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*  Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-kappa B) complexes by antibody...
... studies showed that transcription factor IFN-alpha-activated factor (AAF), IFN-stimulated gene factor 3 (ISGF3), and nuclear ... The suppression of antiviral transcription factor complexes was shown to depend on replicating virus and was not simply a ... and IFN regulatory factor 1 (IRF-1), as well as for IFN-inducible protein 10 (IP-10) and IFN-beta; the transcription of a ... ablated or diminished message for tumor necrosis factor alpha (TNF-alpha), nitric-oxide synthase 2 (NOS2), ...
  https://www.semanticscholar.org/paper/Suppression-of-lipopolysaccharide-induced-antiviral-Mahalingam-Lidbury/03ff79f01621588c38ca32818d8418413ee39866
*  Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors....
Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors ... Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors ... RESULTS: HRPE cells constitutively expressed two members of the IFN regulatory factor (IRF) family of transcription factors, ... Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors ...
  https://iovs.arvojournals.org/article.aspx?articleid=2162065
*  Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1 | Molecular Pharmacology
Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1. Vivian W. Y. Lui, Amanda L. ... Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1. Vivian W. Y. Lui, Amanda L. ... Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1. Vivian W. Y. Lui, Amanda L. ... Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1 ...
  http://molpharm.aspetjournals.org/content/early/2007/02/26/mol.106.032284.1
*  Publikationen - KNHI
Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus - adenovirus receptor during viral ... Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac ... Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation. Eur J med Genet, 2010 ... Lack of association between insulin-like growth factor-1 or insulin-like growth factor-binding protein-3 and left ventricular ...
  http://knhi.de/research/publications/
*  Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma | PNAS
S30). Notably, signal transducer and activator of transcription 1 (STAT1), an anticarcinogenic transcription factor (28), is ... targeting a certain transcription factor (reporter transcription factors). For each directionality class (up-, down-, or mixed ... In addition, a potential activation of STAT1 transcription factor was associated only with ccRCC. Such activation would trigger ... Apart from VHL loss-mediated stabilization of HIF, other transcription factors may be triggered only in ccRCC, thus shedding ...
  https://www.pnas.org/content/111/9/E866
*  C/EBPδ overexpression decreases BIM expression and par | Open-i
... transcription factors. To this end, we presently evaluated the role of the transcription factor CCAAT/enhancer binding protein ... 10 and CCL20 in β-cells by hampering IRF-1 up-regulation and increasing STAT1 activation in response to cytokines. These ... transcription factors. To this end, we presently evaluated the role of the transcription factor CCAAT/enhancer binding protein ... The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3275575_pone.0031062.g007&req=4
*  ZFIN Publication: Song et al., 2011
STAT1 Transcription Factor/genetics; STAT1 Transcription Factor/metabolism*; Synteny/genetics; Zebrafish/embryology*; Zebrafish ... Stat1α, Stat1β, hematopoiesis, myeloid, granulocyte, zebrafish. MeSH Terms:. Animals; Biomarkers/metabolism; Cell Lineage; Gene ... Zebrafish stat1a encodes all five domains of the human STAT1-alpha splice form but, like the human STAT1-beta splice variant, ... To explore embryonic functions of STAT1, we investigated stat1b, an unstudied zebrafish co-ortholog of human STAT1. ...
  https://zfin.org/ZDB-PUB-110920-26
*  Protein motion in the nucleus: from anomalous diffusion to weak interactions | Biochemical Society Transactions
2011) Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus. Biophys. J. 101, 2592- ... 2007) Probing transcription factor dynamics at the single-molecule level in a living cell. Science 316, 1191-1194 doi:10.1126/ ... 2017) DNA residence time is a regulatory factor of transcription repression. Nucleic Acids Res. 45, 11121-11130 doi:10.1093/nar ... transcription factor. Introduction. Mammalian gene expression and its regulation take place in the nucleus, a highly complex ...
  http://www.biochemsoctrans.org/content/early/2018/07/29/BST20170310
*  Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue | SpringerLink
13). Moreover, ELK1, ETF and STAT1 transcription factor binding sites are significantly overrepresented in the inflammation ... Key transcription factors overrepresented in Clusters 1, 2 and 3 are HNF4, ELK1 and E2F, respectively (Fig. 5b; Suppl. Table 13 ... Table 11). The transcription factor Klf6 was among the strongest transcriptionally upregulated genes of this cluster. Klf6 is a ... Botella LM, Sanz-Rodriguez F, Komi Y et al (2009) TGF-beta regulates the expression of transcription factor KLF6 and its splice ...
  https://link.springer.com/article/10.1007%2Fs00204-016-1761-4
*  Srikumar P. Chellappan | Moffitt
IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and ... GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and ... The E2F transcription factor is a cellular target for the RB protein. Cell. 1991 Jun;65(6):1053-1061. Pubmedid: 1828392. ... ChIP on Chip and ChIP-Seq Assays: Genome-Wide Analysis of Transcription Factor Binding and Histone Modifications. Methods Mol ...
  https://moffitt.org/research-science/researchers/srikumar-chellappan/
*  Reduced surface expression of MHC class I antigens in d | Open-i
Reduced surface expression of MHC class I antigens in different subsets of STAT1−/− lymphocytes. Freshly isolated lymphocytes ... STAT1 Transcription Factor. *Transcription Factors/genetics. *Tumor Suppressor Proteins. Related in: MedlinePlus ... 2) suggested that STAT1 may be important even in the absence of IFN. To further examine the role of constitutive IFN signaling ... 2) suggested that STAT1 may be important even in the absence of IFN. To further examine the role of constitutive IFN signaling ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195695_JEM990804.f4&req=4
*  Novel role and mechanisms of histone deacetylases in traumatic brain injury - Albert Einstein College of Medicine
5) HDAC3 inhibition reduces the activation of signal transducer and activator of transcription 1 (STAT1), a key molecule that ... Aim 2: Test if genetic knockout of the HDAC3-STAT1 signaling pathway shifts microglia/macrophages toward the beneficial and ... thereby regulating not only gene transcription but also the activity of various proteins through post-translational ...
  https://einstein.pure.elsevier.com/en/projects/novel-role-and-mechanisms-of-histone-deacetylases-in-traumatic-br
*  Graduate School of Medicine - Keio University
STAT1 Transcription Factor Medicine & Life Sciences Histamine Receptors Medicine & Life Sciences Cytokines Medicine & Life ...
  https://keio.pure.elsevier.com/en/organisations/2061-graduate-school-of-medicine
*  Frontiers | Chromatin Landscape Distinguishes the Genomic Loci of Hundreds of Androgen-Receptor-Associated LincRNAs From the...
... that comprise chromatin regions with ARA-lincRNAs exhibit transcription factor contents, epigenetic marks and gene ... To find relevant epigenetic signatures enriched at the ARA-lincRNAs' transcription start sites (TSSs) we used a machine ... transcription factor. Androgen hormone binding to AR promotes its displacement from the cytoplasm to the nucleus and AR binding ... transcription factor. Androgen hormone binding to AR promotes its displacement from the cytoplasm to the nucleus and AR binding ...
  https://www.frontiersin.org/articles/10.3389/fgene.2018.00132/full
*  Enhanced STAT1 phosphorylation in infected SOCS-3 defic | Open-i
Enhanced STAT1 phosphorylation in infected SOCS-3 deficient MEF correlates with elevated induction of IFNβ-stimulated genes. ... phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1) was strongly reduced. This impaired ... Bottom Line: Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B ... To rule out that this STAT1 phosphorylation is due to altered secretion of IFNβ or other STAT1-activating cytokines in SOCS-3 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2572141_ppat.1000196.g007&req=4
*  Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab10096) References
Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. ... Davis SJ et al. The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age- ... Jaldety Y et al. Sperm epidermal growth factor receptor (EGFR) mediates a7 acetylcholine receptor (AChR) activation to promote ...
  http://www.abcam.com/nicotinic-acetylcholine-receptor-alpha-7-antibody-ab10096-references.html
*  Impact of genome assembly status on ChIP-Seq and ChIP-PET data mapping | BMC Research Notes | Full Text
We next assessed mapping success with the ChIP-PET data sets obtained with human p53 and STAT1 transcription factors [10]. The ... Transcription factor binding sites were detected ("Peak calling", Figure 1) with sissrs [14], run with a false discovery rate ... These models can be complex to build in part because the DNA-binding domain of a transcription factor is susceptible to bind to ... To this end, we first used the ChIP-Seq datasets obtained for 15 mouse embryonic stem cell specific transcription factors (plus ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-2-257
*  Molecular profile of CD34-lineage- cells differentiated | Open-i
STAT1 Transcription Factor/agonists/immunology/metabolism. *STAT3 Transcription Factor/agonists/immunology/metabolism ... The expression of mRNA specific for the NK-associated transcription factor Id2 and for Bcl-2 and GATA-3 was investigated by ... Mentions: We next aimed to get insights into the expression levels of mRNA encoding for NK-associated transcription factors. ... The expression of mRNA specific for the NK-associated transcription factor Id2 and for Bcl-2 and GATA-3 was investigated by ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2743656_1471-2172-10-46-4&req=4
*  Cyclin-dependent kinase 8 - Wikipedia
"CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response". Immunity. 38 (2): 250- ... regulation of transcription, DNA-templated. • phosphorylation. • protein phosphorylation. • transcription initiation from RNA ... CDK8 binds to and/or phosphorylates several transcription factors, which can have an activating or inhibitory effect on ... transcription factor function.[7][8] CDK8 phosphorylates the Notch intracellular domain,[9] SREBP,[10] and STAT1 S727.[11] CDK8 ...
  https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_8
*  Perlecan - Wikipedia
Presumably the loss of perlecan expression stems from downregulation of transcription via STAT1 transcription factor activity ... This led the investigators to believe that the transcription factor STAT1 was interacting with the Pln promoter in the distal ... but in each case intact STAT1 transcription factor was required for the signal to take effect. ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ...
  https://en.wikipedia.org/wiki/Perlecan
*  Global Identification of Transcription Factor Binding Sites in Humans
... for the STAT1 transcription factor (Euskirchen et al., 2007). We found that these two technologies were comparable in terms of ... We then performed a multivariate analysis on all the factors collectively. This grouped the transcription factors into sequence ... Ellrott, K., Yang, C., Sladek, F.M., Jiang, T. (2002). Identifying transcription factor binding sites through Markov chain ... Horak, C. and Snyder, M. (2002). ChIP chip: A genomic Approach for Identifying Transcription Factor Binding Sites. Methods ...
  http://archive.gersteinlab.org/papers/subjects/encode/Overall-Summary-Related-to-ChIPchip.html
*  IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo | JEM
The STAT1 transcription factor plays an important role in IFN-γ-induced signaling, and indicates that IFN-γ-induced STAT1 ... reported on an impaired development of CD25+CD4+ T reg cells in signal transducer and activator of transcription (STAT)-1- ... STAT1, signal transducer and activator of transcription-1; T reg, regulatory T. ... 2). Although CD25+CD4+ T cells displayed a 50-fold greater basal transcription level of CTLA4 compared with CD25−CD4+ T cells, ...
  http://jem.rupress.org/content/201/12/1925
*  Paracrine signalling - Wikipedia
... causing a premature and constitutive activation of the Stat1 transcription factor. Chondrocyte cell division is prematurely ... Growth and differentiation factors (GDFs) Growth factor and clotting factors are paracrine signaling agents. The local action ... Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and ... The R-SMAD/Co-SMAD forms a complex with importin and enters the nucleus, where they act as transcription factors and either up- ...
  https://en.wikipedia.org/wiki/Paracrine_signalling