Interleukin-4 receptor - Wikipedia
... forming the type II IL4 receptor). This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane ... The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the ... Interleukin-4 receptor has been shown to interact with SHC1. The N-terminal (extracellular) portion of interleukin-4 receptor ... They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a ...
Regulation of Hepatic Drug-Metabolizing Enzyme Genes by Toll-Like Receptor 4 Signaling Is Independent of Toll-Interleukin 1...
... pregnane X receptor; CAR, constitutive androstane receptor; RXR, retinoid X receptor; LPS, lipopolysaccharide; IL, interleukin ... Toll-like receptor; TIRAP, Toll-interleukin 1 receptor domain-containing adaptor protein; IκB, inhibitor of nuclear factor-κB; ... pregnane X receptor, constitutive androstane receptor, and retinoid X receptor α (RXRα)]. The bacterial endotoxin, ... LPS binds to the cell-surface receptor, Toll-like receptor 4 (TLR4), which initiates a signal transduction cascade, including ...
OPUS 4 | Expression of interleukin-18 receptor in fibroblast-like synoviocytes
... and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL- ... Expression of interleukin-18 receptor in fibroblast-like synoviocytes. Burkhard Möller, Uta Kessler, Stefan Rehart, Uwe Kalina ... and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL- ...
Antibodies to Canine Interleukin-4 Receptor Alpha - CovalX
In order to identify the epitopes that are recognized by anti-canine IL-4 receptor alpha mAbs, CovalX completed epitope mapping ... The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences ... The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha. ... that are within the extracellular domain of canine IL-4 receptor alpha. For mAbs 2E2, one of the epitopes that was identified ...
IL20RA interleukin 20 receptor subunit alpha [Homo sapiens (human)] - Gene - NCBI
cytokine receptor family 2 member 8. interleukin 20 receptor alpha subunit. interleukin 20 receptor, alpha. interleukin-20 ... IL20RA interleukin 20 receptor subunit alpha [Homo sapiens] IL20RA interleukin 20 receptor subunit alpha [Homo sapiens]. Gene ... The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This ... Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III. * NM_001278723.3 → NP_001265652.2 interleukin-20 receptor ...
Soluble Interleukin-6 Receptor (sIL-6R)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, ... Soluble Interleukin-6 receptor (sIL-6R). Scientific background. Interleukin-6 (IL-6) is a multifunctional cytokine that ... Soluble interleukin-6 receptor as a prognostic factor in numerous clinical disorders:. In healthy individuals, blood levels of ... Soluble IL-6 receptor (sIL-6R) is a 50-55 kDa ligand binding protein, derived from the extracellular part of the gp80 receptor ...
Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension | Repository UHC Osijek
"Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension." Kidney and Blood Pressure Research, vol. 42, ... "Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension." Kidney and Blood Pressure Research 42, no. 1 ... 2017) Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension, Kidney and Blood Pressure Research, 42 ... Šimundić T, Jelaković B, Džumhur A, Turk T, Šahinović I, Dobrošević B, and sur.. Interleukin 17A and Toll-like Receptor 4 in ...
Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha -...
Interleukin-4 receptor subunit α | IL-2 receptor family | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY
IL-2 receptor family. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug ... IL-2 receptor family: Interleukin-4 receptor subunit α. Last modified on 11/04/2017. Accessed on 27/09/2023. IUPHAR/BPS Guide ... 1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J ... 2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its ...
Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4<...
Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4. In: Nature. 2002 ; Vol. 416, No. ... Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4. Nature. 2002 Apr;416(6882):750-754 ... Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4. / Suzuki, Nobutaka; Suzuki, ... Severe impairment of interleukin-1 and toll-like receptor signalling in mice lacking IRAK-4. ...
Interleukin 3 News, Research - Page 4
Toll-like receptor 2 (TLR2) detects the SARS-CoV-2 envelope protein and generates inflammatory cytokines Researchers at St Jude ... A team of scientists from the USA and Belgium has recently revealed that the ErbB family of receptor tyrosine kinases play a ... lifecycle in host cells and that inhibition of these receptors can protect against SARS-CoV-2-induced acute and chronic lung ... Childrens Research Hospital found that toll-like receptor 2 detects the SARS-CoV-2 envelope protein-producing inflammatory ...
Endometrial Toll-like Receptor 4 (TLR4) and Interleukin-8 (IL-8) Expression in Mares Resistant (RM) or Susceptible (SM) to...
Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role in. modulating ... Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role inmodulating ... Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role inmodulating ... Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role inmodulating ...
25-hydroxycholesterol, 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll...
7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or ... 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or ... 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or ... 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or ...
IL1R2 Protein | Interleukin 1 Receptor Type 2 Human | ProSpec
IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. IL1R2 is expressed mainly by T cells, ... IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, IL-1 type II receptor, Interleukin-1 receptor beta, CD121 ... Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. ... IL1R2 binds IL1A, IL1B and IL1RN preventing them from binding to their regular receptors and thus inhibiting the transduction ...
MedlinePlus: Genetic Conditions: I
Interleukin-6 (88-121), human; IL-6 (88-121), human; [145990-81-4]
IL-6 (88-121) competitively inhibits the binding of human IL-6 to its receptor. Ekida, T; et al., Biochem. Biophys. Res. Commun ... Home » Shop » Catalog Peptides » Interleukin Fragments » Interleukin-6 (88-121), human [145990-81-4] ... Synonym: Interleukin-6 (88-121), human. CAS Number: [145990-81-4]. Molecular Weight: 4023.57. Molecular Formula: C179H281N45O58 ... Interleukin-6 (88-121), human [145990-81-4]. Catalog Number: P001905. Sequence: Ile-Ile-Thr-Gly-Leu-Leu-Glu-Phe-Glu-Val-Tyr-Leu ...
Frontiers | Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy
Interleukin; IP, Intraperitoneal; IRAK4, Interleukin 1 Receptor Associated Kinase 4; IRES, Internal Ribosomal Entry Site; iTr35 ... Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc Natl Acad Sci USA (1997) 94( ... Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol Lett (2007) 114(1):1-8. doi: 10.1016 ... Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity (2015) 42(5):826-38. doi: 10.1016/ ...
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy? | Annals of the Rheumatic...
FBG, fibrinogen-like globe; IL, interleukin; TLR4, toll-like receptor 4; TNF, tumour necrosis factor. ... Selective antibody intervention of Toll-like receptor 4 activation through Fc γ receptor tethering. J Biol Chem 2014;289:15309- ... Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. Nat Commun ... Activation of toll-like receptor 4 (TLR4) by tenascin-C, a matrix molecule persistently expressed at high levels in people with ...
Pediatric Nephrotic Syndrome: Practice Essentials, Background, Pathophysiology
Binding of interleukins or microbial products to toll-like receptors on the surface of the podocyte may lead to overexpression ... Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med. 2011 Jul 31. 17 (8):952-60. [QxMD ... Soluble urokinase receptors in focal segmental glomerulosclerosis: a review on the scientific point of view. J Immunol Res. ... Use of ACE inhibitors or angiotensin II receptor blockers (ARBs) in conjunction with volume depletion can also precipitate AKF. ...
IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4
2-type chemokine receptors on IL-4-expressing cells can be demonstrated in an in vivo setting and therefore that these cells ... Background: The concept of the polarization of chemokine receptor expression by T(H)1 and T(H)2 cells provides an attractive ... Conclusion: We have provided evidence that polarization of T(H)2-type chemokine receptors on IL-4-expressing cells can be ... Methods: We used single-cell analysis to investigate the relationship between chemokine receptor expression and cytokine ...
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer
Targeting interleukin-4 receptors for effective pancreatic cancer therapy. Cancer Res. 2002;62:3575-3580. [PubMed] [DOI] [Cited ... Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors. Cancer Gene Ther. 2002;9:522-532. [PubMed] [ ... 2000;4:580-588. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 57] [Cited by in F6Publishing: 61] [Article ... 2002;4:141-149. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 18] [Cited by in F6Publishing: 18] [Article ...
Human IRAK4 Alexa Fluor® 647-conjugated Antibody IC39191R-100UG: R&D Systems
EC 2.7.11; EC 2.7.11.1; interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; IRAK-4; NY-REN-64; REN64; Renal carcinoma ... IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that help mediate signaling from Toll-like receptor (TLR ... and IL-1 receptor family members. Four human IRAKs have been identified: IRAK1, IRAK2, IRAK-M, and IRAK4. Upon TLR ligand ... 4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial ...
TLR2 Antibody (NB100-56720): Novus Biologicals
TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts... Read full blog post.. ... IRAK4, also known as Interleukin-1 receptor-associated kinase 4, is a serine/threonine-protein kinase that plays a critical ... Toll-like receptors in the intestinal epithelial cells. By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are ... Toll-like receptor 2 activation contributes to oral squamous cell carcinoma development and miRNA-mediated drug resistance. By ...
Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain | Journal of Neuroscience
2000) Astrocytic alterations in interleukin-6/soluble interleukin-6 receptor alpha double-transgenic mice. Am J Pathol 157:1485 ... 1993) The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 23:473-480, doi:10.1002/eji.1830230226, pmid: ... 1999) Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 19: ... 1992) Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4:96-100, doi:10.1016/1043- ...
Bengt Eriksson | University of Gothenburg
Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes. ... Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux ... Nucleostemin- and Oct 3/4-positive stem/progenitor cells exhibit disparate anatomical and temporal expression during rat ...
Healthcare | Free Full-Text | Tissutal and Fluidic Aspects in Osteopathic Manual Therapy: A Narrative Review
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity 2015, 43, 803- ... which are activated in the turnover of ECM and would be influenced by some types of interleukins (IL-13 and IL-4) [63,64]. ... Med. 2020, 35, 1-4. [Google Scholar] [CrossRef][Green Version]. *Bergna, A.; Vismara, L.; Parravicini, G.; Dal Farra, F. A new ... Biol. 2021, 4, 436. [Google Scholar] [CrossRef] [PubMed]. *Pollack, G.H. The Fourth Phase of Water: Beyond Solid, Liquid, and ...
Frontiers | Roles of Macrophages in the Development and Treatment of Gut Inflammation
2014). Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. ... 2019). Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation. ... Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor (PRR) of the surface immunoglobulin ... IL: interleukin; TNF-α: tumor necrosis factor-α; IFN-γ: interferon-γ; Th1: interferon-γ-producing type 1 helper T cells; Th17: ...
Il5 (interleukin 5) - Rat Genome Database
... interleukin-5 receptor binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); interleukin-5-mediated ... interleukin-4 signaling pathway; interleukin-5 signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); ... signaling pathway (ortholog); positive regulation of B cell proliferation (ortholog); PARTICIPATES IN Fc epsilon receptor ... interleukin-5 receptor binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); interleukin-5-mediated ...
Priv.-Doz. Dr. med. Formentini | Universitätsklinikum Ulm
Expression of Interleukin 4 and 13 and their receptors in colorectal cancer A. Formentini, D. Henne-Bruns, M. Kornmann. Int J ... Serum Konzentrazion von Epidermal Growth Factor (EGF) und Epidermal Growth Factor Receptor (EGF-R). Ein Marker für die ... Expression of Interleukin 4 and 13 and their receptors in gastric cancer. A. Formentini, D. Henne-Bruns, M. Kornmann. ... Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer and its expression correlates with a ...
SMART: FN3 domain annotation
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor. ... Leptin receptor (P48357) (SMART). OMIM:601007: LEPTIN RECEPTOR; LEPR. Cytokine receptor common subunit gamma (P31785) (SMART). ... Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2. ... A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor. ...