Loading...


*  Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted...
Transplantation of rod photoreceptors is feasible, provided donor cells are at an appropriate stage of development when ... maximum 11,965 cells). Finally, as the OLM remains largely intact in many retinal disorders, we tested whether transient ZO-1 ... Transplantation of rod precursors in wild-type mice achieved 949 +/- 141 integrated cells. By contrast, integration is ... 58 cells without treatment to 919 +/- 198 cells after ZO-1 knockdown. This study shows that targeted disruption of OLM ...
  https://www.ndcn.ox.ac.uk/publications/107265
*  Study of Selected Rod Photoreceptor-Enriched Transcripts in Zebrafish Retina | IOVS | ARVO Journals
... analysis identified numerous transcripts differentially expressed in rod photoreceptors as compared to other retinal cells. Rxr ... RNA-seq of FACS-sorted dissociated retinal cells was performed to identify differentially expressed (in GFP+ vs. GFP- cells) ... Study of Selected Rod Photoreceptor-Enriched Transcripts in Zebrafish Retina You will receive an email whenever this article is ... Methods : We used a transgenic zebrafish line (XOPS:eGFP) in which rod photoreceptors express green fluorescent protein (GFP) ...
  http://iovs.arvojournals.org/article.aspx?articleid=2559383
*  Plus it
Retinal rod photoreceptors rely on the prototypical GPCR-mediated pathway to detect light (Stryer, 1986). They present a unique ... Our results obtained in intact mammalian rod photoreceptor cells address the role of the G-protein βγ-complex in modulating ... This high amplification system allows retinal rod photoreceptors to detect single photons of light. Although much is now known ... Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells ...
  http://www.jneurosci.org/content/31/22/8067
*  Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. | Sigma-Aldrich
... allow late retinal progenitors to exit the cell cycle and enter a terminal differentiation pathway into rod photoreceptors. In ... Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase.. [Carolina Pinzon-Guzman, ... We conclude that one or both of these phosphatases are key components regulating the formation of rod photoreceptors in mouse ... Inhibition of Shp1/2 phosphatases was also sufficient to abolish the IGF1-mediated induction of rod photoreceptor ...
  https://www.sigmaaldrich.com/catalog/papers/25108518
*  Ion transport modeling for retinal rod photoreceptor cells
The model can effectively describe the rod photoreceptor response to different light stimuli. Model simulation of the a-wave ... a mathematical model is developed to describe the ion transport activities associated with the response of rod photoreceptor to ... In the model, the cell body is modeled as two capacitors connected via the connecting cilium. Roles of different ion channels ... during a photoreceptor light response are analyzed, and the relations between changes in ion concentration and response ...
  https://mospace.umsystem.edu/xmlui/handle/10355/44856
*  Deletion of the Insulin Receptor in Rod Photoreceptor Cells Results in Light-Induced Retinal Degeneration | IOVS | ARVO Journals
Deletion of the Insulin Receptor in Rod Photoreceptor Cells Results in Light-Induced Retinal Degeneration ... Deletion of the Insulin Receptor in Rod Photoreceptor Cells Results in Light-Induced Retinal Degeneration ... Deletion of the Insulin Receptor in Rod Photoreceptor Cells Results in Light-Induced Retinal Degeneration. Invest. Ophthalmol. ... Conclusions:: Loss of the IR rod photoreceptor cells increases their susceptibility to light-induced apoptosis and suggests ...
  https://iovs.arvojournals.org/article.aspx?articleid=2387325
*  Comparison of fundus autofluorescence with photopic and scotopic fine matrix mapping in patients with retinitis pigmentosa: 4-...
Retinal Cone Photoreceptor Cells / physiology. Retinal Rod Photoreceptor Cells / physiology. Retinitis Pigmentosa / ... Previous Document: Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration .... ... was largely coincident with progressive centripetal photopic threshold elevation led by worsening of rod photoreceptor function ...
  http://www.biomedsearch.com/nih/Comparison-fundus-autofluorescence-with-photopic/22899761.html
*  Rods (A-C) and ganglion cells (D-F) in retinal area | Open-i
... and ganglion cells (D-F) in retinal areas 4 (A, D), 2 (B, E) and 9 (C, F) of DR12 (Refer to caption of Fig. 5). D-F are taken ... fig_003: Rods (A-C) and ganglion cells (D-F) in retinal areas 4 (A, D), 2 (B, E) and 9 (C, F) of DR12 (Refer to caption of Fig ... fig_003: Rods (A-C) and ganglion cells (D-F) in retinal areas 4 (A, D), 2 (B, E) and 9 (C, F) of DR12 (Refer to caption of Fig ... In area 2 corresponding to the dorsal thin part of the tapetum, rods are large in diameter, and ganglion cells are low in ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4363019_jvms-77-175-g003&req=4
*  ERG responses in 4 week old GHL+ and GHL+/Chop−/− m | Open-i
Retinal Rod Photoreceptor Cells/physiology*. *Retinitis Pigmentosa/genetics*. *Transcription Factor CHOP/genetics* ... We examined the role of the ER stress proteins, Chop and Ask1, in regulating the death of rod photoreceptors in a mouse line ... We examined the role of the ER stress proteins, Chop and Ask1, in regulating the death of rod photoreceptors in a mouse line ... The cornea-negative leading edge of the ERG waveform, the a-wave, originates from photoreceptor cells [46], and the maximal ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3921110_pone.0083871.g002&req=4
*  Howard Hughes Medical Institution - Research Output - Johns Hopkins University
Retinal Cone Photoreceptor Cells Retinal Rod Photoreceptor Cells Vertebrate Photoreceptor Cells Epigenomics ... Epigenomic landscapes of retinal rods and cones. Mo, A., Luo, C., Davis, F. P., Mukamel, E. A., Henry, G. L., Nery, J. R., ... Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Riccomagno, M. M., Sun, L. O., ... Schuller, A. P., Wu, C. C. C., Dever, T. E., Buskirk, A. R. & Green, R. Apr 20 2017 In : Molecular Cell. 66, 2, p. 194-205.e5. ...
  https://jhu.pure.elsevier.com/en/organisations/howard-hughes-medical-institution-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
*  Back -phosphorylation of GluR1 in the retina of the rdt | Open-i
Background: The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are ... Background: The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are ... receptors are altered in the retinae of rdta mice that lack rod photoreceptors. Because the rods are lost at an early stage in ... receptors are altered in the retinae of rdta mice that lack rod photoreceptors. Because the rods are lost at an early stage in ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC32198_1471-2202-2-7-4&req=4
*  Barrow, Jeffery
Conditional deletion of PhLP1 from retinal rod or cone photoreceptor cells demonstrates an essential role for PhLP1 in G ... Phosducin-Like Protein 1 is Essential for G-Protein Assembly and Signaling in Retinal Rod Photoreceptors. The Journal of ... By modifying gene activity in subsets of cells in the limb and then observing the behavior of these modified cells over time, ... Wnt/planar cell polarity signaling: An important mechanism to coordinate growth and patterning in the limb. Thomas J. Carroll, ...
  http://lifesciences.byu.edu/About/Faculty-and-Staff/ctl/FacultyProfile/mid/1424/NetID/jrb298
*  PDE6B - Wikipedia
... the retinal rod photoreceptor cells begin degenerating at about postnatal day 10, and by 3 weeks no rod photoreceptors remain. ... Bennett J, Tanabe T, Sun D, Zeng Y, Kjeldbye H, Gouras P, Maguire AM (Jun 1996). "Photoreceptor cell rescue in retinal ... There are two types of photoreceptors: cones and rods. The rod and cone PDE6 complexes have different structures. PDE6β ... "The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression ...
  https://en.wikipedia.org/wiki/PDE6B
*  High-resolution retinal imaging of cone-rod dystrophy. - Semantic Scholar
It can provide a quantitative measurement of photoreceptor loss in retinal disease. ... METHODS High-resolution retinal images of a patient with cone-rod dystrophy were obtained with the University of Rochester ... Here we use adaptive optics ophthalmoscopy to image cone-rod dystrophy in vivo and compare these results with standard clinical ... RESULTS Adaptive optics images were acquired at multiple retinal locations throughout a clinically detected bull's-eye lesion. ...
  https://www.semanticscholar.org/paper/High-resolution-retinal-imaging-of-cone-rod-Wolfing-Chung/a6fdef51651b309f493287346d32c748c999c25e
*  S-arrestin Antibody (PDS-1) (NB100-2385): Novus Biologicals
Besides retinal rod photoreceptor cell outer segment, S-arrestin is also expressed in the pineal gland where its function is ... S-arrestin is rod specific and constitutes major proteins of retinal rod outer segments and associate with photoactivated/ ... Arrestin knockout mice develop photoreceptor cell degeneration because of continuous phototransduction upregulation, as a ... are localized to retinal rods and cones, respectively, whereas the non-visual proteins arrestin 2 (beta-arrestin 1) and ...
  https://www.novusbio.com/products/s-arrestin-antibody-pds-1_nb100-2385
*  Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy | IOVS | ARVO...
CD73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells. Invest Ophthalmol Vis Sci. 2009; ... Grafted photoreceptors integrated into the retinal host tissue, acquired mature photoreceptor morphology, expressed rod- ... Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells. 2011; 29: ... the use of a single cell surface marker to enrich rod photoreceptors from retinal organoids might be sufficient to ensure ...
  https://iovs.arvojournals.org/article.aspx?articleid=2532329
*  The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit |...
In the current study, we focused on neurotransmission between rod photoreceptor cells and rod bipolar cells in the retina. We ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit ... The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit ...
  http://www.jneurosci.org/content/37/41/9889?rss=1
*  Photoreceptor cell - Wikipedia
... rods, cones, and photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each ... The membranous photoreceptor protein opsin contains a pigment molecule called retinal. In rod cells, these together are called ... The retina has many layers of various cell types. The best-known photoreceptor cells (rods and cones) form the outermost layer ... The human retina contains about 120 million rod cells, and 6 million cone cells. The number and ratio of rods to cones varies ...
  https://en.wikipedia.org/wiki/Photoreceptor_cell
*  First nanoengineered retinal implant could help the blind regain functional vision | Kurzweil
... photosensitive silicon nanowires 1 micrometer in diameter stimulate residual undamaged retinal cells to induce visual ... Retinal photoreceptor cells: rods (yellow) and cones (green). (right) Fabricated silicon nanowires (1 micrometer in diameter) ... the silicon nanowires mimic the retina's light-sensing cones and rods to directly stimulate retinal cells. The nanowires are ... at the same spatial magnification as photoreceptor cells. (credit: Science Photo Library and Sohmyung Ha et al./ J. Neural Eng ...
  http://www.kurzweilai.net/first-nanoengineered-retinal-implant-could-help-the-blind-regain-functional-vision
*  Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging | British Journal...
Within this same region, rod photoreceptors were enlarged and were thus identifiable at single-cell resolution (figure 3H, I, L ... The increased rod spacing in patient IV-5 indicates that rod loss may be present in early disease and that rod loss in the ... rod photoreceptors are not expected to be discernible in normal retinae and are not regularly identified at single-cell ... and histological data23 were used for rods and foveal cones. The sign test was used to compare photoreceptor cell spacing ...
  https://bjo.bmj.com/content/102/1/136.long
*  Researchers Use Human Stem Cells to Create Light-Sensitive Retina in a Dish - Healthcanal.com : Healthcanal.com
... the lab-grown photoreceptors responded to light the way retinal rods do. Human retinas contain two major photoreceptor cell ... They did so by placing an electrode into a single photoreceptor cell and then giving a pulse of light to the cell, which ... In this case, the Johns Hopkins team turned them into retinal progenitor cells destined to form light-sensitive retinal tissue ... a structure essential for photoreceptors to function. Retinal tissue is complex, comprising seven major cell types, including ...
  https://www.healthcanal.com/eyes-vision/51814-researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish.html
*  In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors | Journal of Neuroscience
E3 chick retinal cells, and PN1 rat retinal cells for 5-7 d, and examined for the expression of opsin, a rod photoreceptor ... E18 retinal progenitors normally generate rod photoreceptors, bipolar cells, Müller glia, and a subset of amacrine cells. It ... Cells from an early stage of retinal histogenesis inhibit differentiation of late retinal progenitors into rod photoreceptors. ... 6B). However, to rule out an alternative possibility that the negative influence of E3 chick retinal cells on rod photoreceptor ...
  http://www.jneurosci.org/content/23/23/8193.long
*  Table of Contents - August 15, 1997, 17 (16) | Journal of Neuroscience
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro Edward M. Levine, Henk Roelink, ... GABAergic and glycinergic IPSCs in Ganglion Cells of Rat Retinal Slices Dario A. Protti, Hersch M. Gerschenfeld and Isabel ... Intracortical Axonal Projections of Lamina VI Cells of the Primary Somatosensory Cortex in the Rat: A Single-Cell Labeling ... The Role of CED-3-Related Cysteine Proteases in Apoptosis of Cerebellar Granule Cells Basil A. Eldadah, Alexander G. Yakovlev ...
  http://www.jneurosci.org/content/17/16
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Neuroscience, Issue 94, Primary photoreceptor cell culture, Inherited retinal degeneration, Rod-derived Cone Viability Factor, ... is carried out by the rod and cone photoreceptor cells1-4. Rod photoreceptors are responsible for vision in dim light, cones in ... a rod photoreceptor specific marker. Alternatively, the photoreceptor layer (97% rods) can be used for gene or protein ... Light-induced retinal degeneration (LIRD) is commonly used in both rodents and zebrafish to damage rod and cone photoreceptors ...
  https://www.jove.com/visualize/abstract/26196397/modeling-photo-bleaching-kinetics-to-create-high-resolution-maps-rod
*  NEI FY2013 Budget Request | National Eye Institute
XLRP is a severe retinal disease that affects both rod and cone photoreceptor cells. Patients with XLRP experience night ... Treatment restored lost photoreceptor cell structure and repaired photoreceptor cell connections to other retinal neurons that ... The RPE is a highly specialized layer of cells adjoining the retina that support photoreceptor cell function. SMD and AMD are ... This gene is thought to play a role in the development of the optic nerve head, where retinal ganglion cell axons, which ...
  https://www.nei.nih.gov/news/congresstest/budget2013