SCOPe 2.08: Protein: Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF
Timeline for Protein Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF from b.55.1.1: Pleckstrin-homology domain (PH domain ... Lineage for Protein: Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF. *Root: SCOPe 2.08 *. Class b: All beta proteins [ ... Protein Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF from b.55.1.1: Pleckstrin-homology domain (PH domain) appears in ... Protein Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF from b.55.1.1: Pleckstrin-homology domain (PH domain) first ...
Arhgef38 Mouse Gene Details | Rho guanine nucleotide exchange factor 38 | International Mouse Phenotyping Consortium
ALS2 gene: MedlinePlus Genetics
ALSIN RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR ALS2; ALS2. Gene and Variant Databases. *NCBI Gene ... Two of the mutations that cause this disorder delete nucleotides, and one mutation replaces one nucleotide with an incorrect ... nucleotide. These mutations alter the instructions for producing alsin. As a result, alsin is unstable and is broken down ...
ARHGEF35 - Wikipedia
RALGDS | Cancer Genetics Web
rho GTP-Binding Proteins. *ral Guanine Nucleotide Exchange Factor. *Tumor Suppressor Gene ... Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases ( ... RalGPS2 is a Ras-independent Guanine Nucleotide Exchange Factor (GEF) for RalA containing a PH domain and an SH3-binding region ... Although the Rgr proto-oncogene belongs to the RalGDS family of guanine nucleotide exchange factors (GEFs), we show that upon ...
Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway...
Heo J, Thapar R, Campbell SL . Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. ... Barrio-Real L, Kazanietz MG . Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci Signal 2012; 5: ... Liu BP, Burridge K . Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol ... Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl ...
KEGG T01002: 16800
Rho GTPase associated proteins. Rho guanine nucleotide exchange factors (GEFs). 16800 (Arhgef2). ... RefSeq) Rho/Rac guanine nucleotide exchange factor 2. KO. K12791 Rho guanine nucleotide exchange factor 2. ...
KEGG PATHWAY: hsa05152
ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]. 387 RHOA; ras homolog family member A [KO:K04513]. ... RFXAP; regulatory factor X associated protein [KO:K08063]. 4800 NFYA; nuclear transcription factor Y subunit alpha [KO:K08064] ... NFYB; nuclear transcription factor Y subunit beta [KO:K08065]. 4802 NFYC; nuclear transcription factor Y subunit gamma [KO: ... TGFB3; transforming growth factor beta 3 [KO:K13377]. 1594 CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438 ...
MMRRC:040563-MU
Immune cell - IFRD1 - The Human Protein Atlas
MMRRC:039824-MU
Phosphorylation of Homer3 by Calcium/Calmodulin-Dependent Kinase II Regulates a Coupling State of Its Target Molecules in...
2004) GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J Biol ... 1999) Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is ... a common and essential factor is a postsynaptic [Ca2+]i elevation (Hartell, 2002; Safo et al., 2006). Indeed, some upstream ( ...
ARHGEF7 Proteins
Rho guanine nucleotide exchange factor 7 (ARHGEF7) Proteins. Rho guanine nucleotide exchange factor 7 S homeolog (arhgef7.S) ... Rho guanine nucleotide exchange factor 7 (Arhgef7) Proteins. Rho guanine nucleotide exchange factor (GEF7) (Arhgef7) Proteins. ... rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7)). Rho GTPases play a fundamental role in numerous cellular processes ... Rho guanine nucleotide exchange factor (GEF) 7b (arhgef7b) Proteins. ARHGEF7 Proteins. arhgef7 Proteins. bbh Proteins. BETA-PIX ...
sos2 Summary
KEGG T01001: 9181
Rho GTPase associated proteins. Rho guanine nucleotide exchange factors (GEFs). 9181 (ARHGEF2). ... RefSeq) Rho/Rac guanine nucleotide exchange factor 2. KO. K12791 Rho guanine nucleotide exchange factor 2. ...
Intermediate CMT - Types of Charcot-Marie-Tooth Disease (CMT) - Diseases | Muscular Dystrophy Association
Stendel, C. et al. Peripheral Nerve Demyelination Caused by a Mutant Rho GTPase Guanine Nucleotide Exchange Factor, Frabin/FGD4 ... Nakhro, K. et al. SET binding factor 1 (SBF1) mutation causes Charcot-Marie-Tooth disease type 4B3. Neurology (2013). doi: ... Hirano, R. et al. SET binding factor 2 (SBF2) mutation causes CMT4B with juvenile onset glaucoma. Neurology (2004). doi:10.1212 ... Kim, H.-J. et al. Mutations in PRPS1, Which Encodes the Phosphoribosyl Pyrophosphate Synthetase Enzyme Critical for Nucleotide ...
SMART: RhoGEF domain annotation
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and ... Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH ... These putative guanine nucleotide exchange factors for Rho family small GTP-binding proteins (G proteins) all contain a Dbl ... is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family ...
Cytokinesis, RhoA and Contractile Ring | Cell Biology | JoVE
The activation of RhoA is regulated by a guanine nucleotide exchange factor (Rho-GEF). This protein is found in the cortex ... Rho-GEF exchanges the GDP bound to RhoA with GTP. The binding of GTP activates RhoA, which in turn triggers the formation of ... Animal cell cytokinesis: the rho-dependent actomyosin-anilloseptin contractile ring as a membrane microdomain gathering, ...
ARHGEF11 (NM 198236) Human Tagged ORF Clone - RC208729 | OriGene
Human Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript variant 2 ... ARHGEF11 (untagged)-Human Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript variant 2. * * 10 ug. 10 ug ... ARHGEF11 (tGFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript variant 2. * * 10 ug. 10 ... Lenti-ORF clone of ARHGEF11 (Myc-DDK-tagged)-Human Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript ...
SMART: RhoGEF domain annotation
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and ... Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH ... These putative guanine nucleotide exchange factors for Rho family small GTP-binding proteins (G proteins) all contain a Dbl ... is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family ...
SMART: RhoGEF domain annotation
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and ... Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH ... These putative guanine nucleotide exchange factors for Rho family small GTP-binding proteins (G proteins) all contain a Dbl ... is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family ...
CDD Conserved Protein Domain Family: BAR DNMBP
Plus it
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J ... Yamashita T, Tohyama M (2003) The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 6: ... Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-248. ... Neurotrophins (NTs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4/5, regulate ...
Publications Citing Globals Software - Laboratory for Fluorescence Dynamics
The Rho guanine nucleotide exchange factor (RhoGEF) Trio promotes actin polymerization by directly activating the small GTPase ... Single tryptophan mutants of FtsZ: nucleotide binding/exchange and conformational transitions.. Biochim Biophys Acta. 2014; ... We observed dynamic exchange of the ataxin-1 protein into these NBs; notably, cell exposure to a pro-oxidant stress could ... Some of those factors include, but are not limited to, interactions with mobile and immobile targets or obstacles. Besides ...
Corey S. Goodman - Publications
Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron. ... The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell. 69: 963-75. PMID ... A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and ... Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Current ...
Regulatory sequence analysis of semaphorin 4D 5' non-coding region
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. The ... which binds two guanine nucleotide exchange factors (GEFs) for Rho and is mediated by the activation of Rho-initiated (Ras ... Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. Biochemical and biophysical ... The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. ...
Hyperimmunoglobulinemia E (Job) Syndrome: Background, Pathophysiology, Epidemiology
DOCK8 belongs to the DOCK180 superfamily of proteins which have a role in guanine nucleotide exchange for Rho family GTPases. ... DOCK180- related guanine nucleotide exchange factors are shown to have roles in actin cytoskeletal rearrangement, cell ... macrophage-colony stimulating factor (M-CSF), granulocyte-colony stimulating factor (G-CSF), leptin, and growth hormone. [17] ... ciliary neurotropic factor, oncostatin M, leukemia inhibitory factor), IFNs, and the IL-10 family (IL-10, IL-19, IL-20, IL-22, ...
The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble...
Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix ... Cdc42 is activated by recruitment of the Cdc42/Rac guanine-nucleotide exchange factor (GEF) βPIX to the LE by Scrib, which ... Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in ... The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis ...