*  What we have learned from ribosome structures | Biochemical Society Transactions
What we have learned from ribosome structures. V. Ramakrishnan. Biochemical Society Transactions Aug 01, 2008, 36 (4) 567-574; ... What we have learned from ribosome structures Message Subject (Your Name) has forwarded a page to you from Biochemical Society ... The determination of the high-resolution structures of ribosomal subunits in the year 2000 and of the entire ribosome a few ... and the high-resolution structure of the entire 70S ribosome complexed with mRNA and tRNA. ...
  http://www.biochemsoctrans.org/content/36/4/567
*  Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. - Walter Lab
SRP arrests further elongation, causing ribosomes to stack behind the arrested ribosome. Upon interaction of SRP with its ... Ribosomes synthesizing nascent secretory proteins are targeted to the membrane by the signal recognition particle (SRP), a ... We have examined the distribution of unattached and membrane-bound ribosomes during the translation of mRNAs encoding two ... We also demonstrate that two previously described populations of membrane-associated ribosomes, distinguished by their ...
  http://walterlab.ucsf.edu/publication/462/discrete-nascent-chain-lengths-are-required-for-the-insertion-of-presecretory-proteins-into-microsomal-membranes/
*  GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding...
Thus, GPR41 expression is mediated via an internal ribosome entry site located in the intergenic region of a bicistronic mRNA. ... and we were able to map a potential internal ribosome entry site-containing region to a 2474-nucleotide region of the ... Thus, GPR41 expression is mediated via an internal ribosome entry site located in the intergenic region of a bicistronic mRNA. ... GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding ...
  https://www.dpag.ox.ac.uk/publications/650659
*  Watching single ribosome translation in real time: a quantitative study of ribosome helicase activity | School of Physics
The ribosome translates the genetic information encoded in messenger RNA into protein. Folded structures in the coding region ... Watching single ribosome translation in real time: a quantitative study of ribosome helicase activity. ... Watching single ribosome translation in real time: a quantitative study of ribosome helicase activity. ... The ribosome translates the genetic information encoded in messenger RNA into protein. Folded structures in the coding region ...
  http://www.physics.gatech.edu/event/watching-single-ribosome-translation-real-time-quantitative-study-ribosome-helicase-activity
*  Ribosome and ribosomal RNA Structure : An experimental and computational analysis of expansion segments in eukaryotic ribosomal...
The eukaryotic ribosome is larger compared to its prokaryotic counterpart. The size differences are due to a larger protein ... The juxtaposition of ES6 close to ES3 in the Cryo-EM image of the yeast ribosome suggested that ES3 and ES6 might interact. A ... 3. Analysis of the secondary structure of expansion segment 39 in ribosomes from fungi, plants and mammals.. Open this ... eukaryotes, expansion segment, ribosomes, rRNA, secondary structure, structure of rRNA. National Category Cell and Molecular ...
  http://su.diva-portal.org/smash/record.jsf?pid=diva2:198453
*  Stringent Response: Antibiotics affecting ribosome's protein composition
stringent response RelA ppGpp ribosome microscopy GTPase SpoT our papers single molecule antibacterials mitochondria protein ... That usually means that the ribosome is stalled at a certain step, be it initiation or elongation or ribosomal recycling.. ... Sometimes antibiotics also mess up the ribosome itself and affect its composition.. Exhibit A: kasugamycin, an antibiotic that ... Several proteins dissociate from the small ribosomal subunit (S1, S2, S6, S12, S18 and S21) which turns the 70S ribosome into a ...
  http://stringentresponse.blogspot.com/2011/05/antibiotics-affecting-ribosomes-protein.html
*  ASMscience | Ribosomes Play Role in Gene Regulation; Possible Applications in Antibiotics Design
When bound, tryptophan inhibited release factor action and stalled the ribosome. The stalled ribosome, in turn, inhibited Rho, ... created a binding site for tryptophan within the translating ribosome. ... Ribosomes can recognize features of a nascent peptide and exploit these features to regulate gene expression. Luis R. Cruz-Vera ... Home / Periodicals / Ribosomes Play Role in Gene Regulation; Possible Applications in Antibiotics Design / Article ...
  http://www.asmscience.org/content/journal/microbe/10.1128/microbe.3.425.1
*  TOWARDS A CONSISTENT CHRONOLOGY TO EXPLAIN THE EVOLUTION OF THE RIBOSOME | ScholarBank@NUS
The ribosome is a molecular witness to the origin of life as it comprises the conserved mechanism for the translation of ... Similar methods can be adapted to the chronology model of ribosome small subunit of E. coli, with which, the evolutionary story ... ZHANG BO (2012-08-24). TOWARDS A CONSISTENT CHRONOLOGY TO EXPLAIN THE EVOLUTION OF THE RIBOSOME. ScholarBank@NUS Repository. ... of the integrated E. coli ribosome can be presented as a 3D animation using Autodesk Maya. It would enlarge our knowledge about ...
  http://scholarbank.nus.edu.sg/handle/10635/38817
*  Role of ribosome recycling factor (RRF) in translational coupling | The EMBO Journal
Janosi L, Hara H, Zhang S and Kaji A (1996a) Ribosome recycling by ribosome recycling factor (RRF)-an important but overlooked ... Janosi L, Shimizu I and Kaji A (1994) Ribosome recycling factor (ribosome releasing factor) is essential for bacterial growth. ... This is because ribosomes (probably as 70S ribosomes; Petersen et al., 1978), in the absence of RRF, slide down the mRNA and ... Ogawa K and Kaji A (1975) Requirement for ribosome releasing factor for the release of ribosomes at the termination codon. Eur ...
  http://emboj.embopress.org/content/19/14/3788
*  Stringent Response: All ribosomes are equal, but some ribosomes are more equal than others
Here it an example of ITC used for studying these rRNA-modified ribosomes.. 2. Ribosomes can have different rRNA and proteins ... All ribosomes are equal, but some ribosomes are more equal than others ... stringent response RelA ppGpp ribosome microscopy GTPase SpoT our papers single molecule antibacterials mitochondria protein ... PS: what all the ribosomes have in common is their color. They all are yellow.. References:. 1. Gilbert VW. Functional ...
  http://stringentresponse.blogspot.com/2011/01/all-ribosomes-are-equal-but-some.html
*  Surveying the relative impact of mRNA features on local ribosome profiling read density in 28 datasets. | Haldane's Sieve
However, ribosome profiling data are characterized by a substantial number of outliers due to technical and biological factors ... Patrick O'Connor , Dmitry Andreev , Pavel Baranov doi: http://dx.doi.org/10.1101/018762 Ribosome profiling is a promising ... Surveying the relative impact of mRNA features on local ribosome profiling read density in 28 datasets. ... Ribosome profiling is a promising technology for exploring gene expression. However, ribosome profiling data are characterized ...
  https://haldanessieve.org/2015/05/01/surveying-the-relative-impact-of-mrna-features-on-local-ribosome-profiling-read-density-in-28-datasets/
*  INVOLVEMENT OF RIBOSOMAL PROTEINS IN RIBOSOME BIOGENESIS, CELL CYCLE PROGRESSION, AND BUDDING PATTERNS IN SACCHAROMYCES...
Ribosome biogenesis and cell cycle are coordinated processes (Du and Stillman, 2001 Bernstein and Baserga, 2004; Fatica and ... These results showed that depletion of RpL17 leads to a defect in 27S processing and degradation of pre-existing ribosomes. My ... Mutations in genes encoding factors that are involved in ribosome biogenesis cause defects in ribosomal RNA processing as well ... Recent studies with mammalian cell lines have shown that ribosome biogenesis is also linked to tumorgenesis, that is mutation ...
  http://contentdm.ad.umbc.edu/cdm/singleitem/collection/ETD/id/24644/rec/11096
*  Ribosome | Research | Craig Lab | Biochemistry | UW-Madison
Specialized ribosome-associated molecular chaperones. During their synthesis on ribosomes, proteins are particularly ... The Hsp70 Ssb, which is associated with ribosomes regardless of their translational state, is the major ribosome-associated ... We are studying ribosome-associated molecular chaperones that are tethered near the site from which the nascent chain exits the ... It can be crosslinked to short nascent chains that extend only a few amino acids beyond the ribosome exit site. Like all Hsp70s ...
  https://biochem.wisc.edu/labs/craig/research/ribosome
*  The polypeptide tunnel exit of the mitochondrial ribosome is tailored to meet the specific requirements of the organelle. -...
In mitochondrial ribosomes, this site has been considerably modified in the course of evolution. In contrast to all other ... translation systems, mitochondrial ribosomes are responsible for the synthesis of only a few hydrophobic membrane proteins that ... and speculate how alteration of the ribosomal tunnel exit might allow the establishment of a subset of specialized ribosomes ... One core, two shells: bacterial and eukaryotic ribosomes. *Sergey Melnikov. , Adam Ben-Shem. , Nicolas Garreau de Loubresse. , ...
  https://www.semanticscholar.org/paper/The-polypeptide-tunnel-exit-of-the-mitochondrial-r-Gruschke-Ott/d39390d5c1927be0f4bb4ad26fed9c0405459bb6
*  Ribosomes lacking protein S20 are defective in mRNA binding and subunit association
ribosome, protein synthesis, ribosomal proteins, translation initiation, ribosome biogenesis, fitness costs, compensatory ... Ribosomes lacking protein S20 are defective in mRNA binding and subunit association. Tobin, Christina Uppsala University, ... 1. Removal and Replacement of Ribosomal Proteins: Effects on Bacterial Fitness and Ribosome Function. Open this publication in ... This clearly demonstrates the robustness and plasticity of the ribosome and protein synthesis in general and it also implies ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:374647
*  HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions
... Zhang, Yanqing Tsinghua Univ, Sch Life ... Our data reveal that HflX is a heat shock-induced ribosome-splitting factor capable of dissociating vacant as well as mRNA- ... Accordingly, loss of HflX results in an increase in stalled ribosomes upon heat shock, These results suggest a primary role of ... Adverse cellular conditions often lead to nonproductive translational stalling and arrest of ribosomes on mRNAs. Here, we used ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:877200
*  What does ribosome inactivating proteins mean?
... Information and translations of ribosome inactivating proteins in the most ... Definition of ribosome inactivating proteins in the Definitions.net dictionary. Meaning of ribosome inactivating proteins. ... ribosome subunits, large, archaeal. Alternative searches for ribosome inactivating proteins:. *Search for Synonyms for ribosome ... What does ribosome inactivating proteins mean?. Definitions for ribosome inactivating proteins. Here are all the possible ...
  http://www.definitions.net/definition/ribosome%20inactivating%20proteins
*  "The Role of SmpB in Licensing tmRNA Entry into Stalled Ribosomes" by Mickey R. Miller
The ribosome releases the truncated mRNA and resumes translation on the tmRNA template. The open reading frame found on tmRNA ... A portion of the C-terminal tail forms a helix within the mRNA channel, monitoring the length of mRNA bound in the ribosome to ... A stop codon at the end of the open reading frame allows the ribosome to be recycled and engage in future rounds of translation ... Transfer-messenger RNA (tmRNA) and its protein partner SmpB mimic a tRNA by entering the A site of the ribosome and accepting ...
  https://scholarsarchive.byu.edu/etd/4162/
*  Ribosome display for selection and evolution of affibody molecules
... Grimm, Sebastian KTH, School of Biotechnology (BIO), ... Ribosome display was further applied to the selection of affibody molecules binding to SATB1, a suggested marker protein for ... affibody molecule, VHH antibody fragment, phage display, ribosome display, SATB1 Identifiers. urn:nbn:se:kth:diva-33425 (URN) ... 1. Ribosome Display Selection of a Murine IgG(1) Fab Binding Affibody Molecule Allowing Species Selective Recovery Of ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:413896
*  Ribosome - Wikipedia
Membrane-bound ribosomes[edit]. When a ribosome begins to synthesize proteins that are needed in some organelles, the ribosome ... Free ribosomes[edit]. Free ribosomes can move about anywhere in the cytosol, but are excluded from the cell nucleus and other ... Role of the Ribosome, Gwen V. Childs, copied here. *Ribosome in Proteopedia - The free, collaborative 3D encyclopedia of ... A ribosome is made from complexes of RNAs and proteins and is therefore a ribonucleoprotein. Each ribosome is divided into two ...
  https://en.wikipedia.org/wiki/Ribosome
*  Mimicking Living Cells: Synthesizing Ribosomes - Redorbit
Cells require ribosomes to live.. Jewett likens a ribosome to a chef. The ribosome takes the recipe, encoded in DNA, and makes ... "Then we can alter ribosomes to do new things for us.". "The ability to make ribosomes in vitro in a process that mimics the way ... an advanced understanding of how ribosomes form and function; and the creation of tailor-made ribosomes to produce new proteins ... "We can mimic nature and create ribosomes the way nature has evolved to do it, where all the processes are co-activated at the ...
  http://www.redorbit.com/news/science/1112888159/mimicking-living-cells-synthesizing-ribosomes/
*  Ribosome-binding site - Wikipedia
9] Sequences within ribosome binding site affecting messenger RNA translatability and method to direct ribosomes to single ... Internal ribosome entry site (IRES)[edit]. Eukaryotic ribosomes are known to bind to transcripts in a mechanism unlike the one ... the rate at which a ribosome is recruited to the RBS. *the rate at which a recruited ribosome is able to initiate translation ( ... A ribosome binding site, or ribosomal binding site (RBS), is a sequence of nucleotides upstream of the start codon of an mRNA ...
  https://en.wikipedia.org/wiki/Ribosome_binding_site
*  Where Are Ribosomes Produced? | Reference.com
... the subunits that will become ribosomes are produced within the subnuclear structure called the nucleolus, and the subunits ... and the subunits then combine in the cell's cytoplasm to become functioning ribosomes. Because the ribosomes are the protein ... Mature and functioning ribosomes are comprised of more than 50 proteins and contain their own ribosomal RNA, which can also be ... Ribosomes are found floating throughout the cell's cytosol, which is the fluid portion of the cytoplasm, and many are also ...
  https://www.reference.com/science/ribosomes-produced-a2aa6b3a16a73095
*  Ribosome | cytology | Britannica.com
Ribosome, particle that is present in large numbers in all living cells and serves as the site of protein synthesis. Ribosomes ... the cell are made on ribosomes that are scattered throughout the cytoplasm. Bacterial ribosomes are different from ribosomes in ... Ribosome, particle that is present in large numbers in all living cells and serves as the site of protein synthesis. Ribosomes ... In eukaryotes, ribosomes are about half protein and half rRNA. Ribosomes are usually made up of three or four rRNA molecules ...
  https://www.britannica.com/science/ribosome
*  Function of the Ribosomes
The ribosome is an incredibly complex organelle found in all living cells. They serve as the main source of protein synthesis, ... Function of the Ribosomes. The ribosome is an incredibly complex organelle found in all living cells. They serve as the main ... When a ribosome is finished reading an mRNA molecule, the large and small subunits split apart.. Ribosomes can differ in size ... Then, the attached chains are joined together by another part of the ribosome.. Ribosomes have two major components: the ...
  http://softschools.com/science/biology/function_of_the_ribosomes/