Combined Inotropic and Bradycardic Effects of a Sodium Channel Enhancer in Conscious Dogs with Heart Failure: A Mechanism for...
1997) Increase in force of contraction by activation of the Na+/Ca2+-exchanger in human myocardium. Br J Clin Pharmacol 43:399- ... 1998) Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure. Am J ... 1978) Sodium sensitivity of baroreceptors: reflex effects on blood pressure and fluid volumes in the cat. Circ Res 42:714-720. ... Synthetic sodium channel enhancers prolong the open state of the Na+ channel, probably by inhibiting Na+ channel inactivation, ...http://jpet.aspetjournals.org/content/303/2/673
Sodium/potassium/calcium exchanger 4
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in ... Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis ... A Functional Study of Mutations in K+-dependent Na+-Ca2+ Exchangers Associated with Amelogenesis Imperfecta and Non-syndromic ... These findings support a key role for SLC24A4 in calcium transport during enamel formation.. ...https://pharos.nih.gov/idg/targets/Q8NFF2
Cardiac expression of the Na(+)/Ca(2+) exchanger NCX1 is GATA factor dependent. - Semantic Scholar
Of the three Na(+)/Ca(2+) exchanger genes cloned (NCX1, NCX2, and NCX3), only NCX1 is expressed in cardiac myocytes. NCX1 has ... exchanger plays a primary role in Ca(2+) efflux and is important in regulating intracellular Ca(2+) and beat-to-beat ... The sodium/calcium exchanger family-SLC8. *Beate D. Quednau. , Debora A. Nicoll. , Kenneth D. Philipson ... Retinoic acid increased expression of the Na+/Ca2+ exchanger in the heart and brain.. *S Hudecova. , P Stefanik. , D Macejova. ...https://www.semanticscholar.org/paper/Cardiac-expression-of-the-Na-Ca-2-exchanger-NCX1-i-Nicholas-Philipson/9324741da39b172c8787b6ba5160a7f25f551473
SLC8A3 Pre-design Chimera RNAi - (H00006547-R02) - Products - Abnova
... sodium-calcium exchanger), member 3 (SLC8A3), transcript variant b, mRNA. (H00006547-R02) - Products - Abnova ... sodium-calcium exchanger form 3,sodium/calcium exchanger SLC8A3,solute carrier family 8 (sodium-calcium exchanger), member 3 ... This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family ... Homo sapiens solute carrier family 8 (sodium-calcium exchanger), member 3 (SLC8A3), transcript variant b, mRNA. ...http://www.abnova.com/products/products_detail.asp?catalog_id=H00006547-R02
Pathophysiological basis and clinical application of T-wave alternans | JACC: Journal of the American College of Cardiology
Ca2+is sequestered in the SR by the SR Ca2+adenosine triphosphatase and extruded from the cell by the sodium calcium exchanger ... 1994) Effects of treppe and calcium on intracellular calcium and function in the failing heart from the spontaneously ... so-called calcium-induced calcium release), activating the myofilaments and leading to contraction. During relaxation, ... Calcium homeostasis is not only important for excitation-contraction coupling but it also significantly influences the action ...http://www.onlinejacc.org/content/40/2/207
Regulation of Intracellular and Mitochondrial Sodium in Health and Disease | Circulation Research
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation. 1994; 90: 391-399. ... Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. ... We review evidence implicating the increase of intracellular sodium to either increased influx of sodium (via either sodium ... Regulation of sodium-calcium exchange and mitochondrial energetics by Bcl-2 in the heart of transgenic mice. J Mol Cell Cardiol ...http://circres.ahajournals.org/content/104/3/292
British Library EThOS: Ischaemic injury and protection of the mammalian central white matter
... or the sodium/calcium exchanger (NCX). Endothelin-1 (ET-1, a potent vasoconstrictor) was injected into the spinal cord to ... The findings are consistent with an interpretation that intracellular sodium accumulation, probably via open sodium channels, ... The sodium channel blocking agent phenytoin was found to improve axonal conduction during the first 4.5 hours post ET-1 ... It is concluded that partial blockade of sodium channels, or the NCX, may be effective in protecting central axons from ...http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625216
Targeted SERCA2a Gene Delivery to Restore Electrical Stability in the Failing Heart | Circulation
Moreover, SERCA2a, cardiac ryanodine receptor (RyR2) and sodium calcium exchanger (NCX) protein expression were decreased in HF ... Background-Recently, we reported that SERCA2a, the pump responsible for re-uptake of cytosolic calcium during diastole, plays a ... Heart failure (HF) is associated with impaired myocardial calcium handling, deficient SERCA2a, and increased susceptibility to ... isolated HF myocytes demonstrated slower SR calcium uptake, decreased Ca2+ release and increase diastolic Ca2+ (p,0.05) ...http://circ.ahajournals.org/content/early/2012/09/26/CIRCULATIONAHA.111.071480
Sodium/Calcium Exchanger | Application of Computational Methods for the Design of BACE-1 Inhibitors
Sodium/Calcium Exchanger History RNF122 is a recently discovered RING finger proteins that is. April 27, 2017. Norma Chavez ... we discovered calcium-modulating cyclophilin ligand (CAML) as an RNF122-interacting proteins. To examine the relationship ...http://world-of-links.com/category/sodiumcalcium-exchanger/
Plasma membrane Ca2+ ATPase - Wikipedia
The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations. Since it ... The structure of the PMCA is similar to that of the SERCA calcium pumps, which are responsible for removing calcium from the ... Calcium is an important second messenger, so its levels must be kept low in cells to prevent noise and keep signalling accurate ... Plasma Membrane Calcium-Transporting ATPases at the US National Library of Medicine Medical Subject Headings (MeSH). ...https://en.wikipedia.org/wiki/Plasma_membrane_Ca2+_ATPase
The Role of Sodium-Calcium Exchanger in the Calcium Homeostasis of Airway Smooth Muscle | IntechOpen
The Role of Sodium-Calcium Exchanger in the Calcium Homeostasis of Airway Smooth Muscle. By Ricardo Espinosa-Tanguma, Paola ... The Role of Sodium-Calcium Exchanger in the Calcium Homeostasis of Airway Smooth Muscle, Current Basic and Pathological ... The Role of Sodium-Calcium Exchanger in the Calcium Homeostasis of Airway Smooth Muscle, Current Basic and Pathological ... to-the-function-of-muscle-cells-and-tissues-from-molecules-to-humans/the-role-of-sodium-calcium-exchanger-in-the-calcium- ...https://www.intechopen.com/books/current-basic-and-pathological-approaches-to-the-function-of-muscle-cells-and-tissues-from-molecules-to-humans/the-role-of-sodium-calcium-exchanger-in-the-calcium-homeostasis-of-airway-smooth-muscle/
Sodium-calcium exchanger - Wikipedia
The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, NCX, or exchange protein) is an antiporter membrane protein ... Sodium-calcium exchanger at the US National Library of Medicine Medical Subject Headings (MeSH) Diagram at cvphysiology.com ... Active transport Cardiac action potential Potassium-dependent sodium-calcium exchanger Yu SP, Choi DW (Jun 1997). "Na(+)-Ca2+ ... DiPolo R, Beaugé L (Jan 2006). "Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions". ...https://en.wikipedia.org/wiki/Sodium-calcium_exchanger
Potassium-dependent sodium-calcium exchanger - Wikipedia
Potassium-dependent sodium-calcium exchanger also known as solute carrier family 24 (SLC24) is a type of sodium-calcium ... potassium-dependent sodium-calcium exchanger at the US National Library of Medicine Medical Subject Headings (MeSH). ... Human genes that encode members of the potassium-dependent sodium-calcium exchanger family include: Schnetkamp PP (February ... 2004). "The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond". Pflugers Arch. 447 (5): 683-8. doi:10.1007/s00424-003-1069- ...https://en.wikipedia.org/wiki/Potassium-dependent_sodium-calcium_exchanger
Lenti ORF particles, Slc8a2 (Myc-DDK-tagged ORF) - Rat solute carrier family 8 (sodium/calcium exchanger), member 2 (Slc8a2),...
... sodium/calcium exchanger), member 2 (Slc8a2), 200 uL, ,10^7 TU/mL, 200 µl. ... RR208988L1V Lenti ORF particles, Slc8a2 (Myc-DDK-tagged ORF) - Rat solute carrier family 8 (sodium/calcium exchanger), member 2 ... Properties for Lenti ORF particles, Slc8a2 (Myc-DDK-tagged ORF) - Rat solute carrier family 8 (sodium/calcium exchanger), ... sodium/calcium exchanger), member 2 (Slc8a2), 200 uL, ,10^7 TU/mL ...https://www.acris-antibodies.com/orf/rat-lenti-orf-particles/lenti-orf-particles-slc8a2-myc-ddk-tagged-orf-rat-solute-carrier-family-8-sodium-calcium-exchanger-member-2-slc8a2-200-ul-10-7-tu-ml-rr208988l1v.htm
SLC24A1 - Sodium/potassium/calcium exchanger 1 - Homo sapiens (Human) - SLC24A1 gene & protein
Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and ... controlling the calcium concentration of outer segments during light and darkness. ... the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light ... Sodium/potassium/calcium exchanger 1Add BLAST. 1099. ,p>This subsection of the 'PTM / Processing' section denotes the presence ...https://www.uniprot.org/uniprot/O60721
Cloning of the multipartite promoter of the sodium-calcium-exchanger gene NCX-1 and characterization of its activity in...
SODIUM-CALCIUM EXCHANGE + SODIUM-CALCIUM EXCHANGER (MEMBRANE TRANSPORT, BIOLOGY); PROMOTER (MOLECULAR GENETICS); ... Cloning of the multipartite promoter of the sodium-calcium-exchanger gene NCX-1 and characterization of its activity in ... NATRIUM-CALCIUM-AUSTAUSCH + NATRIUM-CALCIUM AUSTAUSCHER (MEMBRANTRANSPORT, BIOLOGIE); PROMOTOR (MOLEKULARE GENETIK); ...https://www.research-collection.ethz.ch/handle/20.500.11850/143848
Novel inhibitors of sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives. | PR...
Novel inhibitors of sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives.. In: ... Novel inhibitors of sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives. Primary ... Home» Novel inhibitors of sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives. ... pure.fundp.ac.be/portal/en/publications/novel-inhibitors-of-sodiumcalcium-exchanger-benzene-ring-analogues-of-nguanidino- ...https://dial.unamur.be/pr/UNamur/object/pure:158031
Sodium/Calcium Exchanger | Targeting NRAS in Melanoma and Acute Myelogenous Leukemia
Category Archives: Sodium/Calcium Exchanger. We hypothesized that immunoreactivity against antigens from nephritic strains of ...http://scienceofgreathealth.com/category/sodiumcalcium-exchanger/
Membrane Proteins Flashcards by Laura Myers | Brainscape
Sodium-calcium exchanger.. Antiport, secondary active transporter.. Uses the inward sodium gradient from Na/K ATPase for the ... 3Na in per sodium). Low affinity and high capacity so it's good when there is high calcium in the cell (protective). Has a role ... Calcium also accumulates, which is toxic.. If a cell depolarises with high intracellular sodium the protein reverses ... NHE - sodium hydrogen exchanger. Electroneutral, regulates volume and pH, found in most cells. Stimulated by growth factors and ...https://www.brainscape.com/flashcards/membrane-proteins-3315180/packs/5198845
Yoni Haitin - Mendeley
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms. *Giladi M ...https://www.mendeley.com/profiles/yoni-haitin/
Thyroid Disease and the Heart | Circulation
... and the sodium calcium exchanger, which together coordinate the electrochemical responses of the myocardium.1,4,39 The β1 ... Effects of thyroid hormone on sodium pump sites, sodium content, and contractile responses to cardiac glycosides in cultured ... 24-26 These T3-mediated effects include changes in various membrane ion channels for sodium, potassium, and calcium, effects on ... The increase in diastolic pressure occurs with low serum renin levels35 and is a sodium sensitive form of hypertension.36 ...http://circ.ahajournals.org/content/116/15/1725.long
... sodium-calcium exchanger (NCX), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal standard were measured as ... sodium-calcium exchanger; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; CPA, cyclopiazonic acid. ... Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium ... Hasenfuss G and Pieske B (2002) Calcium cycling in congestive heart failure. J Mol Cell Cardiol 34: 951-969. ...http://jpet.aspetjournals.org/content/318/3/1102
Frontiers | Myocyte [Na+]i Dysregulation in Heart Failure and Diabetic Cardiomyopathy | Physiology
... the mitochondrial sodium calcium exchanger. J. Mol. Cell Cardiol. 59, 205-213. doi: 10.1016/j.yjmcc.2013.03.012 ... Chattou, S., Diacono, J., and Feuvray, D. (1999). Decrease in sodium-calcium exchange and calcium currents in diabetic rat ... 1999). Reduced sodium pump (1, (3 and β1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger ... Keywords: heart failure, type-2 diabetes, Na+-glucose cotransporter, Na+/H+ exchanger, Na+/K+-ATPase, Na+/Ca2+ exchanger ...https://www.frontiersin.org/articles/10.3389/fphys.2018.01303/full
ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, TONER CARTRIDGE, PROCESS CARTRIDGE,...
0181] Thereafter, pH in the system is adjusted to 8.0 by using a sodium hydroxide aqueous solution having a concentration of ... by a heat exchanger. The CAVITRON is operated under the conditions of a speed of rotation of a rotor of 60 Hz and a pressure of ... calcium carbonate, magnesium carbonate, tricalcium phosphate, cerium oxide, and the like.  Examples of the organic ... preferably alkylbenzene sodium sultanate, as a dispersant, and the mixture is added to 100 ml to 150 ml of the electrolyte. The ...http://www.patentsencyclopedia.com/app/20130071781
This study analyzed 42 strains collected between 2009C2012 from different hospitals | Targeting NRAS in Melanoma and Acute...
Sodium Channels *Sodium/Calcium Exchanger *Sodium/Hydrogen Exchanger *Somatostatin (sst) Receptors *Spermidine ...http://scienceofgreathealth.com/this-study-analyzed-42-strains-collected-between-2009c2012-from-different-hospitals/