Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The ... SP1 and YAP1 mRNAs are direct targets of miR-375-5p. Transcription factor Sp1 has been shown to interact with: AATF, CEBPB, ... Sp1+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook SP1 This article ... September 1991). "The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized ...

Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 3) ... NMR structure of transcription factor Sp1 DNA binding domain. Oka, S., Shiraishi, Y., Yoshida, T., Ohkubo, T., Sugiura, Y., ... It is proposed that this relaxed property of finger 1 allows transcription factor Sp1 to bind various DNA sequences with high ... To understand the DNA recognition mechanism of zinc finger motifs of transcription factor Sp1, we have determined the solution ...

... of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (REST ... Keywords: MeHg; REST (RE-1 silencing transcription factor); SOD1-G93A; Sp transcription factors; motor neuronal cell death. ... The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates ... Furthermore, MeHg increased the expression of the transcriptional factor Sp1 and promoted its binding to REST gene promoter ...

Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I ). *張, 文昌 (PI) ... UTR of Sp1 by using in vitro transcription assay to search a probe for the IRES-transacted factor (ITAF) complex, and then use ... In order to target Sp1 or its regulated genes in the treatment of brain injury, several points about the functional role of Sp1 ... First, how does Sp1 use the internal ribosome entry site (IRES)-system to speed translation efficiency to protect neuron cells ...

Sp1 Transcription Factor / drug effects * Sp1 Transcription Factor / genetics * Sp1 Transcription Factor / physiology ... but also its modulation of ER transcription activity. ... Sp1 Transcription Factor * TFF1 protein, human * Trefoil Factor ...

Pro-oxidants can affect cell transcription activity via changes in redox-sensitive transcription factors. Egr-1 and Sp-1 may ... Redox-sensitive transcription factors EGR-1 and SP1 IN the pathogenesis of experimental gastric ulcer. 24.07.2015 Uncategorized ... Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci. 2003 May 1;23(9): ... Interaction between transcription factors Egr-1 and Sp1 in inflammatory bowel disease pathogenesis. Med Chem. 2010;(3):10-15. ( ...

Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase. / Chang, Wen Chang; ... Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase. In: Biochemical and ... Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase. Biochemical and ... Chang, W. C., & Chen, B. K. (2005). Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S ...

A number of members of the Sp1-like/KLF family of transcription factors (SP1, SP5, KLF10, KLF11, KLF13, KLF15, KLF16, KLF3, ... Kaczynski, J.; Cook, T.; Urrutia, R. Sp1- and Kruppel-like transcription factors. Genome Biol. 2003, 4, 206. [Google Scholar] ... The AT-hook transcription factors, of which AKNA is a member, repress or activate gene networks controlling inflammation, ... Figure 5. Increased expression of AT-hook transcription factor (AKNA, Chr 9, − strand) during acute HCV infection. (A) RNA ...

Sp1 Transcription Factor. Nian H, Delage B, Pinto JT, Dashwood RH. 2008. Allyl mercaptan, a garlic-derived organosulfur ... Sp3 Transcription Factor. Nian H, Delage B, Pinto JT, Dashwood RH. 2008. Allyl mercaptan, a garlic-derived organosulfur ... Transcription, Genetic. Nian H, Delage B, Pinto JT, Dashwood RH. 2008. Allyl mercaptan, a garlic-derived organosulfur compound ...

Compound: Transcription factor Sp1. Species: Homo sapiens [TaxId:9606]. Gene: SP1. Database cross-references and differences ( ... Description: Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 2). Class: transcription. Keywords ... Transcription Factor, DNA-Binding Protein. Deposited on 2004-02-07, released 2005-02-08. The last revision prior to the SCOPe ... R-factor: N/A. AEROSPACI score: 0.02 (click here for full SPACI score report) Chains and heterogens:. *Chain A:. ...

Sp1 ELISA Kit, Mouse Transcription factor Sp1 ELISA Kit. EF016252 Lifescience Market 96 Tests. ... Description: Description of target: Transcription factor that can activate or repress transcription in response to ... Positively regulates the transcription of the core clock component ARNTL/BMAL1.;Species reactivity: Mouse;Application: ;Assay ... Genetic Diversity and Virulence Factors of S. aureus Isolated from Food, Humans, and Animals ...

Note that the transcription factor SP1 is not bound. The p53 wt protein is a repressor (green) for HEK293 cells, but mutant ( ... 5-Azacytidine Treatment of HA-A Melanoma Cells Induces Sp1 Activity and Concomitant Transforming Growth Factor Alpha Expression ... TBP and SP1 (40) are bound at a de-methylated CMV promoter (grey) promoting transcription. In the presence of Aza an inhibition ... Wild-Type p53 Binds to the TATA-binding Protein and Represses Transcription. Proc Natl Acad Sci USA (1992) 89:12028-32. doi: ...

Santpere, G., Nieto, M., Puig, B. & Ferrer, I. Abnormal Sp1 transcription factor expression in Alzheimer disease and ... The NF-κB transcription factor, formed in neurons mainly by the p65-p50 dimer45, is sequestered in the cytosol through its ... and nuclear factor-kappaB (NF-κB) that induces SOD2 transcription, a gene encoding the mitochondrial manganese-dependent ... Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures. J. Neurochem. ...

SP1 blocking peptide, available in 100 μg package(s). ... Sp1 Transcription Factor , Sp1 Background The protein encoded ... by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is ... There are currently no reviews for SP1 blocking peptide (GTX89511-PEP). Be the first to share your experience with this product ... There are currently no references for SP1 blocking peptide (GTX89511-PEP). Be the first to share your publications with this ...

The G-allele binds a transcription factor, Sp-1, better than the T-allele [42]. Ten base pairs away from this Sp-1 site is an ... ER binding site and the Sp-1 and ER transcription factors can interact so that the highest levels of MDM2 mRNA and protein are ... The first intron of the MDM2 gene contains sites for transcription factors that regulate the levels of the MDM2 mRNA. ... 4/6 that acts upon the Rb protein freeing the E2F transcription factor for entry into the cell cycle [28, 29]. (3) WIP1, ...

Binding of NFκB-, AP-1-, and Sp1-like transcription factors. J Biol Chem. 1995; 270(8):3849-3857. https://doi.org/10.1074/jbc. ... Figure 6.Staining of tissue factor-positive macrophages in sections of colon carcinoma. (A) Tissue factor (TF) (red) and CD206 ... Figure 2.Tissue factor-specific mRNA induction by alternative polarization. (A) Tissue factor (TF) mRNA levels at the indicated ... Figure 3.Tissue factor protein induction in different macrophage populations. (A) Tissue factor (TF) protein levels in ...

Specific autoantibodies to HSP60, HSP65, and transcription factor Sp1 were identified in patients with UCTD and proposed to be ... Environmental factors likely trigger the onset of this final stage. A clinical diagnosis of early UCTD [14] may be made in the ... The transcriptional activator Sp1, a novel autoantigen. Arthritis Rheum. 1997 Jun. 40(6):1085-95. [QxMD MEDLINE Link]. ... were the leading factors associated with evolution to a defined CTD. [34] The likelihood of evolution to a defined CTD is ...

1. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and kruppel-like factor family of transcription factors in cell growth ... 2. Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppel-like transcription factors. Genome Biol. 2003;4:206 ... Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule ... Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [1, 2]. ...

In contrast, immunoblotting of these nuclear extracts with antibody against transcription factor Sp1 demonstrated that shear ... Mutation of the Sp1 sites, but not the EGR-1 sites, attenuated the response of TF promoter to shear stress. Thus, Sp1 is a ... Affected patients present with a moderate bleeding tendency and have Factor V and Factor VIII levels in the range of 5-30% of ... Identification of this gene should provide new insight into the biology of Factor V and Factor VIII production. ...

In mIMCD3 cells it was demonstrated that the transcription factor Sp1 up-regulates ATP12A (HKalpha2) gene expression [44,61,62 ... by sodium butyrate may be mediated by an up-regulation of ATP12A and CD86 gene expression via the transcription factor Sp1 [62, ... Yu Z, Li M, Zhang D, Xu W, Kone BC: Sp1 trans-activates the murine H+-K+-ATPase α2-subunit gene. Am J Physiol Renal Physiol ... Real-time reverse-transcription PCR (qRT-PCR). The effect of butyrate stimulation of HL-60 cells on ATP12A mRNA expression was ...

Decreased association of the transcription factor Sp1 with genes downregulated in Huntingtons disease. Neurobiology of Disease ... Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during ... In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell. 123: ... Sp1 and TAFII130 transcriptional activity disrupted in early Huntingtons disease. Science (New York, N.Y.). 296: 2238-43. PMID ...

A crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [array]. ... A crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. ... genotype: Sp1 +/+ wild type. Growth protocol. ES cells were trypsinised and allowed to form embryoid bodies by plating in base ...

... which involves the presence of Sp1 and the p65 subunit of NFkappaB transcription factors. PubMed ... transcription factor p65. Names. NF-kappa-B p65delta3. NF-kappa-B transcription factor p65. nuclear factor NF-kappa-B p65 ... IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a ... IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a ...

Chem., 272, 21137 - 21141 (1997), "Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase" ... Kvietikova I., Wenger R. H., Marti H. H.Gassmann M., Kidney Int., 51, 564 - 566 (1997), "The Hypoxia-Inducible Factor-1 DNA ... Nguyen P. V., Abel T.Kandel E. R., Science, 265, 1104 - 1107 (1994), "Requirement of a Critical Period of Transcription for ... Begum N.Ragolia L., Endocrinology, 137, 2441 - 2446 (1996), "Effect of Tumor Necrosis Factor-Alpha on Insulin in Cultured Rat ...

Chem., 272, 21137 - 21141 (1997), "Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase" ... Kvietikova I., Wenger R. H., Marti H. H.Gassmann M., Kidney Int., 51, 564 - 566 (1997), "The Hypoxia-Inducible Factor-1 DNA ... Nguyen P. V., Abel T.Kandel E. R., Science, 265, 1104 - 1107 (1994), "Requirement of a Critical Period of Transcription for ... Begum N.Ragolia L., Endocrinology, 137, 2441 - 2446 (1996), "Effect of Tumor Necrosis Factor-Alpha on Insulin in Cultured Rat ...

Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. A total of 1160 ... Key roles of the transcription factors GATA2, Sp1 and TBP. J. Neurochem. 134, 21-38. https://doi.org/10.1111/jnc.13099 (2015). ... Construction of gene-transcription factor regulatory network. To construct gene-transcription factor (TF) regulatory network, ... As a member of the forkhead box transcription factor family, forkhead box C1 (FOXC1) is involved in the development of embryo, ...

LEDGF/p75 TATA-less promoter is driven by the transcription factor Sp1. Journal of Molecular Biology 414(2), pp. 177-193, 2011 ... The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor. FEBS letters ... The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum ... Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells. ...

... of important endogenous factors involved in HIV immunopathogenesis like TNFalpha and transcription factors NFkB and Sp1. ... The inhibition of HIV replication observed with DLE treatment could be mediated by TNF and transcriptions factors modulation ... Conclusions DLE effect on cellular factors involved in HIV replication correlates with DLE inhibitory effect on HIV in vitro ... We hypothesises that active molecules from DLE modulate cellular factors involved in HIV infection. ...

First Place: Rakshamani Tripathi, "c-Abl/Arg Modulation of Cathepin Secretion Via Sp1/Ets1/NF-κB Transcription Factor ...

The transcription factor Sp1 and the co-activator p300 have previously been shown to regulate DKK1 expression (Peng et al., ... and anti-Sp1(1:50 Santa Cruz) antibodies were used. For Sp1 and p300 interaction studies, Sp1 (Millipore, 1:100) and p300 ( ... SP1 is a member of the Krüppel-like factors (KLFs) all of which share a highly conserved DNA binding domain with high sequence ... Mouse monoclonal Sp1. Santa Cruz. Sc-17824. 1:50 for PLA. Antibody. Rabbit Polyclonal Sp1 Rabbit. Merck Millipore. 07-645. 1: ...