*  Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted...
Transplantation of rod photoreceptors is feasible, provided donor cells are at an appropriate stage of development when ... maximum 11,965 cells). Finally, as the OLM remains largely intact in many retinal disorders, we tested whether transient ZO-1 ... Transplantation of rod precursors in wild-type mice achieved 949 +/- 141 integrated cells. By contrast, integration is ... 58 cells without treatment to 919 +/- 198 cells after ZO-1 knockdown. This study shows that targeted disruption of OLM ...
  https://www.ndcn.ox.ac.uk/publications/107265
*  Study of Selected Rod Photoreceptor-Enriched Transcripts in Zebrafish Retina | IOVS | ARVO Journals
... analysis identified numerous transcripts differentially expressed in rod photoreceptors as compared to other retinal cells. Rxr ... RNA-seq of FACS-sorted dissociated retinal cells was performed to identify differentially expressed (in GFP+ vs. GFP- cells) ... Study of Selected Rod Photoreceptor-Enriched Transcripts in Zebrafish Retina You will receive an email whenever this article is ... Methods : We used a transgenic zebrafish line (XOPS:eGFP) in which rod photoreceptors express green fluorescent protein (GFP) ...
  http://iovs.arvojournals.org/article.aspx?articleid=2559383
*  Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. | Sigma-Aldrich
... allow late retinal progenitors to exit the cell cycle and enter a terminal differentiation pathway into rod photoreceptors. In ... Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase.. [Carolina Pinzon-Guzman, ... We conclude that one or both of these phosphatases are key components regulating the formation of rod photoreceptors in mouse ... Inhibition of Shp1/2 phosphatases was also sufficient to abolish the IGF1-mediated induction of rod photoreceptor ...
  https://www.sigmaaldrich.com/catalog/papers/25108518
*  Comparison of fundus autofluorescence with photopic and scotopic fine matrix mapping in patients with retinitis pigmentosa: 4-...
Retinal Cone Photoreceptor Cells / physiology. Retinal Rod Photoreceptor Cells / physiology. Retinitis Pigmentosa / ... Previous Document: Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration .... ... was largely coincident with progressive centripetal photopic threshold elevation led by worsening of rod photoreceptor function ...
  http://www.biomedsearch.com/nih/Comparison-fundus-autofluorescence-with-photopic/22899761.html
*  Howard Hughes Medical Institution - Research Output - Johns Hopkins University
Retinal Cone Photoreceptor Cells Retinal Rod Photoreceptor Cells Vertebrate Photoreceptor Cells Epigenomics ... Epigenomic landscapes of retinal rods and cones. Mo, A., Luo, C., Davis, F. P., Mukamel, E. A., Henry, G. L., Nery, J. R., ... Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Riccomagno, M. M., Sun, L. O., ... Schuller, A. P., Wu, C. C. C., Dever, T. E., Buskirk, A. R. & Green, R. Apr 20 2017 In : Molecular Cell. 66, 2, p. 194-205.e5. ...
  https://jhu.pure.elsevier.com/en/organisations/howard-hughes-medical-institution-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
*  Back -phosphorylation of GluR1 in the retina of the rdt | Open-i
Background: The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are ... Background: The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are ... receptors are altered in the retinae of rdta mice that lack rod photoreceptors. Because the rods are lost at an early stage in ... receptors are altered in the retinae of rdta mice that lack rod photoreceptors. Because the rods are lost at an early stage in ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC32198_1471-2202-2-7-4&req=4
*  PDE6B - Wikipedia
... the retinal rod photoreceptor cells begin degenerating at about postnatal day 10, and by 3 weeks no rod photoreceptors remain. ... Bennett J, Tanabe T, Sun D, Zeng Y, Kjeldbye H, Gouras P, Maguire AM (Jun 1996). "Photoreceptor cell rescue in retinal ... There are two types of photoreceptors: cones and rods. The rod and cone PDE6 complexes have different structures. PDE6β ... "The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression ...
  https://en.wikipedia.org/wiki/PDE6B
*  Researchers Use Human Stem Cells to Create Light-Sensitive Retina in a Dish
... which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of ... Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, ... the lab-grown photoreceptors responded to light the way retinal rods do. Human retinas contain two major photoreceptor cell ... Credit: Rod photoreceptors (in green) within a "mini retina" derived from human iPS cells in the lab/ Image courtesy of Johns ...
  http://www.newswise.com/articles/researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish
*  The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit |...
In the current study, we focused on neurotransmission between rod photoreceptor cells and rod bipolar cells in the retina. We ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit ...
  http://www.jneurosci.org/content/37/41/9889?rss=1
*  Photoreceptor cell - Wikipedia
... rods, cones, and photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each ... The membranous photoreceptor protein opsin contains a pigment molecule called retinal. In rod cells, these together are called ... The retina has many layers of various cell types. The best-known photoreceptor cells (rods and cones) form the outermost layer ... The human retina contains about 120 million rod cells, and 6 million cone cells. The number and ratio of rods to cones varies ...
  https://en.wikipedia.org/wiki/Photoreceptor_cell
*  In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors | Journal of Neuroscience
E3 chick retinal cells, and PN1 rat retinal cells for 5-7 d, and examined for the expression of opsin, a rod photoreceptor ... E18 retinal progenitors normally generate rod photoreceptors, bipolar cells, Müller glia, and a subset of amacrine cells. It ... Cells from an early stage of retinal histogenesis inhibit differentiation of late retinal progenitors into rod photoreceptors. ... 6B). However, to rule out an alternative possibility that the negative influence of E3 chick retinal cells on rod photoreceptor ...
  http://www.jneurosci.org/content/23/23/8193.long
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Neuroscience, Issue 94, Primary photoreceptor cell culture, Inherited retinal degeneration, Rod-derived Cone Viability Factor, ... is carried out by the rod and cone photoreceptor cells1-4. Rod photoreceptors are responsible for vision in dim light, cones in ... a rod photoreceptor specific marker. Alternatively, the photoreceptor layer (97% rods) can be used for gene or protein ... Light-induced retinal degeneration (LIRD) is commonly used in both rodents and zebrafish to damage rod and cone photoreceptors ...
  https://www.jove.com/visualize/abstract/26196397/modeling-photo-bleaching-kinetics-to-create-high-resolution-maps-rod
*  NEI FY2013 Budget Request | National Eye Institute
XLRP is a severe retinal disease that affects both rod and cone photoreceptor cells. Patients with XLRP experience night ... Treatment restored lost photoreceptor cell structure and repaired photoreceptor cell connections to other retinal neurons that ... The RPE is a highly specialized layer of cells adjoining the retina that support photoreceptor cell function. SMD and AMD are ... This gene is thought to play a role in the development of the optic nerve head, where retinal ganglion cell axons, which ...
  https://www.nei.nih.gov/news/congresstest/budget2013
*  Cytogenetics sub-cluster 37
... leads to early impairment of vision due to the simultaneous involvement of both cone and rod photoreceptor cells. Several loci/ ... Retinal dystrophies are a common cause of blindness in purebred dogs. Progressive retinal atrophy, the canine equivalent of ... Cone-rod dystrophy 1 (cord1) is a recessive condition that occurs naturally in miniature longhaired dachshunds (MLHDs). We ... Several retinal dystrophies, including retinitis pigmentosa type 12 and Leber congenital amaurosis, are caused by a large ...
  http://www.biomedsearch.com/cluster/35/Cytogenetics/sub-37-p2.html
*  A visual pigment expressed in both rod and cone photoreceptors. - PubMed - NCBI
Retinal Cone Photoreceptor Cells/metabolism*. *Retinal Pigments/biosynthesis*. *Retinal Rod Photoreceptor Cells/metabolism* ... In contrast, the two cells express distinct G protein transducin alpha subunits: rod alpha transducin in green rods and cone ... A visual pigment expressed in both rod and cone photoreceptors.. Ma J1, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono ... This suggests that neither the cell topology or the transducin is sufficient to differentiate the rod and the cone response. ...
  https://www.ncbi.nlm.nih.gov/pubmed/11709156
*  The Mouse Crx 5′-Upstream Transgene Sequence Directs Cell-Specific and Developmentally Regulated Expression in Retinal...
Rods mediate dim light vision. Both rod and cone photoreceptors elaborate a specialized structure, the outer segment, to catch ... and amacrine cells; and the ganglion cell layer (GCL), containing primarily ganglion cells. Photoreceptors, bipolar cells, and ... rod;A), calbindin (horizontal cell; D), vimentin (Müller glia; G), HPC-1 (amacrine cell;J), chx10 (bipolar cell;M), and lacZ (B ... rod; A), chx10 (bipolar cell;D), calbindin (horizontal cell; G), vimentin (Müller glia; J), HPC-1 (amacrine cell; M), and lacZ ...
  http://www.jneurosci.org/content/22/5/1640
*  Assessment of Cone Survival in Response to CNTF, GDNF, and VEGF165b in a Novel Ex Vivo Model of End-Stage Retinitis Pigmentosa ...
Streichert LC Birnbach CD Reh TA . A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in ... and to rod outer segments, 27 with no evidence of CNTFRα expression in photoreceptor cell bodies. 7 Müller cells are also ... 3A), confirming that the presence of rod photoreceptors is of great importance for the survival of cone photoreceptors. Daily ... Maier K . Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic ...
  http://iovs.arvojournals.org/article.aspx?articleid=2165560
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Neuroscience, Issue 94, Primary photoreceptor cell culture, Inherited retinal degeneration, Rod-derived Cone Viability Factor, ... Medicine, Issue 79, Photoreceptor Cells, Rodentia, Retinal Degeneration, Retinal Detachment, animal models, Neuroscience, ... a rod photoreceptor specific marker. Alternatively, the photoreceptor layer (97% rods) can be used for gene or protein ... Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells. Authors: Peter Westenskow, Zack Sedillo, Ashley ...
  https://www.jove.com/visualize/abstract/25786237/lens-status-influences-association-between-cfh-polymorphisms-age
*  VisionAware Blog - VisionAware Blog - VisionAware
The RPE helps to maintain the health of the retinal photoreceptor cells, called rods and cones. These cells are triggered by ... Atrophy: Degeneration of the deepest cells of the retina, called the retinal pigment epithelium (RPE). ... The degeneration of the RPE cells also leads to the death of the rods and cones. ... "Atrophy" refers to the degeneration of cells in a portion of the body; in this case, the cell degeneration occurs in the retina ...
  https://www.visionaware.org/blog/visionaware-blog/1
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... the majority of cells that are electroporated at P0 are rods. For this reason, rod photoreceptors are the easiest retinal cell ... Once retinal cell types become post-mitotic, electroporation is much less efficient. Given the high rate of rod birth in ... GFP expressing cells targeted through this approach showed typical axonal projections, as previously described for mitral cells ... In recent years, the ability to efficiently generate cardiomyogenic cells from human pluripotent stem cells (hPSCs) has greatly ...
  https://www.jove.com/visualize/abstract/22448256/identification-analysis-conserved-cis-regulatory-regions-meis1
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... the majority of cells that are electroporated at P0 are rods. For this reason, rod photoreceptors are the easiest retinal cell ... Once retinal cell types become post-mitotic, electroporation is much less efficient. Given the high rate of rod birth in ... Neural stem/precursor cells (NPCs) are a promising stem cell source for transplantation approaches aiming at brain repair or ... These experimental data have identified the cell delivery route as one of the main hurdles of restorative stem cell therapies ...
  https://www.jove.com/visualize/abstract/24705533/nucleosomes-are-stably-evicted-from-enhancers-but-not-promoters-upon
*  Binding of retinoids to ABCA4, th... preview & related info | Mendeley
... which has been implicated in the clearance of all-trans retinal derivatives from rod and cone photoreceptor cells fo... ... which has been implicated in the clearance of all-trans retinal derivatives from rod and cone photoreceptor cells following ... This immunoaffinity matrix is then used to isolate ABCA4 from photoreceptor outer segments or transfected cells. All-trans ... These procedures and related radiometric assays using titrated retinal have been used to study the binding of N-retinylidene-PE ...
  https://www.mendeley.com/research-papers/binding-retinoids-abca4-photoreceptor-abc-transporter-associated-stargardt-macular-degeneration/
*  Chickens | Harvard Catalyst Profiles | Harvard Catalyst
Retinal Rod Photoreceptor Cells. *Gene Expression Regulation, Developmental. *Body Patterning. *Avian Proteins ... PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc ...
  https://connects.catalyst.harvard.edu/Profiles/display/Concept/Chickens
*  Ru Xiao | Harvard Catalyst Profiles | Harvard Catalyst
Retinal Cone Photoreceptor Cells. *Oxygen Consumption. *Retinal Rod Photoreceptor Cells. *Cerebrovascular Circulation ... AAV9 targets cone photoreceptors in the nonhuman primate retina. PLoS One. 2013; 8(1):e53463. PMID: 23382846; PMCID: PMC3559681 ...
  https://connects.catalyst.harvard.edu/Profiles/display/Person/110451
*  RHO Gene - GeneCards | OPSD Protein | OPSD Antibody
... is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed ... Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) ... Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a ... Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=RHO