Protein Tyrosine Phosphatase, Non-Receptor Type 11 * Protein Tyrosine Phosphatases * SH2 Domain-Containing Protein Tyrosine ... Protein Tyrosine Phosphatase, Non-Receptor Type 11 * Protein Tyrosine Phosphatases / genetics* * SH2 Domain-Containing Protein ...

An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. 152 (2): 325-34. doi:10.1083/jcb. ... a single membrane-spanning helix domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain and a carboxylic ... Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic ... This chimeric protein, unlike the PDGFRB protein: a) has continuously active PDGFRB-mediated tyrosine kinase due to its forced ...

Classification - Tyrosine specific protein phosphatase, Src homology 2 (SH2) domain Cellular location - cytoplasmic ... The csw gene encodes a putative nonreceptor protein tyrosine phosphatase covalently linked to two N-terminal SH2 domains, which ... Engagement of the N-terminal SH2 domain with a tyrosine-phosphorylated protein releases the block of the catalytic domain, ... The N-terminal SH2 domains of the CSW protein share between 45% and 65% identity with the next most closely related SH2 domains ...

AT2 receptor stimulation activates several phosphatases like protein tyrosine phosphatase, MAP kinase phosphatase 1 (MKP-1), ... MAP kinase phosphatase 1, SH2-domain-containing phosphatase 1 (SHP-1), and serine-threonine phosphatase 2A [51-53]. This ... SH2-domain-containing phosphatase 1 (SHP-1), and serine threonine phosphatase 2A. When this phosphatase gets activated, there ... protein kinase C; PTP: protein tyrosine phosphatase; PP2A: serine/threonine phosphatase 2A; ERK: extracellular signal-regulated ...

SHP2 is one of the two SH2 domain-containing protein tyrosine phosphatases and is encoded by the PTPN11 gene. Binding sites for ... GAB1 is a PH-containing scaffolding protein for diverse RTKs and binds both SH2 and SH3 domains (55). These data are consistent ... Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 ... Receptor-specific regulation of phosphatidylinositol 3-kinase activation by the protein tyrosine phosphatase Shp2 ...

Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. ... This mechanism is regulated by the activities of both protein-tyrosine kinases and protein tyrosine phosphatases. The discovery ... Both NH2-terminal and COOH-terminal SH2 domains of Syp, made as glutathione S-transferase fusion proteins, were able to bind to ... of phosphotyrosine phosphatases that contain SH2 domains suggests roles for these molecules in growth factor signaling pathways ...

Src-homology 2 domain (SH2)-containing protein tyrosine phosphatases], which act to attenuate the TCR activation signal (18). ... of a fluorescently labeled LAG-3 fusion protein [DyLight (Dyl)-650 LAG-3 huIgG1-Fc]. LAG-3 fusion protein/antibody mixtures ... LAG-3 protein expression in non-small cell lung cancer and its relationship with PD-1/PD-L1 and tumor-infiltrating lymphocytes ... LAG-3 is a transmembrane protein of the Ig superfamily, expressed on a host of immune cell subtypes, including T cells, natural ...

SH2 domain-containing tyrosine phosphatase-2) within a lipid raft microdomain [28]. ... Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive ... Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive ... Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2. ...

SH2 Domain-Containing Protein Tyrosine Phosphatases 17% 6 Citations (Scopus) * The sweet taste receptor, glucose transporters, ... Structure, function, and signaling of taste g-protein-coupled receptors. Sanematsu, K., Yoshida, R., Shigemura, N. & Ninomiya, ...

SH2 Domain-Containing Protein Tyrosine Phosphatases 100% * Helicobacter Infections 66% * Helicobacter pylori 60% ... Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling. Wang, Y. C. ... Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level. Huang, S. C. ... The prevalence and characteristics of cows milk protein allergy in infants and young children with iron deficiency anemia. Lai ...

SH2 Domain-Containing Protein Tyrosine Phosphatases 32% * MAP Kinase Signaling System 22% ... The role of protein synthesis and digestive enzymes in acinar cell injury. Logsdon, C. D. & Ji, B., Jun 2013, In: Nature ...

SH2 Domain-Containing Protein Tyrosine Phosphatases 58% * NADPH Oxidase 2 57% * Protein Tyrosine Phosphatases 45% ...

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. ... a linker domain (LD); an Src homology 2 (SH2) domain; and a C-terminal transactivation domain (TAD) with a conserved tyrosine ... for protein-protein interactions, central DNA-binding domain (DBD), linker domain (LD) that affects DNA-binding stability, SH2 ... Phosphorylation of Tyr985 activates signaling related with SH2-containing protein tyrosine phosphatase 2 (SHP2) and mediates ...

... mitogen-activated protein/ERK kinase; SHP-2, SH2 domain-containing tyrosine phosphatase-2; PKA, cAMP-dependent protein kinase; ... exchange protein directly activated by cAMP; C/EBP, CCAAT/enhancer binding protein; JAK, Janus kinase; MEK, ... Cyclic AMP, Exchange protein directly activated by cyclic AMP, Interleukin-6, Extracellular signalling-regulated kinase, ... Keywords: Cyclic AMP; exchange protein directly activated by cyclic AMP; interleukin-6; extracellular signalling-regulated ...

... experiments revealed that oxidized LDL induced transient Siglec-E tyrosine phosphorylation and recruitment of SHP-1 phosphatase ... By performing proximity labeling and proteomic analysis, we identified scavenger receptor CD36 as a cell surface protein ... Potential Siglec-E-interacting proteins were identified by proximity labeling in conjunction with proteomic analysis and ... binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2- ...

The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2). ... Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form. 3qkp. Protein Tyrosine Phosphatase 1B - Apo ... Engineered protein tyrosine phosphatase beta catalytic domain. 2hnp. CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B ... Human receptor protein tyrosine phosphatase gamma, domain 1, apo. 3qcc. Human receptor protein tyrosine phosphatase gamma, ...

Here, we investigated whether SH2-containing protein tyrosine phosphatase 1 (SHP-1) decreases p-PKM2Y105 expression and, thus, ... SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma. ...

PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 ... study points out a slight potential role for PTPH1 in spontaneous pain sensitivity and it indicates that this phosphatase might ... Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunol Res. ... The role of protein tyrosine kinases (PTKs) has been widely studied but less is known on the protein tyrosine phosphatases ( ...

It was there that I started working on the role of the SH2 domain-containing protein tyrosine phosphatase SHP2 in skeletal ... Anton Bennett, I first became aware of a class of proteins called tyrosine phosphatases. ... a RASopathy gene encoding the protein tyrosine phosphatase SHP2 and responsible for ,50% of Noonan Syndrome (NS) and nearly all ... scaffolding or adaptor proteins, ubiquitin ligases, phosphatases and pathway inhibitors. Although these mechanisms are diverse ...

... that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell ... Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed ... Comu S, Weng W, Olinsky S, et al. The urine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein ... Kharitonenkov A, Chen Z, Sures I, et al. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature ...

... regulation of the alpha/beta Interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. ... leading to tyrosine phosphorylation of Stat transcription factors. Previous studies implicated protein-tyrosine phosphatase ( ... We have found that SH2 domain-containing PTP1 (SHPTP1; also called PTP1C, HCP, or SHP) reversibly associates with the IFN-alpha ... Interferons (IFNs) induce early-response genes by stimulating Janus family (Jak) tyrosine kinases, ...

Oncogenic protein tyrosine phosphatases have long been viewed as drug targets of interest, and recently developed allosteric ... inhibitors of SH2 domain-containing phosphatase-2 (SHP2) have entered clinical trials. However, the ability of phosphatases to ... Measuring protein phosphorylation and expression in glioblastoma cells across 40 signaling pathway nodes in response to ... many targets directly or indirectly and to both promote and antagonize oncogenic signaling may make the efficacy of phosphatase ...

... direct interaction and impairs the association between the N-SH2 domain and the catalytic protein tyrosine phosphatase domain ... Cancerous inhibitor of protein phosphatase 2A, a cellular inhibitor of protein phosphatase 2A, mediated the apoptotic effect of ... Furthermore, cancerous inhibitor of protein phosphatase 2A negatively regulated protein phosphatase 2A activity. Ectopic ... SH2) domain-containing phosphatase 1 (SHP-1) is a major target of sorafenib and generates a series of sorafenib derivatives to ...

SH2) domain-containing tyrosine phosphatase 1 (SHP1), Src homology 2 (SH2) domain-containing tyrosine phosphatase 2 (SHP2), and ... Recombinant proteins including the catalytic domains of proteins tyrosine phosphatase 1B (PTP1B), T cell proteins tyrosine ... Proteins tyrosine phosphatase 1B (PTP1B) can be an established therapeutic focus. * Post author By gasyblog ... Proteins tyrosine phosphatase 1B (PTP1B) can be an established therapeutic focus on for type 2 diabetes mellitus (T2DM) and ...

... repeat region in the C-terminal of CagA protein. This repeat region is thought to play an important role in the pathogenesis of ... CagA can specifically bind to the SH2 domain of Src homology 2 (SH2)-containing protein tyrosine phosphatase (SHP-2), which ... SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. ... Higashi H. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 2002;295(5555): ...

... and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulat ... The reversible phosphorylation of proteins on serine, threonine, ... encoding a novel protein-tyrosine kinase containing SH2 domains ... protein kinase C; PTP, protein tyrosine phosphatase; RTK, receptor tyrosine kinase; STP, serine/threonine protein phosphatase. ... protein kinase C; PTP, protein tyrosine phosphatase; RTK, receptor tyrosine kinase; STP, serine/threonine protein phosphatase. ...

... induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase ... Synonyms: Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76, SLP-76 tyrosine ... SH2 domain-containing leukocyte protein of 76 kilodaltons), a hematopoietically expressed adaptor protein and PTK substrate [7] ... FYB/SLAP has the hallmarks of an adaptor protein that binds to the SH2 domains of the Src kinase FYN-T and SLP-76 [22]. ...