Frontiers | The Role of FcRn in Antigen Presentation | Immunology
In addition to the classical Fcγ receptors (FcγR) which bind IgG at the cell surface, the neonatal Fc receptor (FcRn) is a ... In addition to the classical Fcγ receptors (FcγR) which bind IgG at the cell surface, the neonatal Fc receptor (FcRn) is a ... The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an ... The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an ...https://www.frontiersin.org/articles/10.3389/fimmu.2014.00408/full
"Effects of immunoglobulin structure on fc receptor binding: a mouse my" by B K. Birshtein, R Campbell et al.
Birshtein, B K.; Campbell, R; and Diamond, B, "Effects of immunoglobulin structure on fc receptor binding: a mouse myeloma ... Effects of immunoglobulin structure on fc receptor binding: a mouse myeloma variant immunoglobulin with gamma2b-gamma2a hybrid ... with gamma2b-gamma2a hybrid heavy chain having a complete gamma2a fc region fails to bind to gamma2a fc receptors on mouse ... heavy chain having a complete gamma2a fc region fails to bind to gamma2a fc receptors on mouse macrophages. ...https://mouseion.jax.org/ssbb1982/205/
Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic...
Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic ... Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic ... These results suggested that the loss was not secondary to capping or interiorization of Fc receptors. The results of other ... This loss was not a result of inhibition of Fc receptors by solubilized complexes nor of release of soluble factors by the ...http://jem.rupress.org/content/151/1/32
Fc receptor - Wikipedia
FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR ... Only one Fc receptor belongs to the FcαR subgroup, which is called FcαRI (or CD89). FcαRI is found on the surface of ... All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing ... This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which ...https://en.wikipedia.org/wiki/Fc_receptor
Fcγ Receptors of Myeloid Cells | SpringerLink
Fc receptors (FcRs) are cell surface molecules that mediate interactions between cells and immunoglobulins. Phagocytic cells, ... Kurosaki, T., Gander, I., and Ravetch, J. V., 1991, A subunit common to an IgG Fc receptor and the T-cell receptor mediates ... and n chains of T-cell receptor and the chain of Fc receptors, Nature (London) 347: 189-191.Google Scholar ... Ratio of complement receptor over Fc-receptor III expression: A sensitive parameter to monitor granulocyte-macrophage colony- ...https://link.springer.com/chapter/10.1007/978-1-4757-9534-9_10
Fc receptor legal definition of Fc receptor
What is Fc receptor? Meaning of Fc receptor as a legal term. What does Fc receptor mean in law? ... Definition of Fc receptor in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Fc receptor legal definition of Fc receptor https://legal-dictionary.thefreedictionary.com/Fc+receptor ... receptor. (redirected from Fc receptor). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.. Related to Fc ...https://legal-dictionary.thefreedictionary.com/Fc+receptor
Neonatal Fc receptor - Wikipedia
The neonatal Fc receptor is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with ... The neonatal Fc receptor (FcRn), also known as the Brambell receptor, is a protein that in humans is encoded by the FCGRT gene ... Further studies revealed a similar receptor in humans, leading to the naming as a neonatal Fc receptor. In humans, however, it ... Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ. FcRn helps ...https://en.wikipedia.org/wiki/Neonatal_Fc_receptor
RCSB PDB - Protein Feature View - Immunoglobulin alpha Fc receptor - P24071 (FCAR HUMAN)
Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2. UniProt ... Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. UniProt ...http://www.rcsb.org/pdb/protein/P24071
Fc receptor-like molecule - Wikipedia
Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number ... FCRLB Fc receptor Davis RS (2007). "Fc receptor-like molecules". Annual Review of Immunology. 25: 525-60. doi:10.1146/annurev. ... Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. ... "Immunoregulatory Roles for Fc Receptor-Like Molecules". In Ahmed R, Honjo T. Negative Co-Receptors and Ligands. Current Topics ...https://en.wikipedia.org/wiki/Fc_receptor-like_molecule
Antibodies | Free Full-Text | Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21
This review summarises our current understanding of TRIM21's role as a cytosolic Fc receptor and briefly discusses pathological ... that traffic surface-bound antibodies into the cell during infection recruit TRIM21 via a high affinity interaction between Fc ... TRIM21 has emerged as an atypical Fc receptor that is broadly conserved and widely expressed in the cytoplasm of mammalian ... TRIM21 has emerged as an atypical Fc receptor that is broadly conserved and widely expressed in the cytoplasm of mammalian ...http://www.mdpi.com/2073-4468/5/4/21
Differential Effects of B Cell Receptor and B Cell Receptor-FcγRIIB1 Engagement on Docking of Csk to GTPase-activating Protein ...
... and inhibitory receptors such as Fcγ receptors of the IIB1 type (FcγRIIB1) intersect in ways that are poorly understood at the ... Mediating such signals at the B cell surface are stimulatory receptors such as the BCR and inhibitory receptors such as Fcγ ... Differential Effects of B Cell Receptor and B Cell Receptor-FcγRIIB1 Engagement on Docking of Csk to GTPase-activating Protein ... Differential Effects of B Cell Receptor and B Cell Receptor-FcγRIIB1 Engagement on Docking of Csk to GTPase-activating Protein ...http://jem.rupress.org/content/186/2/259
FCRL6 - Fc receptor-like protein 6 precursor - Homo sapiens (Human) - FCRL6 gene & protein
Does not act as an Fc receptor (PubMed:18991291). ... Acts as a MHC class II receptor (PubMed:20519654). When ... Fc receptor-like protein 6Add BLAST. 415. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... Cluster: Fc receptor-like protein 6. 19. Q6DN72-4. A0A2I3SB31. Pan troglodytes (Chimpanzee). 311. UniRef90_Q6DN72-4. Cluster: ... Cluster: Fc receptor-like protein 6. 42. Q6DN72-4. A0A2I3SB31. A0A2I3HFE7. Pan troglodytes (Chimpanzee). Nomascus leucogenys ( ...http://www.uniprot.org/uniprot/Q6DN72
Stimulatory Effects of Peroxisome Proliferator-Activated Receptor- on Fc Receptor-Mediated Phagocytosis by Alveolar Macrophages
... on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors ... Stimulatory Effects of Peroxisome Proliferator-Activated Receptor-. γ. on Fc. γ. Receptor-Mediated Phagocytosis by Alveolar ... "Stimulatory Effects of Peroxisome Proliferator-Activated Receptor-. on Fc Receptor-Mediated Phagocytosis by Alveolar ...https://www.hindawi.com/journals/ppar/2007/052546/cta/
CiNii 論文 - Fcγ Receptor Signaling in Phagocytes
Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II(Fc gamma RII) on monocytic cells activates a signal ... Inhibition of Fcγ receptor-mediated phagocytosis by a nonphagocytic Fcγ receptor HUNTER S ... Chimeric receptors composed of phosphoinositide 3-kinase domains and Fcγ receptor ligand-binding domains mediate phagocytosis ... The inositol 3-phosphatase PTEN negatively regulates Fcγ receptor signaling, but supports Toll-like receptor 4 signaling in ...http://ci.nii.ac.jp/naid/10018303865
Immature Neutrophils Mediate Tumor Cell Killing via IgA but Not IgG Fc Receptors | The Journal of Immunology
Mature neutrophils express FcαRI, but only low levels of FcγRI (16) (Fig. 1⇓A). To compare FcαRI- and FcγRI-mediated Ab therapy ... Differential effect of cytokine treatment on Fcα receptor I- and Fcγ receptor I-mediated tumor cytotoxicity by monocyte-derived ... Ex vivo triggering of FcαRI and FcγRI on mouse blood and bone marrow cells. Expression levels of FcαRI (bold line) and FcγRI ( ... To study whether the observed differences between FcαRI- and FcγRI-mediated ADCC could be extrapolated to FcαRI × FcγRI doublehttp://www.jimmunol.org/content/174/9/5472.long
Immunoglobulin G Fc Receptor-Mediated Clearance in Autoimmune Diseases | Annals of Internal Medicine | American College of...
Immunoglobulin G Fc Receptor-Mediated Clearance in Autoimmune Diseases MICHAEL M. FRANK, M.D.; THOMAS J. LAWLEY, M.D.; MAX I. ... Immunoglobulin G Fc Receptor-Mediated Clearance in Autoimmune Diseases. Ann Intern Med. 1983;98:206-218. doi: 10.7326/0003-4819 ... Studies in patients with active systemic lupus erythematosus show a profound defect in Fc-receptor-specific clearance that ... Patients with other autoimmune diseases have defects in Fc receptor functional activity when their illness is characterized by ...http://annals.org/aim/article-abstract/696264/immunoglobulin-g-fc-receptor-mediated-clearance-autoimmune-diseases
The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. | The Journal of Immunology
The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation.. D Maurer, C Ebner, B Reininger, E ... The discovery that the high affinity IgE receptor (Fc epsilon RI) is expressed on APCs of patients with atopic diseases raised ... The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. ... The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. ...http://www.jimmunol.org/content/154/12/6285.long
A field guide to human Fc-gamma receptors
In many cases this process occurs via cellular receptors for IgG on immune cells, the Fc-gamma receptors (FcγRs). These ... Chapter 7: Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human ... Chapter 2: Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus ... A field guide to human Fc-gamma receptors. Subtitle. Genetics, cellular expression and interaction with immunoglobulins. ...http://dare.uva.nl/search?identifier=d6aaf779-527d-4352-8378-96e4683ba49c
Towards IVIg mimetics: Understanding the interplay between complement and Fc receptor signalling in secondary injury after SCI
Towards IVIg mimetics: Understanding the interplay between complement and Fc receptor signalling in secondary injury after SCI ... we will treat SCI mice with just the specific portion of the immunoglobulin molecule that binds these receptors (i.e. the Fc ... Methods and expected results: Immunoglobulin molecules can modulate the inflammatory response by binding to specific receptors ...http://www.wingsforlife.com/en/research/towards-ivig-mimetics-understanding-the-interplay-between-complement-and-fcreceptor-signalling-in-secondary-injury-after-sci-3114/
A Soluble Form of the High Affinity IgE Receptor, Fc-Epsilon-RI, Circulates in Human Serum
In summary, we here describe the alpha-chain of Fc\(\epsilon\)RI as a circulating soluble IgE receptor isoform in human serum. ... A soluble form of the high affinity IgE receptor, Fc-Epsilon-RI, Circulates in Human Serum. PLoS ONE 6(4): e19098. ... A Soluble Form of the High Affinity IgE Receptor, Fc-Epsilon-RI, Circulates in Human Serum. ... Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic ...https://dash.harvard.edu/handle/1/5084272
Fcγ receptors in cancer and infectious disease | Springer for Research & Development
IgG Fc receptors provide an interface between specific humoral immunity and FcγR-bearing host cells. FcγR trigger such diverse ... Petroni KC, Shen L, Guyre PM: Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated ... IgG Fc receptors provide an interface between specific humoral immunity and FcγR-bearing host cells. FcγR trigger such diverse ... Fc receptors for IgG on human monocytes and macrophages are not infectivity receptors for HIV. Proc Natl Acad Sci USA 1991;88: ...https://rd.springer.com/article/10.1007/BF02919127
Suppressors of Cytokine Signaling Regulate Fc Receptor Signaling and Cell Activation during Immune Renal Injury | The Journal...
... the common activation subunit required for surface assembly and signaling of some Fc receptors (FcεRI, FcγRI, FcγRIII, and Fc ... Both kinases are implicated in signaling via T cell and B cell Ag receptors and IgG receptors (FcγR) (17, 18), thus suggesting ... Tec kinases associate with multiple cell surface receptors, including Ag receptor and FcεR (17, 18), and are able to interact ... Similar to other immunoreceptor tyrosine-based activation motif-containing receptors, such as the TCR, FcγRI and FcγRIII ...http://www.jimmunol.org/content/172/11/6969
Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function -...
... wherein said Fc receptor is Fc activating receptor. 13. A method according to claim 11, wherein said Fc receptor is FcγRIIIA ... the increased Fc receptor binding affinity is increased binding to a Fcγ activating receptor, such as the FcγRIIIa receptor. ... The increased Fc receptor binding affinity is preferably increased binding to Fc activating receptors such as FcγRIIIa. ... and the increased Fc receptor binding is increased binding to an Fc activating receptor such as FcγRIIIA. Preferably, the ...http://www.freepatentsonline.com/8859234.html
Characteristics and interrelation of two types of immunoglobulin G Fc receptors on human monocytes | Biochemical Society...
Characteristics and interrelation of two types of immunoglobulin G Fc receptors on human monocytes. JAN G. J. van de WINKEL, ... Characteristics and interrelation of two types of immunoglobulin G Fc receptors on human monocytes ... Characteristics and interrelation of two types of immunoglobulin G Fc receptors on human monocytes ... Characteristics and interrelation of two types of immunoglobulin G Fc receptors on human monocytes ...http://www.biochemsoctrans.org/content/16/5/734
Heartache of Fc Receptors | JACC: Journal of the American College of Cardiology
... including 3 high-affinity and 5 low-affinity receptors (12). All these Fcγreceptors, with the exception of Fcγreceptor IIb ( ... A role of Fc receptors in autoimmunity has been supported by knock out and transgenic experiments (11). Eight Fcγreceptors have ... γreceptors in DCM. Although there are limitations with their investigation, the study of the role of Fc receptors by Staudt et ... Heartache of Fc Receptors Message Subject (Your Name) has forwarded a page to you from JACC: Journal of the American College of ...http://www.onlinejacc.org/content/49/16/1693