*  IJMS | Free Full-Text | Tenomodulin Inhibits Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy
... on retinal neovascularization in an oxygen-induced retinopathy (OIR) mouse model. OIR was induced in C57BL/6 mice by exposing ... Retinal blood vessel patterns were visualized by fluorescein angiography. We quantified the number of neovascular nuclei that ... and the number of nuclei in new blood vessels breaking through the ILM in each retinal cross-section significantly differed ... indicating its potential role in prevention and treatment of ocular neovascularization. ...
  http://www.mdpi.com/1422-0067/13/11/15373
*  Choroidal Involution Is a Key Component of Oxygen-Induced Retinopathy | IOVS | ARVO Journals
Retinal structure is altered in OIR/ROP. (A) Hematoxylin and eosin-stained central and peripheral retinal cross-sections of ... Triamcinolone Reduces Neovascularization, Capillary Density and IGF-1 Receptor Phosphorylation in a Model of Oxygen-Induced ... Retinal structure is altered in OIR/ROP. (A) Hematoxylin and eosin-stained central and peripheral retinal cross-sections of ... Retinal structure is altered in OIR/ROP. (A) Hematoxylin and eosin-stained central and peripheral retinal cross-sections of ...
  http://iovs.arvojournals.org/article.aspx?articleid=2187312
*  Human Apolipoprotein(a) Kringle V Inhibits Ischemia-Induced Retinal Neovascularization via Suppression of Fibronectin-Mediated...
rhLK8 inhibits retinal neovascularization in a dose-dependent manner without cellular or retinal toxicity. rhLK8 did not induce ... complications of retinal neovascularization in DR come from the proliferation of retinal neovessels into the vitreous cavity. ... Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy. J Cell Mol Med ... Retinal neovascularization peaks at P17. We intravitreally injected rhLK8 (0.1-10 μmol/L in 1 μL PBS) at P14. Quantitative ...
  http://diabetes.diabetesjournals.org/content/61/6/1599
*  Antiangiogenic Activity of Aganirsen in Nonhuman Primate and Rodent Models of Retinal Neovascular Disease after Topical...
Topical aganirsen inhibited retinal neovascularization after OIR in rats (P , 0.05); furthermore, a single intravitreal ... Higgins RD Yu K Sanders RJ Nandgaonkar BN Rotschild T Rifkin DB . Diltiazem reduces retinal neovascularization in a mouse model ... An important feature of our findings is that topical application of aganirsen effectively reduces retinal neovascularization by ... Retinal delivery after topical administration was confirmed, and retinal expression of IRS-1 was demonstrated to be elevated in ...
  http://iovs.arvojournals.org/article.aspx?articleid=2188090
*  Cyclooxygenase-2 in Human and Experimental Ischemic Proliferative Retinopathy | Circulation
1 Retinal ischemia is a common precursor to vitreal neovascularization in retinal diseases2 and is associated with a local ... Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF ... Etodolac caused a marked decrease in retinal neovascularization (studied at 5 days after the first injection) (Figure 5A and 5B ... Expression of thrombospondin-1 in ischemia-induced retinal neovascularization. Am J Pathol. 1999; 154: 343-354. ...
  http://circ.ahajournals.org/content/108/2/198
*  The Vitreous Glycoprotein Opticin Inhibits Preretinal Neovascularization | IOVS | ARVO Journals
Preretinal neovascularization is an angiogenic process whereby new blood vessels grow from the preexisting retinal vasculature ... Squalamine Improves Retinal Neovascularization. Molecular Targeting of Antiangiogenic Factor 16K hPRL Inhibits Oxygen-Induced ... Mori K Duh E Gehlbach P . Pigment epithelium-derived factor inhibits retinal and choroidal neovascularisation. J Cell Physiol. ... Wu Z Wang S Sorenson CM Sheibani N . Attenuation of retinal vascular development and neovascularisation in transgenic mice over ...
  http://iovs.arvojournals.org/article.aspx?articleid=2126835
*  am j pathology Archives - Retraction Watch at Retraction Watch
Ocular neovascularization occurs when growth signals in the eye stimulate the creation of many new blood vessels. Over time ... The retraction notice for "Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase ... in an expression of concern for a paper in the American Journal of Pathology on a treatment for ocular neovascularization, ... Enhances the Efficacy of Anti-Vascular Endothelial Growth Factor Therapy in Multiple Models of Ocular Neovascularization": ...
  http://retractionwatch.com/category/by-journal/am-j-pathology/
*  Retinal Vasculopathy Is Reduced by Dietary Salt RestrictionSignificance | Arteriosclerosis, Thrombosis, and Vascular Biology
Objective-Neovascularization and vaso-obliteration are vision-threatening events that develop by interactions between retinal ... An LS diet reduced retinal neovascularization and vaso-obliteration, the mRNA and protein levels of the angiogenic factors, ... Conclusions-An LS diet reduced retinal vasculopathy, by modulating glial cell function and the retinal renin-angiotensin- ... Retinal Vasculopathy Is Reduced by Dietary Salt RestrictionSignificance. Devy Deliyanti, Roksana Armani, David Casely, William ...
  http://atvb.ahajournals.org/content/34/9/2033.short?rss=1
*  Inhibition of Oxygen-Induced Retinopathy in RTP801-Deficient Mice | IOVS | ARVO Journals
In addition to retinal neovascularization, it involves retinal degeneration, of which apoptosis is the main cause. A prior ... Dependence of retinal neovascularization response on the severity of retinal vaso-obliteration. The analysis was performed as a ... Dependence of retinal neovascularization response on the severity of retinal vaso-obliteration. The analysis was performed as a ... Dependence of retinal neovascularization response on the severity of retinal vaso-obliteration. The analysis was performed as a ...
  http://iovs.arvojournals.org/article.aspx?articleid=2123998
*  Retinal Clock Genes Influence Retinal Neovascularization | IOVS | ARVO Journals
Retinal Clock Genes Influence Retinal Neovascularization You will receive an email whenever this article is corrected, updated ... Lili Xu, Douglas McMahon, John S Penn; Retinal Clock Genes Influence Retinal Neovascularization. Invest. Ophthalmol. Vis. Sci. ... These data indicate that the Period clock genes influence the retinal neovascularizing response and suggest that retinal PERIOD ... OIR-induced neovascularization was significantly increased in Per1/Per2 KO mice at P18 when measured as proportion of vascular ...
  http://iovs.arvojournals.org/article.aspx?articleid=2270990
*  Triamcinolone Acetonide Inhibits Retinal Neovascularization Induced by Hypoxic Stimuli | IOVS | ARVO Journals
Triamcinolone Acetonide Inhibits Retinal Neovascularization Induced by Hypoxic Stimuli N. Kitaya; H. Yokota; R. Sugawara; M. ... Triamcinolone Acetonide Inhibits Retinal Neovascularization Induced by Hypoxic Stimuli You will receive an email whenever this ... In the present study, we investigated if triamcinolone acetonide inhibited retinal neovascularization in a retinopathy of ... Conclusions: This study showed that triamcinolone acetonide inhibits retinal neovascularization and improves the morphologic ...
  https://iovs.arvojournals.org/article.aspx?articleid=2412357
*  Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165 |...
Tissue Kallikrein Inhibited Retinal Neovascularization in a Murine OIR Model. The effect of tissue kallikrein on retinal ... Irreversible vision loss and blindness has been increasing because of abnormal retinal neovascularization. Retinal neovascular ... Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165. Shinsuke ... The inhibitory effect of tissue kallikrein for retinal neovascularization in a murine OIR model. A, Shown are original images ( ...
  http://atvb.ahajournals.org/content/31/5/1041
*  Microarray Analysis of Retinal Gene Expression in a Rat Model of Retinal Neovascularization | IOVS | ARVO Journals
F. M. Recchia, L. Xu; Microarray Analysis of Retinal Gene Expression in a Rat Model of Retinal Neovascularization. Invest. ... Microarray Analysis of Retinal Gene Expression in a Rat Model of Retinal Neovascularization ... Microarray Analysis of Retinal Gene Expression in a Rat Model of Retinal Neovascularization ... the ischemic phase preceding retinal neovascularization) and P20 (the peak of the proliferative phase of retinal ...
  https://iovs.arvojournals.org/article.aspx?articleid=2386124
*  Characterization of DL-2-aminoadipic acid-induced retinal neovascularization and leakage in nonhuman primates | IOVS | ARVO...
Characterization of DL-2-aminoadipic acid-induced retinal neovascularization and leakage in nonhuman primates ... Characterization of DL-2-aminoadipic acid-induced retinal neovascularization and leakage in nonhuman primates ... Characterization of DL-2-aminoadipic acid-induced retinal neovascularization and leakage in nonhuman primates. Invest. ... suggesting the retinal vascular leakage was likely due to a disruption of the retinal microvascular endothelium rather than ...
  http://iovs.arvojournals.org/article.aspx?articleid=2562438
*  Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization...
Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats. Rosemary J. Santulli, William A. Kinney ... Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats. Rosemary J. Santulli, William A. Kinney ... Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats. Rosemary J. Santulli, William A. Kinney ... Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats Message Subject (Your Name) has forwarded ...
  http://jpet.aspetjournals.org/content/324/3/894
*  The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity |...
Retinal Cell Biology , February 2017. The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse ... in retinal vascular development and ischemia-induced retinal neovascularization (NV). Methods: The expression of nAChR subtypes ... Retinal neovascularization (rNV) was induced in neonatal mice as previously described.22 Briefly, at postnatal day 7 (P7), ... Grossniklaus HE, Kang SJ, Berglin L. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res. 2010; 29: ...
  https://iovs.arvojournals.org/article.aspx?articleid=2607075
*  Anti-Angiogenic Effect of Luteolin on Retinal Neovascularization via Blockade of Reactive Oxygen Species Production | IOVS |...
Luteolin inhibits retinal neovascularization in OIR. (A, B, C) Retinal vasculatures of control and luteolin-treated mice with ... Luteolin inhibits retinal neovascularization in OIR. (A, B, C) Retinal vasculatures of control and luteolin-treated mice with ... Luteolin inhibits retinal neovascularization in OIR. (A, B, C) Retinal vasculatures of control and luteolin-treated mice with ... Luteolin inhibits retinal neovascularization in OIR. (A, B, C) Retinal vasculatures of control and luteolin-treated mice with ...
  https://iovs.arvojournals.org/article.aspx?articleid=2127446
*  The Impact on Vision and Regression of Retinal Neovascularization of Anti-VEGF Induction in Combination with Quarterly Anti...
The Impact on Vision and Regression of Retinal Neovascularization of Anti-VEGF Induction in Combination with Quarterly Anti- ... The Impact on Vision and Regression of Retinal Neovascularization of Anti-VEGF Induction in Combination with Quarterly Anti- ... Victor Gonzalez; The Impact on Vision and Regression of Retinal Neovascularization of Anti-VEGF Induction in Combination with ... versus standard PRP is better at preserving vision and inducing regression of retinal neovascularization. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2149474
*  Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR | IOVS | ARVO...
Squalamine Improves Retinal Neovascularization. Soluble Forms of EphrinB2 and EphB4 Reduce Retinal Neovascularization in a ... Retinal vascular area and retinal neovascularization were assessed by adenosine diphosphatase staining of retinal flatmounts ... Retinal Cell Biology , February 2007. Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization ... 9 in retinal neovascularization. The susceptibilities of MMP-2−/− and -9−/− mice to preretinal neovascularization were ...
  https://iovs.arvojournals.org/article.aspx?articleid=2124958
*  Quantification of aflibercept and ranibizumab efficacy in DL-2-aminoadipic acid (DLAAA)-induced retinal neovascularization and...
Purpose : To define the optimal strategy for grading and quantifying the retinal neovascularization and leakage induced by ... Quantification of aflibercept and ranibizumab efficacy in DL-2-aminoadipic acid (DLAAA)-induced retinal neovascularization and ... Quantification of aflibercept and ranibizumab efficacy in DL-2-aminoadipic acid (DLAAA)-induced retinal neovascularization and ... induced retinal neovascularization and vascular leakage in nonhuman primates. Invest. Ophthalmol. Vis. Sci. 2017;58(8):210. ...
  http://iovs.arvojournals.org/article.aspx?articleid=2637000
*  Mueller cell derived VEGF164 knockdown reduces retinal neovascularisation in the rat model of retinopathy of prematurity. |...
... to total retinal area were determined by retinal flat mounts. TUNEL assay was done on retinal cryosections. ... Mueller cell derived VEGF164 knockdown reduces retinal neovascularisation in the rat model of retinopathy of prematurity. ... Mueller cell derived VEGF164 knockdown reduces retinal neovascularisation in the rat model of retinopathy of prematurity. ... Mueller cell derived VEGF164 knockdown reduces retinal neovascularisation in the rat model of retinopathy of prematurity.. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2270994
*  Gene delivery of vasostatin via a self-complementary adeno-associated virus 2 inhibits retinal neovascularization in a rat...
Purpose : Retinal neovascularization is a common pathological feature in diabetic retinopathy and retinopathy of prematurity, ... Gene delivery of vasostatin via a self-complementary adeno-associated virus 2 inhibits retinal neovascularization in a rat ... Gene delivery of vasostatin via a self-complementary adeno-associated virus 2 inhibits retinal neovascularization in a rat ... Conclusions : Intravitreal scAAV2-VS112 and scAAV2-VS180 gene therapy effectively inhibit retinal neovascularization in a rat ...
  http://iovs.arvojournals.org/article.aspx?articleid=2640753
*  Involvement of Nox2 NADPH Oxidase in Retinal Neovascularization | IOVS | ARVO Journals
Inhibits Pathologic Retinal Neovascularization. Pathological but Not Physiological Retinal Neovascularization Is Altered in TNF ... but its role in retinal neovascularization is unclear. We have analyzed the dependence of retinal neovascularization on the ... Pathologic retinal neovascularization typically occurs in the context of retinal hypoxia that is a consequence of the loss of ... Persistent Inhibition of Oxygen-Induced Retinal Neovascularization by Anthrax Lethal Toxin. Hyperoxia/Normoxia-Driven Retinal ...
  http://iovs.arvojournals.org/article.aspx?articleid=2203066
*  Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical...
Topical aganirsen inhibited retinal neovascularization after OIR in rats (P , 0.05); furthermore, a single intravitreal ... Topical application of aganirsen offers a safe and effective therapy for both choroidal and retinal neovascularization without ... Retinal delivery after topical administration was confirmed, and retinal expression of IRS-1 was demonstrated to be elevated in ... the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal neovascularization. ...
  https://www.ncbi.nlm.nih.gov/pubmed?term=Cloutier%20F%2C%20Lawrence%20M%2C%20Goody%20R%2C%20Lamoureux%20S%2C%20Al
*  Immune Recovery Uveitis: Pathogenesis, Clinical Symptoms, and Treatment
Neovascularization of the Retina or Optic Disc [13, 52, 53]. Wright et al. reported extensive peripheral retinal ... M. E. Wright, D. L. Suzman, K. G. Csaky, H. Masur, M. A. Polis, and M. R. Robinson, "Extensive retinal neovascularization as a ... The retina is protected by the blood-retinal barrier (BRB) which is composed of human retinal microvascular endothelial cells ( ... A perivascular yellow-white retinal lesion frequently associated with retinal hemorrhage or a focal white granular infiltrate, ...
  https://www.hindawi.com/journals/mi/2014/971417/