*  50, 51. Oncology Flashcards by Tung Nguyen | Brainscape
... receptor agonist. B. Dopamine blocker. C. Neurokinin-1 receptor blocker. D. Substance P inhibitor. E. Serotonin (5-HT3) ... B. Nonselective norepinephrine receptor modulator. C. Selective estrogen receptor modulator. D. Nonselective estrogen receptor ... but can act as estrogen agonists elsewhere. They are used if the tumor is estrogen-receptor positive. ... A. Estrogen-receptor positive. B. ALK positive. C. Over-expresses HER2/neu. D. No K-ras mutations. E. EGRF positive ...
  https://www.brainscape.com/flashcards/50-51-oncology-3983287/packs/2464117
*  These highlights do not include all the information needed to use ONDANSETRON safely and effectively. See full prescribing...
5.3 Serotonin Syndrome. The development of serotonin syndrome has been reported with 5-HT3 receptor antagonists. Most reports ... While ondansetron's mechanism of action has not been fully characterized, it is not a dopamine-receptor antagonist. ... Serotonin syndrome occurring with overdose of ondansetron alone has also been reported. The majority of reports of serotonin ... 5.3 Serotonin Syndrome 5.4 Masking of Progressive Ileus and Gastric Distension 5.5 Effect on Peristalsis 6 ADVERSE REACTIONS ...
  https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ff42153c-9c0e-40e0-b21c-376010548dcc&type=display
*  Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease - Full Text View -...
MEM 3454 is a novel nicotinic alpha-7 receptor selective partial agonist having serotonin type 3 (5-HT3) receptor antagonist ... Receptor selective nicotinic alpha-7 receptor agonists can modulate acetylcholine in selective brain regions and contribute to ... Received any investigational drug within 2 months of randomization or treatment with other nicotinic receptor agonists within 3 ... Received AChE inhibitor therapy (e.g., rivastigmine, tacrine or galantamine) or NDMA-receptor antagonist, memantine, within 30 ...
  https://clinicaltrials.gov/ct2/show/NCT00454870?term=MEM+3454&rank=3
*  ACG Releases Evidence-Based Systematic Review on Management of Irritable Bowel Syndrome | SYS-CON INDIA
... serotonin) receptor agonist tegaserod; the chloride channel activator lubiprostone; psychologic therapies; herbal preparations ... 5HT 3 antagonists are efficacious in IBS patients with diarrhea and the quality of evidence is good. Patients need to be ... 5HT 4 agonists are modestly effective in IBS patients with constipation and the quality of evidence is good although the ... Tricyclic anti-depressants and selective serotonin reuptake inhibitors have been shown to be effective in IBS patients of all ...
  http://in.sys-con.com/node/782059
*  Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus - Tabular View - ClinicalTrials.gov
... serotonin) receptor antagonists, opioid antagonists, opioid agonist-antagonists, propofol, and nonsteroidal antiinflammatory ... mediated central µ opioid receptors, Dopamine (D2) receptors, Serotonin (5-HT3) receptors, prostaglandin system, GABA receptors ... and glycine receptors, so that why opioid-induced pruritus is difficult to manage. Many medications have been used to treat ... 5 such as type of operation, incidence of bradycardia, and ASA classification. Results are expressed as mean+SD for normal ...
  https://clinicaltrials.gov/ct2/show/record/NCT01236859
*  Gastroparesis - Wikipedia
Mirtazapine acts on the same serotonin receptor (5-HT3) as does the popular anti-emetic ondansetron. Camicinal is a motilin ... agonist for the treatment of gastroparesis. In specific cases where treatment of chronic nausea and vomiting proves resistant ... Similarly, the dopamine receptor antagonist domperidone is also used to treat gastroparesis. Erythromycin is known to improve ... Metoclopramide, a dopamine D2 receptor antagonist, increases contractility and resting tone within the GI tract to improve ...
  https://en.wikipedia.org/wiki/Gastroparesis
*  5-HT3 receptor - Wikipedia
These agents are not agonists at the receptor, but increase the affinity or efficacy of the receptors for an agonist: Indole ... or serotonin) receptors which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal ... 1000x selectivity over other serotonin receptors SR-57227 Varenicline YM-31636 Antagonists for the receptor (sorted by their ... When the receptor is activated to open the ion channel by agonists, the following effects are observed: CNS: nausea and ...
  https://en.wikipedia.org/wiki/5-HT3_receptor
*  2-Methyl-5-hydroxytryptamine - Wikipedia
Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of ... is a tryptamine derivative closely related to the neurotransmitter serotonin which acts as a moderately selective full agonist ... 5-Carboxamidotryptamine 5-Methoxytryptamine α-Methyl-5-hydroxytryptamine Elz S, Zimmermann H, Rehse K (1993). "Selectivity of ... Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). "5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine- ...
  https://en.wikipedia.org/wiki/2-Methyl-5-hydroxytryptamine
*  Oxycodone and Vicks Nyquil Cough Drug Interactions - Drugs.com
Shakoor M, Ayub S, Ahad A, Ayub Z "Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin ... "Venlafaxine + tramadol: serotonin syndrome." Prescrire Int 13 (2004): 57. *Gillman PK "Possible serotonin syndrome with ... Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. *Meyer D, Halfin V "Toxicity secondary to meperidine in ... Serotonin syndrome is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5 ...
  https://www.drugs.com/drug-interactions/oxycodone-with-vicks-nyquil-cough-1770-0-2950-13458.html
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... other receptor types; ion channels; transporters; enzymes, and other protein- and non-protein cellular structures. This review ... other receptor types; ion channels; transporters; enzymes, and other protein- and non-protein cellular structures. This review ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  Toxins | Free Full-Text | Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391
Serotonin receptors are involved in those effects. In this study, we have expanded the characterization of the antinociceptive ... The agonist inhibited the formalin's nociceptive response, supporting an antinociceptive role for 5-HT3 receptors. Our study is ... suggesting that this compound does not directly bind to these receptors. The effect of biguanide, a selective 5-HT3 receptor ... a selective 5-HT3 receptor antagonist, blocks the effect of BDS 391, whereas ketanserin, a 5-HT2 receptor antagonist, partially ...
  https://www.mdpi.com/2072-6651/10/1/12
*  Irritable Bowel Syndrome | Denver Health
Serotonin receptor agonists and antagonists (also called 5-HT3 antagonists)-May be helpful for treating diarrhea, as well as ... Serotonin receptor agonists and antagonists (also called 5-HT3 antagonists)-May be helpful for treating diarrhea, as well as ... Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J ...
  https://www.denverhealth.org/conditions/i/irritable-bowel-syndrome
*  Meta-Chlorophenylpiperazine - Wikipedia
It behaves as an agonist at most serotonin receptors. mCPP has been shown to act not only as a serotonin reuptake inhibitor but ... Charney DS, Woods SW, Goodman WK, Heninger GR (1987). "Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP ... receptor agonists". Bioorg. Med. Chem. Lett. 14 (9): 2367-70. doi:10.1016/j.bmcl.2003.05.001. PMID 15081042. Silverstone PH, ... a central serotonin agonist causing powerful anorexia in rats". Naunyn-Schmiedeberg's Archives of Pharmacology. 308 (2): 159-63 ...
  https://en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine
*  Learn: Mersfelder IM Rotation Study Guide (by tylerwise) - Memorize.com - Remember and Understand
Serotonin Syndrome. Question Answer Causes of serotonin syndrome. 5-HT3 receptor antagonists, linezolid, lithium, MAOIs, 5-HT1 ... receptor agonists, mirtazapine, SNRIs, SSRIs, TCAs, tramadol, trazodone, valproic acid. Serotonin syndrome triad. Neurologic ... Selective estrogen receptor modulators (SERMs). Some cancer therapies. Heparin --> HIT. Warfarin MOA. Inhibits clotting factors ... Increases sensitivity for receptor activation by extracellular calcium which reduces PTH and serum calcium concentrations. ...
  http://memorize.com/mersfelder-im-rotation-study-guide/tylerwise
*  SL-067 | N-Methylquipazine dimaleate, 98% | 28614-26-8 | Life Science Products | SynInnova
It is a tertiary amine analogue of quipazine, agonist at 5-HT3 serotonin receptors with an affinity similar to that of ... but no affinity with central 5-HT1B serotonin receptors.. Reference : Glennon. R. A. et. al.: Eur. J. Pharmacol., 168(3), 387, ...
  http://www.syninnova.com/catalog/product/SL-067
*  Irritable Bowel Syndrome | Blake Medical Center | Bradenton, FL
Serotonin receptor agonists and antagonists (also called 5-HT3 antagonists)-may be helpful for treating diarrhea, as well as ... Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J ...
  https://blakemedicalcenter.com/hl/?/11755/irritable-bowel-syndrome&com.dotmarketing.htmlpage.language=1
*  Nutmeg seeds and anxiety
Further, the effect of diazepam (1 mg/kg i.p.), serotonin 5-HT3 receptor antagonist, ondansetron (1 mg/kg i.p.), and 5-HT1A ... receptor agonist, buspirone (1 mg/kg i.p.), on the occupancy in open arm and entries in open arm was significantly reduced by ... receptor] suggests a nonspecific anxiogenic activity of TM and also a link between 5-HT and GABA systems in the anxiogenic ... Inhibition of anxiolytic activity of ondansetron (5-HT3 receptor antagonist), buspirone (5-HT1A receptor agonist), and diazepam ...
  https://www.moodfoods.com/nutmeg.html
*  Exam 10 Drugs Quiz - By nberlon
Weak µ receptor agonists. Osteoarthritis. Muscarinic receptor antagonist, intended to reduce influence of the vestibular system ... intended to block serotonin activation of the vagus nerve and the chemoreceptor trigger zone. Nausea and vomiting associated ... D2 receptor antagonists (metoclopramide also a muscarinic receptor agonist), intended to block dopamine activation of the ... Recombinant IL-1 receptor antagonist. Rheumatoid arthritis. H1 receptor + muscarinic receptor antagonists, intended to reduce ...
  https://www.sporcle.com/games/nberlon/exam-10-drugs
*  Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis -...
Intraperitoneal administration of 5-HT3 receptor antagonists (tropisetron or MDL 72222) prevented cisplatin-induced emesis and ... Intraperitoneal injection of selective and nonselective 5-HT3 receptor agonists potently, and in a dose-dependent fashion, ... 5-HT (p , 0.05) ,5-HTQ (p , 0.01) ,mCPBG (p , 0.001). As with other established experimental animal emesis models, the present ... induced emesis in the least shrew with the following ED50 potency order: 2-methyl 5-HT ≈ ...
  https://www.semanticscholar.org/paper/Serotonin-5-HT3-receptor-antagonists-prevent-emesis-Darmani/b8f153254f4df92afbf96fd99e400b0457ee2467
*  Bufotenidine - Wikipedia
Bryan L. Roth (17 August 2008). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. Springer Science & ... serotonin, and other tryptamines which is found in the venom of a variety of toads. It acts as a selective 5-HT3 receptor ... agonist, and has been used in scientific research to study the function of the 5-HT3 receptor, though this use has been limited ... 2-Methyl-5-HT Chlorophenylbiguanide Wieland, Heinrich; Konz, Wilhelm; Mittasch, Heinz (1934). "Toad poisons. VII. Constitution ...
  https://en.wikipedia.org/wiki/Bufotenidine
*  Drug design - Wikipedia
Small molecules (for example receptor agonists, antagonists, inverse agonists, or modulators; enzyme activators or inhibitors; ... selective serotonin reuptake inhibitors), a class of antidepressants Zanamivir, an antiviral drug 5-HT3 antagonists ... Acetylcholine receptor agonists Angiotensin receptor antagonists Bcr-Abl tyrosine-kinase inhibitors Cannabinoid receptor ... This can be done with a diverse training set including many types of ligands and receptors to produce a less accurate but more ...
  https://en.wikipedia.org/wiki/Drug_design
*  Trifluoromethylphenylpiperazine - Wikipedia
Due to the serotonin agonist effects and increase in serotonin, norepinephrine, and dopamine levels produced by the BZP/TFMPP ... receptors, and functions as a full agonist at all sites except the 5-HT2A receptor, where it acts as a weak partial agonist or ... Robertson DW, Bloomquist W, Wong DT, Cohen ML (1992). "mCPP but not TFMPP is an antagonist at cardiac 5HT3 receptors". Life ... and evokes the release of serotonin. It has no effects on dopamine or norepinephrine reuptake or efflux. TFMPP is rarely used ...
  https://en.wikipedia.org/wiki/Trifluoromethylphenylpiperazine
*  Velusetrag - Wikipedia
Velusetrag demonstrates less selectivity for other serotonin receptors, such as 5-HT2 and 5-HT3, to earlier generation 5-HT ... receptor agonist with high intrinsic activity". Naunyn-Schmiedeberg's archives of pharmacology. 378 (1): 125-37. doi:10.1007/ ... agonists like cisapride and tegaserod. In a large clinical trial in patients with chronic idiopathic constipation (n=401), ... As of May 10, 2017, Velusetrag is being studied, at doses of 5, 15 and 30 mg over a 12 week treatment period, for symptomatic ...
  https://en.wikipedia.org/wiki/Velusetrag
*  SR-57227 - Wikipedia
SR-57227 is a potent and selective agonist at the 5HT3 receptor, with high selectivity over other serotonin receptor subtypes ... Maksay, G.; Simonyi, M.; Bikádi, Z. (2004). "Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists". ... Li, Y.; Raaby, K. F.; Sánchez, C.; Gulinello, M. (2013). "Serotonergic receptor mechanisms underlying antidepressant-like ... A potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo". European Journal of ...
  https://en.wikipedia.org/wiki/SR-57227
*  Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder - Full Text View -...
Serotonin Receptor Agonists. Serotonin 5-HT1 Receptor Antagonists. Serotonin Antagonists. Serotonin 5-HT3 Receptor Antagonists ... Serotonin Uptake Inhibitors. Neurotransmitter Uptake Inhibitors. Membrane Transport Modulators. Molecular Mechanisms of ... Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder. The safety and scientific ... The purpose of this study is to evaluate the efficacy of vortioxetine (5, 10, and 20 mg) versus placebo during the first 28 ...
  https://www.clinicaltrials.gov/ct2/show/study/NCT02371980?show_locs=Y