Protection of Mouse Retinal Ganglion Cell Axons and Soma from Glaucomatous and Ischemic Injury by Cytoplasmic Overexpression of...
However, one of the most novel findings in the present study is that the apoptotic death of RGC soma in glaucoma 2-4 was robustly prevented in cytNmnat1-Tg mice. This counters the consistent documentation in PNS injury models that Wlds does not protect neuronal cell bodies, 36-38 as well as the conclusions from several studies of CNS injury, including some in retina. In particular, RGC soma were not protected from glaucomatous dropout in the Wlds transgenic rat 39 nor were soma from Wlds mice subjected to optic nerve crush. 35 In contrast, in one of the earliest studies of Wlds retinal phenotypes, "retrograde degeneration" of Nissl-stained RGC soma was delayed in parallel with that noted for RGC axons following optic nerve transection. 34 And in the double-mutant Wlds.DBA/2J mice carrying the Wlds allele, while soma loss was not prevented in glaucomatous mice exhibiting severe axonal degeneration, the extent to which Nissl-stained RGC soma survived ...http://iovs.arvojournals.org/article.aspx?articleid=2188669
Letter by Hiltunen and Jolkkonen Regarding Article, "Secondary Neurodegeneration in Remote Regions After Focal Cerebral...
To the Editor:. We read with interest the recent article by Zhang et al.1 The authors described secondary degeneration in remote regions after experimental cerebral ischemia, which could provide a target for stroke management. We completely agree that this is an appealing approach. However, the underlying pathology may be different in ischemic rodents and patients with stroke.. Remote areas such as the thalamus connected to the cortical infarct are affected because of delayed retrograde degeneration of afferent connections. This is associated with extensive and complex pathology including inflammatory reactions, β-amyloid (Aβ) accumulation, calcification, and angiogenesis in rats subjected to middle cerebral artery occlusion.2 The Aβ deposition is particularly robust after an ischemic insult, which starts as a diffuse aggregation and over time transforms into dense plaque-like deposits together with calcium in the ventroposterior medial and ventroposterior ...http://stroke.ahajournals.org/content/43/9/e96
Abstract WP102: Retrograde Neurodegeneration of Substantia Nigra Projections to the Striatum Following Long Term Survival After...
Introduction: Stroke survivors suffer from long-term physical, cognitive and affective disabilities. These disabilities lower the quality of life, contribute to social isolation and anhedonia, and clinical disorders such as post-stroke depression (PSD), which disproportionately affects women. Preclinical studies show that lesions of the substantia nigra (pars compacta) impair both motor performance and reward seeking behavior. Neurons from the SNc project to the striatum, a region that is significantly infarcted by middle cerebral artery occlusion (MCAo).. Hypothesis: Ischemia induced by MCAo leads to retrograde degeneration of the SNc pathway projecting to the striatum.. Methods: Middle-aged Sprague-Dawley female rats (12 months old) were subjected to ischemic stroke using a silicon-coated nylon filament suture to occlude the middle cerebral artery (MCA) which was removed 75min after to allow for reperfusion. After 14 weeks of survival, rats were again anesthetized and ...http://stroke.ahajournals.org/content/48/Suppl_1/AWP102
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress | JCB
The results described here may be important for understanding neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementias, and others, which are characterized by elevated and aggregated tau protein (for reviews see Buee et al., 2000; Hutton, 2001). Alzheimer's disease is traditionally characterized by two types of protein deposits in the brain, the extracellular amyloid plaques, consisting largely of the peptide Aβ, a derivative of the membrane protein APP, and the intracellular neurofibrillary tangles, consisting mostly of tau protein (Price et al., 1998). However, these visible signs of pathology must be preceded by more subtle changes. The progression of the disease correlates with the spreading of the neurofibrillary tangles, whereas the amyloid plaques have a more generalized distribution (Braak and Braak, 1991; Arriagada et al., 1992). One of the earliest detectable signs is the loss of synapses and retrograde degeneration ("dying back") of ...http://jcb.rupress.org/content/156/6/1051
Axon degeneration | definition of axon degeneration by Medical dictionary
Looking for online definition of axon degeneration in the Medical Dictionary? axon degeneration explanation free. What is axon degeneration? Meaning of axon degeneration medical term. What does axon degeneration mean?http://medical-dictionary.thefreedictionary.com/axon+degeneration
Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions | Journal of Neuroscience
SARM has been reported to associate with mitochondria (Kim et al., 2007; Panneerselvam et al., 2012, 2013); accordingly, we found that GFP-tagged human SARM and endogenous murine SARM associate with neuronal mitochondria. Proteinase K treatment of neuronal mitochondrial fractions reveals that SARM mostly resides on the cytosolic surface of the mitochondria. While the genetic disruption of a previously reported SARM mitochondrial targeting sequence disrupts SARM mitochondrial localization in DRG axons, it does not affect the ability of SARM to promote axon degeneration. These findings suggest that the axonal degradation functions of SARM likely take place within the cytosol and that its association with mitochondria is not essential for this activity.. We have shown that the SAM and TIR domains of SARM are essential for its role in promoting elimination of injured axons. SARM mutants with disrupting mutations in either of these domains fail to restore injury-induced axon ...http://www.jneurosci.org/content/33/33/13569.full
Synaptic Plasticity and Transsynaptic Signaling
www.MOLUNA.de Synaptic Plasticity and Transsynaptic Signaling  - Brain functions are realized by the activity of neuronal networks composed of a huge number of neurons. The efficiency of information transfer within the networks is changeable. Even the networks themselves can change through experience. Information transfer between neurons is performed at the synapse (the site of the neurons' contact)https://www.moluna.de/buch/4174086-synaptic+plasticity+and+transsynaptic+signaling/
Simran Somal CRA - Ophthalmic Photographers' Society
11/3/2017EyeKor, Inc Partner with OPS to Develop Clinical Trial Imaging Certification. 9/13/2017Board of Certification Recruiting CRA & OCT-C Advisors. 6/16/2017Seeking Donations for Art Auction. 4/18/2017BOC Changes CRA Exam in 2018 ...http://www.opsweb.org/person/10543095/Harvard-Vanguard-Medical-Associates-Simran-Somal-CRA.htm
Dr Jonathan Gilley :: Cambridge Neuroscience
My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.http://www.neuroscience.cam.ac.uk/directory/profile.php?jongil
nerve degeneration - Symptoms, Treatments and Resources for nerve degeneration
nerve degeneration - MedHelp's nerve degeneration Center for Information, Symptoms, Resources, Treatments and Tools for nerve degeneration. Find nerve degeneration information, treatments for nerve degeneration and nerve degeneration symptoms.http://www.medhelp.org/tags/show/57303/nerve-degeneration
ZFIN Publication: Furutani-Seiki et al., 1996
Forty zebrafish mutants with localized or general neural degeneration are described. The onset and duration of degeneration and the distribution of ectopically dying cells are specific characteristics of each mutant. Mutants are classified into four groups by these parameters. Class I: late focal neural degeneration mutants. These 18 mutants have restricted cell death mainly in the tectum and the dorsal hindbrain after 36 hours. The degeneration does not spread and disappears at later stages of development. Class II: early focal neural degeneration mutants. Ten mutants in this class exhibit transient restricted degeneration affecting mainly the diencephalon, the hindbrain and the spinal cord at 20 hours. The midbrain is less affected. The degeneration shifts to the dorsal diencephalon and the tectum at 36 hours. Class III: late spreading neural degeneration mutants. The 8 ...https://zfin.org/ZDB-PUB-970210-19
Nerve degeneration | Article about nerve degeneration by The Free Dictionary
Looking for nerve degeneration? Find out information about nerve degeneration. see nervous system nervous system, network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment.... Explanation of nerve degenerationhttps://encyclopedia2.thefreedictionary.com/nerve+degeneration
Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration : Figure 1
Figure 1: Proposed theoretical framework. After nerve injury, AA derivatives produced in neurons and microglia participate in nerve degeneration and regeneration, through local, remote, and molecular pathways. Injury promotes SC infiltration and activation as well as phospholipase, COX and LOX upregulation with the ensuing production of eicosanoids. These signals promote degeneration initially and later regulate the regenerative process. NRAGs are in turn heavily influenced by these signals. SC: Schwann cell; NRAGs: nerve regeneration associated genes; LOX: lipooxygenases; COX: cyclooxygenases ...https://www.hindawi.com/journals/tswj/2012/168953/fig1/
Gene therapy rescues nerve degeneration in diabetic rats and rabbits
Researchers have used gene therapy to halt and reverse nerve degeneration in diabetic rats and rabbits. Introducing blood vessel-promoting genes into diabetic animals has reversed nerve damage caused by poor circulation. The team, led by Jeffrey Isner of Tufts University School of Medicine in Boston, Massachusetts, injected the VEGF-1 and VEGF-2 genes into the leg muscles of diabetic rats and rabbits to stimulate blood vessel growth around degenerating nerves.. Eight weeks after the rabbits had received the VEGF gene the researchers found that the number of blood vessels surrounding a nerve in the leg rose from 16 to 49, which was similar to non-diabetic animals. The results were similar with both forms of VEGF. The increase in blood vessel number was also accompanied by the restoration of motor and sensory nerve functions. Measurements of electrical activity within the nerves indicated that they were conducting signals in a manner similar to healthy animals.. Comparable results were seen in ...http://www.genomenewsnetwork.org/articles/05_01/Nerve_degeneration.shtml
Mechanisms of dopamine neuron degeneration - Robert Burke
Parkinson's disease (PD) is the most common neurodegenerative disorder of the basal ganglia. Although many effective treatments for the motor symptoms of PD exi...http://grantome.com/grant/NIH/P50-NS038370-14S1
ORBi: Browsing ORBi
in Glia (2011), 59(3), 379-396. Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively ... [more ▼]. Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively in successful and aborted axon regeneration. In the peripheral nervous system, Schwann cells (SCs) and macrophages, under the control of a network of cytokines and chemokines, represent the main cell types involved in this process. Within this network, the role of placental growth factor (PlGF) remains totally unknown. However, properties like monocyte activation/attraction, ability to increase expression of pro-inflammatory molecules, as well as neuroprotective effects, make it a candidate likely ...http://orbi.ulg.ac.be/browse?type=author&value=FANIELLE%2C+Julien+p013591
NIH awards Acelerox grant to develop PEG-HCC nanoparticle for treatment of Alzheimer's Disease | Editor Spride
HOUSTON, TX (December, 2017) - The National Institute of Aging has awarded Acelerox, LLC, a Fannin Innovation Studio® company, a $224,813 grant to develop poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCC) antioxidant nanoparticles as a novel therapeutic to minimize neural degeneration by targeting brain cells.. Acelerox is a preclinical biotechnology company developing novel antioxidant nanoparticles for therapeutic use in cancer, neurological and autoimmune diseases. In partnership with Baylor College of Medicine, this award will be used to optimize the therapeutic approach. Proper axonal transport is essential for maintenance of neuronal homeostasis and optimum function. Deficiencies of axonal transport have been linked to Alzheimer's disease (AD) and can be modeled in cultured cells and animal models. Oxidative stress has been shown to be a key contributor to the pathogenesis of AD, including deficient axonal transport. Reduction of oxidative stress through ...http://www.editorspride.com/story/136691/nih-awards-acelerox-grant-to-develop-peghcc-nanoparticle-for-treatment-of-alzheimers-disease.html
There have been suggestions in the past that Alzheimer's is a hormone problem, but only recently has research into this hypothesis grown promising. When Doctor Suzanne de la Monte discovered that the brain produces a supply of insulin independent of the rest of the body, she surmised that the hormone must play a crucial role in brain function. In 2006, Dr. Monte published a study in the Journal of Alzheimer's Disease demonstrating that depleting insulin in the brains of rats produced neural degeneration in a pattern similar to Alzheimer's. This study did not explain how Alzheimer's interfered with insulin, but it did make a strong case for the idea that insulin deprivation is tied to brain malfunction. Later studies trying insulin in the brain to memory formation gave further support to Dr. Monte's theory ...http://www.treatmentonline.com/articles_pre/index.asp?article_id=46484&category=
Guru Technology News24: MIT team refines optical 'lab on a chip'
The research published this month goes one step further. Yanik and two collaborators, lead authors Fei Zeng, a postdoctoral fellow in the Research Laboratory of Electronics, and Christopher B. Rohde, a graduate student in electrical engineering and computer science, said they were able to render the animals motionless in the chip with an unprecedented stability for several minutes instead of seconds. This then allowed them not only to conduct three-dimensional imaging of the worms at the sub-cellular resolution but also to reliably operate on the animals with a high-precision surgery laser to study neural degeneration and regeneration on the chip. Yanik's team had previously demonstrated that neural regeneration can be studied in C. elegans using femtosecond laser micro-surgery ...http://24hoursnews.blogspot.com/2008/04/mit-team-refines-optical-lab-on-chip.html
Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis. - Wellcome Centre for Integrative Neuroimaging
Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration
The Scientific World Journal is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journal's Editorial Board as well as its Table of Contents are divided into 81 subject areas that are covered within the journal's scope.https://www.hindawi.com/journals/tswj/2012/168953/abs/
Muscle and nerve degeneration - Brain & Body Fitness - MedHelp
I have been having alot of pain, swelling, and discoloring of my left foot and ankle. My arch has fallen due to the tendion tearing. After going through alot of tests they found I have severe muscle an...https://www.medhelp.org/posts/Brain--Body-Fitness/Muscle-and-nerve-degeneration/show/1834008
In Case of Diabetic Nerve Degeneration, Expanding on a Recent Study, The Most Promising Diet For Obesity and Diabetes is a R...
Miami, Florida (PRWEB) September 18, 2011 -- Nutri-Med Logic Corp: A recent study published in 'Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy',http://www.prweb.com/releases/2011/9/prweb8806169.htm
CiNii 論文 - Probing the molecular mechanisms of neuronal degeneration : importance of...
内野 博之 , 田上 正 , 富野 美紀子 , 岩瀬 直人 , 益本 憲太郎 , 半田 典子 , 奈倉 武郎 , 近江 明文 蘇生 29(2), 78-90, 2010-06-25 医中誌Web 参考文献34件 ...http://ci.nii.ac.jp/naid/10021942407
hemiplegia | THE UNTITLED MAGAZINE
HAERTS the New York band released their four track Hemiplegia EP via Columbia Records (10/8). Last week, HAERTS partnered with Spotify to premiere the EP a week early on NYLON Magazine HERE. The band just finished up their tour with Washed Out, and will play the Neon Gold Records Showcase and a KEXP Live Session… ...http://untitled-magazine.com/tag/hemiplegia/