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*  Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4
The transcription factors interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) ... The genomic regions bound by the transcription complexes mediated by IRF5 and STAT4 were examined for transcription factor ... By participating in transcription complex with other co-factors, IRF5 and STAT4 harbour the potential of regulating a large ... Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:543452
*  Interleukin Receptors - Interleukin Receptor Summary Report | CureHunter
STAT4 Transcription Factor Related Therapies and Procedures. 1. Axotomy CureHunter Inc. provides medical information and ... 08/01/2008 - "This review summarizes some of the most recent research concerning the use of tumor necrosis factor alpha ... have shown promising results in the treatment of both acute and chronic lumbar radicular pain with tumor necrosis factor alpha ...
  http://www.curehunter.com/public/keywordSummaryD018123.do
*  T helper cell - Wikipedia
The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... "Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... The key Th2 transcription factors are STAT6 and GATA3.[10] IL-4 is the positive feedback cytokine for Th2 cells differentiation ... The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to ...
  https://en.m.wikipedia.org/wiki/T_helper_cell
*  JCI Insight - Monocyte dysregulation and systemic inflammation during pediatric falciparum malaria
... and transcription factors (HIF1A, STAT4) (62). In contrast to the functional changes characteristic of monocyte tolerance, ... and underexpression of the transcription factors HIF1A and STAT4. It is important to take into account the underlying health ... systemic inflammatory factors as well as local factors in the bone marrow may provide signals that lead to an increased ... These systemic inflammatory factors are likely produced by several different cell types, including monocytes, neutrophils, and ...
  https://insight.jci.org/articles/view/95352
*  Correlations between Psoriasis and Inflammatory Bowel Diseases
Both IL-23 and IL-12 can activate the transcription factor STAT4 and stimulate the production of IFN-γ. Unlike IL-12, which ... This protein mediates the activation of nuclear factor κB (NF-κB), upon binding to muramyl dipeptide (MDP: minimum essential ... N. Manel, D. Unutmaz, and D. R. Littman, "The differentiation of human TH-17 cells requires transforming growth factor-β and ... An altered recruitment and/or function of T-regs can be an important pathogenetic factor in skin diseases, although the exact ...
  https://www.hindawi.com/journals/bmri/2013/983902/
*  Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease | Haematologica
Inhibition of transcriptions factors such as Tbet and STAT4 represent key molecular targets for the treatment of autoimmune ... These results suggested that deficiency of Th1-cell signaling (IFN-γR) or transcription factors (STAT1, STAT4) directly ... We evaluated key Th1 transcription factors, including STAT1 and STAT4, in modulating chronic GvHD.11 ... and Th17-driving transcription factors allows FoxP3+ Treg reconstitution and prevents acute GvHD.3,4 However, transcription ...
  http://www.haematologica.org/content/102/8/1446
*  Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice | The...
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 114: 4721-4728. ... Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity 32: ... p-STAT4 Alexa488 (38/p-Stat4), p-STAT5 Alexa488, and p-STAT6 Alexa488 (18/P-Stat6), all from BD Biosciences. Phosphorylation of ...
  http://www.jimmunol.org/content/188/12/6145?ijkey=81f9c302b61463b09697a2b564ac486a90e2ba81&keytype2=tf_ipsecsha
*  The AMEDEO Literature Guide
Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the ... Body mass index ,/=23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report.. PLoS One. 2018; ... The willingness of Saudi men with type 2 diabetes to discuss erectile dysfunction with their physicians and the factors that ... Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a ...
  https://amedeo.com/medicine/diab/diab8.htm
*  JCI - Welcome
The vitamin D receptor (VDR) is a transcription factor that mediates the actions of its ligand, 1,25-dihydroxyvitamin D3 [1,25( ... Antigen-stimulated spleen cells from VDR KO mice showed an impaired Th1 cell response and had decreased expression of STAT4, a ... Th1 cell transcription factor. These results demonstrate the absolute requirement of VDR for 1,25(OH)2D3-induced monocyte/ ... Thymocyte emigration is mediated by active movement away from stroma-derived factors. ...
  https://www.jci.org/tags/25?content=articles&page=69
*  STAT4 - Wikipedia
Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family. It ... STAT4 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH). ... homodimerizes via its SH2 domain and translocates into nucleus to activate gene transcription. STAT4 binds to hundreds of sites ... Distribution of STAT4 is restricted to myeloid cells, thymus and testis. In resting human T cells it is expressed at very low ...
  https://en.wikipedia.org/wiki/STAT4
*  Arthritis Research & Therapy | Articles
Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding ... 4.269 - 2-year Impact Factor. 4.668 - 5-year Impact Factor. 1.329 - Source Normalized Impact per Paper (SNIP). 2.154 - SCImago ... Among the environmental factors, smoking ha... Authors: Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira ... Factors associated with physicians' prescriptions for rheumatoid arthritis drugs not filled by patients This study estimated ...
  https://arthritis-research.biomedcentral.com/articles?searchType=journalSearch&sort=PubDate&page=4
*  SCOP: Class: All alpha proteins
Transcription factor STAT-4 N-domain [48091] (1) multihelical; can be divided into two subdomains *TerB-like [158681] (1) ... Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1) 4 helices; bundle, closed, right-handed twist *Ectatomin ... A DNA-binding domain in eukaryotic transcription factors [47453] (1) 4 helices; the long C-terminal helix protrudes from the ... Triger factor/SurA peptide-binding domain-like [109997] (1) multihelical; irregular array of long and short helices *DNA ...
  http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.b.html
*  XRCC5 VNTR, XRCC6 -61C|G, and XRCC7 6721G|T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case...
... transcription factor II-I; STAT4 = signal transducer and activator of transcription 4; c-Ets-1 = c-E-twenty-six-1; E2F-1 = E2F ... transcription factor 1; GR-beta = glucocorticoid receptor-beta; GCF = GC factor; NF-kappaB = nuclear factor-kappaB; RelA = v- ... Figure 4: Potential binding sites for transcription factors of 1R, 2R, and 3R tandem repeat elements of the XRCC5 VNTR: XBP-1 ... K. S. El-Darwish, M. Parvinen, and J. Toppari, "Differential expression of members of the E2F family of transcription factors ...
  https://www.hindawi.com/journals/ije/2017/4795076/
*  Immunopathogenesis of psoriasis - Sabat - 2007 - Experimental Dermatology - Wiley Online Library
... they are polarized into Th1 cells through activation of the transcription factors STAT4 and T-bet. The generation of Th1 cells ... If IL-4 is present, naïve T cells are polarized into Th2 cells through activation of the transcription factors STAT6 and GATA-3 ... Malkani A K, Baker B S, Garioch J J et al. Normal response to tumor necrosis factor-alpha and transforming growth factor-beta ... Pincelli C, Sevignani C, Manfredini R et al. Expression and function of nerve growth factor and nerve growth factor receptor on ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00629.x/full
*  Anti-STAT4 Antibody (C-Terminus) for IHC, WB/Western, IP LS-C51706
... and rat STAT4. Validated for IHC-frozen, immunoprecipitation, and western blot. ... STAT4 antibody LS-C51706 is an immunoaffinity-purified rabbit polyclonal that binds the C-terminus of human, mouse, ... STAT4 Antibody, SLEB11 Antibody. Description:. STAT4 is a member of the STAT family of transcription factors. In response to ... Most Popular STAT4 Antibodies. Anti-STAT4 Antibody (N-Terminus) IHC-plus™ LS-B1904 ...
  https://www.lsbio.com/antibodies/anti-stat4-antibody-c-terminus-ihc-ip-wb-western-ls-c51706/52060
*  Julia Fridman Simard, ScD | Stanford Medicine Profiles
... in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism ( ... Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect ... traditional risk factors do not capture the main underlying risk factors for CVM in SLE. Rather, cystatin C levels, ... Perinatal factors and adult-onset lupus 40th Annual Meeting of the Society-for-Epidemiologic-Research Simard, J. F., Karlson, E ...
  https://med.stanford.edu/profiles/julia-simard?tab=bio
*  Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
The transcription factor STAT4 (signal transducer and activator of transcription 4) is an important element in mediating IL-12 ... Here we show that IL-12 induces STAT4 phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 ... and are required for STAT4 full transcriptional activity induced by IL-12, establishing the MKK6/p38alpha/STAT4 pathway as an ... STAT4 is inducibly phosphorylated on tyrosine and serine in response to IL-12, but the kinase(s) responsible for the latter ...
  http://www.uniprot.org/citations/10961885
*  The Treg/Th17 Paradigm in Lung Cancer
The key transcription factors driving Th1 cell differentiation are T-bet, STAT-1, and STAT-4, whereas the transcription factors ... as critical transcription factors [71]. STAT3 regulates IL-6-induced expression of RORgt and RORa and IL-17 production [72]. In ... which express the forkhead lineage-specific transcription factor FoxP3 protein. TGF-. 1 together with IL-2 is also needed for ... were regulatory T cells as they express high levels of Foxp3 transcription factor and CTLA-4. Moreover, pleural CD4+CD25+ T ...
  https://www.hindawi.com/journals/jir/2014/730380/
*  A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus...
... in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism ( ... Results The STAT4 risk allele was more frequent in patients with SLE with previous arterial events (combined OR (ORc)=1.5, 95% ... A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus ... A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus ...
  http://ard.bmj.com/content/69/5/834
*  Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with...
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ... Here, we show that an intronic UNC13D regulatory sequence, bound by transcription factors ELF1 and STAT4, represents an ... Predicted transcription factor binding sites are labeled, and the location of the c.118-308C,T mutation is marked in red. ... We used transcription factor binding prediction software (Heinemeyer et al., 1998) to identify potential binding sites within ...
  http://jem.rupress.org/content/211/6/1079
*  Dual Roles of IL-27 in Cancer Biology and Immunotherapy
In the C26 model, the Th1-related transcription factor T-bet, but not STAT4, was strictly required for IL-27 antitumor activity ... which is the Th2-specific transcription factor that impairs Th1 development by downregulation of STAT4, in murine CD4+ T cells ... The IFN-inducible transcription factor BST-2 was required for APOBEC-3 gene activation by IL-27, in a similar fashion as IFN-γ ... C. Pot, H. Jin, A. Awasthi et al., "Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the ...
  https://www.hindawi.com/journals/mi/2017/3958069/
*  Genetic Regulator for Coronary Artery Smooth Muscle Cells Identified
They screened 54 different transcription factors and found that one, known as STAT4, was 10 times higher in the white carneau ... The group's aim was to see if certain transcription factors might be found in altered amounts in the smooth muscle cells of ... "Interfering with these factors and the signaling pathways involving STAT4 may be potentially important in atherosclerosis ... He said that by finding the transcription factor, researchers can concentrate on modifying its pathway, and won't need to know ...
  http://www.rxpgnews.com/research/cardiology/coronaryarterydisease/printer_4754.shtml
*  Targeting T cells in Chronic Inflammatory Bowel Diseases | OMICS International
... and T-bet and Stat4, two transcription factors that promote Th1 cell responses [60,61]. In both CD and UC there is also high ... 2002) The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med ... 2005) Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. ... 2000) Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates ...
  https://www.omicsonline.org/targeting-t-cells-in-chronic-inflammatory-bowel-diseases-2155-9899.1000155.php?aid=15993
*  anti-IL12RB2 Primary Antibodies
Signaling through the IL-35 receptor required the transcription factors STAT1 (zeige STAT1 Antikörper) and STAT4 (zeige STAT4 ... and STAT4 (zeige STAT4 Antikörper) and an increase in IL-4 (zeige IL4 Antikörper) in natural killer cells ... activation helped ensure that Treg cells do not readily complete STAT4 (zeige STAT4 Antikörper)-dependent Th1 (zeige HAND1 ... The effects of rs3762315 and rs3762316 single nucleotide polymorphisms in 5' flanking region on IL12RB2 transcription ...
  https://www.antikoerper-online.de/jak-stat-signalweg-pathway-6/il12rb2-antibody-7534/
*  Frontiers | Role of Transcription Factors in Peripheral Nerve Regeneration | Frontiers in Molecular Neuroscience
Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2012.00008/full