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*  Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation | Cell Communication...
P2X1-P2X7). Recombinant P2X1, P2X2, P2X3, P2X4, P2X2/3, P2X2/6, P2X4/6, P2X1/5 as well as P2X7 receptors, when activated in a ... Intracellular calcium signaling and purinergic receptors. *Purinergic receptors triggering ICS in the nervous system and neural ... purinergic receptors are divided into metabotropic P1 and P2Y receptors as well as P2X ionotropic receptors. ... Oscillations of [Ca 2+ ] i levels and purinergic receptors. Ionotropic P2X receptors trigger calcium spikes characterized by ...
  https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-12
*  Purinergic receptors expressed in human skeletal muscle fibres | SpringerLink
Purinergic receptors are present in most tissues and thought to be involved in various signalling pathways, including neural ... P2X receptor expression in mouse urinary bladder and the requirement of P2X1 receptors for functional P2X receptor responses in ... P2X1 receptor membrane redistribution and down-regulation visualized by using receptor-coupled green fluorescent protein ... Erlinge D, Burnstock G (2008) P2 receptors in cardiovascular regulation and disease. Purinergic Signal 4:1-20PubMedCrossRef ...
  https://link.springer.com/article/10.1007%2Fs11302-011-9279-y
*  ATP-Evoked Sustained Vasoconstrictions Mediated by Heteromeric P2X1/4 Receptors in Cerebral Arteries | Stroke
Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits. Purinergic Signal. In ... P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. Int J Cardiol. 2005;98:291-297. ... P2X1 receptors are characterized by slow resensitization and only ≈6% of the IFP2X initial response was observed with ... P2X1 and P2X4 Receptor Subunits Are Expressed in RMCA VSMCs. We initially investigated the expression and cellular distribution ...
  http://stroke.ahajournals.org/content/45/8/2444
*  Positive Inotropic Effects by Uridine Triphosphate (UTP) and Uridine Diphosphate (UDP) via P2Y2 and P2Y6 Receptors on...
Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem. 1997; 272: 31969-31973 ... Increase in cardiac P2X1-and P2Y2-receptor mRNA levels in congestive heart failure. Life Sci. 1999; 65: 1195-1206. ... P2 receptors), which is one of the largest known receptor families.10 P2 receptors are divided into two classes: ligand-gated ... The receptors P2Y2, P2Y4, and P2Y6 are Gq-coupled receptors mediating their response via PLC, resulting in increased IP3 and ...
  http://circres.ahajournals.org/content/98/7/970
*  P2RY8 - Wikipedia
"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". ... "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8". Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, ... "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening". Leukemia ... P2Y receptor GRCh38: Ensembl release 89: ENSG00000182162 - Ensembl, May 2017 "Human PubMed Reference:". Adrian K, Bernhard MK, ...
  https://en.wikipedia.org/wiki/P2RY8
*  LPAR4 - Wikipedia
Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic ... Lysophospholipid receptor P2Y receptor GRCh38: Ensembl release 89: ENSG00000147145 - Ensembl, May 2017 GRCm38: Ensembl release ... "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106-12 ... Lysophosphatidic acid receptor 4 also known as LPA4 is a protein that in humans is encoded by the LPAR4 gene. LPA4 is a G ...
  https://en.wikipedia.org/wiki/LPAR4
*  LPAR6 - Wikipedia
"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". ... "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5". Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf ... It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in ... Li Q, Schachter JB, Harden TK, Nicholas RA (1997). "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate ...
  https://en.wikipedia.org/wiki/LPAR6
*  P2RY10 - Wikipedia
"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". ... "Entrez Gene: P2RY10 purinergic receptor P2Y, G-protein coupled, 10". Berchtold S, Ogilvie AL, Bogdan C, Mühl-Zürbes P, Ogilvie ... The protein encoded by this gene belongs to the family of G-protein coupled receptors that is preferentially activated by ... P2Y receptor GRCh38: Ensembl release 89: ENSG00000078589 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000050921 - ...
  https://en.wikipedia.org/wiki/P2RY10
*  Publication List for for Hanna Kälvegren
... platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 ... Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and ... purinergic P2Y1 and P2Y12 receptor activation. Thrombosis and Haemostasis, 2010, 103(2), 398-407. Web of Science® Times Cited: ... The role of platelets in inflammation at sites of infection; toll like receptor 2/1 mediated platelet adhesion on bacterial ...
  http://www.ep.liu.se/PubList/Default.aspx?userid=hanjo55
*  Neuroeffector junction - Wikipedia
The post-junctional membrane beneath the varicosity can possess a patch about 1 μm2 of purinergic P2X1 receptors in high ... Post-junctional receptors also include some ionotropic receptors such as nicotinic receptors in the central nervous system (CNS ... and the post junctional receptors include metabotropic receptors or slower acting ionotropic receptors. Almost all tissues that ... Nonsynaptic post-junctional receptors are mostly G-protein coupled metabotropic receptors that produce a slower response. They ...
  https://en.wikipedia.org/wiki/Neuroeffector_junction
*  Most recent papers with the keyword vasoactive infusions | Read by QxMD
Immunofluorescence was performed to assess purinergic P2X1 receptor (P2X1R) expression in isolated mouse coronary arteries... ... There is a wide expression of the NMDA and AMPA/Kainate receptors within the DH. Glutamate administration into the DH triggers ... The combined angiotensin receptor blocker-neprilysin inhibitor, sacubitril/valsartan, is a novel therapy that can increase ... Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and ...
  https://www.readbyqxmd.com/keyword/81804
*  Genetics of Recessive Cognitive Disorders
Adrian K, Bernhard MK, Breitinger HG and Ogilvie A (2000) Expression of purinergic receptors (ionotropic P2X1‐7 and ... Paschen W, Hedreen JC and Ross CA (1994b) RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue ... Contractor A, Swanson G and Heinemann SF (2001) Kainate receptors are involved in short‐ and long‐term plasticity at mossy ... Paschen W, Blackstone CD, Huganir RL and Ross CA (1994a) Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0025835.html
*  Practical Fragments: June 2015
The researchers were interested in the P2X1 purinergic receptor, which allows calcium ions to pass into cells when ATP binds. ... Control cells not expressing P2X1 do not behave this way.) By adding potential ligands first and then adding ATP, both agonists ... The paper is heavily focused on assay development and validation, in this case using cells stably transfected with P2X1. These ... For confirmation, the researchers used a fluorescently labeled analog of ATP that binds to the P2X1 on transfected cells but ...
  http://practicalfragments.blogspot.co.uk/2015/06/
*  Recent Peer-Reviewed Publications (Late June-Early August 2015 Publications from PubMed) :: Nationwide Children's Hospital
Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X1, P2X2, P2X3 channels, P2Y and A3 ... The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice. Vascul Pharmacol. 2015 ... Mechanisms of chorioamnionitis-associated preterm birth: Interleukin 1 β inhibits progesterone receptor expression in decidual ... metabotropic receptors in neurotransmission. Neuropharmacology. 2015 Aug;95:83-99. doi: 10.1016/j.neuropharm.2015.02.014. Epub ...
  http://www.nationwidechildrens.org/medical-professional-publications/recent-peer-reviewed-publications-late-june-early-august-2015-publications-from-pubmed?contentid=144743
*  Gene Expression Literature Summary - MGI
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 (Synonyms: P2x, P2X1 receptor, Pdcd3, RP-2) ... purinergic receptor P2X, ligand-gated ion channel, 1. MGI:1098235 7 matching records from 7 references.. Summary by Age and ... Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas ...
  http://www.informatics.jax.org/gxdlit/marker/MGI:1098235
*  Time-of-day-dependent expression of purinergic receptors in mouse suprachiasmatic nucleus
In this study, the Ir of seven subtypes of P2X receptor (P2X1-7) and eight subtypes of P2Y receptor (P2Y1-2, P2Y4, P2Y6 and ... Purinergic (P) receptors play a role in cell-cell communication mediated by adenosine (P1 receptors) or ATP (P2 receptors; ... P2X1 , P2X6 = P2Y2 (Fig. ​(Fig.7).7). Among the detectable purinergic receptors, the following 10 showed a time-of-day- ... In the brain, purinergic receptors are located on astrocytes and neurons (Kanjhan et al. 1999; Vulchanova et al. 1996). In the ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5579179/
*  Frontiers | Ionotropic P2X ATP Receptor Channels Mediate Purinergic Signaling in Mouse Odontoblasts | Physiology
However, functional expression patterns and their biophysical properties of ionotropic ATP (P2X) receptors (P2X1-P2X7) in ... P2X1-P2X7) in odontoblasts were still unclear. We examined these properties of P2X receptors in mouse odontoblasts by patch- ... K+-ATP-induced currents were inhibited by P2X4 and P2X7 selective inhibitors (5-BDBD and KN62, respectively), while P2X1 and ... We could not observe P2X1,2/3,3 selective agonist (αβ-MeATP) induced currents. Amplitudes of K+-ATP-induced current were ...
  https://www.frontiersin.org/articles/10.3389/fphys.2017.00003/full
*  Hemostasis, bleeding and thrombosis in liver disease
These nucleotides bind various type-2 purinergic/pyrimidinergic (P2Y1-14 and P2X1-7) receptors on platelets, endothelium, ... Fisette PL, Denlinger LC, Proctor RA, Bertics PJ (1996) Modulation of macrophage function by P2Y-Purinergic Receptors. Drug Dev ... Burnstock G, Vaughn B, Robson SC (2014) Purinergic signalling in the liver in health and disease. Purinergic Signal 10: 51-70. ... 1998) ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor. Mol Pharmacol 53: 727- ...
  https://www.oatext.com/Hemostasis-bleeding-and-thrombosis-in-liver-disease.php
*  The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents
... suggesting that P2Y receptors may also contribute to altered sensations in PBS/IC. To date, seven P2X subunits (P2X1-P2X7) have ... Gerevich Z, Illes P. P2Y receptors and pain transmission. Purinergic Signal. 2004;1:3-10. [PMC free article] [PubMed] ... P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci U S A. 1996; ... The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. Xiaowei Chen,1 Derek C Molliver ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2828760/
*  Rostral ventromedial medulla - Wikipedia
Histological staining by another research group examined the distribution of purinergic receptor subtypes throughout the RVM. ... a large majority were co-labeled with purinergic antibodies. Fifty-five percent of TPH+ neurons stained for P1, 63% for P2X1, ... Close, L.N. (January 2009). "Purinergic Receptor Immunoreactivity in the Rostral Ventromedial Medulla". Neuroscience. 158 (2): ... NK1 agonism induced hypersensitivity is dependent on 5-HT3 receptors, and modulated by GABAA and NMDA receptors as well. ...
  https://en.wikipedia.org/wiki/Rostral_ventromedial_medulla
*  Molecules | Free Full-Text | Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery | HTML
... and inflammatory and neuropathic diseases having been linked to the participation of purinergic (P2) receptors, there has been ... ranging from P2X1 to P2X4 and P2X7, and P2Y1, P2Y2, P2Y4, and P2Y6. In addition, there were seventeen animal sources that ... Of those, nine different plant sources demonstrated effects on P2X2, P2X3, P2X7, and possibly P2Y12 receptor subtypes. ... Natural products have provided some fascinating new mechanisms and sources to better understand the P2 receptor antagonism. ...
  http://www.mdpi.com/1420-3049/17/11/13009/htm
*  Crosstalk between purinergic receptors and lipid mediators in leishmaniasis | Parasites & Vectors | Full Text
... which activate the purinergic receptors system. Herein, we discuss the role of extracellular nucleotides and the resulting ... These receptors are intrinsic ion channels for Na+, K+, and Ca2+. To date, seven subtypes of P2X family have been cloned: P2X1 ... mannose receptor (MR) [24, 25], Fc gamma receptors (FcγRs) [26], fibronectin receptors (FNRS) [18], and Toll-like receptors ( ... Purinergic receptors are classified into two large families: P1 and P2. The P1 receptor family is characterized by metabotropic ...
  https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1781-1
*  carbenoxolone: Topics by WorldWideScience.org
Following purinergic receptor stimulation, ATP is released via calcium-dependent exocytosis, activated P2X1,7 receptors, ... triggered by several ionotropic P2X purinergic receptor agonists (ATP, αβMeATP and Bz-ATP and a G protein-coupled P2Y receptor ... The propagation of those Ca2+ responses was not blocked by suramin, a blocker of purinergic ATP receptors, indicating that ... These data suggest that P2X3 receptor function controls a new type of feed-forward purinergic signaling on surrounding cells, ...
  https://worldwidescience.org/topicpages/c/carbenoxolone.html
*  Capacity for Purinergic Control of Renin Promoter via P2Y11 Receptor and cAMP Pathways | Hypertension
Increase in cardiac P2X1-and P2Y2-receptor mRNA levels in congestive heart failure. Life Sci. 1999;65:1195-1206. ... Capacity for Purinergic Control of Renin Promoter via P2Y11 Receptor and cAMP Pathways. Louise van der Weyden, David J. Adams, ... Purinergic-P(2Y) receptors stimulate renin secretion by rat renal cortical slices. J Pharmacol Exp Ther. 1993;266:160-163. ... Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem. 1997;272:31969-31973. ...
  http://hyper.ahajournals.org/content/36/6/1093
*  Functional expression of muscarinic and purinoceptors in the urinary bladder of male and female rats and guinea pigs - Murdoch...
mRNA for the purinergic P2X1, P2X2, P2X4, P2X5 and P2X7 receptors was detected in both male and female rats, whereas P2X3 and ... Purpose: The objectives of this study were to compare the functional expression of muscarinic and purinergic receptors in the ... The tonic component and the ACh response were inhibited by the M3 receptor antagonist, darifenacin (10-6 M, P≤0.05), but not by ... The P2X1 purinoceptor antagonist pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4', 8'-disulphonate) (PPNDS), only inhibited ...
  http://researchrepository.murdoch.edu.au/id/eprint/3346/