOCjournals
*  Dalfampridine and Gait in Spinocerebellar Ataxias - Study Results - ClinicalTrials.gov
Spinocerebellar Ataxias Type 1. Spinocerebellar Ataxias Type 2. Spinocerebellar Ataxias Type 3. Spinocerebellar Ataxias Type 6 ... Dalfampridine and Gait in Spinocerebellar Ataxias. The safety and scientific validity of this study is the responsibility of ... Scale for the assessment and rating of ataxia (SARA) is a clinical scale that is based on a semiquantitative assessment of ... Change in Scale of Assessment and Rating of Ataxia (SARA) [ Time Frame: Baseline and 4 weeks after Dalfampridine or placebo ]. ...
  https://clinicaltrials.gov/ct2/show/results/NCT01811706?cond=%22spinocerebellar+ataxia+type+2%22+OR+%22Spinocerebellar+Ataxias%22&rank=15
*  Spinocerebellar Ataxia 15 - CAGS
1 patient harboring a deleterious variant of ITPR1 was diagnosed with spinocerebellar ataxia 15 (SCA15). The patient had ... the condition has been noted as the most common non-trinucleotide repeat spinocerebellar ataxia in Central Europe. ... SCA15 is a cerebellar ataxia characterized by postural tremor, hyperreflexia, dysarthria and scanning speech, as well as gait, ... limb and truncal ataxia. Ocular anomalies include dysmetric saccades, impaired smooth pursuits and horizontal, gaze-evoked ...
  http://www.cags.org.ae/ctga/details.aspx?id=2333&pg=10&se=Latest
*  Spinocerebellar Ataxia 1 - CAGS
Spinocerebellar ataxias (SCAs) are a group of disorders affecting the brain and spinal cord, characterized by progressive loss ... The age of onset varied from 5 to 12 years (mean of 8.2 years), and all the patients presented with slowly progressive ataxia, ... Four of them had in addition to cerebellar ataxia, loss of saccades, and spasticity in lower limbs with one had generalized ... SCA1 was the first of these ataxias for which the molecular basis was discovered. SCA1 is characterized by progressive ...
  http://www.cags.org.ae/ctga/details.aspx?id=1204
*  JCI - Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1
Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6. J Med Genet. 2014;51(7):479-486.. View this ... Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. Chandrakanth Reddy Edamakanti,1 Jeehaeh Do,2 ... Seidel K, Siswanto S, Brunt ER, den Dunnen W, Korf HW, Rüb U. Brain pathology of spinocerebellar ataxias. Acta Neuropathol. ... Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disease caused by a polyglutamine expansion in the ...
  https://www.jci.org/articles/view/96765
*  Search of: 'spinocerebellar ataxia type 3' OR 'Spinocerebellar Ataxias' - List Results - ClinicalTrials.gov
119 Studies found for: 'spinocerebellar ataxia type 3' OR 'Spinocerebellar Ataxias'. Also searched for Spino Cerebellar ... Natural History of Spinocerebellar Ataxia Type 7 (SCA7). *Spinocerebellar Ataxia. Observational. *National Eye Institute (NEI) ... Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3. *Spinocerebellar Ataxia Type 3 ... Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3. *Spinocerebellar Ataxia Type 3 ...
  https://clinicaltrials.gov/ct2/results?cond=%22spinocerebellar%20ataxia%20type%203%22%20OR%20%22Spinocerebellar%20Ataxias%22
*  Trial in Adult Subjects With Spinocerebellar Ataxia - Full Text View - ClinicalTrials.gov
Spinocerebellar Ataxias Spinocerebellar Ataxia Genotype Type 1 Spinocerebellar Ataxia Genotype Type 2 Spinocerebellar Ataxia ... Spinocerebellar ataxia type 1 Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 3 Spinocerebellar ataxia type 6 ... Spinocerebellar Ataxia Genotype Type 7 Spinocerebellar Ataxia Genotype Type 8 Spinocerebellar Ataxia Genotype Type 10 Drug: BHV ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Dyskinesias. Neurologic Manifestations. ...
  https://clinicaltrials.gov/ct2/show/NCT02960893?term=sca3&rank=16
*  Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias - Full Text View - ClinicalTrials.gov
Spinocerebellar Ataxia Spinocerebellar Ataxia 3 Spinocerebellar Ataxia 2 Spinocerebellar Ataxia 1 Spinocerebellar Ataxia Type 6 ... Spinocerebellar Ataxia Type 1 Spinocerebellar Ataxia Type 2 Spinocerebellar Ataxia Type 3 Spinocerebellar Ataxia Type 6 Genetic ... Spinocerebellar ataxia type 1 Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 3 Spinocerebellar ataxia type 6 ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Machado-Joseph Disease. Dyskinesias. ...
  https://clinicaltrials.gov/ct2/show/NCT01060371
*  Lithium Treatment for Patients With Spinocerebellar Ataxia Type I - Full Text View - ClinicalTrials.gov
Spinocerebellar ataxia type 1 Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 3 Spinocerebellar ataxia type 6 ... Ataxia. Cerebellar Ataxia. Spinocerebellar Ataxias. Spinocerebellar Degenerations. Cerebellar Diseases. Dyskinesias. Neurologic ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 1 ... Lithium Treatment for Patients With Spinocerebellar Ataxia Type I. The safety and scientific validity of this study is the ...
  https://clinicaltrials.gov/ct2/show/NCT00683943?term=Ataxias+and+Cerebellar+or+Spinocerebellar+Degeneration&rank=13
*  Lithium Treatment for Patients With Spinocerebellar Ataxia Type I - Full Text View - ClinicalTrials.gov
... spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 ... Spinocerebellar Ataxias. Spinocerebellar Degenerations. Ataxia. Cerebellar Ataxia. Dyskinesias. Neurologic Manifestations. ... Genetic and Rare Diseases Information Center resources: Spinocerebellar Ataxia Spinocerebellar Ataxia 1 ... This study will evaluate the side effects and tolerability of the drug lithium in patients with spinocerebellar ataxia type I ( ...
  https://clinicaltrials.gov/ct2/show/NCT00683943?cond=%22spinocerebellar+ataxia+type+2%22+OR+%22Spinocerebellar+Ataxias%22&rank=8
*  Marijuana for Spinocerebellar Ataxia | Marijuana Doctors
See how medical marijuana could help relieve your Spinocerebellar Ataxia symptoms. Find patient reviews on local doctors and ... What Is Spinocerebellar Ataxia?. Spinocerebellar ataxia, also known as SCA, is the name for a group of degenerative and ... Medical Marijuana and Spinocerebellar Ataxia. Receiving a diagnosis of spinocerebellar ataxia can be bewildering. You may not ... Why Marijuana Is an Effective Treatment for Spinocerebellar Ataxia. Research into medical cannabis for spinocerebellar ataxia ...
  https://www.marijuanadoctors.com/conditions/spinocerebellar-ataxia/
*  Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes |...
McMahon SJ, Pray‐Grant MG, Schieltz D, Yates III JR, Grant PA (2005) Polyglutamine‐expanded spinocerebellar ataxia‐7 protein ...
  http://msb.embopress.org/content/7/1/503
*  Molecular Pathways to Polyglutamine Aggregation | SpringerLink
Identification and characterization of the gene causing type 1 spinocerebellar ataxia. Nat Genet 1994; 7(4):513-520.PubMed ... The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3pl2-p21.1. Nat Genet ...
  https://link.springer.com/chapter/10.1007/978-1-4614-5434-2_7