Fc receptor - Wikipedia
Sun PD (2003). "Structure and function of natural-killer-cell receptors". Immunologic Research. 27 (2-3): 539-48. doi:10.1385/ ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Fc gamma receptors belong to the group of non-catalytic tyrosine-phosphorylated receptors which share a similar signalling ... All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing ...
Target-Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy
Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation
Receptors, Immunologic * Signal Transduction* / genetics * Signal Transduction* / immunology * ZAP-70 Protein-Tyrosine Kinase ... Card9 signaling also responds to intracellular danger sensors, such as retinoic acid-inducible gene 1 (RIG-I)-like receptors ( ... coupled C-type lectin receptors to inflammatory responses. ...
Alcoholic Cardiomyopathy: Overview, Cardiac Effects of Alcohol, Quantity of Alcohol Intake in Cardiac Disease
Vasodilators - ACE inhibitors, angiotensin receptor blockers (the work of Cheng and colleagues in 2006 suggested that these may ... Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006 Jul 18. 114(3):226-36. [QxMD ... reduced receptor expression, abnormal membrane structure, disruption of zinc homeostasis, and an increase in myocardial ... Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. Alcohol ...
Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus...
McElroy AK, Akondy RS, Mcllwain DR, Chen H, Bjornson-Hooper Z, Mukherjee N, et al. Immunologic timeline of Ebola virus disease ... Marcenaro E, Carlomagno S, Pesce S, Della Chiesa M, Parolini S, Moretta A, et al. NK cells and their receptors during viral ... Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, et al. Killer cell immunoglobulin-like receptor 3DL1 variation ... Boelen L, Debebe B, Silveira M, Salam A, Makinde J, Roberts CH, et al. Inhibitory killer cell immunoglobulin-like receptors ...
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Interleukin-5 Receptor alpha Subunit | Harvard Catalyst Profiles | Harvard Catalyst
Receptors, Cell Surface [D12.776.543.750]. *Receptors, Immunologic [D12.776.543.750.705]. *Receptors, Cytokine [D12.776.543.750 ... Receptors, Interleukin-5 [D12.776.543.750.705.852.420.380]. *Interleukin-5 Receptor alpha Subunit [D12.776.543.750.705.852. ... A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high ... "Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ...
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Frontiers | Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for...
NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors ... The NK cell is now accepted as an integral part of the immunologic antitumor response. A number of promising NK-targeting ... Death Receptor-Induced Apoptosis. Death receptor-induced apoptosis is a perforin-independent mechanism by which NK cells lyse ...
Frontiers | Roles of Macrophages in the Development and Treatment of Gut Inflammation
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor (PRR) of the surface immunoglobulin ... Weiner, H. L. (2000). Oral tolerance, an active immunologic process mediated by multiple mechanisms. J. Clin. Invest. 106, 935- ... Lu, Y., Li, X., Liu, S., Zhang, Y., and Zhang, D. (2018). Toll-like receptors and inflammatory bowel disease. Front. Immunol. 9 ... Toll-like receptors (TLRs) play a key role in maintaining intestinal homeostasis. After recognizing PAMPs, TCLs are activated ...
Frontiers | The Role of Paracrine Regulation of Mesenchymal Stem Cells in the Crosstalk With Macrophages in Musculoskeletal...
Stein, M., Keshav, S., Harris, N., and Gordon, S. (1992). Interleukin 4 potently enhances murine macrophage mannose receptor ... activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176, 287-292. doi: 10.1084/jem.176.1.287 ... receptor-ligand binding, and hydrophobic insertion have been commonly applied as methods of biological membrane modifications ( ... Mφs phenotype could be commonly associated with the secretion of the anti-inflammatory cytokine IL-10 and scavenger receptors ...
Plus it
... vitamin D receptor, and the pregnane X receptor (PXR), as well as G-protein coupled membrane receptors, including Takeda G- ... immunologic toxicity (Miranda et al., 2008; Thompson et al., 2019; Shah et al., 2020), and metabolic disease (Park et al., 2010 ... protein-coupled receptor 5, muscarinic receptors 1 and 2, and the Sphingosine-1-phosphate receptor 2 (Xie et al., 2001; ... BAs are endogenous ligands for many receptors, the best-known receptor being FXR. In the liver, FXR induces its target gene SHP ...
Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
The binding of the HLA/antigen complex to T-cell receptors (TCR) is not sufficient for T-cell activation. The final immunologic ... the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic ... T. Martinu, K. M. Gowdy, J. L. Nugent et al., "Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft- ... It works as a decoy receptor for IL-33 and drives Th2 cells to Th1-cell phenotype, which may be important in the pathogenesis ...
CXCR4 - wikidoc
"Chemokine Receptors: CXCR4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Immunologic Research. 27 (2-3): 261-76. doi:10.1385/IR:27:2-3:261. PMID 12857973.. ... "CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin". The Journal of Biological Chemistry. 285 (20 ... C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in ...
Receptors, KIR | Profiles RNS
Receptors, Cell Surface [D12.776.543.750]. *Receptors, Immunologic [D12.776.543.750.705]. *Receptors, Natural Killer Cell [ ... A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three ... Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role ... "Receptors, KIR" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.
Receptors, NK Cell Lectin-Like. *Receptors, Immunologic. *NK Cell Lectin-Like Receptor Subfamily D ... NK cells express several families of receptors that play central roles in target cell recognition. These NK cell receptors are ... Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.. Publication , ... "Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells." J Immunol 169, no ...
Antibody - Wikipedia
B cell receptors[edit]. Main article: B-cell receptor. The membrane-bound form of an antibody may be called a surface ... Rus H, Cudrici C, Niculescu F (2005). "The role of the complement system in innate immunity". Immunologic Research. 33 (2): 103 ... Functions mainly as an antigen receptor on B cells that have not been exposed to antigens.[28] It has been shown to activate ... Ravetch JV, Bolland S (2001). "IgG Fc receptors". Annual Review of Immunology. 19 (1): 275-90. doi:10.1146/annurev.immunol.19.1 ...
Issue | November 1991 | November 1991 | The Scientist Magazine®
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Abstract IA01: Turning the heat up on pancreatic cancer: Lessons on overcoming a "cold" immunologic microenvironment | Cancer...
T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma. JCI ... Abstract IA01: Turning the heat up on pancreatic cancer: Lessons on overcoming a "cold" immunologic microenvironment Elizabeth ... Elizabeth M. Jaffee; Abstract IA01: Turning the heat up on pancreatic cancer: Lessons on overcoming a "cold" immunologic ... Turning the heat up on pancreatic cancer: Lessons on overcoming a "cold" immunologic microenvironment [abstract]. In: ...
Role of Type 1 IFNs in Antiglioma Immunosurveillance-Using Mouse Studies to Guide Examination of Novel Prognostic Markers in...
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single ... Experimental Design: We induced de novo gliomas in Ifnar1−/− (deficient for type 1 IFN receptors) or wild-type mice by ... Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide ... RB6-8C5 was originally developed as a mAb recognizing a surface antigen, granulocyte receptor 1 (28), which is a member of the ...
AACR Journals Editors' Picks for February | AACR Blog
Toll-like receptors (TLRs) initiate immune responses against bacterial, fungal, or viral pathogens; agonists of various TLRs ... This first-in-human study evaluated the safety, efficacy, and immunologic activity of intratumoral G100, a synthetic TLR4 ... In this study, the authors investigated the activation of mitochondrial assembly receptor (MasR) for the treatment of cancer ... Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer ...
Medical Science Monitor | An Overview of the Effects of anti-IgE Therapies - Article abstract #890137
... a humanized mAb that binds to the CH3 domain near the binding site for the high-affinity type-I IgE Fc receptors of human IgE, ... Immunologic, Oxidative Stress - drug effects, Receptors, IgE - metabolism ... Omalizumab, a humanized mAb that binds to the CH3 domain near the binding site for the high-affinity type-I IgE Fc receptors of ...
cytokine receptors | NAL Agricultural Thesaurus
... immunologic receptors , cytokine receptors. Fields of Study , biochemistry , biochemical compounds , amino acids, peptides and ... proteins , proteins , receptors , immunologic receptors , cytokine receptors. Research, Technology, Methods , chemical ... substances , biochemical compounds , amino acids, peptides and proteins , proteins , membrane proteins , immunologic receptors ... A cytokine receptor is a protein on the cell surface that specifically binds cytokine ligands which are small proteins secreted ...
Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a nuclear hormone receptor superfamily transcription factor ... Bcl3 deficiency was found with only minor immunologic defects. Therefore, it may also be considered a plausible drug target [43 ... Interleukin-1 receptor type 2 (IL1R2), was discovered to be a negative immune regulator, and is three-fold up-regulated in ... Lpl functions as a triglyceride hydrolase and receptor-mediated factor for lipoprotein uptake [37]. Loss of Lpl expression was ...
Targeting Macrophages for Tumor Therapy | SpringerLink
Zhang C, Zhuang Q, Liu J, Liu X. Synthetic biology in chimeric antigen receptor T (CAR T) cell engineering. ACS Synth Biol. ... a marker of alternative immunologic macrophage activation. J Exp Med. 1992;176(1):287-92. https://doi.org/10.1084/jem.176.1.287 ... Moreover, the genetic engineering of macrophages with chimeric antigen receptor (CAR) allows them to recognize tumor antigens ... Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: ...
Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified...
immunologic. Background. Despite the numerous and successful advances in cancer therapeutic strategies in the past few years, ... The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma ... Tweak-Fn14 Cytokine-Receptor axis: a new player of myocardial remodeling and cardiac failure. Front Immunol 2014;5:50. doi: ... The cell surface receptor Fn14 for the cytokine TWEAK has emerged as a valuable target for cancer therapy because it displays ...
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Hereditary Nonpolyposis Colorectal Cancer: Practice Essentials, Background, Pathophysiology
... which may be explained by immunologic factors. Immunologic studies in mice with colon cancer have demonstrated that tumors ... Jarvinen TA, Pelto-Huikko M, Holli K, Isola J. Estrogen receptor beta is coexpressed with ERalpha and PR and associated with ... influence host immune response by altering host T-cell receptors. [7] However, the defective T-cell response was observed only ...