Takami, Y.; Nakayama, T. 1992: Presence of distinct transcriptional regulatory elements in the 5'-flanking region shared ... Kimura, N.; Takamatsu, N.; Yaoita, Y.; Osamura, R.Y.; Kimura, N. 2008: Identification of transcriptional regulatory elements in ... Transcriptional regulatory elements in the 5-flanking region of human endothelin-A receptor gene Circulation 90(4 Part 2): I292 ... Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse ...

... that occur during murine astrocyte maturation in vivo that are accompanied by chromatin remodelling at enhancer elements. ... Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and identify transcription ... which in turn induce in a modular manner the transcriptional and chromatin changes underlying astrocyte maturation. Astrocytes ... Dbx2 and Lhx2 and improves astrocyte maturity based on transcriptional and chromatin profiles. Therefore, extrinsic signals ...

The results validate that the CisTransMine approach is a robust method to uncover the hidden transcriptional regulatory ... Specifically, this method will predict potential cis-regulatory elements in promoter regions which could regulate gene ... mechanisms that can facilitate the discovery of mechanisms of transcriptional regulation. ... From: Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression ...

FIREWACH: A Functional approach for elucidating transcriptional regulatory elements within mammalian genomes.. Dr. Lisa Dailey ... Lisa Dailey FIREWACH: A Functional approach for elucidating transcriptional regulatory elements within mammalian genomes. ...

Functional flexible cis-regulatory modules are called billboards. Their transcriptional output is the summation effect of the ... There are cis-regulatory and trans-regulatory elements. Cis-regulatory elements are often binding sites for one or more trans- ... Cis-regulatory modules are one of several types of functional regulatory elements. Regulatory elements are binding sites for ... cis-regulatory elements are present on the same molecule of DNA as the gene they regulate whereas trans-regulatory elements can ...

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. ... Regulatory Elements, Transcriptional* * Transcription Elongation, Genetic * Transcription Initiation Site* * Transcription, ... CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. ...

In addition, five ABA-responsive elements were enriched in CmNAC1 promoter. The CmNAC1-EE plants exhibited different root ... In addition, five ABA-responsive elements were enriched in CmNAC1 promoter. The CmNAC1-EE plants exhibited different root ... stress-responsive cis-acting regulatory elements (Supplementary Figure S5). Stress response-related cis-acting elements, that ... GmNAC11 is a transcriptional activator, whereas GmNAC20 is a mild transcriptional repressor. The EE of GmNAC20 improves the ...

Regulatory Elements, Transcriptional. *eIF-2 Kinase. *Apoptosis. *Endoplasmic Reticulum Stress. *Plasma Cells ... This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X ... The tumor suppressor p53/p21 axis is a core pathway controlling cell cycle progression; however, its regulatory mechanism has ... XBP1-s promotes colorectal cancer cell proliferation by inhibiting TAp73 transcriptional activity.. Biochem Biophys Res Commun ...

Transcriptional targeting in the airway using novel gene regulatory elements. Burnight ER, et al. Am J Respir Cell Mol Biol, ... iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits. ... iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits. ... iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits. ...

This study sheds new light on the design principles underpinning the organization of transcriptional regulatory networks, ... Here, we unravel the transcriptional regulatory network of Escherichia coli by separating it into its key elements, thus ... We identified a new element in transcriptional regulatory networks never described before: intermodular genes. These are ... based on the topological features of the transcriptional regulatory network, to classify the network elements into one of two ...

Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter. J Biochem. 1997; ... C) Targeted ablation of a Spi1 (encoding PU.1) enhancer -14 kb upstream regulatory element (ΔURE) (77, 78). (D) GATA2-repressed ... Simple combinations of lineage determiningtranscription factors prime cis-regulatory elements required for macrophage and B ... Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat ...

Linhart, C.; Elkon, R.; Shiloh, Y.; Shamir, R. Deciphering transcriptional regulatory elements that encode specific cell cycle ... To this end, we characterized FOXM1-associated cis-regulatory elements through a comprehensive meta-analysis of available high- ... in terms of regulatory elements (promoter vs enhancer), FOXM1 binding sites were classified into either promoter-associated ... possibly through the interaction with the MMB transcriptional regulatory complex [16,18]. Conversely, FOXM1 is a putative ...

Uncover gene regulatory elements and their functions. (2) Study 3D epigenome evolution in mammals. (3) Discover crucial ... disruptions in transcriptional regulation and the epigenome in cancer, informed by insights from genome evolution. [See ...

Functional characterization of transcriptional regulatory elements of three highly expressed constitutive genes in the jewel ... Functional characterization of transcriptional regulatory elements of three highly expressed constitutive genes in the jewel ... Transcriptional differences between the two host strains of Spodoptera frugiperda (Lepidoptera: Noctuidae) - (Peer Reviewed ... The hAT-family transposable element, hopper, from Bactrocera dorsalis is a vector for insect germline transformation - (Peer ...

RNA cis-regulatory element. Regulation, transcriptional elongation Attenuator type: Transcriptional. Strand: reverse. ... small regulatory RNA FnrS cydDC repressor nd nd nd nd [EXP-IEP] [5] ... 1] Cook GM., Membrillo-Hernandez J., Poole RK., 1997, Transcriptional regulation of the cydDC operon, encoding a heterodimeric ...

Regulatory elements; Epigenetics; Regulatory motifs and modules; Epigenomics and chromatin state; Alternative splicing; Pathway ... analysis; Non-coding RNAs; Regulatory networks; Co-transcriptional, post-transcriptional, and translational regulation; Genetic ... Regulatory genomics is the topic of much research activity worldwide. RegGenSIG focuses on bioinformatics for regulatory ... Regulatory evolution or comparative regulatory genomics. Methods related to the protection of individualized genomic and ...

"EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory ... Elements." The Journal of biological chemistry.. 2016 Jun 24; 291(26):13591-607. Epub 2016 Apr 21. ... "Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition." Oncogene.. 2017 May 11; 36(19 ... "Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies." Nucleic ...

... elements. These two classes of 5′ capped and polyadenylated RNA transcripts are indistinguishable with regard to their length, ... We integrated high-resolution maps of transcriptional initiation and transcription to annotate a conservative set of intergenic ... We subclassified intergenic lncRNAs according to chromatin status at transcriptional initiation regions, defined by relative ... number of exons or transcriptional orientation relative to their closest neighboring gene. Nevertheless, elncRNAs are more ...

Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding ...

Semenza decided to trace the transcriptional regulatory elements of the EPO gene in transgenic mice, using clones of different ... Beck, I., Ramirez, S., Weinmann, R., and Caro, J. (1991). Enhancer element at the 3-flanking region controls transcriptional ... including both positive and negative regulatory elements.. A year later, in 1991, Semenza published two additional studies that ... multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol 10, 930-938. ...

Here, we report that transcriptional regulation through cis-regulatory elements only partially accounts for telomerase ... SKP1 localizes to synapsed chromosome axes in meiotic germ cells and specifically to the lateral elements. SKP1 is an essential ...

Diel transcriptional oscillations of light-sensitive regulatory elements in open-ocean eukaryotic plankton communities. Proc ...

... its transcriptional activation and its replication during early S-phase. Together, these results provide a unified model that ... member EZH2 together with PRC1 members BMI1 and M33 are strongly expressed and localized at the INK4/ARF regulatory domain (RD ... containing CDC6 and that coincides with a conserved non coding DNA element identified as a transcriptional regulatory element [ ... we performed ChIP assays to examine whether EZH2 directly binds this transcriptional regulatory element. Oligonucleotide ...

The two proteins then recognize and bind sterol regulatory elements (SRE) in the promoters of sterol biosynthesis genes and ... This regulation involves multiple mechanisms at transcriptional, translational and post-translational levels. Since sterol ... affect transcription of sterol biosynthesis genes through a heme-dependent transcription factor Hap1p and a transcriptional ...

2004). Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element- ... Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L., & Brown, M. S. (1999). Failure to cleave sterol regulatory element-binding ... Magana, M. M., & Osborne, T. F. (1996). Two tandem binding sites for sterol regulatory element binding proteins are required ... Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proceedings of the ...

Long terminal repeats: from parasitic elements to building blocks of the transcriptional regulatory repertoire. PJ Thompson, TS ... Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using ... methylation density-dependent mechanism of transcriptional …. MC Lorincz, D Sch beler, SC Goeke, M Walters, M Groudine, DIK ...

In humans, the promoter and first intronic regions of CYP39A1 contain two putative RORα response elements (ROREs). RORα binding ... We examined the role of transcriptional regulation by retinoic acid receptor-related orphan receptor α (RORα), a nuclear ... Such elements may or may not differ from the sterol regulatory elements identified in genes coding for HMG-CoA synthase and ... Upstream elements are indicated by a minus sign; downstream elements are indicated by a plus sign relative to the transcription ...

Woodchuck Hepatitis Post-transcriptional Regulatory Element enhances transgene expression in target cells. ... Vector Element. Utility. 5 LTR. 5 Long Terminal Repeat necessary for lentiviral particle production and integration of the ... Inducible promoter with Tetracycline Response Element is activated by the Tet-On® 3G protein in the presence of doxycycline. ... Elements of the shMIMIC Inducible microRNA Lentiviral Backbone. ...

This project seeks to elucidate transcriptional and post-transcriptional regulatory networks that determine cell fate and guide ... We are defining regulatory elements/factors that control gene expression in the human retina, and integrating these with ... How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? ... This research holds great potential for elucidating how genetic variation and regulatory elements lead to diverse visual ...

Identification of active transcriptional regulatory elements from GRO-seq data. Nat Methods 12: 433-438. ... A. mtDNA transcriptional regulation elements. Presented is the complementary human sequence of the light mtDNA strand. The ... Transcriptional requirements of the distal heavy-strand promoter of mtDNA. Proc Natl Acad Sci U S A 109: 6508-6512. ... Interactions between RNA polymerase and the "core recognition element" counteract pausing. Science 344: 1285-1289. ...