Spinal IL-33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade
STAT3 Transcription Factor * Stat3 protein, mouse * Gastrin-Releasing Peptide * Jak2 protein, mouse ... the activation of astrocytes and increased phosphorylation of signal transducer and activator of transcription 3 (STAT3) were ... Spinal IL-33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade Glia. 2019 Sep;67(9):1680- ... Our results indicate that the spinal IL-33/ST2 signaling pathway contributes to chronic itch via astrocytic JAK2-STAT3 cascade ...
IJMS | Free Full-Text | Th17 Cells as Potential Probiotic Therapeutic Targets in Inflammatory Bowel Diseases
... transcription factor STAT3 has been reported to regulate the expression of the transcription factor RORγt, which is critical in ... downregulation of Th17 cell transcription factors retinoic-acid-related orphan receptor (ROR)γt, STAT3, and nuclear factor (NF ... Down-Regulation of Th17 Cell Transcription Factors RORγt, STAT3, and NF-ĸB. Retinoic-acid-related orphan receptors (RORγt), has ... TGF-β regulates Th17 differentiation by actiβating transcription factor signal transducer for transcriptor 3 (STAT3) [86]. ...
Transcription factor Stat3 directs self‐renewal of pluripotent mouse embryonic stem (ES) - Engineering a Therapeutic Lectin by...
Transcription factor Stat3 directs self‐renewal of pluripotent mouse embryonic stem (ES). * Post author By admin ... Transcription factor Stat3 directs self‐renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine ... No Comments on Transcription factor Stat3 directs self‐renewal of pluripotent mouse embryonic stem (ES) ... Physique 2 Stat3 regulates directly the mitochondrial DNA To examine further whether Stat3 could directly regulate ...
Regional differentiation - Wikipedia
β-catenin activates the transcription factor stat3. Stat3 coordinates cell movements during gastrulation and contributes to ... These transcription factors regulate other transcription factors, cell surface molecules with roles in cell adhesion, and other ... VegT acts as a transcription factor to activate genes specifying endodermal fate while Vg1 acts as a paracrine factor. β- ... Bicoid functions as a graded morphogen transcription factor that localizes to the nucleus. The head of the embryo forms at the ...
The molecular basis of IL-21-mediated proliferation
STAT1 Transcription Factor / metabolism * STAT3 Transcription Factor / genetics * STAT3 Transcription Factor / metabolism ... Y510 efficiently mediated IL-21-induced phosphorylation of Stat1 and Stat3, but not of Stat5, and CD8(+) T cells from Stat1/ ... Stat3 double knock-out mice exhibited decreased proliferation in response to IL-21 + IL-15. In addition, IL-21 weakly induced ...
Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis...
A significant reduction in STAT3 phosphorylation and a decrease in the number of Th17 cells were observed with RGE treatment. ... the first evidence that RGE can regulate Th17 and reciprocally promote Treg cells by inhibiting the phosphorylation of STAT3. ... Nrf2 is a transcription factor, activating upon the exposure to ROS. Expression of Nrf2 and HO-1 suppressed regulation of ... we investigated whether RGE could suppress STAT3 phosphorylation, and discovered that phosphorylation of STAT3 was decreased in ...
Recombinant Anti-STAT3 antibody [EPR787Y] KO Tested (ab68153) | Abcam
Knockout Tested Rabbit recombinant monoclonal STAT3 antibody [EPR787Y]. Validated in WB, IHC, ICC/IF, Flow Cyt (Intra), ChIC/ ... Signal transducer and activator of transcription 3 (acute phase response factor) antibody ... All lanes : Anti-STAT3 antibody [EPR787Y] (ab68153) at 1/1000 dilution. Lane 1 : Wild-type HeLa cell lysate. Lane 2 : STAT3 ... The band was not seen in STAT3 knockout HAP1 cells. Wild-type and STAT3 knockout samples were subjected to SDS-PAGE. Ab68153 ...
Biblio | Page 2 | Linus Pauling Institute | Oregon State University
STAT3 Transcription Factor. Wang R, Yu Z, Sunchu B, Shoaf J, Dang I, Zhao S, Caples K, Bradley L, Beaver LM, Ho E et al.. 2017 ... NF-E2-Related Factor 2. Wang R, Sunchu B, Perez VI. 2017. Rapamycin and the inhibition of the secretory phenotype.. Exp ...
A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and...
... which induces TME-secreting factors such as TNF, IL-1, CCL2, and CXCL8; and activates transcription factors of NF-Κb, Stat-3, ... StemLight™ Pluripotency Transcription Factor Antibody Kit (9093T) and Hippo Signaling antibody sampler kit (8579T) was from ... For example, TGF-β activates noncanonical SHH signaling by increasing the expression of hedgehog transcription factor GLI2 in ... Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor ...
Biblio | Linus Pauling Institute | Oregon State University
STAT3 Transcription Factor. Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, ... Filters: Author is Kang, Y and Keyword is STAT3 Transcription Factor [Clear All Filters] ... HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.. Cell Death Dis. 5:e1476. ...
Blog - Governing the Fate of Stem Cells With Transcription Factors
Transcription factors have crucial roles in stem cell biology and differentiation. Research in these fields has broad ... STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular ... Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. Their unique ... Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. ...
Jia Zhou, PhD
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers, 2014, 6, 926-957. PMID: 24743778. ... transcription factors as well as epigenetic therapy with the aid of molecular docking and chemical synthesis. Specifically, we ... an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3). Eur. J. Med. ... Targeting Krüppel-Like Factor 5 (KLF5) for Cancer Therapy. Curr. Top. Med. Chem., 2015, 15 (8), 699-713. PMID: 25732792. [Cover ...
Molecules | Free Full-Text | Molecular Docking and Structure-Based Drug Design Strategies
STAT3 disarticulates the correct expression of transcription factors, cell cycle regulators and angiogenesis factors, inducing ... Signal transducers and transcription activators (STATs) are transcription factors activated by phosphorylation and dimerization ... STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proc. Natl ... Figure 10. (A) Structure of STAT3-β in complex with DNA (PDB 1BG1, 2.25 Å). The protein backbone is in cartoon representation ( ...
Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression
SRY-box transcription factor 2; SRSF1: Serine and arginine-rich splicing factor 1; STAT3: Signal transducer and activator of ... MALAT1 increases PI3KCA, AKT and STAT3 activity, promoting resistance to cisplatin. Dai et al[35]. ... Epidermal growth factor-like domain-containing protein 7; ERBB3: Erb-b2 receptor tyrosine kinase 3; ERK: Extracellular signal- ... insulin like growth factor 1 receptor; IL-21R: Interleukin 21 receptor; MALAT1: Metastasis-associated lung adenocarcinoma ...
Frontiers | Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 32(5):605 ... The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest ( ... Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell- ... Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper ...
In Vitro Activation of Stat3 by Epidermal Growth Factor Receptor Kinase - Daniel Nathans - Profiles in Science
Transcription Factors and STAT3 Transcription Factor Format:. Text Extent:. 5 pages Language:. English Legacy Source Citation: ... In Vitro Activation of Stat3 by Epidermal Growth Factor Receptor Kinase Creator:. Schaefer, Timothy S.. Park, Ohkmae K.. ... In Vitro Activation of Stat3 by Epidermal Growth Factor Receptor Kinase. Proceedings of the National Academy of Sciences of ...
Pyogenic Granuloma (Lobular Capillary Hemangioma): Background, Pathophysiology, Etiology
The overexpression of transcription factors P-ATF2 and STAT3 also may play a role in tumorigenesis. [2] Endothelial nitric ... If a clear provoking traumatic factor is causing the pyogenic granuloma, it should be avoided. Instruct patients to avoid ... Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol. 2008 Aug. 35( ... Herpes simplex virus type-I and pyogenic granuloma: a vascular endothelial growth factor-mediated association?. Case Rep ...
Ivy Foundation funds MD Anderson brain cancer study
STAT3 is a type of transcription factor. In humans it is encoded by the STAT3 gene. By shutting down STAT3, researchers hope to ... Transcription factor STAT3 (which stands for signal transducer and activator of transcription 3) has been found to play a key ... The transcription factor STAT3 (signal transducer and activator of transcription 3) plays a key role in the development and ... A transcription factor is a protein that binds to specific DNA sequences and controls the rate of the transcription of genetic ...
Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals (Review)
... growth factor receptor-bound protein 2; Stat3, signal transducer and activation of transcription-3; PI3K, phosphoinositide 3- ... Hepatocyte growth factor (HGF). HGF was cloned as a growth factor for hepatocytes (1,2), is identical to scatter factor (SF) ... hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) (9). By contrast, transforming growth factor (TGF)-β1 was ... Ishikawa T, Factor VM, Marquardt JU, Raggi C, Seo D, Kitade M, Conner EA and Thorgeirsson SS: Hepatocyte growth factor/c-met ...
JCI - CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem. 2014;289(23): ... Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase ... of IL-10 gene expression but also that several known targets that can be regulated by the STAT3 transcription factor. Notably, ... STAT3 reporter gene assay. Dose-response activity to determine IC50 at 8 different doses in triplicate was used in a STAT3 ...
Demyelination induces transcriptional reprograming in proprioceptive and Aβ rapidly adapting low-threshold-mechanoreceptor...
... the transcription factor STAT3 (Benito et al., 2017), by chromatin modifications (Ma and Svaren, 2018) and by Merlin (Mindos et ... In sensory neurons, this reprograming depends on the early transcription factor ATF3 (Renthal et al., 2020). Upon completion of ... This transcriptional reprograming is controlled mainly by the early transcription factors c-Jun (Arthur-Farraj et al., 2012), ... Benito, C., Davis, C.M., Gomez-Sanchez, J.A., Turmaine, M., Meijer, D., Poli, V., Mirsky, R., and Jessen, K.R. (2017). STAT3 ...
Plus it
2000) Occurrence of a transcription factor, signal transducer and activators of transcription 3 (STAT3) in the postsynaptic ... A, EPO stimulation of neurons does not activate the transcription factors STAT1, STAT3, and STAT5, as assessed by fEMSA. Shown ... In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor ... The expression of EPO is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) (Semenza, 2000). Recent ...
Gudmundur GUDMUNDSSON | Professor (Full) of Cell Biology | Doctor of Philosophy | University of Iceland, Reykjavík | HI |...
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors ... Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages ... Several factors in breast milk are known to confer immune protection, but whic... ... Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines ...
Green tea extract attenuates LPS-induced retinal inflammation in rats | Scientific Reports
... probably through its potent anti-oxidative property and a receptor-mediated action on transcription factors that regulate ... These anti-inflammatory effects were associated with a reduced phosphorylation of STAT3 and NF-κB in the retina. Furthermore, ... STAT3 is a transcription factor activated by tyrosine kinases. The phosphorylated STAT3 forms dimers and translocate into the ... Band intensities of p-STAT3 was normalized to total-STAT3 with Gene Tools from Syngene software. ...
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NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte...
2017). Key signaling pathways and transcription factors are closely related to astrocyte activation, including JAK/STAT3 and ... such as transforming growth factor-alpha (TGF-a), interleukin-6 (IL-6), Clq, interleukin-1a (IL-1a), and tumor necrosis factor ... Genes involved in key signaling processes after stroke, including Il-10, Il-12, Hmgb1, Il-13, p38 MAPK, HIF1α, Stat3, and Il-4 ... Reverse Transcription. One microgram of total RNA was reverse-transcribed per sample into first-strand complementary DNA (cDNA ...
Oncogenic Pathways and Iron Phenotypes in Breast Cancer | American University, Washington, DC
Frontiers | Prior Hypoxia Exposure Enhances Murine Microglial Inflammatory Gene Expression in vitro Without Concomitant H3K4me3...
NF-κB; Stat3 was the top transcription factor identified by MAGICTRICKS as the most common factor involved in regulating the Hx ... B) Cumulative distribution functions for the transcription factors Stat3 (left) and NF-κB (right). (C) Target genes for Stat3 ... MAGICTRICKS Reveals Multiple Transcription Factors That Putatively Regulate Hx Primed Genes. Since changes in H3K4me3 do not ... Putative transcription factors and cofactors driving gene expression changes were identified using MAGICTRICKS (Roopra, 2019). ...
T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis | Diabetes ...
Insulin-induced phosphatidylinositol 3-kinase (PI3K)/Akt signaling and interleukin-6 (IL-6)-instigated JAK/STAT3-signaling ... The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression ... while repressing the inhibitory effects of STAT3 (45,46). In particular, STAT3 deacetylation by sirtuin-1 coincides with STAT3 ... Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of ...