*  Enrollment Completed in Ligand's Phase 2 Trial of LGD-6972 in Type 2 Diabetes :: Ligand Pharmaceuticals, Inc. (LGND)
About Ligand's Glucagon Receptor Antagonist Program Glucagon is a hormone produced by the pancreas that stimulates the liver to ... glucagon. Glucagon receptor antagonists (GRA) are designed to lower glucose levels by reducing the production of glucose by the ... Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy ... small-molecule glucagon receptor antagonist LGD-6972 for the treatment of type 2 diabetes mellitus (T2DM). This randomized, ...
  https://www.ligand.com/news-events/press-releases/detail/316/enrollment-completed-in-ligands-phase-2-trial-of
*  Lyxumia (Lixisenatide) - How it Works, Side Effects
Lyxumia is a glucagon-like-peptide-1 (GLP-1) agonist that is taken once daily among people with type 2 diabetes. Lyxumia is the ... Lyxumia is a glucagon-like-peptide-1 (GLP-1) agonist that is taken once daily among people with type 2 diabetes. ... It works by attaching to GLP-1 receptors on the surface of pancreatic cells which produce insulin. Lyxumia then activates these ... Ready-to-use glucagon pen performs well as T1D hypo treatmentFri, 19 Jan 2018 ...
  https://www.diabetes.co.uk/diabetes-medication/lyxumia.html
*  Ligand Initiates Phase 2 Trial with LGD-6972 in Type 2 Diabetes :: Ligand Pharmaceuticals, Inc. (LGND)
About Ligand's Glucagon Receptor Antagonist Program Glucagon is a hormone produced by the pancreas that stimulates the liver to ... Glucagon receptor antagonists are designed to lower glucose levels by reducing the production of glucose by the liver. Glucagon ... Glucagon receptor antagonists are a leading non-insulin mechanism in development for the treatment of T2DM. Based on the Phase ... Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy ...
  https://www.ligand.com/news-events/press-releases/detail/301/ligand-initiates-phase-2-trial-with-lgd-6972-in-type-2
*  BIPHENYL DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS - Patent application
... contributor to the efficacy of glucagon receptor antagonists in rodents (GU, W., et al., "Glucagon Receptor Antagonist-Mediated ... Glucagon mediates its effects by binding to and activating the glucagon receptor that was first described by Rodbell and ... Inhibition 125I-Glucagon Binding to Membranes from HEK293 Cells Expressing the Human Glucagon Receptor (GCGR) [0256] Full- ... The Glucagon Receptor Family.", Pharmacological Reviews, 2003, pp 167-194, Vol. 55). The receptor is mainly expressed in liver ...
  http://www.patentsencyclopedia.com/app/20120302641
*  GCGR polyclonal antibody - (PAB26337) - Products - Abnova
The physiologic effects of glucagon (GCG; MIM 138030) are mediated through the glucagon receptor, a member of the superfamily ... of receptors characterized by a 7-transmembrane domain structure and by their coupling via GTP-binding proteins (G proteins) to ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB26337
*  Coupling of the Glucagon Receptor to Adenylate Cyclase | Biochemical Society Transactions
Coupling of the Glucagon Receptor to Adenylate Cyclase. MILES D. HOUSLAY. Biochemical Society Transactions Oct 01, 1979, 7 (5) ... Coupling of the Glucagon Receptor to Adenylate Cyclase Message Subject (Your Name) has forwarded a page to you from Biochemical ...
  http://www.biochemsoctrans.org/content/7/5/843
*  Glucagon receptor - Wikipedia
In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney ... Furthermore, the structural dynamics of an active state complex of the Glucagon receptor, Glucagon, the Receptor activity- ... "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 ... The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family ...
  https://en.wikipedia.org/wiki/Glucagon_receptor
*  Glucagon receptor family - Wikipedia
Glucagon receptor Glucagon-like peptide 1 receptor Glucagon-like peptide 2 receptor Gastric inhibitory polypeptide receptor The ... glucagon, glucagon-like peptide-1, glucagon-like peptide-2) derived from the proglucagon polypeptide. The last receptor binds ... "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 ... "Glucagon Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
  https://en.wikipedia.org/wiki/Glucagon_receptor_family
*  Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists | Diabetes Care
Glucagon raises blood glucose through its cognate receptor in the liver (rev. in 16). This G-protein-coupled receptor is ... Importantly, exogenous glucagon can still rescue patients treated with LY2409021, as its affinity for the glucagon receptor is ... Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor. ... Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor- ...
  http://care.diabetesjournals.org/content/39/7/1075
*  Glucagon receptor antagonist ups blood pressure in T2DM
... once-daily treatment with the glucagon receptor antagonist LY2409021 is associated with increases in ambulatory blood pressure ... Glucagon receptor antagonist ups blood pressure in T2DM. February 23, 2017 (HealthDay)-For patients with type 2 diabetes, once- ... daily treatment with the glucagon receptor antagonist LY2409021 is associated with increases in ambulatory blood pressure (BP ...
  https://medicalxpress.com/news/2017-02-glucagon-receptor-antagonist-ups-blood.html
*  CiNii 論文 - Whole Body Radioautographic Analysis of the In Vivo Distribution of Glucagon...
Canine kidney glucagon receptor: evidence for a structurally-different, tissue-specific variant of the glucagon receptor IWANIJ ... Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic ... Whole Body Radioautographic Analysis of the In Vivo Distribution of Glucagon Receptors in Mice * * WATANABE Masahito ... Evidence for delayed development of the glucagon receptor of adenylate cyclase in the fetal and neonatal rat heart CLARK C. M. ...
  https://ci.nii.ac.jp/naid/10008607546
*  Mahvash Disease: Pancreatic Neuroendocrine Tumor Syndrome Caused by Inactivating Glucagon Receptor Mutation | OMICS...
Mahvash disease is a novel pancreatic neuroendocrine tumor syndrome caused by inactivating glucagon receptor mutations. Its ... Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon- ... The glucagon receptor family. Pharmacol Rev 55: 167-194.. *Jiang G, Zhang BB (2003) Glucagon and regulation of glucose ... 2004) Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide ...
  https://www.omicsonline.org/open-access/mahvash-disease-pancreatic-neuroendocrine-tumor-syndrome-glucagon-receptor-mutation-1747-0862.1000084.php?aid=19904
*  Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys | Journal...
By binding and activating the glucagon receptor (GCGR), a G protein-coupled receptor (GPCR), glucagon stimulates adenylyl ... ABBREVIATIONS: GCGR, glucagon receptor; GPCR, G protein-coupled receptor; ASO, antisense oligonucleotide; HGO, hepatic glucose ... Despite extensive efforts, there is currently no human therapeutic that directly inhibits the glucagon/glucagon receptor ... 2004) Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide ...
  http://jpet.aspetjournals.org/content/329/1/102.long
*  Talk:Glucagon-like peptide-1 receptor agonist - Wikipedia
Talk:Glucagon-like peptide-1 receptor agonist. From Wikipedia, the free encyclopedia ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Talk:Glucagon-like_peptide-1_receptor_agonist&oldid=740165991" ...
  https://en.wikipedia.org/wiki/Talk:Glucagon-like_peptide-1_agonist
*  Glucagon-like peptide receptor - Wikipedia
The glucagon-like peptide receptors (GLPRs) include the following two receptors: Glucagon-like peptide 1 receptor (GLP-1R) - ... Glucagon-like peptide 2 receptor (GLP-2R) - binds glucagon-like peptide 2 (GLP-2) Glucagon receptor. ...
  https://en.wikipedia.org/wiki/Glucagon-like_peptide_receptor
*  Glucagon-like peptide-1 receptor agonist - Wikipedia
Glucagon-like peptide-1 receptor agonists also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 ... 2013 "GLP-1 Receptor Agonists vs. DPP-4 Inhibitors for Type 2 Diabetes". Liu, J; Li, L; Deng, K; Xu, C; Busse, JW; Vandvik, PO ... Baggio LL (2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". Medscape Diabetes & Endocrinology. Ali ES, Hua J, ... Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 reverses impaired ...
  https://en.wikipedia.org/wiki/Glucagon-like_peptide-1_receptor_agonist
*  Glucagon-like peptide 1 receptor - Wikipedia
"Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 ... The glucagon-like peptide 1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas. It is involved in the ... "Glucagon Receptor Family: GLP-1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... GLP1R binds glucagon-like peptide-1 (GLP1) and glucagon as its natural endogenous agonists. Receptor agonists: GLP-1 - ...
  https://en.wikipedia.org/wiki/Glucagon-like_peptide_1_receptor
*  Glucagon-like peptide 2 receptor - Wikipedia
... is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like ... "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 ... "Entrez Gene: Glucagon-like peptide 2 receptor". Burrin DG, Petersen Y, Stoll B, Sangild P (Mar 2001). "Glucagon-like peptide 2 ... "Glucagon Receptor Family: GLP-2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
  https://en.wikipedia.org/wiki/Glucagon-like_peptide_2_receptor
*  Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase...
The trinitrophenyl group was specifically introduced into the epsilon-amino group of glucagon by reaction of N alpha-citraconyl ... glucagon with trinitrobenzenesulfonic acid. The N alpha-citraconyl blocking group was subsequently removed by acid treatme ... 0/Receptors, Cell Surface; 0/Receptors, Glucagon; 56-87-1/Lysine; 75285-60-8/N-trinitrophenylglucagon; 9007-92-5/Glucagon; EC ... the potency of glucagon in competing for glucagon-specific receptor sites in hepatic plasma membranes. Although the structure ...
  http://www.biomedsearch.com/nih/Effect-specific-trinitrophenylation-lysine-epsilon/6311099.html
*  Glp1r glucagon-like peptide 1 receptor [Mus musculus (house mouse)] - Gene - NCBI
Glp1r glucagon-like peptide 1 receptor [Mus musculus] Glp1r glucagon-like peptide 1 receptor [Mus musculus]. Gene ID:14652 ... Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME) Glucagon-type ligand receptors, organism-specific ... glucagon-like peptide 1 receptor. Names. GLP-1 receptor. GLP-1-R. ... glucagon-like peptide 1 receptorprovided by MGI. Primary source. MGI:MGI:99571 See related. Ensembl:ENSMUSG00000024027 Gene ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=21151924
*  Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques.
The purpose of this study was to determine whether GLP-1 receptors (GLP-1Rs) are found in the skin of healthy volun ... Recent case reports suggest that treatment with glucagon-like peptide-1 (GLP-1) agonists results in clinical improvement of ... The purpose of this study was to determine whether GLP-1 receptors (GLP-1Rs) are found in the skin of healthy volunteers and ... Recent case reports suggest that treatment with glucagon-like peptide-1 (GLP-1) agonists results in clinical improvement of ...
  http://www.biomedsearch.com/nih/Increased-expression-glucagon-like-peptide/23362875.html
*  Glucagon-Like Peptide 1 Receptor Research Areas: R&D Systems
Find Glucagon-Like Peptide 1 Receptor research area related information and Glucagon-Like Peptide 1 Receptor research products ... Glucagon-Like Peptide 1 Receptor Agonists * Glucagon-Like Peptide 1 Receptor Antagonists ...
  https://www.rndsystems.com/research-area/glucagon--like-peptide-1-receptor
*  Chelators - MP Biomedicals
Anti-Macrophage Scavenger Receptor, Human. *Anti-Melanoma Marker, Human. *Anti-Metalloproteinase 2, Human ... Anti-Glucagon, Human. *H*Anti-Haptoglobin, Human. *Anti-Hemagglutinin, 9 aa peptide ...
  http://www.mpbio.com/index.php?cPath=1_6_33_223&country=223
*  Patent US6122536 - Implantable sensor and system for measurement and control of blood ... - Google Patents
The algorithm may also control insulin pump 16 to release a glucagon bolus, (1 mg of glucagon, when blood glucose levels trend ... In addition, peripheral tissues of type II diabetics may possess a smaller number of membrane tissue receptors and possibly a ... Glucagon stimulates the liver to release large amounts of glucose from glycogen when the blood glucose concentration falls ... The pancreas also secretes glucagon, a hormone which has cellular functions that are diametrically opposed to those of insulin ...
  http://www.google.com.au/patents/US6122536