*  Effects of Delta-9-THC and Iomazenil in Healthy Humans - Full Text View - ClinicalTrials.gov
Cannabinoid Receptor Agonists. Cannabinoid Receptor Modulators. Neurotransmitter Agents. Molecular Mechanisms of ... Gamma-Amino Butyric Acid (GABA) Deficits and Vulnerability to Cannabinoid-Induced Psychosis. ...
  https://clinicaltrials.gov/ct2/show/NCT00982982
*  Plus it
1993) GABAA receptor needs two homologous domains of the β subunit for activation by GABA but not by pentobarbital. Nature ( ... The effects of GABAA receptor modulators were examined on control GABA responses using a concentration that elicited 20% of a ... GABA EC50, Hill coefficients, and sensitivity to zinc of GABAA receptors expressed in X. laevis oocytes ... 1993) Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA. Science (Washington D. C.) 262:256- ...
  http://molpharm.aspetjournals.org/content/52/5/874
*  Modulation of hECN GABAARs by intravenous anesthetics, | Open-i
... example trace showing potentiation of GABA-mediated whole-ce ... Ionotropic GABA and glycine receptor subunit composition in ... Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones. ... 1997), also potentiated GABA (EC30; 120 μm)-evoked currents by 75 ± 20 % (Fig. 3A and B; P = 0.01 vs. control, unpaired t test ... 1997), also potentiated GABA (EC30; 120 μm)-evoked currents by 75 ± 20 % (Fig. 3A and B; P = 0.01 vs. control, unpaired t test ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4215781_tjp0592-4353-f3&req=4
*  Phencyclidine-Induced Deficits in Prepulse Inhibition of Startle are Blocked by Prazosin, an Alpha-1 Noradrenergic Antagonist |...
The antagonists foralpha-2, for M1 and for GABA-A receptors had no effect on base-line PPI or on PCP-induced disruptions in PPI ... The purpose of the present investigation was to determine whether alpha-1,alpha-2, M1 or GABA-A receptors might be involved in ... In contrast to the results with prazosin, selective antagonists foralpha-2, M1 and GABA-A receptors failed to affect PCP- ... Specifically, we tested whether selective antagonists foralpha-1, alpha-2, M1 or GABA-A receptors (given individually) would ...
  http://jpet.aspetjournals.org/content/283/2/666.long
*  Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. - Nuffield Department of Clinical...
... we identified antibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAAR) in a patient whose ... Receptors, GABA-A ... Antibodies to GABAA receptor α1 and γ2 subunits: clinical and ... Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. ... we identified antibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAAR) in a patient whose ...
  https://www.ndcn.ox.ac.uk/publications/506532
*  Differential dendritic targeting of AMPA receptor subunit mRNAs in adult rat hippocampal principal neurons and interneurons -...
GABA)ergic interneurons. GluA1-4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in ... Minela Hadzic, Alexander Jack, Petra Wahle, Ionotropic glutamate receptors: Which ones, when, and where in the mammalian ... Next article in issue: Postsynaptic muscarinic m2 receptors at cholinergic and glutamatergic synapses of mouse brainstem ... Differential dendritic targeting of AMPA receptor subunit mRNAs in adult rat hippocampal principal neurons and interneurons. ...
  http://onlinelibrary.wiley.com/doi/10.1002/cne.23292/full
*  Baicalein - Wikipedia
Wang F, Xu Z, Ren L, Tsang SY, Xue H (2008). "GABA A receptor subtype selectivity underlying selective anxiolytic effect of ... Baicalein is also an antagonist of the estrogen receptor, or an antiestrogen. The flavonoid has been shown to inhibit certain ... It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic ... is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. ...
  https://en.wikipedia.org/wiki/Baicalein
*  Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and...
Our results strengthen the idea that GABA(A) receptors containing alpha6 subunits can function as extrasynaptic receptors ... Thy1alpha6 CA1 pyramidal neurons have a five-fold increased tonic GABA(A) receptor-mediated current compared with wild-type ... whereby increased tonic inhibition causes a compensatory decrease in synaptic GABA(A) receptor responses. ... Ligand binding and protein biochemistry show that most forebrain alpha6 subunits assemble as alpha6betagamma2-type receptors, ...
  https://www.neuroscience.ox.ac.uk/publications/329299
*  Thujone - Wikipedia
... a GABAA receptor positive allosteric modulator. By inhibiting GABA receptor activation, neurons may fire more easily, which can ... Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin Dettling A, Grass H, Schuff A, Skopp G, Strohbeck- ... Thujone acts on GABA as an antagonist (opposite to the effects of alcohol) and as a component of several essential oils, is ... These effects are in line with other GABA antagonists. Also, alpha-thujone is metabolized quickly in the liver in mice. ...
  https://en.wikipedia.org/wiki/Thujone
*  2013-05-15 12:11:33 PM
Alcohol affects the GABA receptors, among other things. Phencyclidine is an NMDB receptor antagonist. So yes, dumb comment. ...
  http://www.fark.com/comments/7750903/84223302
*  Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline | DIAL...
Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline. In: ... Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline Primary ... Home» Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:53966
*  Comparative Molecular Neurobiology by Y. Pichon | 9780817627850 | Hardcover | Barnes & Noble®
Pharmacology of the GABA receptor of insect central neurones in culture: A patch-clamp study.- GABA Receptor molecules of ... receptors containing an integral ionic channel), 2) metabotropic receptors (receptors coupled to G- proteins) and 3) voltage- ... Second messenger-linked receptors.- Structural and functional conservation of serotonin receptors throughout evolution.- The ... Acetylcholine receptor molecules of the nematode Caenorhabditis elegans.- Acetylcholine receptor/channel molecules of insects ...
  https://www.barnesandnoble.com/w/comparative-molecular-neurobiology-y-pichon/1101674810
*  Old HGNC Gene Families/Groupings Nomenclature (Archive) | HUGO Gene Nomenclature Committee
Frizzled receptors (FZD). *Fucosyltransferases (FUT). *GABA receptors *GABA(A) receptors (GABRA). *GABA(B) receptors (GABBR) ... 5-HT (serotonin) receptors (HTR) *5-HT (serotonin) receptors, G protein-coupled only ... Glucagon receptors. *Glutamate receptors (GR) *Glutamate receptors, ionotropic (GRI). *Glutamate receptors, metabotropic (GRM) ...
  https://www.genenames.org/genefamilies/a-z
*  A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure
Blockade of GABA receptors increases sensitivity to heat-induced seizures in GEFS+ flies. Reduced repetitive firing in GEFS+ ... Dual staining for GABA and intracellular biocytin: Above procedure modified to include overnight fixation of brains in 4% ... The GEFS+ flies were also more sensitive to heat-induced seizures after feeding with the GABAAR antagonist picrotoxin (PTX), an ... 3A). Immunostaining showed most LNs in this region were GABAergic and biocytin filled neurons were co-labeled with anti-GABA ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3482260/?lang=en-ca
*  anticonvulsants 49/50 Flashcards by Elizabeth DeGroot | Brainscape
GABA molecule bound to lipophillic hexane ring (crosses BBB). DOES NOT actually interact with GABA receptor, but suppress ... tiagabine: inhibit the re-uptake of GABA. vigabatrin: irreversible inhibitor of the GABA-degrading enzyme GABA transaminase ... Barbs (Phenobarbital and primidone) and benzos (clonazepam, diazepam) increase GABA effects at GABAa. ...
  https://www.brainscape.com/flashcards/anticonvulsants-49-50-4557840/packs/6272767
*  Drugs of Abuse Flashcards by MO ROUTH | Brainscape
Alcoholic patient tolerant to ethanol--> cross-tolerance to benzodiazepines - both drugs act at GABA receptors. ... CNS Depressants - via GABA activation +/- GLU inhibition. Respiratory depression, coma (extremely rare with BDZs). ETOH ... CNS Depressants - via GABA activation +/- GLU inhibition. Respiratory depression, coma (extremely rare with BDZs). ... CNS Stimulants - via activation of NE and DA receptors. SNS overactivity, increased HR-BP-temp, chest pain-MI, psychosis. ...
  https://www.brainscape.com/flashcards/drugs-of-abuse-4285382/packs/6402176
*  Patent US5800539 - Method of allogeneic hematopoietic stem cell transplantation without graft ... - Google Patents
Gaba receptor mediated modulation of neurogenesis. WO2010099217A1. Feb 24, 2010. Sep 2, 2010. Braincells, Inc.. Modulation of ... Gaba receptor mediated modulation of neurogenesis. EP2314673A1. Feb 13, 2002. Apr 27, 2011. Anthrogenesis Corporation. Post- ... 5 HT receptor mediated neurogenesis. US7799324. Sep 24, 2004. Sep 21, 2010. Geron Corporation. Using undifferentiated embryonic ... include the expression of a complex of proteins on their cell surfaces that include the CD3 antigen and the T cell receptor ( ...
  http://www.google.com/patents/US5800539?dq=4168396
*  Integrins, Synaptic Plasticity and Epileptogenesis | SpringerLink
GABA receptor function and epilepsy. Adv Neurol 1999; 79: 499-510.PubMedGoogle Scholar ... GABA(B) receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy. Br J Pharmacol 2001; ... Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in mouse model of mesial ... NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of ...
  https://link.springer.com/chapter/10.1007/978-1-4757-6376-8_2
*  KCNJ12 Gene - GeneCards | KCJ12 Protein | KCJ12 Antibody
GABA receptor activation. Activation of GABAB receptors .71 GABA B receptor activation ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNJ12
*  KCNJ3 Gene - GeneCards | KCNJ3 Protein | KCNJ3 Antibody
Activation of GABAB receptors. *G protein gated Potassium channels. *GABA B receptor activation ... This receptor plays a crucial role in regulating the heartbeat. *KCNJ3_HUMAN,P48549 ... potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNJ3
*  MAF1 Gene - GeneCards | MAF1 Protein | MAF1 Antibody
GABA receptor binding. IEA. --. Genes that share ontologies with MAF1: view Phenotypes for MAF1 Gene. MGI mutant phenotypes for ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=MAF1
*  GNAT3 Gene - GeneCards | GNAT3 Protein | GNAT3 Antibody
GABA receptor activation. Activation of GABAB receptors .71 GABA B receptor activation ... G-protein coupled receptor signaling pathway. IEA. --. GO:0007188. adenylate cyclase-modulating G-protein coupled receptor ... GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses ... GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=GNAT3
*  Lactobacillus rhamnosus | GreenMedInfo | Substance | Natural
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse.Sep 20, 2011. ...
  http://www.greenmedinfo.com/substance/lactobacillus-rhamnosus
*  Plus it
Metabotropic GABAB receptors are also expressed in SPNs (Whyment et al., 2004); therefore, the effect of the GABAB antagonist ... GABA receptor composition. Tonic inhibition in SPNs was enhanced by diazepam indicating that the receptor involved is likely to ... These receptors are located away from synapses and so are called perisynaptic or extrasynaptic receptors. A GABA-mediated tonic ... First, receptors are activated by low concentrations of background GABA. Ambient GABA could be from several different sources, ...
  http://www.jneurosci.org/content/28/47/12445