Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool | OptiStem
Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool. ... Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool ... because of fusion of satellite cells, the postnatal myogenic cells, responsible for muscle growth and regeneration. Numerous ... Skeletal muscle fibres form by fusion of mesoderm progenitors called myoblasts. After birth, muscle fibres do not increase in ...http://optistem.org/our-research/publications/pericytes-resident-post-natal-skeletal-muscle-differentiate-muscle-fibers-
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population | JCB
Satellite cells can be copurified with isolated single skeletal muscle fibers. (A-D) Satellite cells are attached to the ... The skeletal muscle satellite cell: stem cell or son of stem cell? Differentiation. 68:193-204. ... Pax7+ cells are present in newt limb skeletal muscle. (A and B) Immunostaining of limb skeletal muscle identifies Pax7+ cells ... Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell. 122: ...http://jcb.rupress.org/content/172/3/433
PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells | Cell...
... induce satellite cell proliferation in vitro and promote muscle regeneration in vivo. Extensively soleus muscle necrosis was ... PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells. Tsung-Chuan ... PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells ... PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells ...http://ajpcell.physiology.org/content/early/2015/06/01/ajpcell.00344.2014
Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading | Cell Physiology
... which has lower skeletal muscle size than the lean Zucker rat (LZR). Because satellite cells are essential for postnatal muscle ... is a primary responsibility of muscle satellite cells. Muscle satellite cells are normally quiescent myogenic precursor cells ... Pax7 and myogenic progression in skeletal muscle satellite cells. J Cell Sci 119: 1824-1832, 2006. ... and become incorporated into a muscle fiber (1). Therefore, BrdU was used to identify satellite cells or muscle precursor cells ...http://ajpcell.physiology.org/content/295/2/C521
'satellite cells skeletal muscle' Protocols and Video...
... and Transplantation of Muscle Satellite Cells', 'Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of ... Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles', 'Isolation and Characterization of Satellite Cells from ... Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle', 'Preparation and Culture ... Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish', 'Engineering Skeletal Muscle Tissues ...https://www.jove.com/keyword/satellite+cells+skeletal+muscle
Hawke's research focus is on the role and regulation of muscle satellite cells, the stem cell population of skeletal muscle, in ... The regenerative capacity of skeletal muscle is due primarily to a rare population of progenitor cells called muscle satellite ... The potential of this cell population is tremendous, however, the use of these cells for cell transplantation into patients ... as the drugs used to induce B-cell death are also capable of impairing satellite cell function. We are currently investigating ...http://fhs.mcmaster.ca/pathology/contact_us/faculty/faculty_bios/hawke.html
Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells | JCB
Satellite cells are self-renewing muscle stem cells, which mediate the growth and repair of skeletal muscle (Zammit et al., ... The skeletal muscle satellite cell: the stem cell that came in from the cold. J. Histochem. Cytochem. 54:1177-1191. doi:10.1369 ... Skeletal muscle satellite cells and adult myogenesis. Curr. Opin. Cell Biol. 19:628-633. doi:10.1016/j.ceb.2007.09.012. ... The muscle regulatory factors MyoD and Myf-5 undergo distinct cell cycle-specific expression in muscle cells. J. Cell Biol. 142 ...http://jcb.rupress.org/content/188/1/39
Age related changes in speed and mechanism of adult skeletal muscle stem cell migration - The Mathematical Institute,...
Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite ... Our study shows that satellite cell migration, a key component of skeletal muscle regeneration, is compromised during aging. ... We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal ... Age related changes in speed and mechanism of adult skeletal muscle stem cell migration. Stem Cells . ...http://eprints.maths.ox.ac.uk/1527/
Factors Influencing Satellite Cell Activity during Skeletal Muscle Development in Avian and Mammalian Species | Korea Science
Muscle Regeneration;Muscle Development;Mitogenic Factors;Meat Production;Poultry;Mammals; ... Factors Influencing Satellite Cell Activity during Skeletal Muscle Development in Avian and Mammalian Species - ... Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell 122: ... the processes of satellite cell activation and highlight the potential role of satellite cells in skeletal muscle growth, ...http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2008_v21n3_456
Frontiers | The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development | Frontiers in Aging...
... head muscle stem cells retain properties of the early head mesoderm and might even be able to switch between a skeletal muscle ... Unlike trunk muscle stem cells, head muscle stem cells do not have a previous history of Pax7 expression, instead Pax7 ... Unlike trunk muscle stem cells, head muscle stem cells do not have a previous history of Pax7 expression, instead Pax7 ... head muscle stem cells retain properties of the early head mesoderm and might even be able to switch between a skeletal muscle ...https://www.frontiersin.org/articles/10.3389/fnagi.2015.00062/full
Project : USDA ARS
In vivo satellite cell responses and skeletal muscle growth will be assessed primarily by immunohistofluorescence imaging with ... Sub-objective 1.A. Determine in vivo the number of skeletal muscle satellite cells undergoing division, apoptosis, and ... Sub-objective 1.B. Determine in vivo the number of skeletal muscle satellite cells undergoing division, differentiation, and ... and muscle mass. To assess the role of epigenetic mechanisms intrinsic to the satellite cell, cells will be harvested from mice ...https://www.ars.usda.gov/research/project/?accnNo=416974
Research Updates Fall 2009 | Quest Magazine Online
Satellite cells are located near muscle fibers in mice and humans and stay in a dormant state until called upon for repair work ... Cardiac actin can substitute for skeletal-muscle actin. A protein present in skeletal muscles during fetal development and in ... Rudnicki found that some satellite cells function as stem cells and maintain overall numbers of satellite cells. He ... Satellite cells are located near mature muscle fibers in mice and humans and stay in a dormant state until called upon for ...http://quest.mda.org/article/research-updates-fall-2009
Short-term protein supplements have little gain for untrained athletes
Satellite cell numbers. The researchers suggested that the increase in skeletal muscle satellite cell numbers induced by whey ... "We do report, however, that whey protein supplementation significantly increases skeletal muscle satellite cell number with ... research has also suggested that increases in satellite cell numbers are a necessary precursor to increasing skeletal muscle ... dietary protein intake mechanistically affects satellite cell turnover and if protein-induced increases in satellite cell ...https://www.nutraingredients.com/Article/2017/09/08/Short-term-protein-supplements-have-little-gain-for-untrained-athletes
Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle...
Skeletal muscle satellite cells (SCs) are involved in remodeling and hypertrophy processes of skeletal muscle. However, little ... Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle ... we investigated the muscle fiber type-specific association between emergence of satellite cells (SCs), muscle growth, and ... Muscle biopsies (vastus lateralis) were analyzed for fiber type-specific SCs, myonuclei, and fiber cross-sectional area (CSA). ...http://www.forskningsdatabasen.dk/catalog/269831595
Scientists Discover Clues to Muscle Stem Cell Functions
... a severe inherited disease of muscle that causes weakness, disability and, ultimately, heart and respiratory failure. ... Research Center Oakland scientists identifies how skeletal muscle stem cells respond to muscle injury and may be stimulated to ... MUSCLE ATROPHY, Muscle Damage, Muscle, Stem Cell, stem cell activation, * Dystrophies, Skeletal Muscle Satellite Cells, ... "satellite cells" that are essential for muscle repair. Normally, satellite cells lie quietly at the periphery of the muscle ...http://www.newswise.com/articles/children-s-hospital-research-center-oakland-scientists-discover-clues-to-muscle-stem-cell-functions-study-reveals-a-potential-key-to-new-treatment-strategies-for-muscular-dystrophy
MacOdrum Library - Carleton's Institutional Repository: The molecular regulation of muscle stem cell function
... satellite cells in skeletal muscle are a heterogeneous population composed of satellite stem cells (Pax7 +/Myf5-) and satellite ... A subset of satellite cells purified from adult skeletal muscle is capable of repopulating the satellite cell pool, suggesting ... Muscle satellite cells are responsible for the postnatal growth and robust regeneration capacity of adult skeletal muscle. ... satellite cells give rise to Pax7 +/Myf5+ satellite cells through basal-apical asymmetric cell divisions. Therefore, ...https://ir.library.carleton.ca/pub/12431
Sharp-1 regulates TGF-β signaling and skeletal muscle regeneration | Journal of Cell Science
1987). Inhibition of skeletal muscle satellite cell differentiation by transforming growth factor-beta. J. Cell. Physiol. 133, ... Skeletal muscle development in Sharp-1−/− mice. We have previously demonstrated that Sharp-1 is expressed in skeletal muscles ... The progeny of activated satellite cells are called muscle precursor cells and they undergo multiple rounds of proliferation, ... Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: ...http://jcs.biologists.org/content/127/3/599
microRNA-128 regulates the proliferation and differentiation of bovine skeletal muscle satellite cells by repressing Sp1 |...
Bovine Skeletal muscle satellite cells Microrna-128 Sp1 Myogenic differentiation Yang Dai and Wei Ran Zhang contributed equally ... However, little is known about the functions of miR-128 in bovine skeletal muscle satellite cell development. In this study, we ... The results of our study reveal a mechanism by which miR-128 regulates bovine skeletal muscle satellite cell proliferation and ... microRNA-128 regulates the proliferation and differentiation of bovine skeletal muscle satellite cells by repressing Sp1. ...https://link.springer.com/article/10.1007%2Fs11010-016-2656-7
Satellite cells in human skeletal muscle : molecular identification quantification and function
... muscle fibre growth and muscle fibre damage and repair.. Keyword. Skeletal muscle satellite cells, Myogenic regulatory factors ... and that the satellite cells are key cells in the regeneration and growth of muscle fibres. Satellite cells are closely ... Skeletal muscle satellite cells located between the plasma membrane and the basal lamina of muscle fibres, could for many years ... satellite cell markers, NCAM, Pax7, MyoD, myogenin, DLK1/FA1, c-Met, human skeletal muscle, immunohistochemistry, muscle growth ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:278182
Nutrients | Free Full-Text | Neonatal Phosphate Nutrition Alters in Vivo and in Vitro Satellite Cell Activity in Pigs
At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured ... deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains ... In vivo satellite cell proliferation was reduced (P , 0.05) among the PO4 deficient pigs, and these cells had altered in vitro ... Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing ...http://www.mdpi.com/2072-6643/4/6/436/xml
Autologous satellite cell seeding improves in vivo biocompatibility of homologous muscle acellular matrix implants
... that co-culture with autologous satellite cells can improve the efficiency of homologous acellular matrix as skeletal muscle ... Autologous satellite cell seeding improves in vivo biocompatibility of homologous muscle acellular matrix implants. *Authors: * ... Satellite cells, isolated from rat dorsal muscle, were cultured in vitro on homologous acellular matrix obtained by detergent- ... Patches of homologous matrix, seeded or not with autologous satellite cells, were implanted in the dorsal muscle of rats. At ...https://www.spandidos-publications.com/ijmm/10/2/177
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle | Development
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle Message Subject (Your Name) has sent you a message from ... Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. John J. McCarthy, Jyothi Mula, Mitsunori Miyazaki, Rod ... Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. John J. McCarthy, Jyothi Mula, Mitsunori Miyazaki, Rod ... Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. John J. McCarthy, Jyothi Mula, Mitsunori Miyazaki, Rod ...http://dev.biologists.org/content/138/17/3657.article-info
International team discovers gene associated with epilepsy
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue ... NASA's Swift satellite detected the strongest, hottest, and longest-lasting sequence of stellar flares ever seen from a nearby ... severe muscle spasms and loss of consciousness. The seizures may not have lasting effects but can affect activities, such as ... In epilepsy, nerve cells in the brain signal abnormally and cause repeated seizures that can include strange sensations, ...http://www.innovations-report.com/html/reports/life-sciences/international-team-discovers-gene-epilepsy-122742.html
Muscular Dystrophy: Stem Cell Therapy - PDF
Muscle satellite cells recruit nonspecific cells to fuse and differentiate into the new muscle fibers, so muscle satellite ... Skeletal muscles Symptoms Myotonia Sustained muscle contraction (myotonia) is a distinctive aspect of myotonic dystrophy. The ... Stem Cells. Part 1: What is a Stem Cell? Stem Cells Part 1: What is a Stem Cell? Stem cells differ from other kinds of cells in ... Stem Cell Quick Guide: Stem Cell Basics Stem Cell Quick Guide: Stem Cell Basics What is a Stem Cell? Stem cells are the ...http://docplayer.net/19549816-Muscular-dystrophy-stem-cell-therapy.html
Muscle atrophy - Wikipedia
... "satellite cells" which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of ... Muscle atrophy is defined as a decrease in the mass of the muscle; it can be a partial or complete wasting away of muscle, and ... Inactivity and starvation in mammals lead to atrophy of skeletal muscle, accompanied by a smaller number and size of the muscle ... Other syndromes or conditions which can induce skeletal muscle atrophy are liver disease, and starvation. Muscle atrophy occurs ...https://en.wikipedia.org/wiki/Muscle_atrophy