A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three ... Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role ... KIR" by people in this website by year, and whether "Receptors, KIR" was a major or minor topic of these publications. ... "Receptors, KIR" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...

Molecular recognition by Ig-like receptors, KIRs and FcγRs Share Share Share ...

Considering the recently defined regulatory mechanisms of NK cells through HLA class I binding receptors, we hypothesized that ... interactions of NK and T cells through the NK receptors may be important in the pathogenesis of BD. ...

A new dual-chimeric antigen receptor (CAR) system enhances the antitumor activity of CAR natural killer cells and makes them ... Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural ... KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape. *Ye Li ORCID: orcid.org/0000- ... Li, Y., Basar, R., Wang, G. et al. KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor ...

Like the similar KIR family, LILR genes are found in the LRC and are polymorphic, though less so than KIR. LILR proteins are ... Endogenous ligands for inhibitory receptors are better characterized than those for activating receptors. Paired receptor ... termed agnathan paired receptors resembling Ag receptors (APAR) in the hagfish. Expression of paired receptors is common in ... Members of this group found in the human genome include: The killer-cell immunoglobulin-like receptor (KIR) family contains ...

In humans, this missing self recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon ... In humans, this "missing self" recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon ... Human NK cell education by inhibitory receptors for MHC class I Immunity. 2006 Aug;25(2):331-42. doi: 10.1016/j.immuni.2006.06. ... We show here that NK cells lacking inhibitory KIR for self MHC class I molecules are present in human peripheral blood. These ...

HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity ... HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity ... HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity ... HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity ...

IL23R, which encodes the receptor for IL-23, is also associated with AS. [41, 42, 43, 44, 34, 35] IL-23 promotes survival of ... This gene encodes the endoplasmic reticulum aminopeptidase, which cleaves cytokine receptors for IL-6, TNF-α, and IL-1 from the ... Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta ... Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 2008 Apr. 58(4):1020-5. [QxMD ...

NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... The KIR gene content varies substantially from individual to individual depending on the inherited KIR haplotype and the KIR ... KIR) family is a dominant group of negative regulators. KIR receptors bind to the self-MHC class I ligands (HLA-A, -B, -C) and ...

Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta ... Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 2008 Apr. 58(4):1020-5. [QxMD ... Anakinra, a recombinant human IL-1 receptor antagonist, may be effective in treatment-resistant AS. ... Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled ...

KIR:. Killer cell immunoglobulin-like receptor. HLA-I:. Human leukocyte antigen class I ... 2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. Frontiers in Immunology,5, 87. ...

... which combine with sulphonylurea receptors (SUR). ...

KIR in Type 1 Diabetes : Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus ... Open the PDF for KIR in Type 1 Diabetes : ,subtitle,Disparate Distribution of Activating and Inhibitory Natural Killer Cell ... View article titled, KIR in Type 1 Diabetes : ,subtitle,Disparate Distribution of Activating and Inhibitory Natural Killer Cell ... Receptors in Patients Versus HLA-Matched Control Subjects,/subtitle, ...

We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We ... Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus ... Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and ... Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus ...

... leukocyte-associated Ig-like receptors (LAIRs) and killer-cell Ig-like receptors (KIRs). The KIRs have a multifaceted role in ... like receptor genes, including gene clusters encoding multiple leukocyte Ig-like receptors (LILRs), ... These epistatic interactions likely require the co-evolution of MHC and KIR, similar to the co-evolution of parasitic and host ... For example, we observed a significant enrichment of HCR CNVs in a chromosome 19 region corresponding to the leukocyte receptor ...

KIR receptors have no structural orthologs in non-primates, although mouse Ly-49 proteins are functional orthologs (3). KIR are ... KIR3DL2 (3DL2, p140, CD158k) is a type I transmembrane protein of the p70 family of killer cell Ig-like receptors (KIR). KIR ... killer cell immunoglobulin-like receptor 3DL2; CD158k; CL-5; killer cell immunoglobulin-like receptor, three domains, long ... Like other inhibitory KIR, KIR3DL2 has two ITIM domains within its long tail (3). KIR3DL2 is diverse, with twelve alleles ...

KIR). The KIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on ,1-8% of NK cells and a subset ... KIR). The KIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on ,1-8% of NK cells and a subset ... CD158a is a 58 kDa membrane glycoprotein, member of the killer-inhibitory receptor ( ... CD158a is a 58 kDa membrane glycoprotein, member of the killer-inhibitory receptor ( ...

... killer cell immunoglobulin-like receptors (KIR), expression quantitative trait loci (eQTL), and fingerprinting/sample tracking ...

... indicating the optimal donor based on the presence of the stronger KIR receptor and a KIR-KIR ligand mismatch - within 48 hours ... When HLA ligands in the patients body bind to KIRs on the donors NK cells, the receptor sends a signal to the NK that either ... The KIR/KIR-Ligand Assay. Now 20 employees strong, the company has been refining the assay for clinical use and plans to begin ... Each NK cell has proteins extending from its surface called killer-cell immunoglobulin-like receptors (KIRs) that regulate the ...

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets ... The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important ... "Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever". ... Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 is a protein that in humans is encoded by the ...

Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons. J Neurosci 17(19): 7220 ... Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% ... Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009). ... Our study demonstrates that KIR current inactivation facilitates depolarization, firing frequency and firing onset in these ...

NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR). ... activating NK-receptor; NK-p46); Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural ... NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated ...

Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol Ther. 2009; 8(23):2211-20. ... a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009 ... 6 NK cells from killer immunoglobulin-like receptor-ligand (KIR-L)-mismatched donors can exert a potent anti-leukemic effect ... natural cytotoxicity receptors, DNAM-1, CD27, and CD69, suggesting that multiple receptors working via different signaling ...

... and KIR (killer cell immunoglobulin-like) receptors and activates anti-tumor responses.. ImmunOs Therapeutics AG is supported ... "iosH2 exerts potent anti-tumor activity by blocking LILRB1/2 and KIR3DL1 receptor signaling" ...

NK cells express KIRs (killer cell immunoglobulin-like receptors), which prevents NK cells from killing tumor cells expressing ... For donor selection, the killer cell immunoglobulin-like receptors (KIRs) genotyping should be mismatched to the human ... Kunert K, Seiler M, Mashreghi MF, Klippert K, Schonemann C, Neumann K, Pratschke J, Reinke P, Volk HD, Kotsch K: KIR/HLA ligand ... Moretta L, Moretta A: Killer immunoglobulin-like receptors. Curr Opin Immunol 2004; 16: 626-633. ...

KIR) receptors and understanding how pathogen and self-peptide can modulate NK cell function through altering levels of NK cell ... activation/inhibition; the role of T cell receptor structure in effector function; correlates of protection in infection and ...

... class I molecules and T cell receptors (TCR) or killer cell Ig-like receptors (KIR) may be accompanied by considerable changes ... in the conformation of selected residues or even entire loops within TCR or KIR, conformational changes between receptor-bound ...

Overview: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells ... The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important ... The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb ... leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several ...

... genotypes of KIR receptors on the NK cells in combination with genotypes of their ligands, HLA-C on fetal trophoblast cells ... Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med. ( ... Maternal KIR in combination with paternal HLA-C2 regulate human birth weight. J Immunol. (2014) 192:5069-73. doi: 10.4049/ ... Homing receptor expression is deviated on CD56+ blood lymphocytes during pregnancy in Type 1 diabetic women. PLoS ONE (2015) 10 ...

ImmunOs lead program is a multi-functional fusion protein that blocks specific LILRB (leukocyte immunoglobulin-like) and KIR ( ... killer cell immunoglobulin-like) receptors and activates anti-tumor responses. ImmunOs is also developing antibodies to block ...