STAT6 protein also regulates other transcription factor as Gata3, which is important regulator of Th2 differentiation. STAT6 is ... Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and ... STAT6+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by ...
STAT6 Transcription Factor / analysis * Trans-Activators / genetics * Transcription Factors * Transcriptional Coactivator with ... Another useful discovery was that the NAB2-STAT6 fusion is characteristic of solitary fibrous tumors. This led to development ... STAT6; Sarcomatoid; Solitary fibrous tumor; WWTR1-CAMTA1; p16; β-catenin. ... of a STAT6 antibody that is a reliable immunohistochemical marker for solitary fibrous tumors. Genetic studies also led to the ...
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper ... transcription factors such GATA-3 and STAT-6 have a major influence on Th2 differentiation and are necessary for expression of ... C) Representative blot showing phosphorylation of STAT-6 on tyrosine groups (p-Tyr-STAT-6) (top blot) and total STAT-6 (bottom ... The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell1997;89:587-96 ...
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ... The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest ( ... Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell- ... Th1 differentiation is initiated and stabilized by transcription factors signal transducer and activator of transcription (STAT ...
... and is controlled by distinct transcription factors (e.g. GATA-3, IRF4, PU.1, STAT6). Th9 polarized cells are present in low ... Intracellular markers include transcription factors that control CD4+ T cell differentiation as well as signature cytokines as ...
Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions. Genetics and ... Rajasundaram, D.; Selbig, J.; Persson, S.; Klie, S.: Co-ordination and divergence of cell-specific transcription and ...
Of note, STAT-6 also promotes the expression to other transcription factors such as peroxisome proliferator-activated receptor ... 13 signaling in AAMs results in the activation of the transcription factor signal transducer and activator of transcription ( ... STAT-6: signal transducer and activator of transcription 6; Mrc1: mannose receptor (CD206); Arg1: arginase 1; Chil3: chitinase- ... PPAR-) γ, Krüppel-like factor (KLF) 4, or interferon regulatory factor (IRF) 4. Upon polarization, AAMs upregulate the gene ...
... independently of well-established transcription factors. In the presence of NAD+, the frequency of T-bet−/− CD4+IFNγ+ T cells ... The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12, 450-459 (2011). ... For real-time PCR reactions, T-bet (Mm00450960_m1), GATA3 (Mm00484683_m1), STAT5a (Mm03053818_s1), STAT6 (Mm00447411_m1), RORγt ... More importantly, T-bet and GATA3, two transcription factors that regulate CD4+ T cell Th1/Th2 fate decision were downregulated ...
Czimmerer Z, Daniel B, Horvath A. The transcription factor STAT6 mediates direct repression of inflammatory enhancers and lmits ... PARP14 is in part regulated by STAT6 as STAT6 activation induces a switch in PARP14 from a repressor to a promoter of STAT6 ... Figure 6.Staining of tissue factor-positive macrophages in sections of colon carcinoma. (A) Tissue factor (TF) (red) and CD206 ... Figure 2.Tissue factor-specific mRNA induction by alternative polarization. (A) Tissue factor (TF) mRNA levels at the indicated ...
On the other side, promoter-associated HERV cCREs are present adjacent to (in a 200 bp window) the transcription start sites of ... STAT3 and STAT6) and IRF (including IRF3 and IRF8) families. The top-10 enriched factors also include SPI1 and JUN factors ( ... The core HERV network also include binding sites for transcription factors of the STAT family and enriched pathways of IL-6/JAK ... HERVs contain in their LTRs a rich repertoire of transcription factor binding sites that may be common in different elements or ...
... but anaphylactic effects in mice depend on IL-4Rα-dependent IL-4/IL-13 activation of the transcription factor, STAT-6 (signal ... Risk factors. As mentioned above, atopy is a risk factor for anaphylaxis. In the Rochester Epidemiology Project, 53% of the ... Asthma is a risk factor for fatal anaphylaxis. Delayed administration of epinephrine is also a risk factor for fatal outcomes. ... Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med. 2008 Jan 3. 358(1):28-35. [QxMD MEDLINE ...
... is a complex process that involves STAT-6-mediated signal transduction and the activation of a variety of transcription factors ... allowing transcription factors and RNA polymerase II to bind and increase gene transcription (15, 16). This process is mediated ... Differentiation into Th2 cells occurs via a pathway that involves STAT-6, GATA-3, nuclear factor of activated T cells-c (NFATc ... and the T-bet transcription factor (1, 3). In the presence of CD8α- DCs and/or IL-4 (which can come from IgE-activated mast ...
Crucial DEGs, Bcl3, ADGRG7, FABP4, VCAN, and IRF4 were regulated by miRNAs, miR-497, miR-574, miR-138 and TFs, CCDN1, STAT6, ... Interferon regulatory factor 8) and BATF (Basic Leucine Zipper ATF-Like Transcription Factor) are very crucial in developing ... Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. PLoS One 2020;15: ... 3.3 Identification of transcription factors and miRNAs binding to DEGs. The Enrichr webtool [13] was exploited to extract miRNA ...
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) ... STAT6). FASEB J. 2015 Jan; 29 (1):152-63 Epub 2014 Oct 28 View PubMed ... The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor beta-induced gene expression ... The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-kappaB positive feedback loop in peripheral T-cell ...
This is a "connection" page, showing publications Alan Leff has written about STAT6 Transcription Factor. ... Publication scores are based on many factors, including how long ago they were written and whether the person is a first or ...
Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig ... Role of the transcription factor Ikaros in development of autoimmune disease. NIH R01AI127709Jun 15, 2018 - May 31, 2023. Role ... Role of the transcription factor Ikaros in development of autoimmune disease. The Journal of Immunology. 2016 May 1; 196(1_ ... Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. Chan LN, Chen Z, ...
订购磷酸化 STAT6 (Thr645) 抗体,可应用于免疫印迹,免疫组化,免疫荧光/细胞化学,免疫沉淀检测,可与人,小 ... Stat6; STAT6_HUMAN; STAT6B; STAT6C; Transcription factor IL 4 STAT; ... STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the ... Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and
STAT6 Transcription Factor 93% * Cell Nucleus Active Transport 70% * Transcription 69% * Macrophage Activation 68% ... Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophages. Kim, J. K., Han, S. B., Park ... Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. Hecht, V. C., Sullivan, L. B., Kimmerling, R ... In Situ Blood Vessel Regeneration Using SP (Substance P) and SDF (Stromal Cell-Derived Factor)-1α Peptide Eluting Vascular ...
STAT6 Transcription Factor 100% * Peroxisome Proliferator-Activated Receptors 77% * ATP-Binding Cassette Transporters 76% ... Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Kong, K. H., Oh, H. J., Lim, B ... Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR-γ expression and activation in macrophages. Kim, M. J., Lee, Y ... Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute ...
STAT6 Transcription Factor / genetics ... Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor- ... STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / metabolism; Signal ... STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / immunology; Signal ... Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / immunology; Transforming Growth Factor beta1 / ...
GATA3, along with other transcription factors, STAT6, STAT5 and c-MAF, induce the transcription of IL4, IL5 and IL13. GATA3 is ... GATA3, along with other transcription factors, STAT6, STAT5 and c-MAF, induce the transcription of IL4, IL5 and IL13. GATA3 is ... The size of the lumen can also be affected by a variety of factors,including the transcription factor CCAAT/enhancer binding ... The balance between different members of the nuclear factor of activated T-cells (NFAT) family of transcription factors also ...
... knockout of the prototypical M2 marker arginase 1 in IM and deletion of the M2-associated transcription factor STAT6 were not ...
STAT6 antibody for detecting human signal transducer and activator of transcription 6. Validated on up to 12 cell lysates for ... STAT6) also known as interleukin 4-induced and transcription factor IL-4 STAT. Encoded by the STAT6 gene, signal transducer and ... Mouse anti STAT6. Product Type. PrecisionAb Monoclonal. Isotype. IgG1. Format. Purified. Specificity. STAT6. Quick Links:. * ... GO:0003700 sequence-specific DNA binding transcription factor activity GO:0005829 cytosol GO:0004871 signal transducer activity ...
... signal transducer and activator of transcription 6) is a member of the STAT family of cytoplasmic transcription factors, which ... STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of cytoplasmic transcription factors ... Recently, STAT6 has received considerable attention in the area of tumor growth and metastasis. Significantly higher STAT6 ... STAT6 is composed of a DNA-binding domain, a C-terminal transcriptional activation domain, and a SH2 domain. STAT signaling is ...
Evaluating the prognostic value and functional roles of transcription factor AP4 in colorectal cancer. Jie Yang, Jin‑Ping Ma, ... Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/ ...
Anemia, Animals, Erythropoiesis, Humans, Interleukins, Malaria, STAT6 Transcription Factor, Tumor Necrosis Factor-alpha ...
STAT6 Transcription Factor. *Stem Cells. *Stroke Volume. *Time Factors. *Trachea. *Truth Disclosure ...