Secretory Pathway Ca²⁺ ATPase - Wikipedia
SPCA, or Secretory Pathway Ca2+-ATPase, is a calcium ATPase-type P-ATPase encoded for by the genes ATP2C1 and ATP2C2. SPCA is ... of these ions from the cytosol can also be looked upon as supplying the golgi apparatus and thus the entire secretory pathway ... Several proteins within the pathway require either Ca2+ ions, Mn2+ ions, or divalent ions to function as metal cofactors, such ...
JCI - A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma
Here, we showed that TP53 loss initiated a pharmacologically actionable secretory process that drove lung adenocarcinoma (LUAD ... These results identified a targetable secretory vulnerability in TP53-deficient LUAD cells. ... myosin IIA-containing protein complex that activates secretory vesicle biogenesis in the Golgi. TP53 loss activated G55- ...
Replication of the Human Secretory Pathway in Yeast | SBIR.gov
DESCRIPTION (provided by applicant): With its ability to secrete high levels of recombinant proteins, the yeast Pichia pastoris is extensively used for protein manufacturing. However, as actual yields vary widely for individual proteins, GlycoFi is focusing on the improvement of protein yields in P. pastoris as part of the companys long term mission to develop yeast-based protein production technology for manufacturing therapeutic proteins with human glycosylation structures. In Phase I of this project a strategy was developed and tested using the model protein alpha 1-antitrypsin for overcoming bottlenecks in yeast secretion that result in less than optimal yields. A combinatorial library/high throughput screening methodology was designed to optimize translocation of the nascent peptide into the
An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds | Journal of Neuroscience
... and is thus possibly a sign of P/rds trafficking through an unconventional secretory pathway. Unconventional secretory pathways ... An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds Message Subject (Your Name) has forwarded a ... An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds. Guilian Tian, Philip Ropelewski, Ina Nemet ... An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds. Guilian Tian, Philip Ropelewski, Ina Nemet ...
Chromogranins A and B are key proteins in amine accumulation, but the catecholamine secretory pathway is conserved without them
Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and ... might compensate for their loss to ensure that vesicles are generated and the secretory pathway conserved. ... Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and ...
Sorting of Processing Enzymes to the Regulated Secretory Pathway - Y. Peng Loh Lab | NICHD - Eunice Kennedy Shriver National...
œ-Helices and Lipid Rafts After being targeted to the immature secretory granule from the TGN, prohormones are processed ... Sorting of Processing Enzymes to the Regulated Secretory Pathway œ-Helices and Lipid Rafts. After being targeted to the ... they must be sorted along with their prohormone substrates to the regulated secretory pathway. These enzymes may share a common ... or a reporter protein to the regulated secretory pathways.. Molecular modeling of these enzymes has revealed an amphipathic ...
Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation | Molecular Pharmacology
Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation. Yanxia Liu, Brian K. Law and ... Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation. Yanxia Liu, Brian K. Law and ... Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation. Yanxia Liu, Brian K. Law and ... Our study indicates that apratoxins are new tools to study the secretory pathway and raises the possibility that inhibition of ...
The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway | eLife
... wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory ... pathway is required for formation and secretion of the bioactive peptides. ... Maturation of the CLEL6 precursor in the secretory pathway.. As a first processing step, the signal peptide is cleaved off upon ... Maturation late in the secretory pathway was also observed for CLEL9. Similar to CLEL6, the Δ-KDEL and Δ-XylT constructs for ...
P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20...
P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 ... In contrast, the surface expression of P-selectin transfected into CHO cells, which do not have a regulated pathway of ... follows the regulated secretory pathway in AtT-20 cells.. J Cell Biol 1 February 1992; 116 (3): 617-625. doi: https://doi.org/ ...
PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation - Research - Institut...
Network Portal - Function Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
osnaDocs: Impact of pathogenic SMS2 variants on lipid landscapes and membrane properties along the secretory pathway
Impact of pathogenic SMS2 variants on lipid landscapes and membrane properties along the secretory pathway. eng. ... Impact of pathogenic SMS2 variants on lipid landscapes and membrane properties along the secretory pathway ... cholesterol synthesized in the ER to promote the formation of a SM/sterol concentration gradient along the secretory pathway. ... that pathogenic SMS2 variants undermine the capacity of cells to uphold nonrandom lipid distributions in the secretory pathway ...
Intracellular trafficking
2. The secretory pathway. 3. General secretion. 4. Polarized secretion. 4.1. Apical secretion. 4.2. Basolateral secretion. 5. ... through recycling pathways and gain components through fusion with vesicles derived from the secretory pathway. Late endosomes ... One component of the general secretory pathway that has been studied in significant detail in C. elegans is SEC-23, a part of ... defect in the secretory pathway and in germline cytokinesis in particular. The presence of such a large and diverse family of ...
Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis
Altmetric - Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of...
... comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. ... comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway ...
Investigations of the early secretory pathway: structure and heterogeneity of the COPII coat
The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins - Research - Institut...
The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins. ... similar to genes coding for components of the main terminal branch of the general secretory pathway (e.g., the Klebsiella ... a component of the pullulanase secretion pathway. Expression of gspG from lacZp leads to production of a protein which (i) is ...
Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data | BMC Systems Biology | Full Text
On the basis of manual curation of the literature on the yeast, human, and mouse secretory pathway, we have compiled a ... The RECON of the secretory pathway represents a strong tool for interpretation of data related to protein secretion as ... we could reconstruct the protein secretory pathway of CHO cells counting 764 CHO components. This RECON furthermore facilitated ... The elucidation of the cell biology of the secretory machinery is of great importance, as it drives protein expression for ...
ATP2C1 gene: MedlinePlus Genetics
PKG II secreted via the classical endoplasmic reticulum-Golgi apparatus secretory pathway blocks the activation of EGFR through...
PKG II secreted via the classical endoplasmic reticulum-Golgi apparatus secretory pathway blocks the activation of EGFR through ... PKG II secreted via the classical endoplasmic reticulum-Golgi apparatus secretory pathway ... acted as a signal peptide to induce the secretion of PKG II via the conventional protein secretory pathway. Moreover, ... suggesting a novel protein secretory pathway. The resuls also indicated that secreted PKG II was a potential diagnostic ...
Nε-lysine acetylation in the endoplasmic reticulum - a novel cellular mechanism that regulates proteostasis and autophagy |...
Adaptation of the secretory pathway. Ex vivo and in vivo studies indicate that the secretory pathway is able to adapt to ... Finally, one of the most pressing gaps in our understanding of Nε-lysine acetylation within the secretory pathway is the ... The ER acetyltransferases ATase1 and ATase2 acetylate proteins that insert within the secretory pathway. Knowledge that ER- ... The ER acetylation machinery regulates proteostasis and autophagy within the secretory pathway. Important functions of the ER ...
Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaard's Cellular Peptide Hormone Synthesis and Secretory Pathways PDF -...
Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaards Cellular Peptide Hormone Synthesis and Secretory Pathways PDF. ... Jan Fahrenkrug (auth.), Jens F. Rehfeld, Jens R. Bundgaards Cellular Peptide Hormone Synthesis and Secretory Pathways PDF. ... It first describes common matters comparable to maturation of secretory granules within the cells, the jobs of the chaperonic ...
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Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. - The...
The short pathway is associated with faster granule release and more efficient killing than the long pathway. Thus, the ... and subsequent delivery by the polarized MTOC directly to the secretory domain-the shortest path. Indolent signaling led to ... moved along microtubules to the periphery of the synapse and then moved tangentially to fuse at the outer edge of the secretory ... We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular ...
Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway...
Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway ... Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway ... Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway ... Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway ...
The Metabolic Pathway Engineering Handbook | Tools and Applications
... of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway ... The Metabolic Pathway Engineering Handbook DOI link for The Metabolic Pathway Engineering Handbook ... Metabolic Engineering of the Secretory Processing Pathway in Eukaryotes Abstract chapter 11. ,. 16 pages. Engineering ... Evolving Pathways and Genomes for the Production of Natural and Novel Compounds Abstract ...
Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultured fibroblasts (L cells)...
Osamura, RY, Suemizu, Y, Yoshimura, S, Hori, S, Inada, K, Watanabe, K, Nakai, Y & Imura, H 1991, Secretory pathways and ... Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultured fibroblasts (L cells) ... Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultured fibroblasts (L cells) ... title = "Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultured fibroblasts (L ...
Protein sorting into protein bodies during barley endosperm development is putatively regulated by cytoskeleton members, MVBs...
... proteins related to the secretory pathway (ER, Golgi, Golgi - ER), plasma membrane, sorting pathway (endocytosis, ESCRT), ... S2). The STRING network indicates that the group of ER markers is linked with proteins associated with the secretory pathway ... 5a). Interestingly, 11 proteins involved in the secretory pathway (e.g., COPII/COPI), and 9 proteins that function in the ... SSPs are produced by the secretory pathway and reach their final destinations by two main routes: soluble albumins and ...
Protein Sorting (L) - course unit details - BSc Molecular Biology with Entrepreneurship - full details (2024 entry) | The...
appraise the maturation of proteins in the endoplasmic reticulum and their subsequent movement through the secretory pathway ...